Search Results (2,289)

Background: Road traffic accidents (RTAs) present a significant public health problem and economic burden. The aim of the study was to determine mental health outcomes and health-related quality of life (HRQOL) of RTA victims 6 months following a road trauma and factors associated with mental and physical components of HRQOL; Methods: A cohort of 200 RTA victims was followed during a 6-month period and a wide range of sociodemographic, health-related, RTA-related, injury-related, psychological and victim-related factors associated with the HRQOL scores were explored using multiple regression analyses; Results: Lower physical component summary score was associated with pre-existing chronic disease, self-perceived life threat, surgical treatment, amnesia following an RTA, permanent pain, increase in pain intensity or frequency and depression symptoms (p < 0.05); lower mental component summary score was associated with irreligiousness, rehabilitation procedure, depression symptoms, anxiety symptoms, permanent pain and increase in medication use (p < 0.05); Conclusions: HRQOL measurement after an RTA should provide holistic assessment of physical, mental and social consequences throughout an extended period of recovery. Together with evaluation of predictors of poorer HRQOL and recovery, this could enable an individual approach to individual needs of RTA victims. Full article

Diabetes-related hypoglycemia contributes substantially to increased morbidity, mortality, health-care utilization, and reduced quality of life. Older adults with diabetes represent a heterogeneous group of patients who need individualized blood glucose targets to avoid hypoglycemia. Since the elderly present with varying degrees of functional and cognitive status and individualized health needs, their management varies among individuals. Complicating this, the hypoglycemia risk in older adults treated with insulin also varies due to aging, renal dysfunction, cognitive impairment, and other comorbidities. The challenge for healthcare providers is in considering all aspects of care in order to avoid hypoglycemia in elderly individuals. In this review, we introduce a Patient and Function Centric Approach to the assessment and management of hypoglycemia in older adults. This holistic framework extends beyond blood glucose values to systematically evaluate the other domains of patients’ health that influence hypoglycemia risk, including biochemical, medication, timing, autonomic, cognitive, mood, renal, pancreatic, hepatic, social, and physical function. The management of hypoglycemia in older adults should also include strategies to address both fear of hypoglycemia and hypoglycemia unawareness. In addition to physical limitations, the psychosocial barriers to self-care in older individuals with hypoglycemia are also of paramount importance. Using tools that measure diabetes burden, diabetes distress, and fear of hypoglycemia provides valuable insights into patient wellbeing. The use of newer anti-hyperglycemic medications, sensor-augmented insulin pump therapy, intranasal glucagon, and continuous glucose monitoring (CGM) has significantly contributed to reduced hypoglycemia incidence in individuals with diabetes. Overall, successful management requires a collaborative approach that empowers patients, respects their individual needs and preferences and helps them face the challenges associated with diabetes management with confidence rather than fear or anxiety. Adopting a patient- and function-centric approach to hypoglycemia management allows clinicians to move beyond a one-size-fits-all model and adopt individualized glycemic targets that improve overall diabetes control and mental well-being. Full article

Background: Fathers may experience psychological difficulties during the transition to parenthood, and depressive symptoms during the antenatal period may be associated with fathers’ well-being and adjustment to the paternal role. Marital satisfaction and paternal attachment may be important psychosocial factors associated with fathers’ mental health during this period. This study aimed to examine the relationships among marital satisfaction, paternal attachment, and depressive symptoms among expectant fathers. Methods: A descriptive cross-sectional study design was employed. The study was approved by the Van Yüzüncü Yıl University Non-Interventional Clinical Research Ethics Committee (20 December 2024; Approval No. 2024/13-07). Institutional permission was obtained from the hospital where the study was conducted. Written and verbal informed consent was obtained from all participants, and the study was conducted in accordance with the principles of the Declaration of Helsinki. Data were collected between January 2025 and September 2025 at a hospital located in the Eastern Anatolia Region of Türkiye. The study was completed with 336 fathers. Data collection instruments included the Personal Information Form, Marital Life Scale (MLS), Paternal–Antenatal Attachment Questionnaire (PAAQ), and Edinburgh Postpartum Depression Scale (EPDS). Multiple regression analysis and forest plot analysis were performed. Results: A statistically significant difference was observed between EPDS scores and MLS, PAAQ, educational status, spouse’s educational status, place of residence, family type, income status, spousal attendance at antenatal visits, and history of depression (p < 0.05). The regression model was statistically significant (F(9326) = 14.4, p < 0.001) and explained 26.4% of the variance in EPDS scores (R² = 0.284). In the adjusted regression model, MLS, educational level, PAAQ, and family type were significantly negatively associated with EPDS scores, whereas a history of depression was significantly positively associated with EPDS scores (p < 0.05). Conclusions: Higher marital satisfaction and paternal attachment were associated with lower depressive symptoms among expectant fathers, whereas a history of depression was associated with higher depressive symptoms. These findings highlight the importance of considering marital and attachment-related factors when assessing fathers’ psychological well-being during the antenatal period. Full article

