Search Results (12,341)

Coronary artery disease (CAD) is the main cause of morbidity and death worldwide, and atherosclerosis represents the leading pathophysiological pathway responsible for CAD. Atherosclerotic process is a complex interplay of mechanisms and mediators resulting in plaque formation, progression and destabilization, the latter being the most frequent cause of acute cardiovascular events. Considering the systemic nature of atherosclerosis, polyvascular disease involvement is possible and has been described since 1960s. Accordingly, epidemiologic studies reported that concomitant CAD and atherosclerosis in other arterial beds like carotid arteries, lower limb arteries, mesenteric and renal circulation, and aorta, is frequent and related to increased chance of future cardiovascular events. Although risk factors, atherosclerotic plaque features and mechanisms of plaque destabilization are largely shared across different sites, many studies have reported some disparities among districts. Moreover, simultaneous polyvascular disease has been associated with increased likelihood of having particular plaque characteristics depending on the affected arterial level. In this comprehensive narrative review, we aim to discuss about epidemiology of concomitant CAD and atherosclerosis in other arterial beds, and to examine differences in risk factors, plaque features and mechanisms of plaque instability between CAD and other atherosclerotic locations. Finally, we review the studies observing differences on plaque features according to involved atherosclerotic sites, focusing on CAD. Full article

A global poly-crisis of climate change, biodiversity loss, dwindling natural resources, geopolitical instability, among other complex challenges, is on the rise. Societal transformations are therefore imminent, whether intended or unintended. The key question is how to steward and facilitate such changes where fragmentation and siloed ways of working persist. The concept of synergies and the notion of synergic action could help overcome fragmented efforts to steer transformative changes. However, there exists a critical research gap in understanding the conditions needed to enable synergic action. This paper thus explores how synergic action is currently undertaken and the key essentials needed to deliver synergic action. The study uses a case study of the Yorkshire food system transformation to learn from its exemplar practitioners. The study used semi-structured interviews and a thematic analysis process to reach our two key findings. First, we highlight the three types of synergic action: (1) Non-systemic synergic action, (2) Non-systemic synergic action with multiple outcomes, and (3) Systemic synergic action. Differentiating types of synergic action can help identify where synergic action is already underway and guide more explicit efforts towards transformative change. The second key finding is the five essentials for synergic action, which are (1) leadership for synergic action; (2) networking, partnerships, and collaborations; (3) care and understanding; (4) a systems approach; and (5) intentionality for synergic action. This study brings to the fore the importance of intentionality, without which the first four essentials are less likely to coalesce. This is important to inform the reflection and learning of practitioners of systemic change about how they are currently and could be working more synergistically in the future, driven by clear intentionality. Full article

Ozone (O₃) occurs in nature as a chemical compound made of three oxygen atoms. It is an unstable, highly oxidative gas that rapidly decomposes into oxygen. The therapeutic use of O₃ dates back to the beginning of the 20th century and is currently based on the application of low doses, inducing a moderate oxidative stress that stimulates the antioxidant cellular defenses without causing cell damage. Low O₃ doses also induce anti-inflammatory and regenerative effects, and their anticancer potential is under investigation. In addition, the oxidative properties of O₃ make it an excellent antibacterial, antimycotic, and antiviral agent. Thanks to these properties, O₃ is currently widely used in several medical fields. However, its chemical instability represents an application limit, and ozonated oil is the only stabilized form of medical O₃. In recent years, novel O₃ formulations have been proposed for their sustained and more efficient administration, based on nanotechnology. This review offers an overview of the nanocarriers designed for the delivery of medical O₃, and of their therapeutic applications. The reviewed articles demonstrate that research is active and productive, though it is a rather new entry in the nanotechnological field. Liposomes, nanobubbles, nanoconstructed hydrogels, polymeric nanoparticles, and niosomes were designed to deliver O₃ and have been proven to exert antiseptic, anticancer, and pro-regenerative effects when administered in vitro and in vivo. Improving the therapeutic administration of O₃ through nanocarriers is a just-started challenge, and multiple prospects may be foreseen. Full article

