Search Results (276)

The study examines how individual skills influence adolescents’ and young adults’ commitment to climate protection and global health. Based on 21st-century skills and transformative education, it focuses on competences in science, geography, mathematics, religion, ethics, and media. A representative online survey of 783 participants in Germany assessed topic relevance, information-seeking behavior, and active engagement. The results show that subject-specific skills significantly affect engagement, especially when closely related to the topics. Scientific, mathematical, and geographical competences enhance all three engagement dimensions. Media competence primarily increases perceived importance, while religious and ethical competences positively influence all areas. Structural equation modeling reveals a process: perceived relevance leads to information search, which then drives engagement. Thus, competences have both direct and indirect effects on active involvement. The findings highlight that long-term engagement is not only driven by campaigns but also by education that equips young people with the skills to recognize important issues, seek information, and take action independently. Full article

Gastrointestinal parasitic diseases pose significant health risks to equine populations. This study investigated the epidemiological patterns of equine gastrointestinal parasites in Xinjiang by analyzing 83 fecal samples collected from Ili (n = 62) and Urumqi (n = 21) between August and November 2024. The modified McMaster technique was employed to quantify fecal egg counts (EPG) and was complemented by morphological identification to assess infection dynamics related to geography, breed specificity, and management practices. The results demonstrated an overall infection prevalence of 66.3% (55/83), with strongyles, Parascaris equorum, and Eimeria oocysts being present. Significant geographical variation was observed, with Ili exhibiting a higher prevalence (74.2%) compared to Urumqi (42.9%). Breed susceptibility analysis revealed that there was a 94.1% prevalence in Yili horses versus 42.9% in Kazakh horses. Pasture-managed herds showed markedly higher infection rates (94.1%) than stable-based systems (50.0%). Parasite community composition was dominated by strongyles (82.1%), followed by Triodontophorus spp. (27.7%) and P. equorum (2.4%). These findings highlight severe parasitic infection risks in Xinjiang’s grazing equids, underscoring the urgency of implementing targeted anthelmintic protocols to mitigate disease transmission. Full article

Loneliness and social isolation are pressing public health concerns, prompting interest in how rural and urban environments shape social wellbeing. However, evidence remains mixed—perhaps because loneliness is a distal psychological outcome with complex, trait-like stability. To address this, we examined geographic variation in upstream patterns of social activity using data from the 2023 Canadian Social Connection Survey (N = 1556). The principal component analysis identified five domains of social behavior, which we analyzed using multivariable regression and supplemented with a series of sensitivity and stratified analyses. Our findings suggest that while broad differences across rural and urban geographies are modest, specific domains of behavior show some variation. For example, residents in rural areas reported lower casual social interaction (b = −0.19, p = 0.019) but similar or even greater engagement in intimate and supportive behaviors. Emotional loneliness was slightly lower in small towns (b = −0.17, p = 0.029), indicating possible protective effects of some smaller community contexts. While the overall structure of social behavior was not invariant across settings, general patterns of engagement appeared largely resilient to geographic differences. These findings underscore the importance of place-sensitive strategies that respond to specific forms of social behavior affected by geography while avoiding overgeneralized assumptions about rural–urban disparities. Full article

Spatial transcriptomics is an emerging technology that maps gene expression within tissue architecture. Its expanding use in medicine and veterinary science supports research, precision diagnostics, biomarker discovery, and development of targeted treatment strategies. While spatial transcriptomics applications in human health are well-documented with significant publication diversity and volume, published applications in veterinary medicine remain limited. A comprehensive search of PubMed was conducted, focusing on studies published from 2016 to early 2025 that employed spatial transcriptomics in the context of disease research, diagnosis, or treatment in human or animal health. The review followed the Arksey and O’Malley framework and adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. A total of 1398 studies met the inclusion criteria. The studies highlighted emerging trends of comparative research with animal model use for human health research. Commonly used spatial transcriptomics platforms included 10× Visium, Slide-seq, Nanostring (GeoMx, CosMX), and multiplexed error-robust fluorescence in situ hybridization (MERFISH). Key gaps in publications include limited veterinary representation, interspecies comparisons, standardized methods, public data use, and therapeutic studies, alongside biases in disease, species, organ, and geography. This review presents the current landscape of spatial transcriptomics publications for human and animal research and medicine, providing comprehensive data and highlighting underrepresented research areas and gaps for future consideration. Full article

