Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

Article Types

Countries / Regions

Search Results (168)

Search Parameters:
Keywords = ion beam radiation

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
12 pages, 1583 KiB  
Article
Photothermal Performance Testing of Lithium Niobate After Ion Beam Radiation
by Junyi Liu, Daiyong Lin, Xing Peng, Yao Wu, Jian Li, Ziqiang Hu, Zhixuan He, Jiaqi Wang, Yuxia Tan, Xiaoshu Xu and Shuo Qiao
Photonics 2025, 12(8), 793; https://doi.org/10.3390/photonics12080793 - 6 Aug 2025
Abstract
To investigate the evolution of the optothermal properties of lithium niobate with ion beam irradiation parameters, the thermal effect theory was analyzed, and ion beam irradiation technology was used to modify lithium niobate samples. The transmittance of lithium niobate crystals after ion beam [...] Read more.
To investigate the evolution of the optothermal properties of lithium niobate with ion beam irradiation parameters, the thermal effect theory was analyzed, and ion beam irradiation technology was used to modify lithium niobate samples. The transmittance of lithium niobate crystals after ion beam irradiation and the relationship between their optothermal properties and transmittance were studied. The results show that the average surface optothermal signal of lithium niobate exhibits a significant dependence on ion beam parameters. When the ion beam voltage is 800 V, the ion beam current is 30 mA, and the irradiation time is 60 s, a distinct absorption peak is observed on the surface of lithium niobate, with an average surface optothermal signal of 5377.34 ppm, demonstrating potential for all-optical modulation. Full article
(This article belongs to the Section Optical Interaction Science)
Show Figures

Figure 1

12 pages, 2086 KiB  
Article
Radiation Hardness of Oxide Thin Films Prepared by Magnetron Sputtering Deposition
by Marko Škrabić, Marija Majer, Zdravko Siketić, Maja Mičetić, Željka Knežević and Marko Karlušić
Appl. Sci. 2025, 15(13), 7067; https://doi.org/10.3390/app15137067 - 23 Jun 2025
Viewed by 187
Abstract
Thin amorphous oxide films (a-SiO2, a-Al2O3, a-MgO) were prepared by magnetron sputtering deposition. Their response to high-energy heavy ion beams (23 MeV I, 18 MeV Cu, 2.5 MeV Cu) and gamma-ray (1.25 MeV) irradiation was studied by [...] Read more.
Thin amorphous oxide films (a-SiO2, a-Al2O3, a-MgO) were prepared by magnetron sputtering deposition. Their response to high-energy heavy ion beams (23 MeV I, 18 MeV Cu, 2.5 MeV Cu) and gamma-ray (1.25 MeV) irradiation was studied by elastic recoil detection analysis and infrared spectroscopy. It was established that their high radiation hardness is due to a high level of disorder, already present in as-prepared samples, so the high-energy heavy ion irradiation cannot change their structure much. In the case of a-SiO2, this resulted in a completely different response to high-energy heavy ion irradiation found previously in thermally grown a-SiO2. In the case of a-MgO, only gamma-ray irradiation was found to induce significant changes. Full article
Show Figures

Figure 1

15 pages, 554 KiB  
Article
Long-Term Clinical Outcomes for Adolescent and Young-Adult Uveal Melanoma Patients Treated with Dedicated Particle-Beam Radiation
by Carly Zako, Arina Nisanova, Vivian Weinberg, Jessica Scholey, Carisa Swason, Armin R. Afshar, Jeanne Quivey, Inder K. Daftari, Tony Tsai, Susanna S. Park, Michael Seider, Robert N. Johnson, Devron H. Char and Kavita K. Mishra
Cancers 2025, 17(12), 2042; https://doi.org/10.3390/cancers17122042 - 19 Jun 2025
Viewed by 431
Abstract
Uveal melanoma (UM) is a rare tumor and a challenging diagnosis for adolescent and young-adult (AYA) patients, as it can threaten vision, quality of life, and life expectancy [...] Full article
(This article belongs to the Special Issue Advances in Uveal Melanoma)
Show Figures

