Search Results (9)

To enhance energy utilization efficiency, dairy farmers have increasingly adopted photovoltaic (PV) panels on barn roofs. However, there is currently a general separation between the barn construction and the additional aspects of the PV system. It is unclear to dairy farmers whether rooftop PV panels will have an impact on the dairy barn, particularly on the thermal environment. This study investigated the influence of air layer properties, specifically thickness and ventilation conditions, on the thermal performance of PV dairy barn roofs. Utilizing the harmonic analysis method, the study quantified its dynamic thermal properties. The results demonstrated that increasing the air layer thickness in ventilated roofs decreases heat flux and improves thermal resistance (1.67–2.15 times higher than non-PV roofs). In contrast, sealed air layers exhibit consistently high thermal resistance (up to 3.33 times higher). Optimizing ventilated air layer thickness (0.20–0.30 m) effectively minimizes heat ingress and prevents PV efficiency degradation. These results provide valuable insights for optimizing the design of energy-efficient PV dairy barns, enhancing thermal comfort, and contributing to low-carbon energy solutions in livestock facilities. Full article

This study addresses the integrated scheduling problem of dry bulk cargo terminal yards, which includes three components: transportation planning, yard selection optimization, and equipment scheduling. Additionally, the research integrates safety considerations and addresses the complexities of dynamic transportation planning. This work presents two innovations. Firstly, this study develops a sophisticated modeling framework that integrates graph structures for precise yard mapping with mixed-integer programming to enforce operational constraints. This integrated approach facilitates a more accurate and comprehensive representation of yard operations, capturing diverse operational aspects while maintaining model clarity and computational efficiency. Secondly, this study proposes an advanced solution methodology that employs a reinforcement learning technique integrating a Dueling Deep Q-Network and Double Deep Q-Network. This hybrid algorithm significantly enhances optimization performance and accelerates the learning process, thereby improving the efficiency of the solutions. The experimental results demonstrate that the proposed model effectively manages the integrated scheduling of bulk material ingress, storage, and egress within the yard. The operational plans generated by the approach outperform traditional first-come, first-served strategies, showcasing substantial improvements in port operational efficiency and reliability. This comprehensive solution underscores the potential for significant advancements in the overall management and performance of dry bulk cargo ports. Full article

The search for solutions that reduce the environmental impact of construction has driven the development of new materials. Bio-concrete represents a significant advance, presenting itself as an alternative to traditional concrete. Recent studies point to durability in outdoor conditions as one of the main challenges in its application. This paper presents natural durability studies performed on bamboo bio-concrete, produced with a bamboo particle volume of 50%. A surface treatment of applying resin externally was tested to reduce water ingress during weathering. The bio-concretes were exposed to natural and outdoor weather conditions for twelve months, and meteorological records were collected during the study period. The effect and influence of the external resin was investigated using visual surface analysis, uniaxial compression, modulus of elasticity and scanning electron microscopy. In terms of visual aspects, the resin was not effective in preventing loss of gloss, while in terms of microstructure, these samples showed better adhesion between the bamboo particles in the matrix. The compressive strength showed significant reductions of 60% (stress) and 73% (Young’s modulus) after twelve months of weathering. External resin could improve microstructures from surfaces to internal portions and more effectively preserve the mechanical strength of bio-concrete. Full article

Eukaryotic cells must accurately transfer their genetic material and cellular components to their daughter cells. Initially, cells duplicate their chromosomes and subsequently segregate them toward the poles. The actomyosin ring, a crucial molecular machinery normally located in the middle of the cells and underneath the plasma membrane, then physically divides the cytoplasm and all components into two daughter cells, each ready to start a new cell cycle. This process, known as cytokinesis, is conserved throughout evolution. Defects in cytokinesis can lead to the generation of genetically unstable tetraploid cells, potentially initiating uncontrolled proliferation and cancer. This review focuses on the molecular mechanisms by which budding yeast cells build the actomyosin ring and the preceding steps involved in forming a scaffolding structure that supports the challenging structural changes throughout cytokinesis. Additionally, we describe how cells coordinate actomyosin ring contraction, plasma membrane ingression, and extracellular matrix deposition to successfully complete cytokinesis. Furthermore, the review discusses the regulatory roles of Cyclin-Dependent Kinase (Cdk1) and the Mitotic Exit Network (MEN) in ensuring the precise timing and execution of cytokinesis. Understanding these processes in yeast provides insights into the fundamental aspects of cell division and its implications for human health. Full article

The SARS-CoV-2 virus infection led to millions of deaths during the COVID-19 pandemic. Hundreds of workers from several other Brazilian cities, as well as from other countries, arrive daily in Macaé to work in the oil supply chain, making this city a putative hotspot for the introduction of new viral lineages. In this study, we performed a genomic survey of SARS-CoV-2 samples from Macaé during the first outbreak of COVID-19, combined with clinical data and a molecular integrative analysis. First, phylogenomic analyses showed a high occurrence of viral introduction events and the establishment of local transmissions in Macaé, including the ingression and spread of the B.1.1.28 lineage in the municipality from June to August 2020. Second, SARS-CoV-2 mutations were identified in patients with distinct levels of COVID-19 severity. Third, molecular interactions of the mutated spike protein from three B.1.1.33 local samples and human ACE2 showed higher interactions than that of the wild-type spike protein from the ancestral virus. Altogether, these results elucidate the SARS-CoV-2 genomic profile in a strategic Brazilian city and further explore the functional aspects of SARS-CoV-2 with a characterization of emerging viral mutations associated with clinical data and the potential targets for drug development against SARS-CoV-2. Full article

