Search Results (1,046)

As augmented reality head-up display (AR-HUD) becomes increasingly integrated into intelligent vehicles, inappropriate interface designs may increase drivers’ cognitive workload and delay hazard responses. This study investigates how cognitive style, driving task type, and AR-HUD navigation design jointly influence drivers’ behavioral performance and visual attention. A total of 55 participants were recruited and screened using the Group Embedded Figures Test, with 38 drivers finally selected for a 2 × 4 × 2 driving-simulation experiment comparing world-fixed (WF) and screen-fixed (SF) interfaces across goal-directed and stimulus-driven tasks. Reaction times and eye-tracking indicators were analyzed using generalized linear models. Results show that stimulus-driven tasks significantly increased reaction times, with rear-vehicle scenarios producing the longest responses (mean = 1.420). During lane-change tasks, WF displays significantly reduced fixation duration (p < 0.001) and fixation counts (p < 0.001), whereas SF displays improved attentional efficiency during pedestrian-warning tasks. In addition, field-dependent drivers exhibited significantly larger pupil diameters, indicating higher cognitive workload. These findings provide sensor-based evidence for AR-HUD systems that dynamically optimize interface presentation according to task context and workload conditions. Full article

Introduction: Elasmobranchs play a crucial role in ecosystem regulation, but they are highly vulnerable to rapid environmental changes, particularly those driven by anthropogenic activities. Therefore, elasmobranchs are among the most threatened vertebrate groups worldwide, with overfishing and habitat degradation representing the primary threats to their survival. To address these challenges, in situ and ex situ conservation programs are complementary approaches. Objective: The implementation of assisted reproductive technologies, still poorly developed for elasmobranchs, represents a critical component of these ex situ strategies. Focused on that aspect, the main goal of this work was to get a better understanding of the sperm cells morphologies of different Mediterranean elasmobranch species. Results: The Elasmobranchii spermatozoa possesses a long and he-lical head, an elongated midpiece, and a flagellum supplemented with additional ultrastructural components to its axoneme. The comparative analysis of sperm head morphology revealed substantial interspecific variation among the studied elasmobranchs. Head length was relatively conserved, ranging from 48.5 to 62.0 μm, whereas helical parameters showed much greater variability. S. canicula and M. mobular exhibited the most compact head morphology, characterized by short helical wavelengths, low amplitudes, and the highest numbers of helices. In contrast, the batoids R. rhinobatos, R. radula, and R. clavata displayed broader, more widely spaced helices and fewer turns. Phylogenetic patterns were partially evident, as the closely related rajids shared very similar sperm morphology, while R. rhinobatos showed a comparable batoid morphotype. However, similarities between the distantly related M. mobular and S. canicula, and differences between the scyliorhinids S. canicula and G. melastomus, suggest that ecological and reproductive factors, in addition to phylogeny, have influenced the evolution of sperm head morphology in elasmobranchs. Conclusion: Elasmobranchii species possess big spermatozoa (compared to bony fishes) with an elongated helical head and tail similar to one currently existing (but later diverged) in birds, reptiles, and amphibians, which can be considered an evolutionary ancient. Sperm head morphology varies markedly among elasmobranchs, mainly regarding helical traits rather than head length. While phylogeny explains similarities among rajids, convergent patterns in distantly related species suggest that additional ecological and reproductive factors influence sperm evolution and structural design. Full article

