Search Results (2,832)

As hybrid organizations that combine market-related logic with social logic, social enterprises (SEs) play a crucial role in addressing the challenges faced by people in employment while creating economic benefits through innovative solutions to drive economic and social rural revitalization. Focusing on social enterprises, this study employs environmental analysis and theoretical reasoning to examine the logic and approaches through which social enterprises participate in rural revitalization in China’s northwest regions from the perspective of “new-quality productive forces.” Research findings indicate that in the face of an external environment characterized by weakened investment and consumption and the decline of the demographic dividend, and an internal environment marked by lagging socio-economic development and ecological fragility, SEs should integrate devotion and profit logic based on a mixed action logic of multi-value co-creation. Through approaches such as cultivating new quality talent, constructing a new quality industrial system, shaping a new quality rural environment, promoting synergistic innovation between science and technology and culture, and actively participating in the revitalization of rural areas in China’s northwest region, SEs can play an active role in China’s rural revitalization efforts. Full article

In response to increasing global sustainability demands, this study examines how green dynamic capabilities influence business performance in Bali Island’s tour and travel SMEs, with green service innovation as a mediating mechanism. Drawing on the resource-based view (RBV) and dynamic capability theory, the research adopts a quantitative approach using survey data from 387 SMEs and employs structural equation modeling (SEM) to analyze the relationships among green dynamic capabilities, green service innovation, and business performance. Findings reveal that green dynamic capabilities significantly enhance both green service innovation and business performance. Notably, green service innovation partially mediates this relationship, underscoring its pivotal role in transforming internal sustainability-oriented capabilities into tangible performance outcomes. The key contribution of this study lies in extending RBV by integrating green service innovation as a strategic conduit that links eco-centric capabilities to competitive advantage in a tourism SME context—a perspective that remains underexplored in emerging economies. Practically, the study provides actionable insights for SME owners and policymakers to prioritize innovation in service design and delivery as a pathway to sustainable tourism performance. Full article

The Sultanate of Oman boasts remarkable biodiversity, exemplified by such species as the Arabian leopard (Panthera pardus nimr) and the Arabian oryx (Oryx leucoryx), national symbols that highlight the extensive conservation efforts required to protect the country’s natural heritage. During decades, Omani authorities have taken significant measures to safeguard wildlife and preserve the natural environment. A sanctuary dedicated to the reintroduction of the Arabian Oryx, after extinction in nature in 1972, was established in 1980 in the Al Wusta Governorate under the patronage of the Royal Diwan and currently administrated by the recently established Environment Authority. During the almost 40 years since the reintroduction and the creation of the sanctuary, the oryx population has grown slowly but constantly. In 2021, the sanctuary hosted 738 oryx, allowing the start of the reintroduction of the species into the natural environment. Small groups of animals were released into the wild in selected areas. No animal health adverse events were recorded, and mortality was generally due to injuries received as a consequence of fighting, in particular during mating season. Standard veterinary care, including control of internal and external parasites, was regularly provided. In some occasions, immunization against certain diseases, such as clostridial infections, pasteurellosis, or mycoplasmosis, was also applied. In 2023, an FMD outbreak in cattle reported in Dhofar, about 500 km from the Al Wusta sanctuary, motivated specific prophylactic actions to prevent the risk of diffusion to oryx. From December 2023 to January 2024, an immunization program was undertaken using an FMD vaccine against serotypes A, O, and SAT 1, mostly in male oryx, while pregnant oryx were avoided for abortion risk due to handling. The following year, in January 2025, a severe outbreak occurred in oryx herds held in the sanctuary. The rapid onset and the spread of clinical symptoms among animals (100% morbidity in the second day after the first appearance of signs in some individuals) were suggestive of a highly contagious disease. The animals suffered from severe depression and inappetence, rapidly followed by abundant salivation, erosions of the oral mucosa and tongue, and diarrhea, with a short course characterized by prostration and death of the animal in the most severe cases. Therapeutical attempts (administration of antibiotics and rehydration) were mostly ineffective. Laboratory investigations (ELISA and PCR) ruled out contagious bovine pleuropneumonia (CBPP), Johne’s disease and Peste des petits ruminants (PPR). Both serology and antigen detection showed positiveness to foot-and-mouth disease (FMD). Out of a total population of 669 present in the sanctuary at the beginning of the outbreak, 226 (33.78%) oryx died. Despite the vaccinal status, the 38.49% of dead animals resulted being vaccinated against FMD. Taking into account the incalculable value of the species, the outbreak represented a very dangerous event that risked wiping out the decades of conservation efforts. Therefore, all the available means, such as accrued biosecurity and adequate prophylaxis, should be implemented to prevent the recurrence of such health risks. The delicate equilibrium of wild fauna in Oman requires study and support for an effective protection, in line with the national plan “Vision 2040”, targeting the inclusion of the Sultanate within the 20 best virtuous countries for wildlife protection. Full article

