Search Results (17)

Background and Objectives: Exploring daily lifestyle characteristics in individuals with gaming disorder (GD) might identify underlying causes and intervention points. However, integrative and subjective assessments are lacking in studies on this topic. This study aimed to assess circadian typology and physical activity in young adults with GD. Materials and Methods: We recruited 60 participants with GD and 120 age- and sex-matched controls. GD and delayed sleep phase syndrome (DSPS) were diagnosed through structured interviews. Physical activity and sleep patterns were measured using actigraphy. Self-reported measures were chronotype and insomnia by using composite scale of morningness (CSM) and the Pittsburg insomnia rating scale (PIRS). Results: We found that DSPS and eveningness chronotype was more prevalent in the GD group than in the control group. The GD group also contained more participants with insomnia with higher PIRS and a longer time to fall asleep compared with the control group. The GD group had lower physical activity levels for daily calorie expenditure, daily steps, and daily walking distance compared with the control group. No significant differences were observed in body weight and sleep duration between these groups. Conclusions: Individuals with GD, compared to HC, exhibit an eveningness chronotype, poorer sleep quality, lower physical activity, and higher obesity risk, suggesting that lifestyle adjustments like increased exercise and earlier sleep might help modify habitual behaviors and potentially further provide a way to treat GD. Full article

In this communication, a compact absorptive bandpass filter (ABPF) characterized by adjustable bandwidth and phase, low group delay (GD), a high absorptive ratio and low insertion loss (IL) is proposed. The presented ABPF consists of a bandpass section that is made of a quarter-wavelength coupled line and four stubs that are basically a lumped resistor in series with a short-circuited quarter-wavelength transmission line. The stubs not only perform the function of absorption but also have the advantage of adjustable bandwidth and phase. To verify the design concept and analysis formulas, an ABPF operating at 2.4 GHz is fabricated and measured; its simulated and measured results are in good agreement. Full article

We analyze the two classic methods for chirped Integrated Bragg Gratings (IBGs) in Silicon-on-Insulator technology using the transfer matrix method based on the effective refractive index (n_eff) technique, which translates the geometry of an IBG into a matrix of n_eff depending on the wavelength. We also implement a procedure that allows engineering of the chirped IBG parameters, given a required bandwidth (BW) and group delay (GD). Finally, a complementary method for designing chirped IBG is proposed, showing a significant improvement in the bandwidth of the device or a moderation in the variation of the geometrical parameters of the grating. Full article

The synchrosqueezing transform (SST) has attracted much attention as a post-processing technique since it was proposed. In recent years, improvements to SST have been made. However, the existing methods are mainly based on the time-domain signal model, and the weak frequency modulation assumption for the components composing the signal is always taken into account. Thus, the signals characterized by a rapidly changing instantaneous frequency (IF) may fail to be adequately tackled. To address this problem, the paper presents a novel seismic time–frequency analysis method via synchrosqueezing transform where a frequency-domain Gaussian modulated linear chirp model is utilized to deduce the SST. The group delay (GD) rather than the IF estimator is implemented to compute an estimation of the ridge. Furthermore, a new synchrosqueezing operator is constructed to rearrange the energy around the ridge. A synthetic example verifies the efficiency and robustness of the proposed SST method, which generates better results than some classic time–frequency analysis (TFA) approaches, e.g., short-time Fourier transform (STFT) and STFT-based SST (FSST). A field dataset further demonstrates this method’s potential in the delineation of subsurface geological structures. Full article

The anti-disialoganglioside (GD2) monoclonal antibody dinutuximab beta is approved for the maintenance treatment of high-risk neuroblastoma. Dinutuximab beta combined with different chemotherapy regimens is being investigated in various clinical settings. We conducted a retrospective clinical chart review of 25 patients with relapsed/refractory neuroblastoma who had failed ≥1 second-line therapy and received compassionate use treatment with dinutuximab beta long-term infusion combined with the induction chemotherapy regimens N5 (cisplatin, etoposide, vindesine) and N6 (vincristine, dacarbazine, ifosfamide, doxorubicin) recommended by the German Pediatric Oncology and Hematology Group [GPOH] guidelines. The treatment did not result in any unexpected severe toxicities or in any major treatment delays. Grade 3/4 pain was reported by 4/25 patients in cycle 1, decreasing to 0/9 patients in cycles 3 and 4. The median follow-up was 0.6 years. The best response in this group was 48% (12/25 patients), which included three patients with minor responses. At 1 year, the estimated event-free survival was 27% (95% confidence interval [CI] 8–47) and overall survival was 44% (95% CI 24–65). Combining long-term infusion of dinutuximab beta with N5 and N6 chemotherapy demonstrated an acceptable safety profile and encouraging objective response rates in heavily pretreated patients with high-risk neuroblastoma, warranting further evaluation in clinical trials. Full article

