Search Results (484)

Increasing evidence demonstrates the mutualistic connection between the microbiome and acute myeloid leukemia (AML) treatment. Drugs disrupt the microbial balance and, conversely, changes in the microbiome influence therapy. A new field, pharmacomicrobiomics, examines the role of the microbiome in pharmacokinetics, pharmacodynamics, and drug toxicity. The multimodal therapeutic management of AML, along with disease-related immunosuppression, infection, and malnutrition, creates the unique microbial profile of AML patients, in which every delicate modification plays a crucial role in pharmacotherapy. While both preclinical and real-world data have confirmed a bilateral connection between standard chemotherapy and the microbiome, the impact of novel targeted therapies and immunotherapy remains unknown. Multi-omics technologies have provided qualitative and mechanistic insights into specific compositional and functional microbial signatures associated with the outcomes of AML therapy, but require a large-scale investigation to draw reliable conclusions. In this review, we outline the role of the microbiome within the therapeutic landscape of AML, focusing on the determinants of post-treatment dysbiosis and its effects on the therapeutic response and toxicity. We explore emerging strategies for microbiota modulation, highlighting their safety and efficacy. Advances in microbiome-based approaches are an inevitable step toward precision medicine in AML. However, clinical research in a well-defined group of immunocompromised patients is needed to study their variable effects on human health and determine safety issues. Full article

Leaf phenology is key to ecosystem functioning by regulating carbon, water, and energy fluxes and influencing vegetation productivity. Yet, detecting land surface phenology (LSP) in drylands using remote sensing remains particularly challenging due to sparse and heterogeneous vegetation cover, high spatiotemporal variability, and complex spectral signals. Unlike the Northern Hemisphere, these challenges are further compounded in the Southern Hemisphere (SH), where several regions experience year-round moderate temperatures. When combined with irregular rainfall, this leads to highly variable vegetation activity throughout the year. However, LSP dynamics in the SH remain poorly understood. This study presents a review of remote sensing-based phenology research in drylands, integrating (i) a synthesis of global methodological advances and (ii) a systematic analysis of peer-reviewed studies published from 2015 through April 2025 focused on SH drylands. This review reveals a research landscape still dominated by conventional vegetation indices (e.g., NDVI) and moderate-spatial-resolution sensors (e.g., MODIS), though a gradual shift toward higher-resolution sensors such as PlanetScope and Sentinel-2 has emerged since 2020. Despite the widespread use of start- and end-of-season metrics, their accuracy varies greatly, especially in heterogeneous landscapes. Yet, advanced products such as solar-induced chlorophyll fluorescence or the fraction of absorbed photosynthetically active radiation were rarely employed. Gaps remain in the representation of hyperarid zones, grass- and shrub-dominated landscapes, and large regions of Africa and South America. Our findings highlight the need for multi-sensor approaches and expanded field validation to improve phenological assessments in dryland environments. The accurate differentiation of vegetation responses in LSP is essential not only for refining phenological metrics but also for enabling more realistic assessments of ecosystem functioning in the context of climate change and its impact on vegetation dynamics. Full article

Gastric cancer remains a major global health challenge, largely due to its biological heterogeneity and limited treatment options for advanced stages. Among the numerous molecular players involved in its pathogenesis, galectins—β-galactoside-binding lectins—have emerged as key modulators of tumor behavior. These multifunctional proteins influence diverse processes including cell proliferation, invasion, immune evasion, stromal remodeling, and therapy resistance. Recent advances in experimental and clinical research have shed light on the complex roles of galectin family members—particularly Galectin-1, -3, and -9—in shaping the tumor microenvironment and driving disease progression. This review highlights the current understanding of galectin biology in gastric cancer, with emphasis on their structural characteristics, cellular localization, functional diversity, and translational relevance. By synthesizing insights from molecular studies and clinicopathological observations, we explore the potential of galectins as biomarkers and therapeutic targets in the evolving landscape of gastric cancer research. Full article

