Search Results (5)

Background/Objectives: Contrast-enhanced ultrasound (CEUS) is a non-invasive imaging technique with similar accuracy to CT and MRI for the diagnosis of hepatocellular carcinoma (HCC). CEUS offers several advantages in patient populations who have contraindications for CT or MRI. There are limited prospective studies in the United States evaluating the diagnostic equivalence of CEUS following transcatheter arterial chemoembolization (TACE) with same-day CT/MRI. This prospective pilot study compared CEUS and CT/MRI in patients with HCC following TACE in a United States population using Lumason^® contrast agent and the Liver Reporting and Data System (LI-RADS). Methods: Following institutional review board protocols, adult patients with a diagnosis of HCC were included. Follow-up CT/MRI was directed by referring clinicians, and CEUS was performed on the same day. CEUS was used to evaluate for treated lesion(s), new lesion(s), and portal vein thrombus before and after Lumason^®. Any subsequent follow-up imaging was reviewed. Results: In 26 enrolled patients, 33 target lesions were identified (size range 0.9–16.8 cm), and 26 were LI-RADS-5 or -M. CEUS identified 19 cases of residual tumor, 12 with no viable disease; CT/MRI identified 17 cases of residual tumor, 16 with no viable disease (p = 0.617). Both CEUS and CT/MRI identified five portal vein thrombi. Two lesions were missed or miscategorized on CEUS, while six were missed or miscategorized on CT/MRI (p = 0.289). Six new lesions were identified on both CEUS and CT/MRI. Of these new lesions, four were identified only by CT/MRI and three only by CEUS. Conclusions: CEUS is comparable to CT/MRI performed at identical follow-up intervals in evaluating for residual versus treated HCC following first-time TACE. Full article

Recent above-normal temperatures, which exacerbated the impacts of precipitation deficits, are recognized as the primary driver of droughts in the Upper Colorado River Basin (UCRB), USA. This research aims to enhance drought prediction models by addressing structural changes in non-stationary temperature time series and minimizing drought misclassification through the ES-CBS-SVR model, which integrates ESSVR and CBS-SVR. The research investigates whether this coupling improves prediction accuracy. Furthermore, the model’s performance will be tested in a region distinct from those originally used to evaluate its generalizability and effectiveness in forecasting drought conditions. We used a change point detection technique to divide the non-stationary time series into stationary subsets. To minimize the chances of drought mis-categorization, category-based scoring was used in ES-CBS-SVR. In this study, we tested and compared the ES-CBS-SVR and SVR models in the Upper Colorado River Basin (UCRB) using data from the Global Land Data Assimilation System (GLDAS), where the periods 1950–2004 and 2005–2014 were used for training and testing, respectively. The results indicated that ES-CBS-SVR outperformed SVR consistently across of the drought indices used in this study in a higher portion of the UCRB. This is mainly attributed to variable hyperparameters (regularization constant and tube size) used in ES-CBS-SVR to deal with structural changes in the data. Overall, our analysis demonstrated that the ES-CBS-SVR can predict drought more accurately than traditional SVR in a warming climate. Full article

This essay presents a substantive Thomist response to neurophilosophy’s main experimental challenge to free will: the Libet-style experiments on the neural antecedents of conscious voluntary actions. My response to this challenge will disclose that Thomists are rationally justified in rejecting both the conclusions of neurophilosophy skeptics of free will, and more fundamentally, the rival philosophical conceptions of voluntary action and free will that were chosen to be operationalized in these neuroscientific experiments. I show how the Thomists’ alternative conception of human action justifies a significantly different interpretation of Libet-style experiments, one which reveals the psychological phenomenon targeted by these experiments is miscategorized as a voluntary action. Full article

Previously, Rahardja (2020) paper (in the first reference list) developed a (pairwise) multiple comparison procedure (MCP) to determine which (proportions) pairs of Multiple Binomial Proportions (with under-reported data), the significant differences came from. Generally, such an MCP test (developed by Rahardja, 2020) is the second part of a two-stage sequential test. In this paper, we derived two omnibus tests (i.e., the overall equality of multiple proportions test) as the first part of the above two-stage sequential test (with under-reported data), in general. Using two likelihood-based approaches, we acquire two Wald-type (Omnibus) tests to compare Multiple Binomial Proportions (in the presence of under-reported data). Our closed-form algorithm is easy to implement and not computationally burdensome. We applied our algorithm to a vehicle-accident data example. Full article

Constructivism proposes that learners construct concepts based on prior knowledge and experiences. Numerous factors may lead to inadequate or improper concept construction, leading to misconceptions. This study provides a foundation for discussing literary misconceptions using discussions with 47 pre-service literature teachers on the origins of diverse misconceptions regarding the narrator and focalizer. The participants identified the narrator and focalizer in two fictional narratives and elucidated each concept. Thus, the causes and aspects of the misconceptions were identified. Misconceptions about the narrator and focalizer were found to involve four factors: over-contextualization of everyday experiences, misunderstanding of terms, transfer of misconceptions in textbooks, and miscategorization of prior knowledge. The transfer of misconceptions and miscategorization had the largest impact. Moreover, the aspects of misconceptions differed for each cause. Over-contextualization led to equating the narrator with the focalizer, and the transfer of misconceptions led to equating the narrator with the author. Miscategorization resulted in miscategorizing the narrator and focalizer as subordinate concepts of speech representation and point of view. Misunderstanding of terms interacted with other causes, leading to equating the narrator with the focalizer, as well as misclassifying them as speech representation. Based on these results, methods to overcome literary misconceptions at the curriculum, class, and teacher education levels were suggested. Full article