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Keywords = micromachined ultrasound transducers

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40 pages, 1298 KiB  
Systematic Review
Systematic Review of Commercially Available Clinical CMUT-Based Systems for Use in Medical Ultrasound Imaging: Products, Applications, and Performance
by Ahmed Sewify, Maria Antico, Laith Alzubaidi, Haider A. Alwzwazy, Jacqueline Roots, Peter Pivonka and Davide Fontanarosa
Sensors 2025, 25(7), 2245; https://doi.org/10.3390/s25072245 - 2 Apr 2025
Viewed by 1737
Abstract
An emerging alternative to conventional piezoelectric technologies, which continue to dominate the ultrasound medical imaging (US) market, is Capacitive Micromachined Ultrasonic Transducers (CMUTs). Ultrasound transducers based on this technology offer a wider frequency bandwidth, improved cost-effectiveness, miniaturized size and effective integration with electronics. [...] Read more.
An emerging alternative to conventional piezoelectric technologies, which continue to dominate the ultrasound medical imaging (US) market, is Capacitive Micromachined Ultrasonic Transducers (CMUTs). Ultrasound transducers based on this technology offer a wider frequency bandwidth, improved cost-effectiveness, miniaturized size and effective integration with electronics. These features have led to an increase in the commercialization of CMUTs in the last 10 years. We conducted a review to answer three main research questions: (1) What are the commercially available CMUT-based clinical sonographic devices in the medical imaging space? (2) What are the medical imaging applications of these devices? (3) What is the performance of the devices in these applications? We additionally reported on all the future work expressed by modern studies released in the past 2 years to predict the trend of development in future CMUT device developments and express gaps in current research. The search retrieved 19 commercially available sonographic CMUT products belonging to seven companies. Four of the products were clinically approved. Sonographic CMUT devices have established their niche in the medical US imaging market mainly through the Butterfly iQ and iQ+ for quick preliminary screening, emergency care in resource-limited settings, clinical training, teleguidance, and paramedical applications. There were no commercialized 3D CMUT probes. Full article
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20 pages, 6026 KiB  
Article
Analysis of Collapse–Snapback Phenomena in Capacitive Micromachined Ultrasound Transducers
by Chloé Halbach, Veronique Rochus, Jan Genoe, Xavier Rottenberg, David Cheyns and Paul Heremans
Micromachines 2025, 16(2), 160; https://doi.org/10.3390/mi16020160 - 29 Jan 2025
Cited by 1 | Viewed by 2811
Abstract
The pull-in and pull-out voltages are important characteristics of Capacitive Micromachined Ultrasound Transducers (CMUTs), marking the transition between conventional and collapse operation regimes. These voltages are commonly determined using capacitance–voltage (C-V) sweeps. By modeling the operating conditions of an LCR meter in COMSOL [...] Read more.
The pull-in and pull-out voltages are important characteristics of Capacitive Micromachined Ultrasound Transducers (CMUTs), marking the transition between conventional and collapse operation regimes. These voltages are commonly determined using capacitance–voltage (C-V) sweeps. By modeling the operating conditions of an LCR meter in COMSOL Multiphysics®, we demonstrate that the measured capacitance comprises both static and dynamic capacitances, with the dynamic capacitance causing the appearance of a peak in the effective C-V curve. Furthermore, Laser Doppler Vibrometer (LDV) measurements and electromechanical simulations indicate the occurrence of collapse–snapback phenomena during the C-V sweeps. This study, through advanced simulations and experimental analyses, demonstrates that the transient membrane behavior significantly affects the apparent capacitance–voltage characteristics of electrostatically actuated Micro-Electromechanical Systems (MEMS). Full article
(This article belongs to the Special Issue MEMS Ultrasonic Transducers)
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16 pages, 5459 KiB  
Article
Impact of Cell Layout on Bandwidth of Multi-Frequency Piezoelectric Micromachined Ultrasonic Transducer Array
by Wanli Yang, Huimin Li, Yuewu Gong, Zhuochen Wang, Xingli Xu, Xiaofan Hu, Pengfei Niu and Wei Pang
Micromachines 2025, 16(1), 49; https://doi.org/10.3390/mi16010049 - 31 Dec 2024
Cited by 1 | Viewed by 3965
Abstract
Piezoelectric micromachined ultrasonic transducers (PMUTs) show considerable promise for application in ultrasound imaging, but the limited bandwidth of the traditional PMUTs largely affects the imaging quality. This paper focuses on how to arrange cells with different frequencies to maximize the bandwidth and proposes [...] Read more.