Background: Breastfeeding enhances infant and maternal health, but global breastfeeding rates remain suboptimal. Virtual reality (VR) emerges as a promising tool for breastfeeding education. The objective of this review was to assess the effectiveness of VR-based interventions on breastfeeding outcomes in pregnant and postpartum women. Methods: PubMed, Embase, Web of Science, Scopus, and CENTRAL were searched until 10 January 2026, for randomized controlled trials (RCTs) and quasi-experimental studies comparing VR-based interventions (immersive simulations, 360° videos, or head-mounted displays) with standard care or non-VR comparators in pregnant or postpartum women. Primary outcomes included breastfeeding self-efficacy, motivation, and breastfeeding technique (LATCH score). Secondary outcomes included exclusive breastfeeding rates, milk production, and maternal anxiety. Risk of bias was assessed using the RoB 2.0 and ROBINS-I tools for RCTs and non-RCTs, respectively. A random-effects meta-analysis was conducted, with results reported as mean differences (MD) or risk ratios (RR), along with 95% confidence intervals (CIs). Certainty of the evidence was assessed using the GRADE approach. Results: Five studies (4 RCTs and 1 quasi-experimental; n = 344) were included. VR improved prenatal breastfeeding self-efficacy (2 studies, MD: 13.93; 95% CI: 10.96–16.90), motivation (1 study, MD: 2.88; 95% CI: 1.66–4.10), and LATCH score (1 study, MD: 1.72; 95% CI: 1.37–2.07), and reduced time to breastfeeding initiation (1 study, MD: −22.4 min; 95% CI: −29 to −15.9), the certainty of evidence was low to very low for these outcomes. No significant effects were observed for postnatal self-efficacy, exclusive breastfeeding, or maternal anxiety. Formal assessment of publication bias could not be done. The small sample sizes for most outcomes, heterogeneity, the open-label nature of the trials, and the subjective nature of the outcomes should be considered when interpreting these results. Conclusions: VR-based interventions may improve process outcomes, such as prenatal breastfeeding self-efficacy, motivation, breastfeeding technique, and early breastfeeding initiation; the certainty of evidence is low to very low. Evidence for clinically important outcomes, including exclusive breastfeeding and maternal anxiety, remains inconsistent. Larger, well-designed RCTs are warranted before these interventions can be considered in routine practice. Full article

Background/Objectives: Optical coherence tomography (OCT) and OCT angiography (OCT-A) provide detailed measurements of retinal structure and vasculature; however, age-related differences in how these parameters correlate with one another remain poorly understood. We hypothesized that vascular–structural integration in the macula is more pronounced in adults than in children. Our aim was to characterize correlation patterns in pediatric and adult populations to inform the development of age-specific clinical interpretation guidelines. Methods: This prospective cross-sectional observational study enrolled 37 healthy children (age 1–17 years) and 28 healthy adults (age 18–65 years). Eyes with ocular or systemic conditions affecting the retina or prior intraocular surgery were excluded. Standardized OCT and OCT-A acquisition protocols provided structural and vascular measures. Univariable correlation analyses applied a stringent threshold (p < 0.001) to identify robust associations. Significant univariable results were entered into multivariable regression models adjusting for age, gender, intraocular pressure, and axial length. A Group-wise Linkage Proportion quantified the percentage of potential significant correlations among eight predefined anatomical parameter groups. Results: Ninety univariable correlations met p < 0.001. Fourteen correlations were shared across age groups, notably foveal avascular zone metrics and vessel density, showing very large negative correlations (r = −0.70 to −0.87). The pediatric cohort displayed 40 unique correlations, primarily linking optic nerve head flow indices to retinal nerve fiber layer thickness. Adults exhibited 36 unique correlations, dominated by macular vascular–thickness coupling concentrated in the parafoveal region. After multivariable adjustment, 52 of 90 associations remained significant. Adult-specific associations lost significance more frequently (58%) than pediatric-specific associations (43%), whereas correlations shared across both groups showed complete stability (100%). The Group-wise Linkage Proportion indicated pronounced macular vascular–structural coupling in adults (48.4%) versus near absence in children (1.2%). Conclusions: Retinal parameter correlation patterns show fundamental differences between pediatric and adult eyes. While optic nerve head-macular thickness relationships remain consistent across ages, adults exhibit mature, localized integration of macular vascular and structural parameters absent in children. These findings suggest that pediatric and adult OCT/OCT-A measurements may benefit from separate reference standards, although prospective validation is required before clinical implementation. Full article