Background/Objectives: The integration of natural compounds in cancer research marked a crucial shift in the modern medical landscape, through a growing acknowledgment of their potential as efficient, less toxic, and cost-effective alternatives to contemporary chemotherapeutics. Liquiritigenin (LIQ) is a compound obtained from different plants, the most important being the Glycyrrhiza species, commonly known as licorice. Methods: This review compiles findings from previously published preclinical studies and experimental research articles focusing on LIQ’s pharmacological effects, with particular attention to its anticancer potential. The relevant literature was identified using established scientific databases and selected based on relevance to cancer biology and LIQ-associated signaling pathways. Results: LIQ demonstrates anti-oxidant, anti-inflammatory, and anti-proliferative effects. It exerts its potential anticancer activities by inducing apoptosis, preventing cell proliferation, and modulating various signaling pathways such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), phosphoinositide 3 kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), and so on. Conclusions: LIQ represents a promising natural agent for cancer therapy, with evidence supporting its multifunctional role in targeting tumor growth and survival mechanisms. By providing a detailed analysis of LIQ, this review aims to highlight its therapeutic efficacy across various cancer types and emphasize its importance as a promising compound in cancer research. In addition, this review seeks to bridge the gap between traditional medicine and modern pharmacology and paves the way for LIQ’s clinical application in cancer therapy. Full article

Tainan’s Cigu, located on Taiwan’s southwestern coast, is a prominent aquaculture hub known for its extensive ponds, tidal flats, and lagoons. This study explored the novel integration of kayaking within aquavoltaic (APV) aquaculture ponds, creating a unique hybrid tourism landscape that merges industrial land use (aquaculture and energy production) with nature-based recreation. We investigated the relationships among facility maintenance and safety professionalism (FM), the perceived value of kayaking training (PV), and green energy and sustainable development recognition (GS) within these APV systems in Cigu, Taiwan. While integrating recreation with renewable energy and aquaculture is an emerging approach to multifunctional land use, the mechanisms influencing visitors’ sustainability perceptions remain underexplored. Using data from 613 kayaking participants and structural equation modeling, we tested a theoretical framework encompassing direct, mediated, and moderated relationships. Our findings reveal that FM significantly influences both PV (β = 0.68, p < 0.001) and GS (β = 0.29, p < 0.001). Furthermore, PV strongly affects GS (β = 0.56, p < 0.001). Importantly, PV partially mediates the relationship between FM and GS, with the indirect effect (0.38) accounting for 57% of the total effect. We also identified significant moderating effects of APV coverage, guide expertise, and operational visibility. Complementary observational data obtained with underwater cameras confirm that non-motorized kayaking causes minimal ecological disturbance to cultured species, exhibiting significantly lower behavioral impacts than motorized alternatives. These findings advance the theoretical understanding of experiential learning in novel technological landscapes and provide evidence-based guidelines for optimizing recreational integration within production environments. Full article

Psoriasis is a chronic, immune-mediated inflammatory skin disease with complex genetic, environmental, and immunological determinants. Beyond the skin, it affects multiple systems, including the joints and cardiovascular system. A hallmark of psoriasis is an overactivation of the innate and adaptive immune responses, leading to dysregulated cytokine signaling, altered keratinocyte function, and aberrant expression of structural and regulatory proteins. In recent years, growing attention has been given to the skin as a neuro–immuno–endocrine organ, with evidence showing the role of stress-related neuropeptides, UVB-induced immune modulation, and vitamin D signaling in the disease pathogenesis. This review highlights emerging evidence on key multifunctional proteins—elafin, chemerin, and NAMPT (visfatin)—that exert both pro- and anti-inflammatory actions. Although still underexplored, these molecules appear to contribute significantly to the psoriatic microenvironment by modulating inflammation, immunity, and skin barrier function. Their dual roles suggest complex interactions within the cutaneous immune–neuroendocrine network, positioning them as potential biomarkers or therapeutic targets in psoriasis. By integrating insights into classical and emerging mediators, this review aims to provide a comprehensive perspective on the evolving landscape of psoriasis pathophysiology. Full article