Background: The burden of type 2 diabetes mellitus (T2DM) in Tabasco from 2013 to 2023 has led to a significant loss in quality of life and life years. This study aims to analyze the impact of T2DM on the population of Tabasco, Mexico, during this period. Methods: A descriptive, observational, longitudinal, and retrospective study was conducted in Tabasco, following Feinstein’s guidelines. The study included 2,402,598 individuals, covering the adult study population of Tabasco (n = 927,047) based on National Institute of Statistics and Geography (INEGI) data. Data were gathered from the General Directorate of Health Information and the Ministry of Health and analyzed using Microsoft Excel, applying central tendency and dispersion measures, and calculating Disability-Adjusted Life Years (DALYs) with validated formulas. Results: DALYs in Tabasco’s adult population from 2013 to 2023 were 23,049 in 2013, 24,576 in 2014, 25,193 in 2015, 34,361 in 2016, 29,771 in 2017, 29,309 in 2018, 29,959 in 2019, 28,087 in 2020, 26,451 in 2021, 23,502 in 2022, and 30,523 in 2023, totaling 304,781 DALYs for the period. Conclusions: T2DM has shown an increase in incidence and mortality, especially in recent years, leading to a significant rise in DALYs. This reflects a higher disease burden in Tabasco compared to other regions in Mexico and the Americas, resulting in a considerable loss of quality of life and life years. Full article

Purpose: Socio-demographic inequities in mental health were magnified by COVID-19, with women experiencing greater household burden with less support in Canada and globally. While some health patterns during COVID-19 have been observed globally, there is a research gap in rural mental health during COVID-19 in Canada. We hypothesize there is a disparity in mental health decline during COVID-19 between men and women. Methods: In rural Ontario, mental health was measured through a survey of approximately 18,000 individuals living in seven counties. In 2021, survey respondents were asked to rate their mental health prior to and during COVID-19. Women reported poorer mental health during COVID-19 in comparison to men when tested via chi-squared tests, odds ratios, and percentage change. Responses to survey questions regarding social, financial, and mental health support were then evaluated. Findings: We found significant disparities in mental health ratings before and during COVID-19 between men and women. Women reported poorer mental health, increased substance use, and increased worry about social, financial, and community stressors. Respondents who self-identified as a woman were associated with poorer mental health outcomes. Conclusions: Interventions should be specific to geographic communities as well as individual needs (e.g., additional financial and childcare support). Rural communities need to be considered as independent geographies rather than as one geography (i.e., urban vs. rural). Full article

The threats posed by Persistent Organic Pollutants (POPs) impact food safety and, by implication, food security in the polar regions. POPs tend to persist in the environment and the fatty tissues of animals, thereby constituting long-term contamination. Due to the cold climate and geography of these polar regions, they create a sink for these pollutants, which travel from their source of production and accumulate in food chains, resulting in health risks to the ecosystem, animals, and humans of the Arctic and Antarctica. In this paper, we draw attention to the threats posed by POPs and how they can lead to food insecurity, negatively affecting health due to unsafe traditional foods. A narrative synthesis methodology was employed, systematically analyzing historical data, activities, and research trends on POP contamination in polar ecosystems. We also highlight resilience promoted by Arctic governance, with a focus on how the issues of POPs became an international matter from the 1970s, with three United Nations (UN) conventions: the UN-Environment Stockholm Convention on Persistent Organic Pollutants, the UN Minamata Convention on mercury, and the UN-ECE Convention on Long-range Transboundary Air Pollution. These conventions led to the start of several monitoring activities in the polar regions, transforming the POPs into a global topic. We also consider the intertwined effect of climate change on POPs. Additionally, the human rights paradigm in relation to food security and sovereignty for polar communities is explored. Strengthening the resilience of communities in the polar regions requires recognition of these nutritious traditional foods as an aspect of cultural identity that must be safe and easily accessible. We focus on developments, improvements, the role of international cooperation, and frameworks to assist in research and regulations. Furthermore, establishing systems that engage local communities to consistently monitor POPs regularly will lead to a better understanding of these threats. Ultimately, this narrative provides a look into the past and current research of POPs and their monitoring in the polar regions. Full article