Piezoelectric micromachined ultrasonic transducers (PMUTs) show considerable promise for application in ultrasound imaging, but the limited bandwidth of the traditional PMUTs largely affects the imaging quality. This paper focuses on how to arrange cells with different frequencies to maximize the bandwidth and proposes a multi-frequency PMUT (MF-PMUT) linear array. Seven cells with gradually changing frequencies are arranged in a monotonic trend to form a unit, and 32 units are distributed across four lines, forming one element. To investigate how the arrangement of cells affects the bandwidth, three different arrays were designed according to the extent of unit aggregation from the same frequency. Underwater experiments were conducted to assess the acoustic performance, especially the bandwidth. We found that the densest arrangement of the same cells produced the largest bandwidth, achieving a 92% transmission bandwidth and a 50% burst-echo bandwidth at 6 MHz. The mechanism was investigated from the coupling point of view by finite element analysis and laser Doppler vibrometry, focusing on the cell displacements. The results demonstrated strong ultrasound coupling in the devices, resulting in larger bandwidths. To exploit the advanced bandwidth but reduce the crosstalk, grooves for isolation were fabricated between elements. This work proposes an effective strategy for developing advanced PMUT arrays that would benefit ultrasound imaging applications. Full article
(This article belongs to the Section A:Physics)
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16 pages, 14457 KiB  
Article
ScAlN PMUTs Based on Flexurally Suspended Membrane for Long-Range Detection
by Shutao Yao, Wenling Shang, Guifeng Ta, Jinyan Tao, Haojie Liu, Xiangyong Zhao, Jianhe Liu, Bin Miao and Jiadong Li
Micromachines 2024, 15(11), 1377; https://doi.org/10.3390/mi15111377 - 14 Nov 2024
Cited by 3 | Viewed by 2521
Abstract
Piezoelectric micromachined ultrasonic transducers (PMUTs) have been widely applied in distance sensing applications. However, the rapid movement of miniature robots in complex environments necessitates higher ranging capabilities from sensors, making the enhancement of PMUT sensing distance critically important. In this paper, a scandium-doped [...] Read more.
Piezoelectric micromachined ultrasonic transducers (PMUTs) have been widely applied in distance sensing applications. However, the rapid movement of miniature robots in complex environments necessitates higher ranging capabilities from sensors, making the enhancement of PMUT sensing distance critically important. In this paper, a scandium-doped aluminum nitride (ScAlN) PMUT based on a flexurally suspended membrane is proposed. Unlike the traditional fully clamped design, the PMUT incorporates a partially clamped membrane, thereby extending the vibration displacement and enhancing the output sound pressure. Experimental results demonstrate that at a resonant frequency of 78 kHz, a single PMUT generates a sound pressure level (SPL) of 112.2 dB at a distance of 10 mm and achieves a high receiving sensitivity of 12.3 mV/Pa. Distance testing reveals that a single PMUT equipped with a horn can achieve a record-breaking distance sensing range of 11.2 m when used alongside a device capable of simultaneously transmitting and receiving ultrasound signals. This achievement is significant for miniaturized and integrated applications that utilize ultrasound for long-range target detection. Full article
(This article belongs to the Special Issue MEMS Ultrasonic Transducers)
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18 pages, 9398 KiB  
Article
Radiation Impedance of Rectangular CMUTs
by Shayan Khorassany, Eric B. Dew, Mohammad Rahim Sobhani and Roger J. Zemp
Sensors 2024, 24(17), 5823; https://doi.org/10.3390/s24175823 - 7 Sep 2024
Cited by 1 | Viewed by 1132
Abstract
Recently, capacitive micromachined ultrasound transducers (CMUTs) with long rectangular membranes have demonstrated performance advantages over conventional piezoelectric transducers; however, modeling these CMUT geometries has been limited to computationally burdensome numerical methods. Improved fast modeling methods, such as equivalent circuit models, could help achieve [...] Read more.