Benzodiazepine misuse is most prevalent among young adults aged 18–25 and has been linked to recreational use, self-medication, and psychosocial stressors. Childhood emotional neglect is associated with adverse mental health outcomes and increased vulnerability to substance misuse; however, its relationship with benzodiazepine misuse among young adults remains understudied. This study examined the association between childhood emotional neglect and lifetime benzodiazepine misuse among young adults in Rhode Island. Data were drawn from 1008 participants aged 18–25 who completed the 2024 Rhode Island Young Adult Survey, a cross-sectional web-based survey of behavioral health. Lifetime benzodiazepine misuse was defined as self-reported use of non-prescribed benzodiazepines. Multivariable logistic regression models examined the association between childhood emotional neglect and lifetime benzodiazepine misuse while adjusting for age, race/ethnicity, sexual and gender identity, and subjective social status. Overall, 5.6% of participants reported lifetime benzodiazepine misuse and 33.4% reported childhood emotional neglect. More than half (55.4%) of participants who reported benzodiazepine misuse also reported a history of emotional neglect (p < 0.001). After adjustment for covariates, childhood emotional neglect was associated with nearly threefold greater odds of lifetime benzodiazepine misuse (aOR = 2.80, 95% CI: 1.57–5.00). Findings identify childhood emotional neglect as a significant correlate of benzodiazepine misuse among young adults and underscore the importance of trauma-informed prevention, screening, and early intervention efforts. Full article

Background: Omega-3 fatty acids may be relevant to mental health, but evidence among university students remains limited. This small exploratory cross-sectional study examined associations between estimated dietary omega-3 intake and anxiety and depressive symptoms among university students in the UK. Methods: Data were collected between February and May 2025. Habitual dietary EPA + DHA and alpha-linolenic acid (ALA) intakes were estimated using an adapted omega-3 food-frequency questionnaire, while 24-h dietary recall was used to estimate energy intake. Anxiety and depressive symptoms were assessed using the GAD-7 and PHQ-9. The primary association between estimated dietary EPA + DHA intake and GAD-7 score was examined using linear regression adjusted for age, sex, energy intake, and alcohol use. Analyses involving ALA and PHQ-9 were exploratory. Results: Of 96 students recruited, 50 (52.1%) were analysed after 46 exclusions, most commonly for omega-3 supplement use (n = 21) or diagnosed mental-health conditions (n = 16). Mean GAD-7 and PHQ-9 scores were 6.66 ± 4.73 and 7.02 ± 4.76, respectively. In the fully adjusted model, each additional 100 mg/day of estimated dietary EPA + DHA intake was associated with a 0.325-point lower GAD-7 score, but the association was not statistically significant (B = −0.325; 95% CI: −0.725 to 0.074; p = 0.108). Exploratory analyses found no significant associations of estimated dietary EPA + DHA or ALA intake with anxiety or depressive symptoms. The inverse coefficient lost statistical significance after full adjustment, and the log-transformed coefficient reversed direction and remained non-significant, arguing against a consistent dose–response relationship. Conclusions: Estimated dietary EPA + DHA intake showed an inverse but inconclusive association with anxiety symptoms in this small exploratory sample. These preliminary findings are hypothesis-generating and require confirmation in larger longitudinal studies using repeated dietary assessments and biomarkers of omega-3 status. Full article

Background: Problematic social media use among adolescents has emerged as a growing public health concern. This study examined gender differences in problems related to social media use and their behavioural, psychosocial, family-related, and school-related correlates among Finnish adolescents. Methods: In this cross-sectional study, binary logistic regression analyses were conducted using data from the Finnish sample of the 2024 European School Survey Project on Alcohol and Other Drugs (ESPAD), including 3293 adolescents aged 15–16 years. Results: Overall, 45% of girls and 30% of boys were classified as having problems related to social media use. Significant gender interactions were observed in the associations of gaming-related problems and perceived family socioeconomic status with problems related to social media use. Gaming-related problems were the strongest correlate, with a substantially stronger association among boys. Elevated psychological distress was associated with a higher likelihood of problems related to social media use, particularly among girls, whereas higher parental monitoring was associated with a lower likelihood only among girls. Truancy and plans for general upper secondary school were both associated with a higher likelihood of problems related to social media use among girls and boys. Conclusions: The findings suggest that problems related to social media use are closely linked to adolescent well-being and behaviour. Prevention and intervention efforts may therefore benefit from addressing problematic social media use as part of adolescent mental health and digital well-being strategies, combining universal approaches with targeted support for adolescents experiencing problematic patterns of digital media use. Full article