Urban biodiversity is essential for sustainable cities, as it helps address the challenges of environmental degradation, ecosystem loss, species decline, and increased vulnerability to climate hazards, which negatively affect human health and well-being. ECOLOPES (ECOlogical building enveloPES) aims to develop a design approach for multi-species as stakeholders to achieve regenerative urban ecosystems. Integrating the diverse data required for stakeholders and beyond—spanning the life sciences, geography, and architecture—and utilising it for design presents a significant challenge. This paper introduces an ontology-driven approach that utilises ontology-based data management (OBDM) as a framework for integrating diverse data sources, enabling ecologists and architects to design sites and buildings that foster urban biodiversity. OBDM offers a unified view of multiple data sources through an ontology, enabling query and update operations to be performed directly on the integrated data. The proposed ontology, developed in collaboration with domain experts and adhering to Semantic Web and Linked Data best practices, serves as a mediator between life sciences data (e.g., species distribution and habitats) and geometric information (e.g., maps and voxel models of building structures). This integration enables the adaptation of sites, buildings, and geometries, respectively, to create habitats that attract and support urban wildlife, contributing to ecological sustainability. The paper illustrates the practical utility of the ontology through a case study, highlighting its role in guiding building designs that promote species attractiveness and urban biodiversity. Full article

Honeybee (Apis spp.) products have been used for centuries due to their nutritional value and diverse healing properties. Propolis, produced by honeybees, is a unique resin collected from tree buds, sap flows, and other plant exudates, which is then mixed with bee enzymes, beewax, and secretions. This comprehensive review starts with a meta-analysis following the PRISMA approach to explore recent advances in the chemical composition of propolis, its biological activities and pharmacological properties, its applications and products, and future perspectives. The composition of propolis varies depending on plant source, season of harvest, geography, type of bee flora, climate, and honeybee species at the site of collection, and some of these are related. Flavonoids, aromatic acids, phenolic acids, and their esters are key bioactive compounds in propolis, contributing to their diverse pharmacological properties, such as antioxidant, antibacterial, antiparasitic, antiviral, antileishmanial, antidiabetic, anti-inflammatory, immunomodulatory, and anticancer effects. In summary, propolis stands out as a multifaceted natural product with a broad spectrum of biological activities. This review aims to provide valuable insights for researchers, practitioners, and decision-makers involved in studying the sources, composition, and biological activities of propolis. The highlighted hotspots and emerging frontiers presented herein are poised to unlock the full potential of propolis, paving the way for innovative applications in health and wellness. Full article