Figure 1

13 pages, 2235 KiB  
Article
Optimization of DD-110 Neutron Generator Output for Boron Neutron Capture Therapy Using Monte Carlo Simulation
by Hossam Donya and Muhammed Umer
Quantum Beam Sci. 2025, 9(2), 12; https://doi.org/10.3390/qubs9020012 - 15 Apr 2025
Cited by 2 | Viewed by 1428
Abstract
Boron neutron capture therapy (BNCT) is a specialized cancer treatment that leverages the high absorption cross-section of boron for thermal neutrons. When boron captures neutrons, it undergoes a nuclear reaction that produces alpha particles and lithium ions, which have high linear energy transfer [...] Read more.
Boron neutron capture therapy (BNCT) is a specialized cancer treatment that leverages the high absorption cross-section of boron for thermal neutrons. When boron captures neutrons, it undergoes a nuclear reaction that produces alpha particles and lithium ions, which have high linear energy transfer (LET) and can effectively damage nearby cancer cells while minimizing harm to surrounding healthy tissues. This targeted approach makes BNCT particularly advantageous for treating tumors situated in sensitive areas where traditional radiation therapies may pose risks to critical structures. In this study, the deuterium–deuterium (DD) neutron generator, specifically the DD-110 model (neutron yield Y = 1 × 1010 n/s), served as the neutron source for BNCT. The fast neutrons produced by this generator were thermalized to the epithermal energy range using a beam-shaping assembly (BSA). The BSA was designed with a moderator composed of 32 cm of MgF2, a reflector made of 76 cm of Pb, and filters including 3 cm of Pb and 1.52 cm of Bi. A collimator, featuring a 10 cm high Pb cone frustum with a 12 cm aperture diameter, was also employed to optimize beam characteristics. The entire system’s performance was modeled and simulated using the MCNPX code, focusing on parameters both in-air and in-phantom to evaluate its efficacy. The findings indicated that the BSA configuration yielded an optimal thermal-to-epithermal flux ratio (φther/φepth) of 0.19, a current-to-flux ratio of 0.87, and a gamma dose-to-epithermal flux ratio of 1.71 × 10−13 Gy/cm2, all aligning with IAEA recommendations. The simulated system showed acceptable ratios for φther/φepth, gamma dose to epithermal flux, and beam collimation. Notably, the advantage depth was recorded at 5.5 cm, with an advantage ratio of 2.29 and an advantage depth dose rate of 4.1 × 10−4 Gy.Eq/min. The epithermal neutron flux of D110 exceeded D109, but D110’s fast neutron contamination increased ~6.6 times. On the other hand, D110’s gamma contamination decreased by 30%. Based on these findings, optimizing neutron source characteristics is crucial for BNCT efficacy. Future research should focus on developing advanced neutron generators that balance these factors, aiming to produce optimal neutron yields for enhanced treatment outcomes and broader applicability. Full article
Show Figures

Figure 1

16 pages, 4328 KiB  
Article
Laser Annealing of Si Wafers Based on a Pulsed CO2 Laser
by Ziming Wang, Guochang Wang, Mingkun Liu, Sicheng Li, Zhenzhen Xie, Liemao Hu, Hui Li, Fangjin Ning, Wanli Zhao, Changjun Ke, Zhiyong Li and Rongqing Tan
Photonics 2025, 12(4), 359; https://doi.org/10.3390/photonics12040359 - 10 Apr 2025
Viewed by 973
Abstract
Laser annealing plays a significant role in the fabrication of scaled-down semiconductor devices by activating dopant ions and rearranging silicon atoms in ion-implanted silicon wafers, thereby improving material properties. Precise temperature control is crucial in wafer annealing, particularly for repeated processes where repeatability [...] Read more.
Laser annealing plays a significant role in the fabrication of scaled-down semiconductor devices by activating dopant ions and rearranging silicon atoms in ion-implanted silicon wafers, thereby improving material properties. Precise temperature control is crucial in wafer annealing, particularly for repeated processes where repeatability affects uniformity. In this study, we employ a three-dimensional time-dependent thermal simulation model to numerically analyze the multiple static laser annealing processes based on a CO2 laser with a center wavelength of 9.3 μm and a pulse repetition rate of 10 kHz. The heat transfer equation is solved using a multiphysics coupling approach to accurately simulate the effects of different numbers of CO2 laser pulses on wafer temperature rise and repeatability. Additionally, a pyrometer is used to collect and convert the surface temperature of the wafer. Radiation intensity is converted to temperature via Planck’s law for real-time monitoring. Post-processing is performed to fit the measured temperature and the actual temperature into a linear relationship, aiding in obtaining the actual temperature under small beam spots. According to the simulation conditions, a wafer annealing device using a CO2 laser as the light source was independently built for verification, and a stable and uniform annealing effect was realized. Full article
(This article belongs to the Section Lasers, Light Sources and Sensors)
Show Figures