Cognitive function is central to healthy aging and is an important health outcome for evaluating long-term care policy. This study examines whether exposure to China’s long-term care insurance (LTCI) pilot is associated with cognitive function among adults aged 45 years and older. Using five waves of the China Health and Retirement Longitudinal Study (CHARLS) from 2011, 2013, 2015, 2018, and 2020, we estimate difference-in-differences (DID) models with individual and survey-wave fixed effects. Ten first-batch pilot cities are retained on the basis of implementation timing, with 2011–2015 classified as pre-policy and 2018–2020 as post-policy. Cognitive function is measured by a 0–21 composite score of episodic memory and mental intactness. In the preferred parsimonious specification, LTCI pilot exposure is associated with a 0.478-point reduction in the composite score (city-clustered SE = 0.168), equivalent to approximately 0.128 standard deviations; wild cluster bootstrap inference yields p = 0.008. The estimate remains negative under alternative covariate specifications, exclusion of the 2018 wave, pre-policy PSM-DID, and province-by-wave fixed effects. Event-study estimates are close to zero before the policy and negative thereafter, while city-level placebo estimates are centered near zero. Formal interaction tests indicate heterogeneity by baseline age, marital status, and hukou after false discovery rate adjustment but not by gender or number of children. The interaction with 2015 baseline CES-D is marginally significant (p = 0.063) and is therefore interpreted as exploratory. Overall, the findings suggest a modest negative association between LTCI pilot exposure and the composite cognitive-function score and highlight the value of monitoring domain-specific cognitive outcomes within long-term care policy. Domain-specific estimates diverged: episodic memory increased (beta = 0.300, p < 0.001), whereas mental intactness decreased (beta = −0.812, p < 0.001). In an age-stratified sensitivity analysis based on 2015 pre-policy age, the estimate was not statistically significant among adults aged 45–59 years (beta = 0.168, p = 0.380) but was negative among those aged 60 years or older (beta = −0.362, p = 0.003); the between-group interaction was significant (beta = −0.530, p = 0.040). Full article

Background/Objectives: Informal caregivers of older adults are a high-burden population for psychological problems, yet evidence on the relationship between physical activity (PA) and mental health in this population is still limited. The aim of this work is to examine the association between PA status and self-reported mental health indicators (psychological distress and the number of poor mental health days) among caregivers of older adults. Methods: This cross-sectional study used data from the 2023 Behavioral Risk Factor Surveillance System (BRFSS) caregiver module. The analytical sample included 1785 informal caregivers of older adults whose care recipients’ main condition was old age/infirmity/frailty or Alzheimer’s disease, dementia, or another cognitive impairment disorder. Physical activity was classified into three groups: meeting both aerobic and muscle-strengthening recommendations, reporting some PA but not meeting both recommendations, and being inactive. The self-reported mental health indicators were psychological distress (≥14 poor mental health days in the past 30 days) and the number of poor mental health days. Survey-weighted logistic regression and quasi-Poisson regression models were fitted, adjusting for sociodemographic, health-related, and caregiving-related covariates. Results: The weighted prevalence of psychological distress was 18.8%, and the mean of poor mental health days was 5.99 days in the previous 30 days. The weighted prevalence of psychological distress was 16.3% among caregivers meeting both recommendations, 18.2% among those reporting some PA, and 23.2% among inactive caregivers; however, differences across PA groups were not statistically significant. The weighted mean number of poor mental health days was 5.5, 6.2, and 6.1 days, respectively, with no significant differences across PA groups. In adjusted logistic regression models, physically inactive caregivers had higher odds of psychological distress than those meeting both activity recommendations (OR = 3.10, 95% CI: 1.58–6.09; p = 0.001). In adjusted quasi-Poisson models, physically inactive caregivers also reported more poor mental health days (RR = 1.51, 95% CI: 1.08–2.10; p = 0.016) compared to those who met both recommendations. No significant differences were observed for caregivers who met only aerobic recommendations or only muscle-strengthening recommendations, or had insufficient physical activity relative to the reference group. Conclusions: In this survey-weighted BRFSS caregiver-module sample from participating US jurisdictions, physical inactivity was associated with poorer self-reported mental health indicators among caregivers of older adults. These findings suggest that physical inactivity may help identify caregivers at higher risk of poorer self-reported mental health, although longitudinal and intervention studies are needed to clarify directionality and causality. Full article