Deep coalbed methane (CBM) reservoirs are characterized by high hydrocarbon content and are considered an important strategic resource. Due to their inherently low permeability and porosity, horizontal well drilling is commonly employed to enhance production, with the length of the horizontal section playing a critical role in determining CBM output. However, during extended horizontal drilling, wellbore instability frequently occurs as a result of drilling fluid invasion into the coal formation, posing significant safety challenges. This instability is primarily caused by the physical intrusion of drilling fluids and their interactions with the coal seam, which alter the mechanical integrity of the formation. To address these challenges, interpenetrating and semi-interpenetrating network (IPN/s-IPN) hydrogels have gained attention due to their superior physicochemical properties. This material offers enhanced sealing and support performance across fracture widths ranging from micrometers to millimeters, making it especially suited for plugging applications in deep CBM reservoirs. A self-degradable interpenetrating double-network hydrogel particle plugging agent (SSG) was developed in this study, using polyacrylamide (PAM) as the primary network and an ionic polymer as the secondary network. The SSG demonstrated excellent thermal stability, remaining intact for at least 40 h in simulated formation water at 120 °C with a degradation rate as high as 90.8%, thereby minimizing potential damage to the reservoir. After thermal aging at 120 °C, the SSG maintained strong plugging performance and favorable viscoelastic properties. A drilling fluid containing 2% SSG achieved an invasion depth of only 2.85 cm in an 80–100 mesh sand bed. The linear viscoelastic region (LVR) ranged from 0.1% to 0.98%, and the elastic modulus reached 2100 Pa, indicating robust mechanical support and deformation resistance. Full article

Understanding the entrepreneurial profile is essential for developing effective regional policies that promote business growth. The path of an entrepreneur is shaped not only by individual decisions but also by the inherent risks of managing a business. This study aims to identify the characteristics of entrepreneurs at the regional level, specifically highlighting the impact of accumulated experience in their fields. Our central hypothesis asserts that entrepreneurial experience significantly influences how business owners perceive and respond to economic challenges. Utilizing survey data from 120 entrepreneurs in Romania’s Center Region (a NUTS 2 area), we reveal that entrepreneurial experience profoundly affects perceptions of key business challenges, such as legislative instability, taxation predictability, governmental support strategies, and access to SME financing. Importantly, our findings demonstrate that entrepreneurs with less than 10 years of experience express greater concerns about these challenges compared to their more seasoned peers. This novel insight highlights the need for tailored policy interventions aimed at enhancing regional economic resilience and fostering entrepreneurial sustainability. By addressing the specific needs of less experienced entrepreneurs, our study contributes to a deeper understanding of how experience shapes business dynamics in the region. Full article

Icing on eight-bundled conductors can significantly alter their aerodynamic behavior, potentially leading to structural instabilities such as galloping. This study employed wind tunnel experiments and numerical simulations to analyze the aerodynamic parameters of each iced conductor across various angles of attack. The simulations incorporated detailed stranded conductor geometries to assess their influence on aerodynamic accuracy. Incorporating stranded geometry in simulations reduced average errors in lift and drag coefficients by 45–50% compared to smooth models. The Den Hartog coefficient prediction error decreased from 15.6% to 3.9%, indicating improved reliability in oscillation predictions. Additionally, conductors with larger windward areas exhibited more pronounced wake effects, with lower sub-conductors experiencing greater wake interference than upper ones. The above results illustrate that explicit modeling of stranded conductor surfaces enhances the precision of aerodynamic simulations, providing a more accurate framework for predicting icing-induced galloping in multi-bundled conductors. Full article

After the 2011 earthquake, lake water depletion has become a widespread issue in Sikkim, especially in regions classified as high to very high seismic zones, where many lakes have turned into seasonal water bodies. This study investigates Chochen Lake in the Barapathing area of Sikkim’s Pakyong district, which is facing severe water seepage and instability. The problem, intensified by the 2011 seismic event and ongoing local construction, is examined through subsurface fracture mapping using Vertical Electrical Sounding (VES) and profiling techniques. A statistical factor method, applied to interpret VES data, helped identify fracture patterns beneath the lake. Results from two sites (VES-1 and VES-2) reveal significant variations in weathered and semi-weathered soil layers, indicating fractures at depths of 17–50 m (VES-1) and 20–55 m (VES-2). Higher fracture density near VES-1 suggests increased settlement risk and ground displacement compared to VES-2. Contrasting resistivity values emphasize the greater instability in this zone and the need for cautious construction practices. The findings highlight the role of seismic-induced fractures in ongoing water depletion and underscore the importance of continuous dewatering to stabilize the swampy terrain. Full article

The integration of large-scale wind power clusters significantly reduces the inertia level of the power system, increasing the risk of frequency instability. Accurately assessing the equivalent virtual inertia of wind farms is critical for grid stability. Addressing the dual bottlenecks in existing inertia assessment methods, where physics-based modeling requires full control transparency and data-driven approaches lack interpretability for inertia response analysis, thus failing to reconcile commercial confidentiality constraints with analytical needs, this paper proposes a symbolic regression framework for inertia evaluation in doubly fed wind farms with limited control information constraints. First, a dynamic model for the inertia response of DFIG wind farms is established, and a mathematical expression for the equivalent virtual inertia time constant under different control strategies is derived. Based on this, a nonlinear function library reflecting frequency-active power dynamic is constructed, and a symbolic regression model representing the system’s inertia response characteristics is established by correlating operational data. Then, sparse relaxation optimization is applied to identify unknown parameters, allowing for the quantification of the wind farm’s equivalent virtual inertia. Finally, the effectiveness of the proposed method is validated in an IEEE three-machine nine-bus system containing a doubly fed wind power cluster. Case studies show that the proposed method can fully utilize prior model knowledge and operational data to accurately assess the system’s inertia level with low computational complexity. Full article