Background/Objectives: Antibody–drug conjugates are a rapidly evolving class of cancer therapeutics that combine the specificity of monoclonal antibodies with the potency of cytotoxic drugs. This review explores experimental and computational advances in ADC design, focusing on structural elements and optimization strategies. Methods: We examined recent developments in the mechanisms of action, antibody engineering, linker chemistries, and payload selection. Emphasis was placed on experimental strategies and computational tools, including molecular modeling and AI-driven structure prediction. Results: ADCs function through both internalization-dependent and -independent mechanisms, enabling targeted drug delivery and bystander effects. The therapeutic efficacy of ADCs depends on key factors: antigen specificity, linker stability, and payload potency. Linkers are categorized as cleavable or non-cleavable, each with distinct advantages. Payloads—mainly tubulin inhibitors and DNA-damaging agents—require extreme potency to be effective. Computational methods have become essential for antibody modeling, developability assessment, and in silico optimization of ADC components, accelerating candidate selection and reducing experimental labor. Conclusions: The integration of experimental and in silico approaches enhances ADC design by improving selectivity, stability, and efficacy. These strategies are critical for advancing next-generation ADCs with broader applicability and improved therapeutic indices. Full article

This study investigates how state-owned enterprises (SOEs) contribute to rural revitalization in China through systemic interventions that enable the transfer of social capital. Addressing the gap between external resource inputs and internal development needs, the study adopts a systems thinking framework to conceptualize social capital as comprising structural, relational, and cognitive components. Drawing on multi-case evidence from assistance projects led by China Southern Power Grid, this study selects 11 assistance projects from a broader pool of 199 cases, to demonstrate how SOEs act as institutional nodes to reshape rural governance systems. They rebuild local organizational networks (structural capital), establish long-term trust through “strong commitment–weak contract” mechanisms (relational capital), and localize technical knowledge to align with rural contexts (cognitive capital). These interlinked processes form an integrated system that enhances rural governance capacity and promotes sustainable development. The findings highlight that SOEs are not merely resource providers but systemic catalysts that support cross-scalar collaboration and social infrastructure building. The study contributes a novel perspective by integrating social capital theory with a systemic governance lens and offer a actionable insights into the institutional design of assistance models for the future interventions by SOEs and similar entities in underdeveloped areas. Full article

This study aims to explore the values of character education in the Chinese animated film Three Monks. This film serves as a teaching tool, not only imparting animation principles to university students majoring in animation but also showcasing Chinese cultural philosophy and educational values in implicit, exaggerated, and humorous action design. We employed a descriptive qualitative method. A total of 73 college students majoring in animation watched the film without any prior explanation of animation principles and moral education and then listened to detailed explanations of the character education and animation principles integrated into the film. Through repeated viewing, analysis, and summarization of the storyline, character behaviors, and action design in Three Monks, the values of character education, such as religion, kindness, diligence, independence, responsibility, tolerance, self-reflection, unity and cooperation, and courage to innovate, were embodied. These values are manifested through the film’s storyline, conflicts, character actions, animated performances, and background music. We compared the students’ pre- and post-viewing attitudes based on their discussions, reflections, and course evaluations. The results revealed that conveying moral values through animated films internalized and transmitted character education among university students, shaping cultural identity and social norms. This approach enhanced students’ learning engagement and improved their learning efficiency. Full article

Facing the pressure of green transformation, studying the relationship between government subsidies and the environmental performance of agricultural enterprises has significant theoretical value and practical significance for achieving sustainable agricultural development. Based on the micro data of 283 A-share listed agricultural enterprises in China from 2013 to 2023, this paper empirically analyzes the impact of government subsidies on the environmental performance of agricultural enterprises and its mechanism. The results show that there is an inverted U-shaped relationship between government subsidies and the environmental performance of agricultural enterprises, that is, when the government subsidies are within a certain scale, increasing government subsidies will have a positive impact on the environmental performance of agricultural enterprises. When the government subsidy reaches a certain scale, increasing the government subsidy will have a negative impact on the environmental performance of agricultural enterprises. External media attention (EMA) and internal control level (IC) play mediating roles in the impact of government subsidies on the environmental performance of agricultural enterprises. Heterogeneity analysis showed that for different types of subsidies, R&D subsidies and environmental protection subsidies had an inverted U-shaped impact on the environmental performance of agricultural enterprises. This study provides useful implications for improving methods of issuing government subsidies and enhancing the driving force of agricultural enterprises to carry out sustainable development actions. Full article