Background/Objectives: Adolescents with anorexia nervosa (AN) face substantial medical and psychiatric risk during hospitalization. We examined predictors of length of stay (LOS), cardiovascular recovery, refeeding safety, and psychiatric comorbidity in a consecutive pediatric cohort at a national tertiary center. Methods: Retrospective cohort of 68 consecutively admitted adolescents (91.2% female; mean age 14.2 ± 1.8 years, range 8–17; 85.3% restricting type) admitted between January 2017 and May 2025. A structured nutritional rehabilitation protocol (1000–1200 kcal/day, escalating by 200 kcal/day every 48 h to 2500–3000 kcal/day) was implemented with daily serum electrolyte monitoring. Statistical analyses included paired tests, Spearman correlations, multivariable regression of log-transformed LOS, and partial correlations controlling for the admission BMI z-score. Results: Nutritional and cardiovascular parameters improved from admission to discharge. Mean supine heart rate (HR) increased by 28.4 bpm (95% CI 25.0–31.8; p < 0.001), and bradycardia prevalence (HR < 50 bpm) improved from 39.7% to 1.5%. Lower admission BMI z-score was associated with longer LOS; each 1-unit higher BMI z-score was associated with an 18.9% shorter LOS in adjusted log-LOS regression (p = 0.003). Exploratory analyses of HR recovery suggested that the magnitude of HR improvement was more closely associated with baseline BMI z-score and baseline supine HR than with caloric escalation. Systematic electrolyte monitoring documented no hypophosphatemia requiring intervention and no refeeding syndrome. Documented mental health comorbidities or clinically significant symptom clusters were present in 82.4% of patients. Conclusions: In this adolescent anorexia nervosa cohort, structured inpatient nutritional rehabilitation was associated with substantial cardiovascular and nutritional improvement. Baseline nutritional status was associated with hospital course and cardiovascular response, while LOS should be interpreted as a composite outcome influenced by nutritional severity, discharge criteria, mental health needs, and family readiness. The absence of refeeding complications is reassuring and suggests that the protocol was metabolically safe under systematic electrolyte monitoring in this specialized tertiary setting. Full article

Background: Although nurses’ health-related quality of life (HRQoL) is critical for mitigating the growing intention to leave the profession, the association between nurse–patient mutuality and nurses’ HRQoL remains unexplored. Therefore, this study aims to examine the association between nurse–patient mutuality and nurses’ HRQoL. Methods: A cross-sectional, multicentre study was conducted across four tertiary hospitals in Italy. Data were collected from a sample of 726 nurses working in medical and surgical inpatient and outpatient wards. Mutuality was measured using the Nurse–patient Mutuality in Chronic Illness scale, comprising three dimensions: developing and going beyond, being a point of reference, deciding and sharing care; HRQoL was assessed via the Short Form-12 Health Status Questionnaire (SF-12), providing Physical (PCS) and Mental (MCS) Component Summaries. Two multiple linear regression models were conducted to evaluate the impact of mutuality dimensions on HRQoL components. Results: Among the 726 participants, none of the three mutuality dimensions were significantly associated with physical HRQoL (PCS). Conversely, two mutuality dimensions were significantly and positively associated with higher MCS scores: developing and going beyond (B = 0.54, 95% CI [0.14, 0.95], p = 0.009) and being a point of reference (B = 0.38, 95% CI [0.09, 0.68], p = 0.010). However, the overall regression model demonstrated a modest explanatory value for MCS (R² = 0.075). Among covariates, female sex (ref: male; B = −2.29, 95% CI [−4.10, −0.49], p = 0.013) and taking care of relatives (B = −2.07, 95% CI [−3.55, −0.60], p = 0.006) were associated with lower MCS, whereas older age (B = 0.17, 95% CI [0.01, 0.34], p = 0.039) was related to higher MCS. Regarding physical health (R² = 0.261), having chronic conditions (B = −5.08, 95% CI [−6.48, −3.69], p < 0.001), previous experience as a patient (B = −1.88, 95% CI [−3.07, −0.69], p = 0.002), and taking care of relatives (B = −1.49, 95% CI [−2.62, −0.36], p = 0.010) were significantly associated with lower PCS scores. Conclusions: The reciprocal nature of mutuality could be a potential relational resource for nurses’ mental HRQoL. Healthcare organizations should prioritize structural frameworks and interventions that allow nurses the time and resources to cultivate these essential clinical connections. Full article