This paper presents an annual, real-world evaluation of the performance and economics of a residential photovoltaic (PV) system coupled with a battery energy storage system (BESS) in southern Poland. The system, monitored with 5 min resolution, operated under time-of-use (TOU) electricity tariffs. Seasonal variation was significant; self-sufficiency exceeded 90% in summer, while winter conditions increased grid dependency. The hybrid system reduced electricity costs by over EUR 1400 annually, with battery operation optimized for high-tariff periods. Comparative analysis of three configurations—grid-only, PV-only, and PV + BESS—demonstrated the economic advantage of the integrated solution, with the shortest payback period (9.0 years) achieved with financial support. However, grid voltage instability during high PV production led to inverter shutdowns, highlighting limitations in the infrastructure. This study emphasizes the importance of tariff strategies, environmental conditions, and voltage control when designing residential PV-BESS systems. Full article

Arrhythmogenic cardiomyopathies (ACMs) are a phenotypically and etiologically heterogeneous group of myocardial disorders characterized by fibrotic or fibro-fatty replacement of ventricular myocardium, electrical instability, and an elevated risk of sudden cardiac death. Initially identified as a right ventricular disease, ACMs are now recognized to include biventricular and left-dominant forms. Genetic causes account for a substantial proportion of cases and include desmosomal variants, non-desmosomal variants, and familial gene-elusive forms with no identifiable pathogenic mutation. Nongenetic etiologies, including post-inflammatory, autoimmune, and infiltrative mechanisms, may mimic the phenotype. In many patients, the disease remains idiopathic despite comprehensive evaluation. Cardiac magnetic resonance imaging has emerged as a key tool for identifying non-ischemic scar patterns and for distinguishing arrhythmogenic phenotypes from other cardiomyopathies. Emerging classifications propose the unifying concept of scarring cardiomyopathies based on shared structural substrates, although global consensus is evolving. Risk stratification remains challenging, particularly in patients without overt systolic dysfunction or identifiable genetic markers. Advances in tissue phenotyping, multi-omics, and artificial intelligence hold promise for improved prognostic assessment and individualized therapy. Full article

Background/Objectives. This manuscript presents an overview of advances in oncological radiotherapy as an effective treatment method for cancerous tumors, focusing on mechanisms of action within metabolite–antimetabolite systems. The urgency of this topic is underscored by the fact that cancer remains one of the leading causes of death worldwide: as of 2022, approximately 20 million new cases were diagnosed globally, accounting for about 0.25% of the total population. Given prognostic models predicting a steady increase in cancer incidence to 35 million cases by 2050, there is an urgent need for the latest developments in physics, chemistry, molecular biology, pharmacy, and strict adherence to oncological vigilance. The purpose of this work is to demonstrate the relationship between the nature and mechanisms of past diagnostic and therapeutic oncology approaches, their current improvements, and future prospects. Particular emphasis is placed on isotope technologies in the production of therapeutic nuclides, focusing on the mechanisms of formation of simple and complex theranostic compounds and their classification according to target specificity. Methods. The methodology involved searching, selecting, and analyzing information from PubMed, Scopus, and Web of Science databases, as well as from available official online sources over the past 20 years. The search was structured around the structure–mechanism–effect relationship of active pharmaceutical ingredients (APIs). The manuscript, including graphic materials, was prepared using a narrative synthesis method. Results. The results present a sequential analysis of materials related to isotope technology, particularly nucleus stability and instability. An explanation of theranostic principles enabled a detailed description of the action mechanisms of radiopharmaceuticals on various receptors within the metabolite–antimetabolite system using specific drug models. Attention is also given to radioactive nanotheranostics, exemplified by the mechanisms of action of radioactive nanoparticles such as Tc-99m, AuNPs, wwAgNPs, FeNPs, and others. Conclusions. Radiotheranostics, which combines the diagnostic properties of unstable nuclei with therapeutic effects, serves as an effective adjunctive and/or independent method for treating cancer patients. Despite the emergence of resistance to both chemotherapy and radiotherapy, existing nuclide resources provide protection against subsequent tumor metastasis. However, given the unfavorable cancer incidence prognosis over the next 25 years, the development of “preventive” drugs is recommended. Progress in this area will be facilitated by modern medical knowledge and a deeper understanding of ligand–receptor interactions to trigger apoptosis in rapidly proliferating cells. Full article