Languages differ in how systematically and obligatorily they encode conceptual categories such as tense and aspect. By drawing on large parallel corpora, these differences can be exploited heuristically: expressive obligatoriness and the systematicity of a conceptual category in one language can function as a probe for other languages that do not (evidently) encode it. This study applies this method—called heuristic translation mining (HTM)—to viewpoint aspect in Mandarin (an aspect-oriented language) and Dutch (a non-aspect-oriented language). Specifically, it takes the Mandarin aspect markers 起来-qilai (“ingressive”) and 下去-xiaqu (“continuative”) and collects translation strategies for these markers from a corpus of five Mandarin novels and their Dutch translations. The outcomes are methodological, descriptive and theoretical in nature. Methodologically, it is shown how conceptual templates consisting of temporal boundaries and phases facilitate annotating specific types of viewpoint aspect consistently. Descriptively, the exercise indicates at which linguistic levels viewpoint aspect may be encoded in a non-aspect-oriented language. Theoretically, conducting an HTM analysis with several aspect markers at once makes it possible to quantify (non-)marking of conceptual content; it turns out that the types of viewpoint under study correspond to varying marking frequencies, which may correlate with conceptual complexity. Full article

Recycled aggregate produced from crushed waste concrete is suitable for use in structural concrete. It reduces the demand for non-renewable resources and also for energy in general. However, RA is more porous than most natural aggregates. The porosity of the concrete cover defines the corrosion resistance of reinforced concrete, and it is therefore disputed how the use of recycled aggregate may affect the durability of reinforced concrete. This paper describes the corrosion-related performance of reinforced concrete with recycled aggregates in the initiation stage (determined by the carbonation and chloride ingress) and propagation stage (determined by the electrical resistivity and cracking) of corrosion. The aspects of interest are not only the porosity of RA but also its effects on the chloride binding, carbonation, electrochemical properties and corrosion cracking development. Full article

Hospitals are controlled yet complex ecosystems which provide a therapeutic environment that promotes healing, wellbeing and work efficiency for patients and staff. As these buildings accommodate the sick and vulnerable, occupant wellbeing and good indoor environmental quality (IEQ) that deals with indoor air quality (IAQ), thermal comfort, lighting and acoustics are important objectives. As the specialist nature of hospital function demands highly controlled indoor environments, this makes them energy intensive buildings due to the complex and varying specifications for their functions and operations. This paper reports on a holistic building performance evaluation covering aspects of indoor air quality, thermal comfort, lighting, acoustics, and energy use. It assesses the performance issues and inter-relationships between IEQ and energy in a new building on a hospital campus in the city of Bristol, United Kingdom. The empirical evidence collated from this case study and the feedback received from the hospital staff help identify the endemic issues and constraints related to hospital buildings, such as the need for robust ventilation strategies in hospitals in urban areas that mitigate the effect of indoor and outdoor air pollution and ensuring the use of planned new low-carbon technologies. Whilst the existing guidelines for building design provide useful instructions for the protection of hospital buildings against ingress of particulate matter from outdoors, more advanced filtration strategies may be required to enact chemical reactions required to control the concentration levels of pollutants such as nitrogen dioxide and benzene. Further lessons for improved performance in operation and maintenance of hospitals are highlighted. These include ensuring that the increasingly available metering and monitoring data in new buildings, through building management systems, is used for efficient and optimal building operations for better IEQ and energy management. Overall, the study highlights the need for an integrated and holistic approach to building performance to ensure that healthy environments are provided while energy efficiency targets are met. Full article

Hydrophilic matrix systems can be found in a wide range of extended release pharmaceutical formulations. The main principle of these systems is that upon contact with water, the hydrophilic component swells to form a hydrated gel layer which controls drug release. The following work demonstrates an explorative study into the use of dissolution imaging and focus variation microscopy with hydrophilic polymers. This study investigated the surface properties of xanthan gum (XG), polyethylene oxide (PEO), and hypromellose (hydroxypropyl methylcellulose, HPMC) compacts with each of these three hydrophilic polymers from one of each classification of natural, semi-synthetic, or synthetic polymer using a focus variation instrument. The auto correlation length (Sal) showed all surface profiles from the compacts displayed a value below 0.1 mm, indicating that only high frequency components (i.e., roughness) were considered and that the analysis had been successful. The developed interfacial area ratio (Sdr) displayed values below 5% in line with ISO guidelines for all the polymers studied with their texture aspect ratio values (Str) > 0.5, indicating uniformity of the surfaces of the produced compacts. Of the various parameters studied, areal material ratio (Smr2) predicted XG to wet and hydrate quicker than PEO, with PEO also wetting and hydrating quicker than the HPMC. The dissolution imaging and initial swelling studies proved to concur with the findings from the areal material ratio (Smr2) parameter, suggesting porosity was not an indicator for the ease with which water ingress occurs. This study suggests the Smr2 surface parameter to potentially predict wetting and initial hydration of hydrophilic polymers, however care should be taken as this study consists of a selected number of hydrophilic polymers. Full article