Background and Objectives: Tobacco smoking is associated with an increased risk of depression and anxiety symptoms, but it remains unclear whether this relationship differs according to the type of nicotine product used. The increasing popularity of heated tobacco products has created a need to better understand their association with mental health, particularly in comparison with combustible cigarettes. Therefore, this study aimed to compare the prevalence of depression and anxiety symptoms among combustible cigarette (CC) users, heated tobacco product (HTP) users, and non-smokers. Materials and Methods: A cross-sectional study was conducted among 497 adults. Participants were classified into three groups according to their tobacco-use status: combustible cigarette smokers, heated tobacco users, and non-smokers. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9), and anxiety symptoms were assessed using the Generalized Anxiety Disorder-7 (GAD-7). Group differences were evaluated using hierarchical linear regression analyses adjusted for sociodemographic, health, and lifestyle factors. Results: Tobacco-use group significantly improved the model fit for PHQ-9 (ΔR² = 0.0575, p < 0.001) and GAD-7 (ΔR² = 0.0764, p < 0.001). In non-smokers, scores of depression were 3.48 lower than in CC users and 1.42 lower than in the HTP users’ group. In HTP users, these scores were 2.06 lower than in the CC users’ group. Anxiety scores were 3.71 lower in non-smokers than in CC users, and 1.29 lower than in the HTP users’ group. In the HTP users’ group, this score was 2.42 lower than in the CC users’ group. HC3 robust standard errors with 5000-sample BCa bootstrap confidence intervals and reduced-adjustment sensitivity analyses confirmed the primary pattern. Conclusions: Our study results showed that combustible cigarette users had the highest adjusted depression and anxiety scores, HTP users had intermediate scores, and non-smokers had the lowest. In both tobacco-using groups, greater product-specific nicotine dependence was associated with higher PHQ-9 and GAD-7 scores. Further interdisciplinary studies incorporating biomarkers of nicotine exposure, HPA axis function, inflammation, and oxidative stress are needed to clarify whether the observed differences reflect the characteristics of individuals who choose specific tobacco products or are partly attributable to product-specific effects. Full article

Background: Commercial digital mental health platforms have expanded across the Gulf since 2020, yet cancellation in this delivery model remains understudied. We aimed to identify factors independently associated with session cancellation on a Saudi Arabic-language commercial platform and to determine whether they describe user or provider behaviour. Methods: We conducted a retrospective cohort analysis of 36,544 booked sessions from 21,904 unique users (October 2023–April 2026); the outcome was binary cancellation (cancelled vs. completed). Multivariable logistic regression with cluster-robust standard errors estimated adjusted odds ratios (aORs) for user, provider, and booking characteristics; secondary analyses decomposed cancellation by recorded initiator and modelled age, lead time, and calendar time flexibly. Reporting followed STROBE guidelines. Results: Crude cancellation was 25.6%. Cancellation was strongly patterned by visit type (follow-up aOR 0.26, 95% CI 0.21–0.32), lead time (≥8 days 2.10, 95% CI 1.90–2.33), session type (free 1.19, 95% CI 1.10–1.27), and provider specialty; age reduced odds modestly (aOR 0.90 per decade, p < 0.001) and gender was null (aOR 0.95, p = 0.119). Cause-specific models showed that the lead-time gradient reverses by initiator: at ≥8 days versus same-day, user-initiated cancellation was less likely (aOR 0.62, 95% CI 0.49–0.78), whereas provider-initiated cancellation was far more likely (aOR 4.75, 95% CI 4.23–5.35), and provider-specialty differences were confined almost entirely to provider-initiated cancellation. The very low adjusted odds for emergency sessions (aOR 0.17, 95% CI 0.13–0.23) reflect how emergency bookings are administratively coded on the platform rather than genuine behavioural non-adherence and are regarded as artefactual. Discrimination was moderate (apparent AUC 0.700, development sample). Conclusions: Cancellation reflected operational features of the booking, but its largest correlates—lead time, free-session status, and provider specialty—operate predominantly through provider-side scheduling rather than patient non-adherence. Full article