Recently, capacitive micromachined ultrasound transducers (CMUTs) with long rectangular membranes have demonstrated performance advantages over conventional piezoelectric transducers; however, modeling these CMUT geometries has been limited to computationally burdensome numerical methods. Improved fast modeling methods, such as equivalent circuit models, could help achieve designs with even better performance. The primary obstacle in developing such methods is the lack of tractable methods for computing the radiation impedance of clamped rectangular radiators. This paper presents a method that approximates the velocity profile using a polynomial shape model to rapidly and accurately estimate radiation impedance. The validity of the approximate velocity profile and corresponding radiation impedance calculation was assessed using finite element simulations for a variety of membrane aspect ratios and bias voltages. Our method was evaluated for rectangular radiators with width:length ratios from 1:1 up to 1:25. At all aspect ratios, the radiation resistance was closely modeled. However, when calculating the radiation reactance, our initial approach was only accurate for low aspect ratios. This motivated us to consider an alternative shape model for high aspect ratios, which was more accurate when compared with FEM. To facilitate the development of future rectangular CMUTs, we provide a MATLAB script that quickly calculates radiation impedance using both methods. Full article
(This article belongs to the Section Sensors Development)
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14 pages, 7528 KiB  
Article
Fine-Tuning of Optical Resonance Wavelength of Surface-Micromachined Optical Ultrasound Transducer Arrays for Single-Wavelength Light Source Readout
by Zhiyu Yan, Cheng Fang and Jun Zou
Micromachines 2024, 15(9), 1111; https://doi.org/10.3390/mi15091111 - 31 Aug 2024
Cited by 1 | Viewed by 1920
Abstract
This article reports the fine-tuning of the optical resonance wavelength (ORW) of surface-micromachined optical ultrasound transducer (SMOUT) arrays to enable ultrasound data readout with non-tunable interrogation light sources for photoacoustic computed tomography (PACT). Permanent ORW tuning is achieved by material deposition onto or [...] Read more.
This article reports the fine-tuning of the optical resonance wavelength (ORW) of surface-micromachined optical ultrasound transducer (SMOUT) arrays to enable ultrasound data readout with non-tunable interrogation light sources for photoacoustic computed tomography (PACT). Permanent ORW tuning is achieved by material deposition onto or subtraction from the top diaphragm of each element with sub-nanometer resolution. For demonstration, a SMOUT array is first fabricated, and its ORW is tuned for readout with an 808 nm laser diode (LD). Experiments are conducted to characterize the optical and acoustic performances of the elements within the center region of the SMOUT array. Two-dimensional and three-dimensional PACT (photoacoustic computed tomography) is also performed to evaluate the imaging performance of the ORW-tuned SMOUT array. The results show that the ORW tuning does not degrade the optical, acoustic, and overall imaging performances of the SMOUT elements. As a result, the fine-tuning method enables new SMOUT-based PACT systems that are low cost, compact, powerful, and even higher speed, with parallel readout capability. Full article
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13 pages, 4868 KiB  
Article
Design, Fabrication, and Characterization of Capacitive Micromachined Ultrasonic Transducers for Transcranial, Multifocus Neurostimulation
by Tamzid Ibn Minhaj, Muhammetgeldi Annayev, Oluwafemi J. Adelegan, Ali Önder Biliroğlu, Feysel Yalçın Yamaner and Ömer Oralkan
Micromachines 2024, 15(9), 1106; https://doi.org/10.3390/mi15091106 - 30 Aug 2024
Cited by 2 | Viewed by 2565
Abstract
In a recent study using 3-D fullwave simulations, it was shown for a nonhuman primate model that a helmet-shaped 3D array of 128 transducer elements can be assembled for neurostimulation in an optimized configuration with the accommodation of an imaging aperture. Considering all [...] Read more.
