Search Results (135)

Solid biomass (agro-residue) is the most important source of renewable energy. The accelerating impacts of climate change and global population growth contribute to air pollution through the use of fossil fuels. These processes increase the demand for energy. The European Union has adopted a climate action plan to address the above challenges. The main aim of this study was to assess the economic performance of the producers of biomass for energy generation in Poland. The detailed objectives were to determine land resources in the studied agricultural farms and to determine the value of fixed and current assets in the analyzed farms. We used questionnaires as the main method to collect data. Purposive sampling was used to choose the farms. We conducted various tests to analyze the revenues from biomass sales and their normality, such as the Dornik–Hansen test, the Shapiro–Wilk test, the Liliefors test, and the Jargue–Berra statistical test. Moreover, we conducted regression analysis to find factors that are the basis for the economic performance (incomes) of farms that sell biomass. Results: This study demonstrated that biomass sales had a minor impact on the performance of agricultural farms, but they enabled farmers to maintain their position on the market. The economic analysis was carried out on a representative group of Polish agricultural farms, taking into account fixed and current assets, land use, production structure, and employment. The findings indicate that a higher income from biomass sales was generally associated with better economic results per farm and per employee, although not always per hectare of land. This suggests that capital intensity and strategic resource management play a crucial role in the profitability of bioenergy-oriented agricultural production. Conclusions: We concluded that biomass sales had a negligible influence on farm income. But a small income from biomass sales could affect a farm’s economic viability. Full article

This study provides a comprehensive assessment and synthesis of the literature on short-selling. It performs a lexicometric analysis, providing a quantitative review of 1093 peer-reviewed journal articles to identify and illustrate the main themes in short-selling research. Almost half the published literature on short-selling is thematically clustered around portfolio management techniques. Other key themes involve short-selling as it relates to risk management, strategic management, and market irregularities. Descending hierarchical classification examines the overall structure of the textual corpus of the short-selling literature and the relationships between its key terms. Similarity analysis reveals that the short-selling literature is highly concentrated, with most conceptual groups closely aligned and fitting into overlapping or conceptually similar areas. Some notable groups highlight prior short-selling studies of market dynamics, behavioral factors, technological advancements, and regulatory frameworks, which can serve as a foundation for market regulators to make more informed decisions that enhance overall market stability. Additionally, this study proposes a conceptual framework in which short-selling can be either a driver or an outcome by integrating the literature on its antecedents, consequences, explanatory variables, and boundary conditions. Finally, it suggests directions for future research. Full article

In the housing sector emission reduction builds on a shift from fossil fuels to renewable energy sources and increasing the efficiency of energy usage, with heating playing a dominant role in comparison to that of electricity. For electricity production in the residential sector, research shows that different settings of (co-)ownership in renewables are linked to a greater tendency to invest in energy-efficient devices or to adopt more energy-conscious behaviours. The empirical analysis demonstrates that fully-fledged prosumers, i.e., consumers who have the option to choose between self-consumption and selling to third parties or the grid, exhibit a higher tendency to invest in energy efficiency and that only this group manifests a greater likelihood of engaging in conscious-energy consumption behaviour. This paper extends the analysis to include heating in the residential sector. The study conducted an ANCOVA based on a sample of 2585 German households. The findings show that, depending on the (co-)ownership setting, the willingness to invest and to adopt energy-efficient practices grows considerably. Consumer-sellers demonstrate the highest willingness to invest and adapt energy conscious behaviour. Furthermore, regarding heating in particular, self-consumers are also inclined to invest and engage in energy-savings behaviour. Full article

The life-cycle economics and greenhouse-gas (GHG) emissions of forest biomass harvesting and utilization for value-added bioproducts were comprehensively evaluated via the development of an integrated modeling framework. Taking the eastern U.S. as the case region, the model innovatively integrated field studies, a Bayesian-based statistical learning model, techno-economic analysis, and life-cycle assessment. In specific, by investigating and summarizing the typical forest biomass harvesting systems across the region, the forest biomass harvesting costs were spatially grouped and mapped for four classified subregions across the eastern US. Overall, with 95% confidence the forest biomass harvesting cost is between USD 21.99 and USD 44.33/dry Mg, while the GHG emissions are between 14.79 and 98.80 kg CO₂ eq./dry Mg. Furthermore, for the forest biomass utilization for four alternative value-added bioproducts, the minimum selling price (MSP) is USD 177.82/Mg for pellet fuel, USD 110.24/MWh for biopower, USD 1059.4/Mg for biochar, and USD 4.98/gallon for aviation fuel. The life-cycle GHG emissions are 149.80 kg CO₂ eq./Mg pellet fuel, 52.22 kg CO₂ eq./MWh biopower, 792.12 kg CO₂ eq./Mg biochar, and 2.13 kg CO₂ eq./gallon aviation fuel, respectively. Considering the uncertainties, 95% confidence intervals of MSPs range from USD 164.77 to USD 190.97/Mg for pellet fuel with an 81.85% probability to be profitable, from USD 100.20 to USD 120.21/MWh for biopower with a 49.38% probability to be profitable, from USD 1000.91 to USD 1109.25/Mg for biochar with a 79.51% probability to be profitable, from USD 4.86 to USD 5.54/gallon for aviation fuel with an 0.03% probability to be profitable. Moreover, the MSPs of pellet fuel and biochar are much less affected by the market changes than those of biopower and aviation fuel. However, the production of biopower and aviation fuel has lower carbon intensities than that of pellet fuel and biochar. Full article