Advances in primary healthcare coverage for the improvement in health outcomes at the population level comprise a major goal of public policies of health, particularly considering increases in hospitalization costs linked to chronic diseases in recent decades. Previous evidence shows the positive effects of access to primary healthcare on hospitalization indicators in high-income countries; however, there is a lack of literature on the subject in Latin American countries. Thus, the present study proposes a quantitative investigation on connections between primary healthcare quality and effectiveness in relation to hospitalization indicators, in addition to the identification of its effects on inequalities in hospitalizations in Brazil. The study was based on an empirical analysis of data from five cross-sectional surveys representative at the population level conducted by the Brazilian Institute for Geography and Statistics (IBGE) in 1998, 2003, 2008, 2013, and 2019. Information on the demographic, socioeconomic, and health characteristics of individuals compatible across surveys were included in the analyses, in addition to data on household and survey characteristics. The statistical analyses were based on the estimation of logistic regression models for the exploration of effects of primary healthcare quality and effectiveness on hospitalizations, inpatient days, and perception of quality of hospital care. Furthermore, the estimation of concentration indexes and their disaggregation allowed to verify trends and determinants of inequalities in hospitalization indicators in Brazil throughout the period. The results indicate that primary healthcare effectiveness is associated with the lower occurrence and frequency of hospitalizations, and a lower length of stay in hospitals. Primary healthcare quality was associated with the perception of higher quality of hospital care. Trends in hospitalization indicators showed reduction in inequalities towards low-income individuals from 1998 to 2013, and primary healthcare quality presented minor influence on inequalities in hospitalizations, inpatient days, and perception of quality of hospital care. Full article

Environmental changes, which have led to frequent and severe climate-related disasters, profoundly affect individuals and communities in Louisiana that display already existing disparities in vulnerability. An increasing body of evidence documents the relationship between the effects of climate change and poor mental health. This underscores the importance of utilizing an environmental justice framework to assess and innovate strategies for addressing disasters’ unequal burden. As part of a broader Community-Based Participatory Research (CBPR) project on the effects of a community-based intervention to improve mental health resilience in communities affected by disasters and crises, we included 12 churches in a community asset mapping process to identify resources within their communities and discuss actions that could improve their neighborhoods and build additional support. We conducted deductive and inductive content analysis of asset maps and field notes from 32 small groups. We found the following: (1) the church was seen as a central asset; (2) key distinctions in how participants discussed their tangible and intangible resources according to their geography, and (3) the themes of charity, resource facilitation, connecting the most vulnerable, and absence of government support typified how groups discussed possibilities of action. Full article

Background: Nepal’s diverse geography creates significant challenges for healthcare accessibility, particularly for neonatal care. Rural areas, especially in the mountainous regions, face severe healthcare gaps due to isolation, inadequate infrastructure, and a shortage of skilled staff. Strengthening healthcare in these underserved regions is essential to reducing neonatal mortality. Helping Babies Breathe (HBB) is a neonatal resuscitation training program designed to reduce neonatal mortality due to birth asphyxia in low-resource settings. Methods: A comprehensive literature search identified studies on neonatal mortality and interventions, particularly HBB, which were analyzed using a narrative synthesis approach. This review examines disparities in neonatal health outcomes, regional differences, and barriers to healthcare access. Findings: This review identifies key themes related to healthcare disparities, neonatal mortality, and birth outcomes in Nepal’s remote regions. Geographical isolation, inadequate healthcare infrastructure, and cultural barriers contribute to persistently high neonatal mortality, particularly in mountainous areas such as Jumla and Dolpa, where rates exceed 60 per 1000 live births. HBB has shown a significant impact, reducing neonatal mortality by up to 60% when effectively implemented. However, infrastructural gaps, lack of emergency transport, and the uneven distribution of skilled birth attendants (SBAs) remain critical challenges. Addressing these disparities requires expanded training, increased availability of neonatal resuscitation equipment, and culturally sensitive healthcare strategies. Full article