Preserving cultural heritage sites requires an interoperable digital framework capable of integrating heterogeneous spatial data and supporting immersive interaction for inspection and management. This study investigates the integration of multiple heritage data representations—including IFC-based Heritage Building Information Modeling (HBIM), terrestrial and UAV LiDAR point clouds, and 3D Gaussian Splatting reconstructions—into a unified digital management environment for the East Hall (Aula Timur) heritage site within the Bandung Institute of Technology (ITB) campus. A semantic–spatial interoperability workflow is proposed to harmonize BIM, point cloud, and landscape-scale data within a common georeferenced context, supported by a CityGML-based base map of the surrounding site. An immersive virtual environment was implemented using a head-mounted display to enable walkthrough-based inspection and damage annotation. All datasets were georeferenced within a unified coordinate system, allowing spatial registration between digital objects and the physical heritage site. The results demonstrate that multi-source heritage datasets can be integrated with high geometric accuracy, achieving TLS registration errors of approximately 2 mm and georeferencing residuals within 11.1 cm (horizontal) and 0.95 cm (vertical), while preserving semantic information and ensuring spatial coherence across HBIM, GIS, and immersive environments. The system is implemented in VR, with an architecture designed to support future MR-based on-site annotation and visualization. The proposed framework establishes a foundation for future heritage digital twin deployments and supports informed conservation decisions. Full article

Mixed reality (MR) technologies enable users to experience computer-generated content within the physical environment through spatial computing and head-mounted displays. By supporting real-time interaction through speech, gesture, gaze, and movement, MR offers new opportunities for game design beyond productivity and educational applications. However, relatively few studies have examined interaction modalities in MR games. In this paper, we present the design and deployment of four MR games on the Microsoft HoloLens 2: three that use monomodal input (speech, gaze, or gesture) and one that uses multimodal input (speech, gaze, and gesture). We conducted a study with ten participants and evaluated player experience using subjective self-reports of task load, emotional engagement, and comfort alongside objective measures, namely brain activity data collected with a five-channel electroencephalogram (EEG) device. Our preliminary findings suggest two clusters of interaction modalities based on subjective measures, a pattern that is also reflected in the objective EEG measures. Our analysis combining subjective and EEG data indicates that interaction modality influences task load and emotional engagement. Additionally, our functional connectivity analysis showed links in activity across the prefrontal, temporal, and occipital brain regions for different input modalities in the MR games. Full article

Background: Cancer is one of the leading causes of disability in both the United States and worldwide. Its high global prevalence is accompanied not only by the burden of the disease itself but also by the adverse effects of treatment, which can significantly diminish patients’ quality of life (QoL). Osteopathic manipulative treatment (OMT), an emerging complementary therapy, seems to show promise in the improvement in quality of life (QoL) in these patients. The purpose of this systematic review is to evaluate the effectiveness of OMT as a complementary and integrative therapy for the relief of symptoms and improved functional capabilities in cancer patients. Methods: The literature search was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using PubMed, Scopus, Science Direct and Web of Science databases. A risk of bias analysis was conducted by evaluating the included randomized controlled trials to assess domains, such as randomization, intended intervention, incomplete outcome data, outcome measurement, and selective reporting. Between the 20 randomized controlled trials and observational studies, information regarding OMT in the treatment of general cancers, oral, pediatric, head and neck, gynecological, breast, and gastric cancers was collected. Results: Our analysis displayed a patient-reported increase in QoL, especially through the reduction in pain and lymphedema, as well as an increase in overall functional capabilities. Conclusions: Overall, the findings underscore the potential role of OMT as an adjunctive therapy for patients with a wide range of cancers, contributing to symptomatic management and enhanced QoL. Full article