Instantaneous frequency (IF) is commonly used in the analysis of electroencephalogram (EEG) signals to detect oscillatory-type seizures. However, IF cannot be used to analyze seizures that appear as spikes. In this paper, we present a novel method for the automatic estimation of IF and group delay (GD) in order to detect seizures with both spike and oscillatory characteristics. Unlike previous methods that use IF alone, the proposed method utilizes information obtained from localized Rényi entropies (LREs) to generate a binary map that automatically identifies regions requiring a different estimation strategy. The method combines IF estimation algorithms for multicomponent signals with time and frequency support information to improve signal ridge estimation in the time–frequency distribution (TFD). Our experimental results indicate the superiority of the proposed combined IF and GD estimation approach over the IF estimation alone, without requiring any prior knowledge about the input signal. The LRE-based mean squared error and mean absolute error metrics showed improvements of up to 95.70% and 86.79%, respectively, for synthetic signals and up to 46.45% and 36.61% for real-life EEG seizure signals. Full article

In the computation systems that are frequently utilized in Digital Signal Processing (DSP)- and Fast Fourier transform (FFT)-based applications, binary multipliers play a crucial role. Multipliers are one of the basic arithmetic components used, and they require more hardware resources and computational time. Due to this, numerous studies have been performed so as to decrease the computational time and hardware requirements. In this research study on reducing the necessary computational time, a high-speed binary multiplier known as the Grouping and Decomposition (GD) multiplieris proposed. The proposed multiplier aims to achieve competency in processing algorithms over existing multiplier architectures through a combination of the parallel grouping of partial products of the same size and the decomposition of each grouped partial-product bit, with the final summation performed using a 5:2 logic adder (5LA). The usage of parallel processing and decomposition logic reduces the number of computation steps and hence achieves a higher speed in multiplication. The front-end and physical design implementation of the proposed GD multiplier have been executed in the 180 nm technology library using the Cadence^® Virtuoso and Cadence^® Virtuoso Assura tools. From the front-end design of the 8 × 8 proposed GD multiplier, it was observed that the GD multiplier achieves a reduction of approximately 56% in computation time and a reduction of 53% in power–delay product when compared to existing multiplier architectures. A further reduction in the power–delay product is achieved by the physical design implementation of the proposed multiplier due to the internal routing of subsystems with the shortest-path algorithm. The proposed multiplier works better with higher-order multiplication and is suitable for high-end applications. Full article

Three-hundred-and-thirty-four cognitive profiles from neuropsychological examinations assessed during a 5-year period (2015 to 2020) from geriatric patients of a day clinic in the south of Germany were analyzed. For this purpose, the profiles were divided into the following subgroups: (1) Mild Cognitive Impairment, no depression (2) Onset or mild dementia, no depression (3) No cognitive deficit, depression (4) cognitively impaired (MCI, dementia) and depression. Subgroups were be compared using analysis of variance (independent variable IV: diagnostic groups, dependent variable DV: cognitive functions) to reveal specific differences that will allow a differential diagnosis. Post-hoc comparisons and a graphical representation of the cognitive profiles were also investigated. All cognitive profiles with a Mini-Mental-State-Examination (MMSE) score of 25 or more points were selected for analysis if they had complete data from the following testing procedures: MMSE, clock drawing test, Geriatric Depression Scale (GDS), Syndrom-Kurztest (SKT), Nuremberg Aging Inventory (NAI) maze test, Wechsler Adult Intelligence Scale (WAIS) similarities, Rivermead Behavioral Memory Test (RBMT) story immediate and delayed. The results will help to improve the differential diagnostic examination of older depressed people with and without cognitive impairment: Depressed patients usually have no objectifiable memory impairment and inconspicuous scores in the logical structure of thought processes, while attention was usually impaired in both depressed and demented patients. Full article