In a recent study using 3-D fullwave simulations, it was shown for a nonhuman primate model that a helmet-shaped 3D array of 128 transducer elements can be assembled for neurostimulation in an optimized configuration with the accommodation of an imaging aperture. Considering all acoustic losses, according to this study, for a nonhuman primate skull, the assembly of the proposed transducers was projected to produce sufficient focusing gain in two different focal positions at deep and shallow brain regions, thus providing sufficient acoustic intensity at these distinct focal points for neural stimulation. This array also has the ability to focus on multiple additional brain regions. In the work presented here, we designed and fabricated a single 15 mm diameter capacitive micromachined ultrasonic transducer (CMUT) element operating at 800 kHz central frequency with a 480 kHz 3 dB bandwidth, capable of producing a 190 kPa peak negative pressure (PNP) on the surface. The corresponding projected transcranial spatial peak pulse average intensity (ISPPA) was 28 Wcm−2, and the mechanical index (MI) value was 1.1 for an array of 128 of these elements. Full article
(This article belongs to the Special Issue MEMS Ultrasonic Transducers)
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9 pages, 2056 KiB  
Article
Design and Fabrication of High-Performance Piezoelectric Micromachined Ultrasonic Transducers Based on Aluminum Nitride Thin Films
by Le Zhang, Kunxian Yan, Lei Ye, Xiangyu Luo, Jian He and Xiujian Chou
Micromachines 2024, 15(8), 1001; https://doi.org/10.3390/mi15081001 - 1 Aug 2024
Viewed by 1848
Abstract
Ultrasound is widely applied in diverse domains, such as medical imaging, non-destructive evaluation, and acoustic communication. Piezoelectric micromachined ultrasonic transducers (PMUTs) capable of generating and receiving ultrasonic signals at the micrometer level have become a prominent technology in the field of ultrasound. It [...] Read more.
Ultrasound is widely applied in diverse domains, such as medical imaging, non-destructive evaluation, and acoustic communication. Piezoelectric micromachined ultrasonic transducers (PMUTs) capable of generating and receiving ultrasonic signals at the micrometer level have become a prominent technology in the field of ultrasound. It is important to enrich the models of the PMUTs to meet the varied applications. In this study, a series of PMUT devices featured with various top electrode configurations, square, circular, and doughnut, were designed to assess the influence of shape on the emission efficacy. It was demonstrated that the PMUTs with a circular top electrode were outperformed, which was calculated from the external acoustic pressure produced by the PMUTs operating in the fundamental resonant mode at a specified distance. Furthermore, the superior performance of PMUT arrays were exhibited through computational simulations for the circular top electrode geometries. Conventional microelectromechanical systems (MEMS) techniques were used to fabricate an array of PMUTs based on aluminum nitride (AlN) films. These findings make great contributions for enhancing the signal transmission sensitivity and bandwidth of PMUTs, which have significant potential in non-destructive testing and medical imaging applications. Full article
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17 pages, 12341 KiB  
Article
PMUT-Based System for Continuous Monitoring of Bolted Joints Preload
by Stefano Sanvito, Marco Passoni, Domenico Giusti, Marco Terenzi, Carlo Prelini, Monica La Mura and Alessandro Stuart Savoia
Sensors 2024, 24(13), 4150; https://doi.org/10.3390/s24134150 - 26 Jun 2024
Cited by 2 | Viewed by 2327
Abstract
In this paper, we present a bolt preload monitoring system, including the system architecture and algorithms. We show how Finite Element Method (FEM) simulations aided the design and how we processed signals to achieve experimental validation. The preload is measured using a Piezoelectric [...] Read more.