Figure 1

23 pages, 8054 KiB  
Article
Electron Beam Irradiation’s Effect on Polyaniline/LiClO4/CuO Nanocomposite: A Study of Dielectric, Conductivity and Electrochemical Properties
by Yesappa Laxmayyaguddi, Sharanappa Chapi and Nagaraj Nandihalli
Appl. Sci. 2025, 15(7), 4001; https://doi.org/10.3390/app15074001 - 4 Apr 2025
Viewed by 484
Abstract
A straightforward chemical polymerization process was used to create the polyaniline/LiClO4/CuO nanoparticle (PLC) nanocomposite, which was then exposed to varying doses of electron beam (EB) radiation and studied. The FESEM, XRD, FTIR, DSC, TG/DTA, and electrochemical measurements with higher EB doses [...] Read more.
A straightforward chemical polymerization process was used to create the polyaniline/LiClO4/CuO nanoparticle (PLC) nanocomposite, which was then exposed to varying doses of electron beam (EB) radiation and studied. The FESEM, XRD, FTIR, DSC, TG/DTA, and electrochemical measurements with higher EB doses showed clear changes. The FTIR spectra of the PLC nanocomposite showed variations in the C-N and carbonyl groups at 1341 cm−1 and 1621 cm−1, respectively. After a 120 kGy EB dose, the shape changed from a smooth, uneven surface to a well-connected, nanofiber-like structure, creating pathways for electricity to flow through the polymer matrix. The EB irradiation improved the thermal stability by decreasing the melting temperature, and the XRD and DSC studies reveal that the decrease in crystallinity is attributed to the dominant chain scission mechanism. The enhanced absorption and red shift in the wavelength (from 374 nm to 400 nm) observed in the UV-Visible spectroscopy were caused by electrons transitioning from a lower to a higher energy state, with a progressive drop in the band gaps (Eg) from 2.15 to 1.77 eV following irradiation. The dielectric parameters increased with the temperature and electron beam doses because of the dissociation of the ion aggregates and the emergence of defects and/or disorders in the polymer band gaps. This was triggered by chain scission, discontinuity, and bond breaking in the molecular chains at elevated levels of radiation energy, leading to an augmented charge carrier density and, subsequently, enhanced conductivity. The cyclic voltammetry study revealed an enhanced electrochemical stability at a high scan rate of about 600 mV/s for the PLC nanocomposite with the increase in the EB doses. The I-V characteristics measured at room temperature exhibited nonohmic behavior with an expanded current range, and the electrical conductivity was estimated, using the I-V curve, to be around 1.05 × 10−4 S/cm post 20 kGy EB irradiation. Full article
Show Figures