Background: Modifiable lifestyle behaviours, including physical activity and smoking, are important determinants of health and may influence the mental well-being of nursing professionals. However, evidence simultaneously examining these factors and their associations with sociodemographic, occupational, and mental health factors remains limited. Objectives: The aim of this study was to analyse the sociodemographic and occupational factors, as well as anxiety and depressive symptoms, associated with smoking status and physical activity among Spanish nursing professionals. Methods: A cross-sectional study was conducted between June and August 2021, including 1216 Spanish nursing professionals. Participants completed an online questionnaire assessing sociodemographic and occupational characteristics, smoking status, physical activity, and symptoms of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS). Bivariate analyses and multivariable logistic regression models identified factors associated with smoking status and physical activity. Results: Overall, 19.0% of participants were current smokers and 49.2% reported physical activity. Self-reported physical activity was positively associated with being a registered nurse, being male, being separated or widowed, living alone, and longer time working in the current service, whereas having children and current smoking were associated with lower odds of being physically active. Current smoking was less likely among older professionals, registered nurses, participants reporting physical activity, and those with anxiety symptoms. Conclusions: Physical activity and smoking showed an inverse association and were related to different sociodemographic and occupational characteristics among Spanish nursing professionals. The inverse association between anxiety symptoms and current smoking was unexpected and should be interpreted with caution. These findings may inform workplace health promotion strategies addressing physical activity and tobacco use together, while considering the specific needs of different professional groups within the nursing workforce. Full article

Objectives: To analyze adolescent suicide rates during the COVID-19 pandemic, examine the relationship between bullying, cyberbullying, and suicidal behavior, and identify evidence-based prevention strategies. Methods: A systematic review of 26 peer-reviewed articles (published between 2020 and 2025) was conducted across five databases. Studies were appraised for quality using STROBE and SRQR guidelines. Results: The pandemic significantly impacted adolescent mental health, increasing depression, anxiety, and suicidal ideation, particularly among females and vulnerable populations. Notably, while traditional bullying decreased during school closures (78.2% reduction), cyberbullying reports saw a substantial increase (with a 264.4% spike documented in national helpline data). Key risk factors included social isolation, excessive social media use, pre-existing mental health conditions, and low socioeconomic status. Protective factors included family support and access to mental health services. Conclusions: COVID-19 created a significant adolescent mental health crisis. The shift to cyberbullying represents a critical emerging threat. Effective prevention requires a multitiered approach including universal screening, telehealth, and social–emotional learning programs while addressing the persistent shortage of mental health professionals. Full article

Background: Depressive symptoms are highly prevalent among patients with thymoma-associated myasthenia gravis (MG) and are associated with poorer clinical status and quality of life. However, their relationship with psychological counseling outcomes remains insufficiently investigated. Objectives: This study aimed to examine the association between baseline depressive tendency, baseline clinical status, and post-counseling clinical outcomes in patients with thymoma-associated MG. Methods: This single-group pre-post exploratory pilot study enrolled 17 patients with thymoma-associated MG who received eight sessions of Gestalt-oriented psychological counseling. A depressive tendency was defined as a baseline Patient Health Questionnaire-9 (PHQ-9) score ≥10 (n = 6, 35.3%). Clinical outcomes, including the Myasthenia Gravis Activities of Daily Living scale (MG-ADL), Myasthenia Gravis Quality of Life 15-item scale (MG-QoL15), mental BMI (mBMI), and PHQ-9 scores, were assessed before and after the intervention. Multivariable linear regression analyses were performed using baseline depressive tendency as the primary predictor of each post-counseling outcome. The models were sequentially adjusted for the corresponding baseline outcome score and subsequently for age and sex. Results: Following the counseling intervention, statistically significant pre–post changes were observed in MG-ADL (p = 0.044), mBMI (p = 0.018), and PHQ-9 (p = 0.002) scores. After adjustment for the corresponding baseline outcome score, age, and sex, baseline depressive tendency was associated with less favorable post-counseling mBMI (β = −3.52, robust 95% CI −6.19 to −0.86, p = 0.014) and MG-ADL scores (β = 1.70, robust 95% CI 0.51 to 2.89, p = 0.009). Conclusions: Baseline depressive tendency was associated with poorer baseline functional and disease-specific quality-of-life status and with less favorable adjusted post-counseling MG-ADL and mBMI scores. These associations met the Benjamini–Hochberg threshold but not the more conservative Benjamini–Yekutieli threshold. Given the small sample and uncontrolled pilot design, the findings should not be regarded as evidence of counseling effectiveness and require confirmation in prospective controlled studies. Full article