In this paper, we present a bolt preload monitoring system, including the system architecture and algorithms. We show how Finite Element Method (FEM) simulations aided the design and how we processed signals to achieve experimental validation. The preload is measured using a Piezoelectric Micromachined Ultrasonic Transducer (PMUT) in pulse-echo mode, by detecting the Change in Time-of-Flight (CTOF) of the acoustic wave generated by the PMUT, between no-load and load conditions. We performed FEM simulations to analyze the wave propagation inside the bolt and understand the effect of different configurations and parameters, such as transducer bandwidth, transducer position (head/tip), presence or absence of threads, as well as the frequency of the acoustic waves. In order to couple the PMUT to the bolt, a novel assembly process involving the deposition of an elastomeric acoustic impedance matching layer was developed. We achieved, for the first time with PMUTs, an experimental measure of bolt preload from the CTOF, with a good signal-to-noise ratio. Due to its low cost and small size, this system has great potential for use in the field for continuous monitoring throughout the operative life of the bolt. Full article
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19 pages, 6973 KiB  
Article
Curved and Annular Diaphragm Coupled Piezoelectric Micromachined Ultrasonic Transducers for High Transmit Biomedical Applications
by Yun Zhang, Tong Jin, Zijie Zhao, Chenfang Yan, Xinchao Lu, Hang Gao and Chengjun Huang
Sensors 2024, 24(9), 2714; https://doi.org/10.3390/s24092714 - 24 Apr 2024
Cited by 1 | Viewed by 2106
Abstract
In this paper, we present a novel three-dimensional (3D) coupled configuration of piezoelectric micromachined ultrasound transducers (pMUTs) by combing a curved and an annular diaphragm for transmit performance optimization in biomedical applications. An analytical equivalent circuit model (EQC) is developed with varied excitation [...] Read more.
In this paper, we present a novel three-dimensional (3D) coupled configuration of piezoelectric micromachined ultrasound transducers (pMUTs) by combing a curved and an annular diaphragm for transmit performance optimization in biomedical applications. An analytical equivalent circuit model (EQC) is developed with varied excitation methods to incorporate the acoustic–structure coupling of the curved and annular diaphragm-coupled pMUTs (CAC-pMUTs). The model-derived results align well with the reference simulated by the finite element method (FEM). Using this EQC model, we optimize the key design parameters of the CAC-pMUTs in order to improve the output sound pressure, including the width of the annular membrane, the thickness of the passive layer, and the phase difference of the driving voltage. In the anti-phase mode, the designed CAC-pMUTs demonstrate a transmit efficiency 285 times higher than that of single annular pMUTs. This substantial improvement underscores the potential of CAC-pMUTs for large array applications. Full article
(This article belongs to the Section Physical Sensors)
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14 pages, 5054 KiB  
Article
Piezoelectric Micromachined Ultrasonic Transducers with Micro-Hole Inter-Etch and Sealing Process on (111) Silicon Wafer
by Yunhao Wang, Sheng Wu, Wenjing Wang, Tao Wu and Xinxin Li
Micromachines 2024, 15(4), 482; https://doi.org/10.3390/mi15040482 - 30 Mar 2024
Cited by 4 | Viewed by 4811
Abstract
Piezoelectric micromachined ultrasound transducers (PMUTs) have gained significant popularity in the field of ultrasound ranging and medical imaging owing to their small size, low power consumption, and affordability. The scar-free “MIS” (micro-hole inter-etch and sealing) process, a novel bulk-silicon manufacturing technique, has been [...] Read more.