Although voiced speech signals are physical signals which are approximately harmonic and electric power signals are true harmonic, the algorithms used for harmonic analysis in electric power systems can be successfully used in speech processing, including in speech enhancement, noise reduction, speaker recognition, and hearing aids. The discrete Fourier transform (DFT), which has been widely used as a phasor estimator due to its simplicity, has led to the development of new DFT-based algorithms because of its poor performance under dynamic conditions. The multiple-resonator (MR) filter structure proposed in previous papers has proven to be a suitable approach to dynamic harmonic analysis. In this article, optimized postprocessing compensation filters are applied to obtain frequency responses of the transfer functions convenient for fast measurements in dynamic conditions. An optimization design method based on the constrained linear least-squares (CLLS) is applied. This way, both the flatness in the passband and the equiripple attenuation in the stopband are satisfied simultaneously, and the latency is reduced. Full article

Improvement of adherence to pharmacotherapy in patients with Parkinson’s disease (PD) is a challenge in routine clinical practice. Our study was aimed at the effect of pillbox organizers with alarms improving adherence to pharmacotherapy and its impact on clinical outcomes. Forty nonadherent patients with PD being treated with ≥ 3 daily doses of levodopa and/or dopamine agonists were pseudorandomized and consecutively ranked to groups A (early-start intervention) and B (delayed-start intervention). We used the following validated diagnostic instruments: MMAS-8 (adherence), PDQ-8 (quality of life, QoL), GDS (depression), NMSS (non-motor symptoms), MDS-UPDRS III (motor involvement), MDS-UPDRS IV, and WOQ-9 (motor and non-motor fluctuations and dyskinesias). We proved a significantly improved rate of adherence with the use of pillbox organizers with alarms. Moreover, after only four weeks of using the pillbox organizer, we detected an improvement in QoL scores, motor involvement, motor-, and non-motor fluctuations. Our study showed that pillbox organizers with alarms are efficient in improving adherence to pharmacotherapy in PD. It also could contribute to better motor states, less severe fluctuations, and improved QoL. Full article

Research in the last decade has focused on assessing financial capacity and incapacity mainly in old age, but new research has turned to address the question of how financial incapacity can be predicted by cognitive factors. The aim of this study was to identify which cognitive domains predict financial capacity and the relevant cognitive skills of patients with mild Alzheimer’s disease (AD) in order to assist neurologists in functional assessment and further patient referral. In this study, 109 patients diagnosed with mild AD were examined with a number of neuropsychological tests: Mini-Mental State Examination (MMSE), Functional Rating Scale for Symptoms of Dementia (FRSSD), Functional Cognitive Assessment Scale (FUCAS), Trail Making Test (TMT)-Part B, Rey-Osterrieth Complex Figure Test (ROCFT)-copy condition and delayed recall condition, Rey Auditory Verbal Learning Test (RAVLT), Boston Naming Test, Rivermead Behavioural Memory Test (RBMT), digit span forward and backward, WAIS-R digit symbol substitution test, Neuropsychiatric Inventory (NPI), Geriatric Depression Scale (GDS-15), and the Legal Capacity for Property Law Transactions Assessment Scale (LCPLTAS). LCPLTAS total score and relevant subdomains were best predicted only by the score of one item coming from MMSE: subtraction of serial sevens. This is the only measure of arithmetic testing in use for the Greek geriatric population. Financial capacity is severely impaired in the group of mild AD patients. In order to prevent financial exploitation cases, neurologists, neuropsychologists, psychiatrists, and geriatrists should pay close attention to the information from the relevant arithmetic question of MMSE, as it is one of the most widely administered screening tests in clinical settings. Full article

