22 Results Found

The aim of the study is to formulate an injectable nanocrystalline suspension (NS) of dutasteride (DTS), a hydrophobic 5α-reductase inhibitor used to treat benign prostatic hyperplasia and scalp hair loss, for parenteral long-acting delivery. A...

We attempted to design irbesartan nanocrystalline (IRB-NC) suspensions by the bead mill method, and we evaluated the bioavailability (BA) in the oral administration of the nanocrystalline drug. The mean particle size of the IRB-NC suspensions was app...

The viscous rheological behavior of suspensions of mixtures of fumed silica nanoparticles (N20) and rod-shaped cellulose nanocrystals (NCC) were studied experimentally. The fumed silica concentration varied from 2 to 11.3 wt% and the NCC concentratio...

The steady shear rheology of suspensions of mixtures of rod-shaped cellulose nanocrystals (NCC) and spherical starch nanoparticles (SNPs) was investigated experimentally over a broad range of NCC and SNP concentrations. The NCC concentration varied f...

In response to the demand for new multifunctional materials characterized by high biocompatibility, hydrogel (HG) nanocomposites as a platform for bioactive compound delivery have been developed and fabricated. A specific crosslinking/copolymerizatio...

We previously reported that the bioavailability (BA) of irbesartan (IRB), a BSC class II drug, was improved by preparing nanocrystalline suspensions. However, nanocrystalline suspensions have chemical and physical instabilities and must be converted...

In the present work, the microstructure and rheological behavior of nanocrystalline cellulose (NCC) and cationically modified NCC (CNCC) were comparatively studied. The resultant CNCC generally showed improved dispersion and higher thermal stability...

One challenge for 3D printing is that the mortar must flow easily through the printer nozzle, and after printing, it must develop compressive strength fast and high enough to support the layers on it. This requires an exact and difficult control of t...

Electrostatic self-assembly of diamond nanoparticles (DNPs) onto substrate surfaces (so-called nanodiamond seeding) is a notable technique, enabling chemical vapor deposition (CVD) of nanocrystalline diamond thin films on non-diamond substrates. In t...

Biodegradable ionic polymer metallic composite (IPMC) electroactive polymers (EAPs) were fabricated using poly(ethylene oxide) (PEO) with various concentrations of lithium perchlorate. Nanocrystalline cellulose (NCC) rods created from a sulfuric acid...

In this work, sulfonated polyetheretherketone (S-PEEK)-based coatings, nanocrystalline ZnS and hydroxyapatite (n-HA) particles were developed on Zr-2.5Nb zirconium alloy substrates by electrophoretic deposition (EPD) combined with subsequent heat tre...

The purpose of this study was to utilize cellulose from tea waste as nanocrystalline cellulose (NCC), which is used as a filler in poly(vinyl) alcohol (PVA) nanocomposites. To obtain the NCC, a chemical process was conducted in the form of alkali tre...

Efficient production of nanocrystalline hydroxyapatite with desirable properties is a key focus in research on nanomaterials based on this mineral. It has been shown that, in the widely used wet synthesis method, fundamental factors such as the choic...

The main goal of the present work was to synthesize a composite consisting of h-BN particles coated with a γ-Al2O3 nanolayer. A method was proposed for applying nanocrystalline γ-Al2O3 to h-BN particles using a sol–gel technique, wh...

While porous silica supports have been previously studied as carriers for nanocrystalline forms of poorly water-soluble active pharmaceutical ingredients (APIs), increasing the loading of API in these matrices is of great importance if these carriers...

The optical behavior exhibited by bimetallic nanoparticles was analyzed by the influence of ultrasonic and nonlinear optical waves in propagation through the samples contained in an ethanol suspension. The Au-Pt nanoparticles were prepared by a sol-g...

Comminution of BCS II APIs below the 1 μm threshold followed by solidification of the obtained nanosuspensions improves their dissolution properties. The breakage process reveals new crystal faces, thus creating altered crystal habits of improved wet...

The sol-gel process was used to create titanium dioxide (TiO2) nanoparticles, a nanocrystalline semiconductor. How several synthesis factors, such as titanium precursor concentration, annealing temperature, and peptization temperature, affected the s...

Nanocomposite powders based on metal-coated graphene were synthesized using an in-situ co-reduction method in order to improve wettability and interfacial bonding between graphene and metal. Graphene oxide (GO) of 2~3 atomic layers was synthesized us...

In the frame of the nanoarchitectonic concept, the objective of this study was to develop simple and easy methods to ensure the preparation of polymorphic HfO2 thin film materials (<200 nm) having the best balance of patterning potential, reproduc...

This study aimed to construct a pH-responsive nanocrystalline hydrogel drug delivery system for topical delivery of insoluble drugs based on the self-assembly behavior of carboxymethyl chitosan (CMC) and oxidized hyaluronic acid (OHA). The tanshinone...

Background: Nanocrystals, a carrier-free nanotechnology, offer significant advantages for pulmonary drug delivery by enhancing the dissolution and solubility of poorly soluble drugs while maintaining favorable biological properties and low toxicity....