Meeting the European Green Deal’s goal of climate neutrality by 2050 calls for a 90 percent decrease in emissions from the transportation sector. Thus, there is need to accelerate the shift to more sustainable mobility for integrated and smarter multimodal and intermodal mobility. In European countries, more than 70% of the inhabitants live in metropolitan areas. Achieving low-carbon and more sustainable mobility is important to ensuring sustainable urban infrastructure. However, current mobility planning frameworks do not consider the key factors and strategies that encourage residents to choose sustainable transport modes. Hence, there is a need to identify the most efficient actions that should be employed either in the short or long term to achieve accessible, safe, cost-effective, and green transport systems specifically through the development of sustainable public transportation. Moreover, a paradigm shift is needed to explore the synergy between transportation and its relationship to the city. Accordingly, this article presents an action plan as an approach to assess key strategies needed to foster sustainable and smart mobility planning and design by deploying effective strategies and design solutions that support different green means of transportation for smart urban development. Qualitative data on sustainable mobility planning and design strategies was collected via secondary sources from the literature, and descriptive data analysis was carried out. Findings from this study identify internal and external factors required to promote sustainable multimodal and intermodal mobility based on the city’s transport policies and actions. Implications from this study provide a use case for the technological requirements required for electric mobility planning, design, and system operation for the actualization of sustainable public transportation to improve smart urban development. Full article

Based on SWOT and TOWS analyses and combined with expert interviews, this study proposes a series of marketing strategies to enhance consumers’ willingness to purchase used electric vehicles (UEVs). In terms of the strengths and opportunities (SO) strategy, it is recommended that enterprises strengthen marketing and brand building, customize services and special features, use price advantages and environmental awareness to attract specific groups, provide convenient charging services, give full play to technical support advantages, and expand channels through cooperation with the government and manufacturers. The strategies for the strengths and threats (ST) scenario include establishing a government relations department, improving product quality and brand image, enhancing information transparency and quality assurance, and building a partner network and customer relationships. In terms of weaknesses and opportunities (WO), it is proposed to transform corporate weaknesses into opportunities by investing in evaluation technology and expanding charging facilities, strengthening market promotion and consumer education, and providing personalized car purchase advice and high-quality after-sales services. In the face of weaknesses and threats (WT), the emphasis is on reducing risks and improving competitiveness by improving quality management, internal management, and providing long-term after-sales and warranty services. The main innovation of this study lies in integrating SWOT-TOWS strategic frameworks with qualitative expert insights to develop actionable and scenario-specific marketing strategies for the UEV market—an area previously underexplored in existing literature. The comprehensive strategy proposed in this study provides a practical path for UEV companies to enhance consumer trust and purchase willingness and promote the industry’s sustainable development. Full article

In recent years, there has been growing interest in developing robots capable of explaining their behavior, thereby improving their acceptance by humans with whom they share their environment. Proposed software designs are typically based on the advances being made in conversational systems built on deep learning techniques. However, apart from the ability to formulate explanations, the robot also needs an internal episodic memory, where it stores information from the continuous stream of experiences. Most previous proposals are designed to deal with short streams of episodic data (several minutes long). With the aim of managing larger experiences, we propose in this work a high-level episodic memory, where relevant events are abstracted to natural language concepts. The proposed framework is intimately linked to a software architecture in which the explanations, whether externalized or not, are shaped internally in a collaborative process involving the task-oriented software agents that make up the architecture. The core of this process is a runtime knowledge model, employed as working memory whose evolution allows for capturing the causal events stored in the episodic memory. We present several use cases that illustrate how the suggested framework allows an autonomous robot to generate correct and relevant explanations of its actions and behavior. Full article

Lack of recognition lays at the root of many of the current challenges for commons and ICCAs—Territories of Life despite the wide range of ongoing, collective action initiatives in Europe acknowledging and fighting this gap. In this paper, using a mixed methods approach, we analyze twelve years of three bottom-up initiatives based on the commons and ICCA—Territory of Life concept, implemented in Spain from 2012 to 2025. The aim of this research is to assess and understand the degree of success of the initiatives, based on an analysis of the source of recognition and the type of goals achieved. In general terms, the three recognition initiatives were successful, especially at the levels of self-, peer, and international recognition. However, all failed to substantially improve public awareness and national and sub-national governmental recognition, especially when addressing policy change and implementation. We conclude that, in the European context, despite these challenges, the concepts of “commons” and “ICCA-Territory of Life” are powerful tools to achieve some level of recognition and are a strategic priority for facing Europe’s challenges fostering solutions that reinforce the role, capacity, responsibility, and rights of Indigenous Peoples and Local Communities. Full article