Healthcare professionals must acquire and maintain both declarative knowledge and fine psychomotor skills across a wide range of clinical procedures. Human working memory is physiologically limited, and the high cognitive demands of clinical environments frequently contribute to medical errors and adverse events. Intra-individual performance variability—driven by fatigue, stress, and motivation—represents a further challenge that conventional medical safety education has not adequately addressed. According to the World Health Organization, patient harm ranks fourteenth in the global burden of disease, with approximately 10% of hospitalised patients in high-income countries experiencing harm within healthcare facilities. This study reports the design, theoretical rationale, and preliminary outcomes of an augmented reality (AR) glasses system for hands-free, self-directed medical procedural training, developed from a human factors and ergonomics (HFE) perspective. The system integrates a see-through head-mounted display (HMD; Epson Moverio BT-40S), bone-conduction earphones (Shokz OpenComm), and an industrial-grade voice recognition application (NEC Solution Innovators), achieving fully hands-free operation compatible with aseptic technique. Content design is grounded in cognitive load theory (CLT) and the cognitive theory of multimedia learning (CTML), extended by neuroscientific evidence on multisensory integration and memory consolidation. More than 40 procedure-specific modules have been developed in-house at Tokyo University of Technology, spanning airway management, vascular access, respiratory therapy, dialysis, and cardiac support. In a four-year longitudinal survey (virtual reality (VR) simulator; n = 286), major satisfaction items consistently exceeded the scale midpoint. In an AR endotracheal suctioning cohort (n = 38/22), procedural flow understanding was rated 3.95/5.0. A peer-reviewed randomised controlled trial (Clinical Simulation in Nursing, n = 36) demonstrated significantly superior skill improvement (p < 0.001) and learning motivation (p = 0.001) in the AR group versus textbook self-practice. Principal ergonomic limitations of current HMD hardware—excessive weight, narrow field of view, and absence of medical-grade certification—are documented, and AI-based real-time procedural assessment is identified as a priority for the next research phase. Full article

Southern Chinese lion dance (nanshi) in Bangkok moves between temple ritual, community representation, school training, public festival display, and judged competition. This article foregrounds the diasporic and minority position of Teochew lion dance in Thailand. It examines codification as cultural negotiation, asking how a temple-linked Chinese ritual practice is made legible to Thai educational, civic, and sporting publics while remaining tied to community ritual authority and lineage memory. The study draws on public documentary traces from the 2000s–2020s and field-based evidence centred on Bangkok. Sources include temple and association commemorative publications, municipal school records, Thai cultural and competition reporting, heritage registers, transnational rule texts, interviews, observations, and community archival/display materials. The article first shows how huiguan, temples, and schools stabilize calendars, resources, and authority; second, how competition rules translate embodied repertoires into auditable norms of time, team composition, safety, difficulty, and scoring; and third, how trophies, certificates, lion heads, photographs, videos, and anniversary volumes turn evaluated performances into community archives of continuity, merit, and public legitimacy. The Bangkok case shows a diasporic minority practice being reshaped through the combined work of ritual governance, competitive codification, and community archiving within a Teochew-centred institutional ecology. Full article

To address the challenge of fragmented, unstructured knowledge in the cultural relic domain, where existing entity and relation extraction models suffer from boundary confusion and feature degradation for long entities and overlapping triples, this paper proposes a subject-guided two-stage joint entity and relation extraction model tailored to cultural relic texts, and constructs a Cultural Relic Knowledge Graph System. Building on CasRel’s cascaded labeling framework, we design a Multi-Head Self-Attention Decoder Enhanced by Relative Position Encoding (MHSA-RPE) to explicitly model inter-entity positional relations and alleviate boundary confusion. We further propose a Boundary–Global Dual-Branch Subject Fusion Module (BGDSFM) to encode local boundary and global contextual features in parallel, alleviating feature degradation from simple average pooling. Experiments on DuIE2.0 and our self-built Palace Museum Cultural Relic Entity–Relation Dataset (PM-CRER) show that the proposed model achieves F1-scores of 79.4% and 75.9% respectively. It outperforms mainstream baselines, surpassing its prototype CasRel by 3.6 percentage points on PM-CRER and the latest cascaded state-of-the-art CECRel by 2.6 percentage points on DuIE2.0. Based on this model, a Chinese Cultural Relic Knowledge Graph System supporting the multimodal display of cultural relic images is constructed, providing technical references for the digital protection, dissemination and utilization of cultural relic knowledge. Full article