Piezoelectric micromachined ultrasound transducers (PMUTs) have gained significant popularity in the field of ultrasound ranging and medical imaging owing to their small size, low power consumption, and affordability. The scar-free “MIS” (micro-hole inter-etch and sealing) process, a novel bulk-silicon manufacturing technique, has been successfully developed for the fabrication of pressure sensors, flow sensors, and accelerometers. In this study, we utilize the MIS process to fabricate cavity diaphragm structures for PMUTs, resulting in the formation of a flat cavity diaphragm structure through anisotropic etching of (111) wafers in a 70 °C tetramethylammonium hydroxide (TMAH) solution. This study investigates the corrosion characteristics of the MIS technology on (111) silicon wafers, arranges micro-pores etched on bulk silicon around the desired cavity structure in a regular pattern, and takes into consideration the distance compensation for lateral corrosion, resulting in a fully connected cavity structure closely approximating an ortho-hexagonal shape. By utilizing a sputtering process to deposit metallic molybdenum as upper and lower electrodes, as well as piezoelectric materials above the cavity structure, we have successfully fabricated aluminum nitride (AlN) piezoelectric ultrasonic transducer arrays of various sizes and structures. The final hexagonal PMUT cells of various sizes that were fabricated achieved a maximum quality factor (Q) of 251 and a displacement sensitivity of 18.49 nm/V across a range of resonant frequencies from 6.28 MHz to 11.99 MHz. This fabrication design facilitates the achievement of IC-compatible and cost-effective mass production of PMUT array devices with high resonance frequencies. Full article
(This article belongs to the Section A:Physics)
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3 pages, 988 KiB  
Abstract
An Acoustically Transparent Electrical Cap for Piezoelectric Ultrasound Transducers on Silicon
by Gandhika K. Wardhana, Tiago L. Costa and Massimo Mastrangeli
Proceedings 2024, 97(1), 50; https://doi.org/10.3390/proceedings2024097050 - 19 Mar 2024
Cited by 1 | Viewed by 1030
Abstract
Bulk piezoelectric ultrasound transducers on integrated circuits offer unique properties for therapeutic applications of ultrasound neuromodulation. However, current implementations of such transducers are not optimized for the high transmit efficiency required to stimulate neurons. This is mainly due to the challenge of implementing [...] Read more.
Bulk piezoelectric ultrasound transducers on integrated circuits offer unique properties for therapeutic applications of ultrasound neuromodulation. However, current implementations of such transducers are not optimized for the high transmit efficiency required to stimulate neurons. This is mainly due to the challenge of implementing a metal layer on top of the piezoelectric film using microfabrication techniques. Here, we propose a micromachined capping structure providing an electrical connection on top of the piezoelectric film with minimal acoustic losses. The structure can potentially be used as a common ground connection in phased-array ultrasound transducers. Full article
(This article belongs to the Proceedings of XXXV EUROSENSORS Conference)
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14 pages, 3199 KiB  
Article
High-Performance PMN-PT Single-Crystal-Based 1-3 Composite Transducer Integrated with a Biopsy Needle
by Benjamin C. Kreager, Huaiyu Wu, Wei-Yi Chang, Sunho Moon, Josh Mitchell, Chang Peng, Chih-Chung Huang, Marie Muller, Jian Tian and Xiaoning Jiang
Biosensors 2024, 14(2), 74; https://doi.org/10.3390/bios14020074 - 31 Jan 2024
Cited by 3 | Viewed by 2752
Abstract
To address the need for high-resolution imaging in lung nodule detection and overcome the limitations of the shallow imaging depth associated with high-frequency ultrasound and the complex structure of lung tissue, we successfully integrated 50 MHz ultrasound transducers with 18-gauge biopsy needles. Featuring [...] Read more.
To address the need for high-resolution imaging in lung nodule detection and overcome the limitations of the shallow imaging depth associated with high-frequency ultrasound and the complex structure of lung tissue, we successfully integrated 50 MHz ultrasound transducers with 18-gauge biopsy needles. Featuring a miniaturized size of 0.6 × 0.5 × 0.5 mm3, the 50 MHz micromachined 1-3 composite transducer was tested to perform mechanical scanning of a nodule within a lung-tissue-mimicking phantom in vitro. The high-frequency transducer demonstrated the ability to achieve imaging with an axial resolution of 30 μm for measuring nodule edges. Moreover, the integrated biopsy needle prototype exhibited high accuracy (1.74% discrepancy) in estimating nodule area compared to actual dimensions in vitro. These results underscore the promising potential of biopsy-needle-integrated transducers in enhancing the accuracy of endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) for clinical applications. Full article
(This article belongs to the Section Biosensors and Healthcare)
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17 pages, 7338 KiB  
Article
Four-Channel Ultrasonic Sensor for Bulk Liquid and Biochemical Surface Interrogation
by Donatas Pelenis, Dovydas Barauskas, Mindaugas Dzikaras and Darius Viržonis
Biosensors 2024, 14(2), 66; https://doi.org/10.3390/bios14020066 - 26 Jan 2024
Cited by 2 | Viewed by 2162
Abstract
Custom electronics tailored for ultrasonic applications with four ultrasonic transmit-receive channels and a nominal 25 MHz single channel frequency were developed for ultrasound BAW and SAW biosensor uses. The designed integrated microcontroller, supported by Python with a SciPy library, and the developed system [...] Read more.