In crisis-stricken economies, leadership effectiveness increasingly hinges not on technical expertise alone but on emotional competence. While emotional intelligence (EI) has been widely acknowledged as a catalyst for effective leadership and employee outcomes, its role in volatile and resource-scarce contexts remains underexplored. This study addresses this critical gap by investigating the impact of five core EI dimensions, namely self-awareness, self-regulation, motivation, empathy, and social skills, on employee performance amid Lebanon’s ongoing multidimensional crisis. Drawing on Goleman’s EI framework and the Job Demands–Resources theory, the research employs a quantitative, cross-sectional design with data collected from 398 employees across sectors in Lebanon. Structural Equation Modeling revealed that all EI dimensions significantly and positively influenced employee performance, with self-regulation (β = 0.485) and empathy (β = 0.361) emerging as the most potent predictors. These findings underscore the value of emotionally intelligent leadership in fostering productivity, resilience, and team cohesion during organizational instability. This study contributes to the literature by contextualizing EI in an under-researched, crisis-affected setting, offering nuanced insights into which emotional competencies are most impactful during prolonged uncertainty. Practically, it positions EI as a strategic leadership asset for crisis management and sustainable human resource development in fragile economies. The results inform leadership training, policy design, and organizational strategies that aim to enhance employee performance through emotionally intelligent practices. Full article

Chromosomal microarray analysis (CMA) was performed for 40 patients with B-ALL undergoing treatment according to the ALL-2016 protocol to investigate the copy number alterations (CNAs) and copy neutral loss of heterozygosity (cnLOH) associated with minimal residual disease (MRD)-positive remission. Aberrations involving over 20,000 genes were identified, and a random forest approach was applied to isolate a subset of genes whose CNAs and cnLOH are significantly associated with poor therapeutic response. We have assembled the triple matched healthy population data and used that data as a reference, but not as a matched control. We identified a recurrent cluster of cnLOH in the 19q13.2–19q13.31 region, significantly enriched in MRD-positive patients (70% vs. 47% in the reference group vs. 16% in MRD-negative patients). This region includes the pregnancy-specific glycoprotein (PSG) gene family and the oncogene ERF, suggesting a potential role in leukemic persistence and treatment resistance. Additionally, we observed significant deletions involving 7p22.3 and 16q13, often as part of large-scale losses affecting almost the entire chromosomes 7 and 16, indicative of global chromosomal instability. These findings highlight specific genomic regions potentially involved in therapy resistance and may contribute to improved risk stratification in B-ALL. Our findings emphasize the value of high-resolution CMA in diagnostics and risk stratification and suggest that PSG genes and other candidate genes could serve as biomarkers for predicting treatment outcomes. Full article

Large-scale wind power grid-connected systems can trigger the risk of power system instability. In order to enhance the stability margin of grid-connected systems, this paper accurately characterizes the topology of the global boundary of stability domain (BSD) of the grid-connected system based on BSD theory, using the method of combining the manifold topologies and singularities at infinity. On this basis, the effect of large-scale doubly fed induction generators (DFIGs) replacing synchronous units on the BSD of the system is analyzed. Simulation results based on the IEEE 39-bus system indicate that the negative impedance characteristics and low inertia of DFIGs lead to a contraction of the stability domain. The principle of singularity invariance (PSI) proposed in this paper can effectively expand the BSD by adjusting the inertia and damping, thereby increasing the critical clearing time by about 5.16% and decreasing the dynamic response time by about 6.22% (inertia increases by about 5.56%). PSI is superior and applicable compared to traditional energy functions, and can be used to study the power angle stability of power systems with a high proportion of renewable energy. Full article

In 2071, the Hydraulic community will commemorate the second centenary of the Baré de Saint-Venant equations, also known as the Shallow Water Equations (SWE). These equations are fundamental to the study of open-channel flow. As non-linear partial differential equations, their solutions were largely unattainable until the development of computers and numerical methods. Following 1960, various numerical schemes emerged, with Preissmann’s scheme becoming the most widely employed in many software applications. In the 1990s, some researchers identified a significant limitation in existing software and codes: the inability to simulate transcritical flow. At that time, Preissmann’s scheme was the dominant method employed in hydraulics tools, leading the research community to conclude that this scheme could not handle transcritical flow due to suspected instability. In response to this concern, several researchers suggested modifications to Preissmann’s scheme to enable the simulation of transcritical flow. This paper will demonstrate that these accusations against the Preissmann scheme are unfounded and that the proposed improvements are unnecessary. The observed instability is not due to the numerical method itself, but rather a mathematical instability inherent to the SWE, which can lead to ill-posed conditions if a specific derived condition is not met. In the context of a friction slope formula based on Manning or Chézy types, the condition for ill-posedness of the 1D shallow water equations simplifies to the Vedernikov number condition, which is necessary for roll waves to develop in uniform flow. This derived condition is also relevant for the formation of roll waves in unsteady flow when the 1D shallow water equations become ill-posed. Full article