Isolated wetlands, as a unique type of wetland, play a key ecological role in hydrological regulation, carbon storage, and biodiversity conservation. Although many studies have been conducted on the monitoring and ecological function assessment of isolated wetlands, a comprehensive and critical review is still lacking. Through a systematic analysis of the literature from the past two decades, we found despite the large number of existing studies on isolated wetlands, direct comparison between them is often difficult due to differences in definitions. Second, human activities and climate change are the primary factors affecting wetland hydrology and leading to wetland isolation in the short term. Third, remote sensing and landscape models serve as basic tools for monitoring and analyzing isolated wetlands, but the low temporal and spatial accuracy of relevant data, along with the short research time spans, limit in-depth studies. Finally, isolated wetlands have multiple ecological functions that exhibit spatial heterogeneity and change over time. In summary, isolated wetlands have indispensable ecological functions that are currently underestimated. It is necessary to scientifically define the concept of isolated wetlands, improve the capability and accuracy of long-term dynamic monitoring, and conduct multi-functional coupling research in the future. Additionally, when formulating future wetland protection and management strategies, attention should be paid to isolated wetlands, and the temporal and spatial differences in their ecological benefits should be considered. Full article

This paper systematically reviews the progress of remote-sensing technology in coastal-ecosystem health assessment. Coastal ecosystems, as transitional zones between land and ocean, play vital roles in maintaining biodiversity, carbon sequestration, and coastal protection, but currently face severe challenges from climate change and human activities. Remote-sensing technology, with its capability for large-scale, long time-series observations, has become a key tool for coastal-ecosystem health assessment. This paper analyzes the technical characteristics and advantages of optical remote sensing, radar remote sensing, and multi-source data fusion in coastal monitoring; constructs a health-assessment framework that includes water-quality indicators, vegetation and ecosystem function indicators, and human disturbance and landscape change indicators; discusses the application of advanced technologies from traditional methods to machine learning and deep learning in data processing; and demonstrates the role of multi-temporal analysis in revealing coastal-ecosystem change trends through typical case studies of mangroves, salt marshes, and coral reefs. Research indicates that, despite the enormous potential of remote-sensing technology in coastal monitoring, it still faces challenges such as sensor limitations, environmental interference, and data processing and validation. Future development should focus on advanced sensor technology, platform innovation, data-processing method innovation, and multi-source data fusion, while strengthening the effective integration of remote-sensing technology with management practices to provide scientific basis for the protection and sustainable management of coastal ecosystems. Full article

Urban forests have a definition that has developed over time. Initially defined as urban greenery or as a measure of human impacts from urbanisation on forest systems, urban forests have varying definitions and are more often referred to for urban greenery. This urban greenery and measures of outcomes in sustainability terms are in urban landscapes and surroundings. With more specific definitions according to forest system definitions the complexity, multiple functions and advanced outcomes and functions of urban forest systems compared to other urban green space (UGS) types is more clearly understood. This article, using a literature review, discusses the definition of urban forests influencing how their impacts are measured, expected, and optimised. With clarified definitions, urban forest quality is considered in the literature review by search terms and topics of selected articles. Examples of selected indicators of the quality of urban forests and then of software and metrics used to plan and design urban greenery are presented. Refined wilding as a concept for urban functional biodiversity is then compared and used as a conceptual frame to analyse findings and prove the relevance and contribution of knowledge of the concept itself. Indicators of measures are provided, and they lead to a suggestion for clearer defining of urban forests. The findings can influence planning, design, implementation, and evaluation of urban forests as a higher-quality UGS type with multiple functions. Urban forests require improved defining of the value, quality, and coverage of their UGS type to be optimised. Refined wilding can give conceptual guidance for understanding the multiple and advanced functions that urban forest biodiversity provides for urban landscapes and populations. Urban tree canopy and urban forest systems in an urban landscape, as compared to other UGSs that connect to forested areas, either urban or peri-urban, are important differentiating definitional factors. Different metrics encourage a measure of this difference. The human realities of an urban landscape and population will determine whether and how a forest system can exist in a suburban landscape and are influential as to whether an urban tree canopy compared to a multifunctional diverse stratified semi-natural system of wild native and non-native varieties is established and can be maintained. The importance of maintaining newly established and existing urban forests and trees is a significant factor. Full article