Figure 1

15 pages, 7943 KiB  
Article
The Effect of He on the Evolution of Radiation-Induced Dislocation Loops near W/Cu Interface
by Huaqing Sang, Yifan Zhang and Jing Wang
Metals 2025, 15(4), 382; https://doi.org/10.3390/met15040382 - 28 Mar 2025
Viewed by 326
Abstract
In the current work, the distribution behaviors of irradiation-induced dislocation loops near the W-Cu interface (contains a thin W2C transition layer) under self-interstitial atom diffusion-dominated conditions were investigated based on the comparative experiment of 3 MeV Fe ion and 100 keV [...] Read more.
In the current work, the distribution behaviors of irradiation-induced dislocation loops near the W-Cu interface (contains a thin W2C transition layer) under self-interstitial atom diffusion-dominated conditions were investigated based on the comparative experiment of 3 MeV Fe ion and 100 keV He ion irradiation. The size distribution and number density of radiation-induced dislocation loops in both sides of the interface were characterized using Transmission Electron Microscopy with different two-beam conditions. The impact of the phase boundary on the dislocation loop distribution and the influence of He on this mechanism was discussed. The results showed that the phase boundary (PB) has a significant effect on the distribution of radiation-induced dislocation loops. In the Fe-irradiated sample, the proportion of b = 1/2<111> type dislocation loops near the phase boundary on the W side increases significantly, and b = 1/2<110> type dislocation loops dominate on the Cu side. He will significantly affect the loop distribution near the W/Cu phase boundary due to the strong binding of He with vacancies in W, which suppresses the recombination of SIA and vacancies and promotes the formation and growth of interstitial-type dislocations. Full article
Show Figures

Figure 1

60 pages, 13122 KiB  
Review
Advancements in Lithography Techniques and Emerging Molecular Strategies for Nanostructure Fabrication
by Prithvi Basu, Jyoti Verma, Vishnuram Abhinav, Ratneshwar Kumar Ratnesh, Yogesh Kumar Singla and Vibhor Kumar
Int. J. Mol. Sci. 2025, 26(7), 3027; https://doi.org/10.3390/ijms26073027 - 26 Mar 2025
Cited by 4 | Viewed by 6054
Abstract
Lithography is crucial to semiconductor manufacturing, enabling the production of smaller, more powerful electronic devices. This review explores the evolution, principles, and advancements of key lithography techniques, including extreme ultraviolet (EUV) lithography, electron beam lithography (EBL), X-ray lithography (XRL), ion beam lithography (IBL), [...] Read more.
Lithography is crucial to semiconductor manufacturing, enabling the production of smaller, more powerful electronic devices. This review explores the evolution, principles, and advancements of key lithography techniques, including extreme ultraviolet (EUV) lithography, electron beam lithography (EBL), X-ray lithography (XRL), ion beam lithography (IBL), and nanoimprint lithography (NIL). Each method is analyzed based on its working principles, resolution, resist materials, and applications. EUV lithography, with sub-10 nm resolution, is vital for extending Moore’s Law, leveraging high-NA optics and chemically amplified resists. EBL and IBL enable high-precision maskless patterning for prototyping but suffer from low throughput. XRL, using synchrotron radiation, achieves deep, high-resolution features, while NIL provides a cost-effective, high-throughput method for replicating nanostructures. Alignment marks play a key role in precise layer-to-layer registration, with innovations enhancing accuracy in advanced systems. The mask fabrication process is also examined, highlighting materials like molybdenum silicide for EUV and defect mitigation strategies such as automated inspection and repair. Despite challenges in resolution, defect control, and material innovation, lithography remains indispensable in semiconductor scaling, supporting applications in integrated circuits, photonics, and MEMS/NEMS devices. Various molecular strategies, mechanisms, and molecular dynamic simulations to overcome the fundamental lithographic limits are also highlighted in detail. This review offers insights into lithography’s present and future, aiding researchers in nanoscale manufacturing advancements. Full article
Show Figures