Background: End-stage kidney disease (ESKD) management presents a significant challenge, with increasing patient burden, escalating costs, and unmet needs in improving survival and quality of life. High-volume hemodiafiltration has been found to offer enhanced solute clearance, improved inflammatory marker profiles, and better patient-centered outcomes in multiple trials compared with high-flux hemodialysis. Recent data also confirm a survival advantage compared to standard high-flux hemodialysis. Methods: We compiled a narrative review for the clinician illustrating evidence supporting the comparative performance of high-volume hemodiafiltration with conventional high-flux hemodialysis in ESKD management. Data on intermediary outcomes including biochemical and clinical benefits, as well as patient-centered outcomes and all-cause and cardiovascular death data from prospective randomized trials, their meta-analyses, and real-world cohort studies were reviewed and summarized. Results: Randomized studies in adults have found that high-volume hemodiafiltration demonstrates superior outcomes, with a 23% improvement in survival rates when achieving convective volumes ≥23 L/session, enhanced removal of uremic toxins, reduced inflammation, and better patient-reported outcomes. Cohort studies in pediatric populations find associations with improvements in growth, cognitive development, and cardiovascular health. Hemodiafiltration appears to be cost-effective when accounting for extended life expectancy and improved quality of life, although the existing data are limited to European geographies. Conclusions: Hemodiafiltration offers enhanced survival, a reduced treatment burden, and improved quality of life for ESKD patients. Given the existing data of superiority versus high-flux hemodialysis, it is plausible that hemodiafiltration will become the standard of care. Full article

Background/Objectives: This study examined factors influencing health behaviours among 13–17-year-olds in Surrey, focusing on rising obesity rates and socioeconomic disparities using a whole systems approach to capture both the stakeholders’ voice and the young people’s voices. Methods: The research involved two components: a survey of youth service providers (e.g., teachers, youth workers; n = 35) and focus groups with adolescents (n = 27). Results: The survey revealed challenges faced by stakeholders, including insufficient training, environmental factors (e.g., schools, social media, food systems), and limited support from parents and healthcare professionals. The focus groups identified two key themes: (1) domains of care, for example diet and how availability and cost of food affects food choices, and (2) barriers and solutions, addressing financial, structural, and emotional obstacles to and facilitators of a healthy lifestyle. Transcending these themes was the key role of health inequalities linked to income, geography, and gender. Conclusions: This study underscores the complexity of adolescent health behaviours and calls for a multi-level, coordinated approach to address inequalities and foster supportive environments for healthier choices. Full article

Background/Objectives: Primary healthcare (PHC) plays a central role in the promotion of universal healthcare coverage within the Brazilian health system. Nevertheless, inequalities across municipalities represent substantial barriers to achieving equity in access to health, particularly due to disparities in the quality of healthcare delivered to patients. Thus, the study aimed to investigate factors associated with perception of PHC quality among adult individuals using private and public facilities within the Brazilian health system. Methods: The empirical approach was based on quantitative analysis of cross-sectional data from five nationally representative surveys conducted by the Brazilian Institute for Geography and Statistics (Instituto Brasileiro de Geografia e Estatística, IBGE) in 1998, 2003, 2008, 2013, and 2019. Pairwise comparisons and marginal analyses allowed for the assessment of differences in patients’ perception of healthcare quality according to source of funding and type of healthcare quality. A logistic regression model was estimated to identify factors associated with the perception of good quality of care. Model discrimination, calibration, and goodness-of-fit were assessed to ensure the robustness of analyses. Results: The results indicate that patients’ satisfaction was positively associated with level of implementation of the national program based on payment for performance in public healthcare facilities, PMAQ-AB (OR = 3.376; p < 0.001), self-assessment of good health status (OR = 3.209; p < 0.001), and healthcare financed through health insurance (OR = 2.344; p < 0.001). Contrarily, receiving healthcare in a public facility (OR = 0.358; p < 0.001) was negatively associated with the evaluation of good quality. Conclusions: The findings showed that patients’ perception of quality of care presents significant associations with patients’ health characteristics, healthcare funding source, and implementation of the PMAQ-AB. Furthermore, patients generally perceived lower healthcare quality in public facilities. The study indicates the need for evidence-based decision-making in public policies of health, particularly regarding further advances in payment for performance programs designed to foster improvements in quality of care within public PHC facilities in Brazil. Full article