Custom electronics tailored for ultrasonic applications with four ultrasonic transmit-receive channels and a nominal 25 MHz single channel frequency were developed for ultrasound BAW and SAW biosensor uses. The designed integrated microcontroller, supported by Python with a SciPy library, and the developed system measured the time of flight (TOF) and other wave properties to characterize the acoustic properties of a bulk of the liquid in a microchannel or acoustic properties of biological species attached to an analytic surface in real time. The system can utilize both piezoelectric and capacitive micromachined ultrasound transducers. The device demonstrated a linear response to changes in water salinity. This response was primarily attributed to the time-of-flight (TOF) changes related to the varying solution density. Furthermore, real-time DNA oligonucleotide-based interactions between oligonucleotides immobilized on the device’s analytical area and oligonucleotides attached to gold nanoparticles (Au NPs) in the solution were demonstrated. The biological interaction led to an exponential decrease in the acoustic interfacial wave propagating across the interface between the solution and the solid surface of the sensor, the TOF signal. This decrease was attributed to the increase in the effective density of the solution in the vicinity of the sensor’s analytical area, as Au NPs modified by oligonucleotides were binding to the analytical area. The utilization of Au NPs in oligonucleotide surface binding yields a considerably stronger sensor signal than previously observed in earlier CMUT-based TOF biosensor prototypes. Full article
(This article belongs to the Special Issue Biosensors Based on Microfluidic Devices)
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19 pages, 6422 KiB  
Article
Design of Zeolitic Imidazolate Framework-8-Functionalized Capacitive Micromachined Ultrasound Transducer Gravimetric Sensors for Gas and Hydrocarbon Vapor Detection
by Mindaugas Dzikaras, Dovydas Barauskas, Donatas Pelenis, Gailius Vanagas, Marius Mikolajūnas, Jingming Shi, Jonas Baltrusaitis and Darius Viržonis
Sensors 2023, 23(21), 8827; https://doi.org/10.3390/s23218827 - 30 Oct 2023
Cited by 1 | Viewed by 1521
Abstract
A capacitive micromachined ultrasound transducer (CMUT) was engineered and functionalized with zeolitic imidazolate framework-8 (ZIF-8) dispersed in a photoresist AZ1512HS (AZ) matrix to function as a gravimetric gas sensor. The sensor response was recorded in the presence of nitrogen, argon, carbon dioxide, and [...] Read more.
A capacitive micromachined ultrasound transducer (CMUT) was engineered and functionalized with zeolitic imidazolate framework-8 (ZIF-8) dispersed in a photoresist AZ1512HS (AZ) matrix to function as a gravimetric gas sensor. The sensor response was recorded in the presence of nitrogen, argon, carbon dioxide, and methane gases as well as water, acetylene, a propane/butane mixture, n-hexane, gasoline, and diesel vapors. The photoresist matrix alone was found to have a negligible response to all the gases and vapors, except for water vapor. No visible difference in sensor response was detected when switching from nitrogen to methane gas. However, a strong shift in the sensor resonance frequency was observed when exposed to higher hydrocarbons, ranging from 1 kHz for acetylene to 7.5 kHz for gasoline. Even longer-chain hydrocarbons, specifically kerosene and more so diesel, had a significantly reduced sensor frequency shift compared with gasoline. Sensors functionalized with a thin film of AZ+ZIF-8 demonstrated higher sensitivity in their response to a hydrocarbon molecular mass than without functionalization. Full article
(This article belongs to the Section Physical Sensors)
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