Figure 1

8 pages, 635 KiB  
Article
Patient Shielding in Ultra-High-Resolution Cone-Beam CT of the Upper Extremity with a Twin Robotic X-Ray System
by Andreas Steven Kunz, Stefan Weick, Jan-Peter Grunz, Andre Toussaint, Gary Razinskas, Anne Richter, Sonja Wegener, Andrea Wittig-Sauerwein, Thorsten Alexander Bley and Henner Huflage
Diagnostics 2025, 15(5), 596; https://doi.org/10.3390/diagnostics15050596 - 28 Feb 2025
Viewed by 788
Abstract
Background/Objectives: Gantry-free cone-beam CT (CBCT) allows for ultra-high-resolution (UHR) upper extremity imaging in a comfortable tableside position. The aim of this study was to assess the organ-specific radiation burden and the effect of dedicated lead shielding in the UHR-CBCT of the wrist [...] Read more.
Background/Objectives: Gantry-free cone-beam CT (CBCT) allows for ultra-high-resolution (UHR) upper extremity imaging in a comfortable tableside position. The aim of this study was to assess the organ-specific radiation burden and the effect of dedicated lead shielding in the UHR-CBCT of the wrist and elbow. Methods: A modified Alderson-Rando phantom was scanned with the tableside UHR-CBCT mode of a twin robotic X-ray system employing identical scan parameters for wrist and elbow imaging. An ion chamber was used in conjunction with an electrometer to obtain representative organ dose measurements for the eye lens, thyroid gland, breast tissue, and abdomen. All measurements were performed with and without lead shielding. Results: Irrespective of the examined upper extremity joint, the highest absorbed dose among the assessed organs was determined for the eye lens (wrist imaging: 0.10 ± 0.01 mGy, elbow imaging: 0.12 ± 0.01 mGy). The most effective organ dose reduction by means of shielding in wrist CBCT was achieved for the thyroid gland (−17%). In elbow CBCT, the abdomen (−48%) and the ipsilateral breast (−39%) benefited particularly from shield protection. Conclusions: Although shielding was more effective in elbow than wrist scans, the overall impact in terms of absolute dose reduction was marginal. Full article
(This article belongs to the Special Issue Advanced Musculoskeletal Imaging in Clinical Diagnostics)
Show Figures

Figure 1

22 pages, 6039 KiB  
Review
Application Progress of Electron Beam Radiation in Adsorption Functional Materials Preparation
by Jie Gao, Xiang Li, Tao Chen, Yuan Zhao, Houhua Xiong and Xiaobing Han
Molecules 2025, 30(5), 1084; https://doi.org/10.3390/molecules30051084 - 27 Feb 2025
Cited by 1 | Viewed by 743
Abstract
To solve the problems of water and air pollution, adsorption functional materials (ASFMs) have been extensively investigated and applied. Among the preparation methods of ASFM, electron beam radiation (EBR) has attracted much attention for its high efficiency, environmental friendliness, and wide applicability. Based [...] Read more.
To solve the problems of water and air pollution, adsorption functional materials (ASFMs) have been extensively investigated and applied. Among the preparation methods of ASFM, electron beam radiation (EBR) has attracted much attention for its high efficiency, environmental friendliness, and wide applicability. Based on the introduction of the application of EBR technology, the EBR preparation of ASFM is summarized by grafting and cross-linking. Secondly, the application of corresponding ASFM for the adsorption of metal ions, inorganic anions, dyes, drugs and chemical raw materials, and carbon dioxide is summarized systematically. Then, the adsorption mechanisms of ASFM are illustrated, according to the different pollutants. Finally, the progress, issues, and prospects of EBR technology for ASFM preparation are discussed. Full article
(This article belongs to the Special Issue Advanced Functional Materials: Challenges and Opportunities)
Show Figures

Figure 1

12 pages, 4934 KiB  
Article
In Situ Study of the Temperature and Fluence Dependence of Yb2+ Luminescence in Yttrium Aluminum Garnet (YAG) Single Crystals
by Ruotong Chang, Yingjie Song, Hongtao Hu, Shasha Lv, Guangfu Wang and Menglin Qiu
Atoms 2025, 13(2), 13; https://doi.org/10.3390/atoms13020013 - 27 Jan 2025
Viewed by 757
Abstract
In this study, ion-beam-induced luminescence with 2 MeV H+ was used to excite YAG single crystals at different temperatures. Under several constant temperatures, the luminescence intensity of Yb2+ monotonically decreases with increasing fluence, eventually reaching approximately 35% of the initial intensity [...] Read more.
In this study, ion-beam-induced luminescence with 2 MeV H+ was used to excite YAG single crystals at different temperatures. Under several constant temperatures, the luminescence intensity of Yb2+ monotonically decreases with increasing fluence, eventually reaching approximately 35% of the initial intensity at a fluence of 3.5 × 1014 cm−2. The nonmonotonic evolution behavior of Yb2+ luminescence intensity with temperature can be effectively described by the intermediate-state model under consecutive temperature variations. The presence of an intermediate state may be the primary cause of the negative thermal quenching of Yb2+ luminescence. Yb2+ luminescence intensity decreased to 60% of the initial intensity when the temperature was continuously varied in the 100–300 K range, although the peak position remained rather stable. The luminescence of Yb2+ exhibits good radiation resistance and thermal stability in the experimental temperature range. Full article
Show Figures