Pyrolysis of oily sludge (OS) faces two significant challenges, dehydration in emulsion and coke formation, which cause extra energy consumption. Targeting energy saving, this paper first reported on solar photothermal dehydration and confined catalytic pyrolysis of OS using a single material. A wood sponge loaded with carbon dots (CM-CDs) can generate heat by absorbing solar energy and promote rapid phase separation and water transport via capillary action of oil–water emulsion in OS under sunlight. Almost all free water in OS with varied content can be removed after 3 h. Hydrocarbons entered the internal space of CM-CDs instead of contacting with soil minerals, contributed to the subsequent confined catalytic pyrolysis, led to a reduction in Ea (35.61 kJ/mol), inhibited coking and caking, and yielded higher oil recovery efficiency. In addition, CDs can form hotspots to enhance pyrolytic behaviors in local regions. When the ratio of OS to CM-CDs reached 10:0.6, the recovery rate of the oil fraction through combined pyrolysis was as high as 89%, which was 17% higher than that of OS pyrolysis alone. This discovery provides a new way to solve the bottleneck problems of OS pyrolysis in the industry. Full article

With growing public concern over environmental issues, organizations are facing increasing pressure to demonstrate a genuine and measurable commitment to environmental sustainability. In this context, understanding how corporate environmental responsibility (CER) shapes employee engagement (EE) is essential. This understanding helps align organizational behavior with both internal goals and broader societal expectations. Although the impact of corporate social responsibility (CSR) on EE has been widely studied, the specific role of CER—a key subdimension of CSR—remains underexplored. To address this gap, we developed a moderated mediation model grounded in social exchange theory, social identity theory, and signaling theory. This model aims to reveal how CER influences EE and through which mechanisms. Based on survey data from 418 employees in large Chinese manufacturing firms, our results show that perceived CER significantly enhances EE. This effect occurs primarily through the strengthening of organizational pride. Furthermore, online media coverage reinforces the relationship between perceived CER and organizational pride. It also amplifies the indirect impact of perceived CER on EE via this pride. These findings contribute to the corporate sustainability literature by showing how credible and visible environmental actions can enhance employee alignment and engagement. Practical implications are discussed for organizations seeking to connect managerial priorities with society’s call for transparent and authentic environmental initiatives. Full article

Atopic dermatitis (AD), a common chronic inflammatory disease in children and adults, is often studied to find the best way to prevent or reduce its severity. One of the substances tested so far is vitamin D. The main aim of this paper was to determine whether vitamin D truly brings benefits to people with AD or whether its action is too insignificant to have clinical significance. The review covered articles—observational studies, several animal studies and randomized controlled trials (RCTs)—available in the PubMed database and published after 2019. Full-text manuscripts in English were used. Observational studies presented both therapeutic effects of vitamin D and its lack of influence on AD. They also determined that vitamin D receptor (VDR) polymorphism may indeed affect the occurrence and severity of this disease. Similarly, the results of vitamin D’s effect on AD are inconclusive in RCTs. Meanwhile, animal studies showed only the attenuation of disease symptoms in mice. The still-growing number of studies on vitamin D and its association with AD, due to many internal and external distorting factors, has not been able to provide us with definitive results. It is necessary to conduct further appropriately designed large-scale studies, including long-term observation. Full article

Antimicrobial resistance (AMR) has reached a critical situation globally, prompting urgent national responses to this escalating crisis, including the prioritization of novel antibiotic research. In 2016, Japan initiated a national AMR action plan that promoted appropriate antibiotic use in the country and encouraged a national environment conducive to mitigation measures. However, tackling AMR remains difficult. From an epidemiological perspective, this challenge now extends beyond severe infections, impacting common community-acquired infections, including uncomplicated urinary tract infections (uUTls) and gonorrhea. In uUTIs, the rising prevalence of extended-spectrum β-lactamase-producing and fluoroquinolone-resistant Escherichia coli diminishes the effectiveness of current, routinely used oral antibiotics, necessitating an exploration into innovative solutions. Similarly, the growing resistance of Neisseria gonorrhoeae to antibiotics such as azithromycin raises concerns about the efficacy of current therapeutic options for gonorrhea, which is a highly prevalent sexually transmitted infection. In Japan, since the removal of azithromycin as the recommended first-line treatment, there are no oral first-line antibiotics available to treat gonorrhea. Therefore, novel oral antibiotics are urgently needed for both serious and commonly occurring community-acquired infections. This narrative review discusses the limited availability of novel antibiotics in Japan, the distinctive features of the Japanese antibiotic repertoire and AMR epidemiology, and potential alternative oral treatments for community-acquired infections, including uUTIs and gonorrhea. Japan has been making significant advances toward tackling the AMR crisis through an updated national action plan, AMR policy changes, and innovative approaches to developing novel antibiotics. Substantial international cooperation and the engagement of diverse industry sectors are essential to address the pressing issue of AMR. Full article