Background/Objectives: The growing elderly population and concomitant increase in physical activity of older adults has led to a growing number of seriously injured elderly patients. The aim of this retrospective cohort study was to investigate the influence of the leading region of injury in severely injured patients on the risk of mortality in different age groups, with focus on elderly patients. Methods: Data from the TraumaRegister DGU^® from 2015 to 2020 were analyzed, including severely injured patients admitted to Swiss, German and Austrian trauma centers. Inclusion criteria were a minimum age of 18 years and an Abbreviated Injury Scale (AIS) score of three or higher in at least one of the body regions. Descriptive analysis and odds ratios for mortality derived from multivariable analysis were calculated, stratified by age and leading region of injury. Results: Out of 213,216 patients, 98,481 met the inclusion criteria. Mortality increased from 6.9% in the control group (18–54 years) to a maximum of 35.9% in the 90+ age group. Leading head injuries had a mortality rate of 22%. The odds ratio for the risk of mortality increased with age and reached a maximum value of 17.0 in the 90+ age group. However, the increase in risk of mortality for leading head injury with increasing age was lower than in the other regions, with an OR of 11.7 in the 90+ age group. In contrast, the group with a leading thoracic injury increased to an OR of 22.5, abdomen to an OR of 75.2 and extremities to an OR of 28.7. Conclusions: The risk of mortality from traumatic head injury is less pronounced in elderly people compared to other injury regions. Our data suggests that traditional scoring systems like the AIS might not display nuances of different injury severities in different age groups, especially for head injuries caused by low-energy trauma and therefore should be reevaluated. Full article

With society’s ever-growing concern for animal welfare, the equestrian industry has focused on passing and enforcing new rules to protect the main athlete, the horse. In jumping, courses go by quickly, with judges using the occurrence of conflict behaviours to assess any welfare breach. This study aimed to evaluate the overall frequency of such behaviours in Brazilian Sport Horses during elite show jumping competitions in Brazil. Conflict behaviour displays were analyzed in 120 different horse–rider pairs in jumping competitions in Brazil. All videos were observed at a slowed-down speed, with the frequency of behaviours being recorded. The observed behaviours included head shaking, tail swishing, neck hyperflexion, excessive pulling on the reins, kicking, bucking, rearing, and disobedience. All horses (100%) presented at least one type of conflict behaviour, with head shaking (100%, n = 120, IQR 3–7, range 1–18) being the most common one (p < 0.001) and tail swishing (45.83%, n = 55, IQR 1–10, range 1–29) being the second most common (p < 0.001). Most horses showed only one (41.67%, n = 50) or two (43.33%, n = 52) different types of behaviours, with few episodes of each throughout the course. Those findings were in line with studies in other disciplines, as the competition environment offers a series of challenging and stressful situations. The low levels of conflict observed in most horses indicate that the current horse welfare rules are working and must continue to be reinforced to consistently protect the horses. Full article

Cannabis sativa glandular trichomes (CsGT) are the primary sites of cannabinoid biosynthesis. They consist of a metabolically active head and a structurally supportive stalk. While the biosynthetic role of the head is well established, understanding of the functional contribution of the stalk has lagged. Here, we performed an integrated proteomic and transcriptomic analysis of isolated CsGT head and stalk tissues to identify their distinct roles. While proteomic analysis found 35 proteins higher in the stalk compared to the head, the transcriptomic analyses suggest the true functionality of the stalk, with 6018 genes showing higher expression in this tissue. Marker gene analysis showed a predominantly epidermal signature for head cells, while stalk cells also showed signatures for vascular cell types. Congruently, the transcriptomic results showed genes with higher expression in the head associated with specialized secondary metabolite production and accumulation, while the stalk displayed enrichment for genes related to active growth, vascular, apoplastic and symplastic transport, as well as sugar and hormone signalling. These findings support a model in which the stalk is a complex epidermal tissue, highly distinct from the head, that facilitates metabolite transport, signalling, and precursor supply to the glandular head. This study provides the first multi-omics characterization of CsGT stalk function, identifying it as a key contributor to trichome productivity and a potential target for optimizing cannabinoid yield. Full article