Figure 1

8 pages, 1932 KiB  
Article
High-Harmonic Generation in an Optical Fiber Functionalized with Zinc Oxide Thin Films
by Idris Tiliouine, Yann Leventoux, Jean-Christophe Orlianges, Aurelian Crunteanu, Marie Froidevaux, Hamed Merdji and Sébastien Février
Photonics 2025, 12(1), 82; https://doi.org/10.3390/photonics12010082 - 17 Jan 2025
Viewed by 1015
Abstract
High-order harmonic generation (HHG) in semiconductor thin films from ultrashort mid-infrared laser drivers holds the potential for the realization of integrated sources of extreme ultraviolet light. Here, we demonstrate solid-state HHG in zinc oxide thin films synthesized by the radiofrequency reactive magnetron sputtering [...] Read more.
High-order harmonic generation (HHG) in semiconductor thin films from ultrashort mid-infrared laser drivers holds the potential for the realization of integrated sources of extreme ultraviolet light. Here, we demonstrate solid-state HHG in zinc oxide thin films synthesized by the radiofrequency reactive magnetron sputtering process directly on the cleaved facets of optical fibers. Harmonics 3 to 13 of the radiation from a fiber-based laser system delivering 500 kW, 96 fs pulses at 3130 nm are produced in the thin film and guided along the fiber. A proper choice of the laser wavelength and fiber material allows for filtering out the mid-IR pump laser and achieving the HHG mode selection. The possibility to nanostructure the fiber exit by, e.g., focused ion beam milling paves the way to an increased control over the HHG spatial mode. Full article
(This article belongs to the Section Lasers, Light Sources and Sensors)
Show Figures

Figure 1

22 pages, 6851 KiB  
Article
Size-Sorted Superheated Nanodroplets for Dosimetry and Range Verification of Carbon-Ion Radiotherapy
by Yosra Toumia, Marco Pullia, Fabio Domenici, Alessio Mereghetti, Simone Savazzi, Michele Ferrarini, Angelica Facoetti and Gaio Paradossi
Nanomaterials 2024, 14(20), 1643; https://doi.org/10.3390/nano14201643 - 13 Oct 2024
Cited by 1 | Viewed by 1429
Abstract
Nanodroplets have demonstrated potential for the range detection of hadron radiotherapies. Our formulation uses superheated perfluorobutane (C4F10) stabilized by a poly(vinyl-alcohol) shell. High-LET (linear energy transfer) particles vaporize the nanodroplets into echogenic microbubbles. Tailored ultrasound imaging translates the generated echo-contrast into a dose [...] Read more.
Nanodroplets have demonstrated potential for the range detection of hadron radiotherapies. Our formulation uses superheated perfluorobutane (C4F10) stabilized by a poly(vinyl-alcohol) shell. High-LET (linear energy transfer) particles vaporize the nanodroplets into echogenic microbubbles. Tailored ultrasound imaging translates the generated echo-contrast into a dose distribution map, enabling beam range retrieval. This work evaluates the response of size-sorted nanodroplets to carbon-ion radiation. We studied how thesize of nanodroplets affects their sensitivity at various beam-doses and energies, as a function of concentration and shell cross-linking. First, we show the physicochemical characterization of size-isolated nanodroplets by differential centrifugation. Then, we report on the irradiations of the nanodroplet samples in tissue-mimicking phantoms. We compared the response of large (≈900 nm) and small (≈400 nm) nanodroplets to different carbon-ions energies and evaluated their dose linearity and concentration detection thresholds by ultrasound imaging. Additionally, we verified the beam range detection accuracy for the nanodroplets samples. All nanodroplets exhibited sensitivity to carbon-ions with high range verification precision. However, smaller nanodroplets required a higher concentration sensitivity threshold. The vaporization yield depends on the carbon-ions energy and dose, which are both related to particle count/spot. These findings confirm the potential of nanodroplets for range detection, with performance depending on nanodroplets’ properties and beam parameters. Full article
(This article belongs to the Special Issue Radiation Technology in Nanomaterials)
Show Figures