Urbanisation and land-use change are among the main pressures on soil health in periurban areas, but the multifunctionality of grassland soils is still not sufficiently recognised. In this study, the physical and chemical properties of soils under grassland, forest and croplands in the periurban area of Zagreb were investigated in a two-year period. Grasslands consistently exhibited multifunctional benefits, including high organic matter content (4.68% vs. 2.24% in cropland), improved bulk density (1.14 vs. 1.24 g cm⁻³) and an active carbon cycle indicated by increased CO₂ emissions (up to 1403 kg ha⁻¹ day⁻¹ in 2021). Forest soils showed the highest aggregate stability (91.4%) and infiltration (0.0006 cm s⁻¹), while croplands showed signs of structural degradation with the highest bulk density and lowest water retention (39.9%). Temporal variation showed that grassland was particularly responsive to favourable climatic conditions, with soil porosity and water content improving yearly. Principal component analysis showed that soil structure, biological activity and moisture regulation were linked, with grassland plots favourably positioned along the axes of resilience. The absence of tillage and the presence of permanent vegetation cover contributed to their high capacity for climate and water regulation and carbon sequestration. These results emphasise the importance of protecting and managing grasslands as an important component of urban green areas. Practices such as mulching, minimal disturbance and continuous cover can maximise the ecosystem services of grassland soils. In addition, the results highlight the potential risk of trace metal accumulation in cropland and grassland soils located near urban and farming infrastructure, underlining the need for regular monitoring in periurban environments. Integrating grassland functions into urban planning and policy is essential for improving the sustainability and resilience of periurban landscapes. Full article

Biodiversity conservation plays a pivotal role in achieving sustainable development and fostering harmonious coexistence between humans and nature. This study identifies avian conservation priority areas across China by analyzing multi-dimensional biodiversity, incorporating species diversity, functional diversity, and phylogenetic diversity. Through systematic conservation planning using Zonation version 4 software, we delineated priority areas across these diversity dimensions. Our results demonstrate a distinct south-to-north diversity gradient in China’s avifauna, with functional and phylogenetic diversity hotspots concentrated in Yunnan Province, the Hengduan Mountains, Hainan Island, Taiwan Island, and southeastern coastal regions. The identified priority conservation areas cover 14.6% of China’s terrestrial territory, protecting 89.8% of the country’s bird species—including 93.5% of endemic species and 88.9% of critically endangered species. Notably, existing nature reserves encompass merely 8.1% of these priority areas, revealing substantial conservation gaps within the current protection framework. Building upon China’s 3C Zoning Framework (Cities and farms, Shared landscapes, and Large wild areas), we propose zone-specific conservation strategies, with particular emphasis on strengthening protected area networks in the eastern coastal regions and the middle-lower Yangtze River basin, where urbanization pressures are most acute. These findings highlight the critical importance of incorporating multi-dimensional diversity in conservation planning and offer novel perspectives for optimizing China’s protected area system. Full article

The sole function of cultivated land of agricultural production is insufficient to meet the diverse demands of modern agriculture. To address land-use conflicts and achieve the United Nations Sustainable Development Goals (SDGs) of zero hunger and reduced carbon emissions by 2030, this study introduces the theory of land sparing and sharing, uses landscape indices to identify spatially fragmented areas, employs a four-quadrant model to assess the matching status of functional supply and demand, and applies correlation analysis to determine the trade-off/synergy relationships between functions. The results indicate the following: (1) Zhengzhou’s farmland landscape exhibits characteristics of low density, low continuity, and high aggregation, with separation zones and sharing zones accounting for 77% and 23% of the total farmland area, respectively. (2) The multifunctional supply (high in the northeast, low in the southwest) and demand (high in the west, low in the east) of farmland show significant mismatches, with PF and EF exhibiting the most pronounced supply–demand mismatches. The “LS-LD and HS-LD” types of farmland account for the largest proportions, at 39% and 35%, respectively. (3) The study area is divided into four primary types: “PCZ, RLZ, BDZ, and MAZ” to optimize supply–demand relationships and utilization patterns. This study enriches the application of land sparing and sharing in related fields, providing important references for policymakers in optimizing land-use allocation and balancing food and ecological security. Full article