Background/Objectives: Post-COVID syndrome (PCS) is frequently associated with persistent cognitive complaints such as fatigue and impaired concentration, yet objective markers related to cognitive dysfunction are lacking. Pupillary oscillation metrics have emerged as non-invasive indicators of task-related cognitive load and autonomic regulation. This study investigated the Index of Pupillary Activity (IPA) and the Low/High Index of Pupillary Activity (LHIPA) in a large cohort of patients with PCS compared with healthy controls. Methods: In this cross-sectional study, 526 participants (397 PCS patients, 129 controls) performed a standardized virtual reality-based stereoscopic task at three disparity levels: 275 arcsec (high difficulty), 550 arcsec (medium difficulty), and 1100 arcsec (low difficulty), using a head-mounted display with integrated eye tracking. Continuous pupillometry data were recorded, and IPA and LHIPA were calculated. Linear mixed-effects models with random intercepts for participants were applied, adjusting for age, sex, and task difficulty. Results: Both IPA and LHIPA were significantly lower in PCS patients than in controls at all three task difficulty levels in post hoc model-based contrasts. In adjusted mixed-effects models, PCS was also associated with lower overall IPA ($\beta =-0.111$, 95% CI $-0.160$ to $-0.062$, $p<0.001$) and lower overall LHIPA ($\beta =-0.164$, 95% CI $-0.253$ to $-0.074$, $p<0.001$). Lower task difficulty was associated with higher values of both metrics: for IPA, $\beta =0.164$ at 550 arcsec and $\beta =0.287$ at 1100 arcsec (both $p<0.001$); for LHIPA, $\beta =0.161$ at 550 arcsec and $\beta =0.254$ at 1100 arcsec (both $p<0.001$), relative to 275 arcsec. Thus, both indices showed an inverse association with task difficulty. Age was negatively associated with both metrics, whereas male sex was positively associated with both. No significant interaction between cohort and task difficulty was observed. Conclusions: PCS was associated with reduced IPA and LHIPA during a standardized stereoscopic task. These findings indicate altered task-related pupillary dynamics in PCS and may reflect altered cognitive-load processing and autonomic regulation. LHIPA, and with caution also IPA, may contribute to the objective assessment of task-related pupillary alterations in PCS. Full article

Genetic resources of small ruminants are essential for food security in arid regions; however, basic data for each breed in Saudi Arabia remain incomplete. This study establishes a comprehensive national database through a systematic survey of 104 farms, covering 21,214 heads of livestock (sheep and goats) across the kingdom’s primary agro-ecological zones between January and October 2025. Although national census data indicate that major breeds of sheep such as Naeemi, Najdi, Arabi, and Harri or goats such as Ardi exceed the FAO’s numerical thresholds for “not at risk,” our analysis reveals a fundamental paradox of “genetic vulnerability,” defined as a high risk of inbreeding depression and genetic stagnation despite high census numbers. The results show significant regional variations in prolificacy (p < 0.05), with the southern region displaying a substantial productivity gap compared to the central and eastern regions, mainly due to reliance on traditional grazing (46.7%) and limited infrastructure. This vulnerability is driven by a high risk of systematic inbreeding, with 65.7% of breeders acquiring sires from their own herds, a situation worsened by a severe 80% shortage of high-quality breeding males in the central region. Furthermore, selection criteria heavily emphasize esthetic phenotypic traits (over 80%) rather than production indicators (less than 8%), hindering genetic progress. Correlation analysis showed that higher farmer education levels were negatively associated with reproductive challenges (r = −0.216), while high feed prices remained a near-universal obstacle (97.1%). To mitigate these risks, we recommend implementing region-specific sire exchange programs to break closed breeding loops and establishing a national performance recording system to shift selection focus from phenotypic traits to measurable productivity. This study provides a vital, evidence-based framework for transitioning toward data-driven, resilient conservation and breeding strategies. Full article