Figure 1

15 pages, 5740 KiB  
Article
Dynamic Deformation in Nuclear Graphite and Underlying Mechanisms
by Melonie Thomas, Hajin Oh, Ryan Schoell, Stephen House, Miguel Crespillo, Khalid Hattar, William Windes and Aman Haque
Materials 2024, 17(18), 4530; https://doi.org/10.3390/ma17184530 - 14 Sep 2024
Cited by 3 | Viewed by 1172
Abstract
Time-dependent deformation in nuclear graphite is influenced by the creation and migration of radiation-induced defects in the reactor environment. This study investigates the role of pre-existing defects such as point defect clusters and Mrozowski cracks in nuclear graphite IG-110. Separate specimens were irradiated [...] Read more.
Time-dependent deformation in nuclear graphite is influenced by the creation and migration of radiation-induced defects in the reactor environment. This study investigates the role of pre-existing defects such as point defect clusters and Mrozowski cracks in nuclear graphite IG-110. Separate specimens were irradiated with a 2.8 MeV Au2+ beam with a fluence of 4.38 × 1014 cm−2 and an 8 MeV C2+ beam with a fluence of 1.24 × 1016 cm−2. Microscopic specimens were either mechanically loaded inside a transmission electron microscope (TEM) or subjected to ex situ indentation-based creep loading. In situ TEM tests showed significant plasticity in regions highly localized around the Mrozowski cracks, resembling slip or ripplocation bands. Slip bands were also seen near regions without pre-existing defects but at very high stresses. Ex situ self-ion irradiation embrittled the specimens and decreased the creep displacement and rate, while heavy ion irradiation resulted in the opposite behavior. We hypothesize that the large-sized gold ions (compared to the carbon atoms) induced interplanar swelling as well as cross-plane channels for increased defect mobility. These findings illustrate the role of pre-existing defects in the dynamic relaxation of stresses during irradiation and the need for more studies into the radiation environment’s impact on the mechanical response of nuclear graphite. Full article
(This article belongs to the Section Carbon Materials)
Show Figures

Figure 1

23 pages, 1736 KiB  
Review
The Potential for Targeting G2/M Cell Cycle Checkpoint Kinases in Enhancing the Efficacy of Radiotherapy
by Emma Melia and Jason L. Parsons
Cancers 2024, 16(17), 3016; https://doi.org/10.3390/cancers16173016 - 29 Aug 2024
Cited by 3 | Viewed by 1984
Abstract
Radiotherapy is one of the main cancer treatments being used for ~50% of all cancer patients. Conventional radiotherapy typically utilises X-rays (photons); however, there is increasing use of particle beam therapy (PBT), such as protons and carbon ions. This is because PBT elicits [...] Read more.
Radiotherapy is one of the main cancer treatments being used for ~50% of all cancer patients. Conventional radiotherapy typically utilises X-rays (photons); however, there is increasing use of particle beam therapy (PBT), such as protons and carbon ions. This is because PBT elicits significant benefits through more precise dose delivery to the cancer than X-rays, but also due to the increases in linear energy transfer (LET) that lead to more enhanced biological effectiveness. Despite the radiotherapy type, the introduction of DNA damage ultimately drives the therapeutic response through stimulating cancer cell death. To combat this, cells harbour cell cycle checkpoints that enables time for efficient DNA damage repair. Interestingly, cancer cells frequently have mutations in key genes such as TP53 and ATM that drive the G1/S checkpoint, whereas the G2/M checkpoint driven through ATR, Chk1 and Wee1 remains intact. Therefore, targeting the G2/M checkpoint through specific inhibitors is considered an important strategy for enhancing the efficacy of radiotherapy. In this review, we focus on inhibitors of Chk1 and Wee1 kinases and present the current biological evidence supporting their utility as radiosensitisers with different radiotherapy modalities, as well as clinical trials that have and are investigating their potential for cancer patient benefit. Full article
(This article belongs to the Special Issue Personalized Radiotherapy in Cancer Care)
Show Figures

Figure 1

Back to TopTop