Background/Objectives: Mental diseases are one of the leading groups of health disorders worldwide, with depressive and anxiety disorders being the most prevalent. Depressive disorders can be treated with pharmacotherapy, psychotherapy, or a combination of both. In cases where these approaches prove ineffective, electroconvulsive therapy may be considered as an alternative. The drugs of choice for treating depressive disorders are selective serotonin reuptake inhibitors (SSRIs). In the Republic of Serbia, commonly prescribed SSRIs include fluoxetine, citalopram, paroxetine, sertraline, and escitalopram. Methods: Data on drug sales for human medicine from the Agency for Medicines and Medical Devices of Serbia (ALIMS) were used for the analysis of consumption in the period 2018–2022. Data on drug consumption in other European countries were obtained from the respective national registers. Results: From 2018 to 2021, sertraline was the best-selling drug in this group, but with a statistically significant decrease (R² = 0.7948, p = 0.042), while escitalopram showed a statistically significant increase (p = 0.006) and became the best-selling drug in the SSRI group in 2022. Overall, SSRI group consumption fluctuated from 2018 to 2022, with the highest values in 2020. However, these variations were not statistically significant (p = 0.6223). Compared to Serbia, out of 12 European countries, 8 had higher and 4 had lower consumption in 2019 and 2020. A positive correlation was found between antidepressant consumption and GDP per capita. Conclusions: Sertraline was the most commonly prescribed SSRI drug in Serbia from 2018 to 2021. However, in 2022, escitalopram became the most commonly used drug in this group both in Serbia and worldwide, with a consistent increase in consumption. Full article

Wilderness areas are declining worldwide. A major reason is large-scale forestry activities like logging. At the same time, wilderness offers unique opportunities for recreation in natural and remote environments, enabling communities to gather economic income based on wilderness tourism. An outstanding element of wilderness areas is primary forests. Wilderness is often understood as untouched nature, unchanged by human intervention. For visitors, wilderness resembles a counter-world, enabling them to escape from everyday life. The present study investigates whether forestry activities have an effect on the attractiveness of primary forests for wilderness tourism. This question is answered based on a case study in the Făgăraş Mountains (Southern Carpathians, Romania). The findings show that primary forests are a unique selling point in tourism. Forestry activities are associated with direct (loss of biodiversity) and indirect (change of target group) effects. Forestry activities not only cause changes in forests as a tourism attractor, but also change the attractor’s contexts, by rendering access difficult or by destroying hiking trails. This paper makes theoretical and practical contributions. From a theoretical point of view, it reflects the concept of wilderness tourism and highlights the importance of contexts (i.e., access paths) for the attractiveness of wild forests. From a practical point of view, it highlights the importance of distinguishing various target groups and different degrees of naturalness to maintain a nuanced portfolio of recreational opportunities in wild forests, for example by referring to established management tools like the recreation opportunity spectrum. Full article