The northern foothills of the Qinling Mountains, a critical ecological barrier and urban–rural transition zone in China, face intensifying rainstorm–flood disasters under climate extremes and rapid urbanization. This study pioneers a remote sensing-driven, dynamically coupled framework by integrating multi-source satellite data, system resilience theory, and spatial modeling to develop a novel “risk identification–resilience assessment–scenario simulation” chain. This framework quantitatively evaluates the nonlinear response mechanisms of town–village systems to flood disasters, emphasizing the synergistic effects of spatial scale, morphology, and functional organization. The proposed framework uniquely integrates three innovative modules: (1) a hybrid risk identification engine combining normalized difference vegetation index (NDVI) temporal anomaly detection and spatiotemporal hotspot analysis; (2) a morpho-functional resilience quantification model featuring a newly developed spatial morphological resilience index (SMRI) that synergizes landscape compactness, land-use diversity, and ecological connectivity through the entropy-weighted analytic hierarchy process (AHP); and (3) a dynamic scenario simulator embedding rainfall projections into a coupled hydrodynamic model. Key advancements over existing methods include the multi-temporal SMRI and the introduction of a nonlinear threshold response function to quantify “safe-fail” adaptation capacities. Scenario simulations reveal a reduction in flood losses under ecological priority strategies, outperforming conventional engineering-based solutions by resilience gain. The proposed zoning strategy prioritizing ecological restoration, infrastructure hardening, and community-based resilience units provides a scalable framework for disaster-adaptive spatial planning, underpinned by remote sensing-driven dynamic risk mapping. This work advances the application of satellite-aided geospatial analytics in balancing ecological security and socioeconomic resilience across complex terrains. Full article

This paper explores how sound design in the Harry Potter film series shapes the symbolic significance of written words within the magical world. Sound mediates between language and meaning; while characters gain knowledge by reading and seeing, viewers are guided emotionally and thematically by how these written texts are framed through sound. For example, Harry’s magical identity is signalled to viewers through the score long before he fully understands himself—first through music when he speaks to a snake, then more explicitly when he receives his letter from Hogwarts. Throughout the series, characters engage with a wide array of written media—textbooks, letters, newspapers, diaries, maps, and inscriptions—that gradually shift in narrative function, from static props to dynamic, multi-sensory agents of transformation. Using a close analysis of selected scenes to examine layers of utterances, diegetic sounds, underscore, and sound design, this study draws on metaphor theory and adaptation theory to examine how sound design gives writing a metaphorical voice, sometimes framing it as character, landscape, or moral authority. As the series progresses, becoming more autonomous from the literary source, written words take on greater symbolic significance, and sound increasingly determines which texts are granted narrative power, whose voices are trusted, and how viewers interpret truth and agency across media. Ultimately, written words in the films are animated through sound into agents of growth, memory, resistance, and transformation. Thus, the audio-visual treatment of written magic reveals not just what is written, but what matters. Full article

This study explores the ways in which Canadian teachers construe the complexity of citizenship education, utilizing the key concepts of affect and difficult knowledge to examine the challenges to democratic citizenship within increasingly diverse intercultural societies. The findings from the semi-structured qualitative interviews with six social studies teachers reveal how affective dynamics emerge prominently as they grapple with tensions between idealized conceptions of multi- and intercultural citizenship and ongoing challenging issues (e.g., social inequality and exclusion). The findings reveal a problematic pattern of antinomical attitudes as a dilemma—where teachers outwardly acknowledge ethical obligations to address ongoing injustices while simultaneously resisting the deeper structural changes necessary for sustainable intercultural societies. In doing so, this study illuminates how affective dynamics function as an onto-epistemological power behind social production that shapes our cognitive rational deliberations on citizenship and undergirding ideology(ies). These findings offer critical insights into the ethical challenges of education for sustainable intercultural societies amid a global landscape where extreme nationalism intertwines with neoliberal market-driven imperatives. This study thus provides implications for critical pedagogical approaches for citizenship that embrace myriad affective dynamics to create transformative learning spaces for citizenship education, particularly in addressing systemic inequalities. Such approaches could pave pathways toward acts of citizenship to disrupt already defined orders, practices, and statuses so integrally as to make claims for justice. Full article