Fifty high-risk bull calves were used in a completely randomized design (ten calves/treatment) to evaluate the optimal period of calcium propionate (CaPr) supplementation following arrival into the feedlot. The variables evaluated were the growth performance, dietary energetics, body fat reserves, serum metabolites, and economic return at day 56 of arrival. Calves, which were weighed at the moment of reception (156.2 ± 1.57 kg off-truck body weight, BW), were received with a 50:50 forage-to-concentrate ratio diet and clean water. At 12 h from reception, they were housed in individual pens during a 56 d feeding period and assigned to treatments consisting of a daily supplementation of a commercial product (Propical^® Dresen Química, SAPI de CV., Mexico City, Mexico) that provided 19 g CaPr/calf for 0, 14, 28, 42, or 56 d following arrival into the feedlot. Compared with the other treatments, the calves receiving CaPr during the initial 42 d had a greater average daily weight gain (p ≤ 0.035) without affecting the dry matter intake (p ≥ 0.24). Thus, the gain efficiency (p ≤ 0.050) and dietary energy utilization were improved (p ≤ 0.046). Rib fat thickness (p ≥ 0.090) and Longissimus lumborum muscle area (p ≥ 0.112) were not affected by the CaPr supplementation, whereas calves showed the greatest values (p ≤ 0.038) to the rump back fat thickness at 42 and 56 days of CaPr supplementation. With the exception of the total albumin (being maximal at day 56 (p ≤ 0.024)) and total cholesterol (which, compared to the controls, was maximal at 28 and 42 d; p = 0.030), the serum metabolic profiles were not affected by the treatments. Using the profit estimated for the control group as a baseline, supplementing CaPr for 42 d yielded a greater net income (USD 34.84 more/calf). CaPr supplementation for more or less than 42 d showed a very similar profit (~USD 6.80/calf). Because the cost of gain was very similar for these treatments and the controls (USD 1.42 vs. 1.46/kg), the positive difference in profit was mediated mainly by an increase in income selling (+USD 13.02/calf) for the CaPr calves. Based on the performance, serum metabolites, and profit, it is concluded that the optimal duration of supplemental CaPr is 42 d. Offering 19 g CaPr during this period enhanced the growth performance, dietary energy, and economic returns. Full article

Short-term patterns in financial time series form the cornerstone of many algorithmic trading strategies, yet extracting these patterns reliably from noisy market data remains a formidable challenge. In this paper, we propose an entropy-assisted framework for identifying high-quality, non-overlapping patterns that exhibit consistent behavior over time. We ground our approach in the premise that historical patterns, when accurately clustered and pruned, can yield substantial predictive power for short-term price movements. To achieve this, we incorporate an entropy-based measure as a proxy for information gain: patterns that lead to high one-sided movements in historical data yet retain low local entropy are more “informative” in signaling future market direction. Compared to conventional clustering techniques such as K-means and Gaussian Mixture Models (GMMs), which often yield biased or unbalanced groupings, our approach emphasizes balance over a forced visual boundary, ensuring that quality patterns are not lost due to over-segmentation. By emphasizing both predictive purity (low local entropy) and historical profitability, our method achieves a balanced representation of Buy and Sell patterns, making it better suited for short-term algorithmic trading strategies. This paper offers an in-depth illustration of our entropy-assisted framework through two case studies on Gold vs. USD and GBPUSD. While these examples demonstrate the method’s potential for extracting high-quality patterns, they do not constitute an exhaustive survey of all possible asset classes. Full article

Early discussions about possible pain in crustaceans often comprised speculation and anecdotes. Experiments to investigate pain took guidance from these early debates, and from studies on other taxa. Many experiments provided data that are consistent with the idea of pain. However, that does not mean that pain has been proved, but they open the possibility. With each study that is consistent with pain being felt, the probability increases, but we will probably never have conclusive proof. Some responses appear to be nociceptive reflexes; however, they at least indicate that the animal responds to stimuli such as tissue damage, heat, acid, alkaline, or electric shock. The data are said to be consistent with pain only if they cannot be explained by reflexes. These studies have encouraged various organisations to improve the welfare of crustaceans, e.g., PETA, Crustacean Compassion, RSPCA, British Veterinary Association, UFAW, and HSA. They also formed much of the evidence included in the highly influential review of sentience for the UK government that resulted in the inclusion of decapod crustaceans in the Animal Welfare (Sentience) Act 2022. This recognises that decapod crustaceans are sentient. By contrast, the New York Declaration recognises there is a possibility of sentience. Others have argued against the idea of pain in crustaceans. Nevertheless, the 2022 Act provided an impetus to groups that campaign for improved welfare. Some UK retailers now require improved slaughter techniques for the shrimp/prawn they sell, and electrical stunning is the preferred slaughter method. Full article

Peptides occupy a significant share of the pharmaceutical market and are among the top-200 selling drugs in the group of non-insulin drugs with analgesic, antibacterial and cardiovascular effects. The aim of this work is to develop a comprehensive analytical approach for quality control of novel synthetic peptides with non-narcotic types of analgesia and to provide docking simulations of dermorphin complex formation at the μ-opioid receptor (MOR) binding site. The materials and methods used include the pharmaceutical substance dermorphin tetrapeptide (DMTP) (tyrosyl-D-arginyl-phenylalanyl-glycinamide); Fourier transform infrared spectroscopy (FT-IR); static and dynamic laser light scattering (DLS, LALLS); scanning optical microscopy (SEM); X-ray fluorescence elements analysis; polarimetry for optical activity determining; and Spirotox method for sample biotesting. FT-IR-Spectra indicated specific amino acid chemical groups in the tetrapeptide sequence at 3300–2700 cm⁻¹, 1670 cm⁻¹. UV-absorption spectra of aqueous solutions of dermorphin tetrapeptide showed an absorption maximum at 275 nm, which is in good agreement with the presented spectrum of the bovine serum albumin (BSA) standard; the Pearson’s r of calibration line “A-C%” in 0.0125% to 0.0500% concentration range is 0.999; and the calculated specific extinction value $E_{1cm }^{1\%}$ = 18.38 ± 0.23. Of the 11 elements detected by X-rays, the elements copper (Cu) and cobalt (Co) have the highest X-ray intensity. Dispersion characteristics of dermorphin solutions were studied in the submicron and micron range. Conglomerates and druzes were detected by SEM, ranging in size from 2 µm to 100 µm. The specific optical activity index was calculated ${\left[\alpha \right]}_D^{20}$ = +36.18 ± 2.04 [°·mL·g⁻¹·dm⁻¹], according to Biot’s Law. Additionally, the orientation and conformation of the dermorphin molecule in the active binding site of the 8E0G receptor were predicted using molecular modeling, revealing that the contact area affects the key amino acid residue arginine (ARG 182). This comprehensive approach to analytical methods for qualitative and quantitative analysis of dermorphin tetrapeptide can be applied in pharmacies to enhance the understanding of its biological activity and aid in the development of regulatory documentation for a new, non-narcotic analgesic based on the dermorphin tetrapeptide. Full article

Selenium is an essential trace element for the human body. However, its intake is usually low. Therefore, the production and utilization of selenium-enriched food are currently a research hotspot. Despite the remarkable scientific interest in this topic, only a few of the numerous studies focus on commercially available products. This study examined the nutritional quality, physical and chemical properties, cooking characteristics, and eating quality of four commercially available hot-selling rice types, both selenium-enriched and non-selenium-enriched, and discovered that selenium-enriched rice outperforms ordinary rice in terms of both nutritional quality and taste. In addition, we employed the gas chromatography–ion mobility spectrometry (GC-IMS) technique to evaluate the volatile chemicals of rice. Some of the chemicals that made selenium-rich rice taste different from regular rice were pentanal, (E)-2-Hexen-1-ol, ethyl-3-methyl butanoate, 2-furan methanol acetate, ethyl heptanoate, ethyl hexanoate, methyl hexanoate, isopentyl pentanoate, and ethyl butyrate. We looked into the metabolite profiles of rice using LC-MS-based untargeted metabolomics to obtain a better idea of the different metabolites that are found in selenium-enriched rice compared to regular rice. We identified a total of 522 metabolites and screened 182, 227, and 100 differential metabolites in selenium-enriched (A) vs. non-selenium-enriched rice (B/C/D) groups, respectively. This study revealed that selenium primarily influenced the metabolism of D-amino acids, starch, sucrose, and linoleic acid in rice. This study systematically analyzed the quality differences between selenium-enriched and non-selenium-enriched rice available on the market. For consumers, it is essential to understand the quality of selenium-rich rice on the market to guide the purchase of rice. Full article

One Health, as a multi-disciplinary approach, considers animal, human, and environmental health. Serbia continuously records high rates of antimicrobial resistance, with a knowledge gap on practices regarding veterinary antibiotic use, as no standardized data regarding veterinary consumption of antibiotics that would allow for temporal or spatial comparison are available in Serbia. This study aimed to describe the sales of veterinary antibiotics in Serbia. Aggregated wholesale data on veterinary drug sales were retrieved from the annual reports available from the Medicines and Medical Devices Agency of the Republic of Serbia for a period between 2017 and 2020. Veterinary use was analyzed using standard European Medicines Agency proposed methodology and expressed in milligrams of active substance per population correction unit (mg/PCU). Overall, there has been a 13% increase in aggregated sales, in mg/PCU, of antibiotic veterinary medicinal products (VMPs) for food-producing animals in Serbia between 2017 and 2020. With sales of around 110 mg/PCU in 2020, Serbia would have ranked ninth in Europe. In 2020, the overall highest-selling antibiotic classes were penicillins (27.62 mg/PCU), tetracyclines (27.54 mg/PCU), and aminoglycosides (12.8 mg/PCU), accounting for 61.9% of the total sales of antibiotic VMPs for food-producing animals, in mg/PCU. An increase in the use of macrolides and lincosamides and a decrease in the use of penicillins and the group classified as “other antibacterials” was noted. The current study identified an increase in the sales of veterinary antibiotics in Serbia and pointed out several potential problem areas. Full article

Oral rehabilitation with dental implants has resulted in high success rates. However, some complications have been described, such as the loss of the prosthetic screw. Some manufacturers sell screws with different coatings to avoid screw loosening, but even these types of screws can come loose. We aimed to investigate the screw coatings that can be applied during a dental appointment to avoid screw loosening. Following PRISMA Guidelines, we searched PubMed/Medline, Embase and Web of Science for studies published up to January 2024. All studies of single dental implant crowns, in which the prosthetic screw was coated with a lubricant and the preload and/or the removal torque value (RTV) was recorded, were analyzed. We excluded studies applying the finite element method (FEM) as well as studies without a control group. The risk of bias was assessed with a tool developed by our research group. Of the 1959 records identified, 19 were selected. Ten studies were considered to have a low risk of bias, and nine were considered to have a medium risk of bias. The coatings tested were adhesives, saliva, chlorhexidine, Vaseline, silicone gel, Polytetrafluoroethylene (PTFE) tape, blood, fluoride, Listerine^® Mouthwash and normal saline. The preload, the RTV with and without cyclic loading and the percentage of RTV loss were recorded. Some coatings show promise, although there is no clear evidence that any option is superior in minimizing screw loosening. Full article

Growing competition, changing customer needs, and growing environmental protection requirements mean companies are forced to change their approach to business. Traditional product sales are being replaced by systemic solutions focused on meeting specific customer requirements while reducing negative impacts on the environment. One such solution is the Product-Service System (PSS). This allows manufacturers to offer their products’ functionalities and features through related services. By extending the life of products, promoting the reuse of materials, and reducing the amount of waste, the implementation of PSS strongly supports sustainable development. The paper focuses on a new product group—garage boxes (GB). It discusses a new PSS business model that responds to the needs of people living in blocks of flats with no tenant storage lockers or rooms in the basement. The new business model sells the function (storing various possessions) and eliminates problems faced by tenants due to the lack of sufficient storage space. It provides customers with high-quality GB for as long as they need them. Customers can pick and choose equipment with additional services depending on their needs. The idea of the model is the outcome of a nationwide study carried out in Poland on a group of 500 residents of blocks of flats and consultations with manufacturers, homeowner associations, wholesale and retail traders, and the financial sector. The study provided us with information and data that provided a comprehensive picture of the problem of the absence of storage lockers or rooms for residents and the needs connected with GB. The results of the conducted research indicate that the developed business model responds to the diverse requirements of residents and supports sustainable solutions. It is an alternative to the lack of a storage unit assigned to each apartment. The business model developed in the paper is highly innovative and comprehensive. This makes it an attractive solution for residents of apartment blocks, and its implementation can significantly reduce the environmental impact. Full article

Objective: Nimodipine still represents a unique selling point in the prevention of delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). Its intrathecal effect is limited by a low oral bioavailability, leading to the development of nanocarrier systems to overcome this limitation. This study investigated the ultrasound-induced release profile of nimodipine from drug-loaded copolymers in artificial cerebrospinal fluid (CSF) within 72 h after a singular versus repeated sonication. Methods: Pluronic^® F127 copolymers (Sigma-Aldrich, Taufkirchen, Germany)were loaded with nimodipine by direct dissolution. Spontaneous and on-demand drug release by ultrasound (1 MHz at 1.7 W/cm²) was determined in artificial cerebrospinal fluid using the dialysis bag method. Nimodipine concentrations were measured at predefined time points within 72 h of sonication. Results: Spontaneous release of nimodipine was enhanced by ultrasound application with significantly increased nimodipine concentrations two hours after a repeated sonication compared to a singular sonication (median 1.62 vs. 17.48 µg/µL, p = 0.04). A further trend was observed after four hours (median 1.82 vs. 22.09 µg/µL, p = 0.06). There was no difference in the overall nimodipine concentrations between the groups with a singular versus repeated sonication (357.2 vs. 540.3 µg/µL, p = 0.60) after 72 h. Conclusions: Repeated sonication resulted in an acceleration of nimodipine release from the drug-loaded copolymer in a CSF medium. These findings confirm the proof of principle of an on-demand guidance of nimodipine release from nimodipine-loaded nanodrugs by means of ultrasound, which suggests that evaluating the concept in an animal model may be appropriate. Full article