Background: The frail elderly are prone to falls and fractures, which can result in dependency, disability, admission to institutions, and even death. They are at increased risk of frailty due to decreased physical activity, cognitive decline, and depression. Some evidence suggests that music therapy with physical activities may be particularly beneficial. Objective: This study aimed to investigate the intervention effect of music therapy with physical activities (MTPA) on frail elderly in the community. Methods: A quasi-experimental design was adopted. We selected 10 community care centers in southern Taiwan, in which elderly people over the age of 65 were assigned to a MTPA group and a comparison group after obtaining their informed consent. The MTPA group performed group music activities once a week for 120 min for 12 weeks, while the comparison group only continued with their daily activities. Instruments in this study included the Kihon Checklist, Senior Fitness Test (with Body Mass Index (BMI) and seven physical fitness items), Mini-Mental Status Examination (MMSE), and Geriatric Depression Scale Short Form (GDS-SF). Results: A total of 132 community elders agreed to participate in this study, and 122 completed both the pretest and posttest, with 62 in the music therapy group and 60 in the comparison group. The results of ANCOVA showed that after intervention, except for BMI, the Kihon frailty assessment, seven fitness scores individually and in total, MMSE, and depression showed significant improvements in the music therapy group relative to the comparison group (all p < 0.05). Conclusion: MTPA can improve the frailty index, cognitive function, depression, and physical fitness index in the community elderly. The results of this study can be used as a reference for the design of activities for the community elderly, to provide them with appropriate activities, improve their physical functions, and improve or delay their disability. Full article

Research has shown that non-pharmacological therapies can be useful in the treatment of Alzheimer’s disease (AD), significantly delaying cognitive decay. However, most AD interventions did not last beyond six months. Hence, little is known about the effect of these programs in the AD patients after six months of treatment. The purpose of this study was to evaluate the efficacy of the twelve-month Comprehensive Program of Cognitive Training (CPCT) for a sample of AD patients and to compare the results with the average annual rate of change. Thirty-nine AD patients participated in the study. The CPCT consists of a set of cognitive stimulations, intervention in activities of daily life (ADL), and motor training for 12 months. All patients were evaluated at baseline and in three-month intervals via the Mini Mental State Examination (MMSE), the Cambridge Cognitive Examination (CAMCOG), the Lawton Instrumental Activities of Daily Living Scale (IADL), and the Global Deterioration Scale (GDS). After CPCT implementation, there were no significant differences in the MMSE, IADL, and GDS evaluations between baseline and twelve months. Concerning the CAMCOG evaluation, there was no significant difference between the baseline and sixth-month assessments. Overall, the participants’ cognitive functioning did not decline when compared to the average annual rate of change. The CPCT extends the benefit of non-pharmacological interventions for AD patients to twelve months. Its implementation might provide the patients’ relatives with some guarantee concerning the delay of the disease. Future research may investigate the efficacy of the CPCT in comparison with a control group and over a more extended period. Full article

A dual-band bandpass filter (BPF) composed of a coupling structure and a bent T-shaped resonator loaded by small L-shaped stubs is presented in this paper. The first band of the proposed BPF covers 4.6 to 10.6 GHz, showing 78.9% fractional bandwidth (FBW) at 7.6 GHz, and the second passband is cantered at 11.5 GHz with a FBW of 2.34%. The bent T-shaped resonator generates two transmission zeros (TZs) near the wide passband edges, which are used to tune the bandwidth of the first band, and the L-shaped stubs are used to create and control the narrow passband. The selectivity performance of the BPF is analyzed using the transfer function extracted from the lumped circuit model verified by a detailed even/odd mode analysis. The BPF presents a flat group delay (GD) of 0.45 ns and an insertion loss (IL) less than 0.6 dB in the wide passband and a 0.92 IL in the narrow passband. A prototype of the proposed BPF is fabricated and tested, showing very good agreement between the numerically predicted and measured results. Full article

Depressive symptoms and memory problems are risk factors for dementia. Exercise can reduce these in older people, and horticultural activity can benefit people with dementia. This study assessed the efficacy of exercise and horticultural interventions for community-dwelling older adults with depressive symptoms and mild memory decline. In this randomized controlled trial, older adults (n = 89) were assigned to exercise, horticultural, or control groups. Exercise and horticultural programs included 20 weekly 90-min sessions. The control group attended two 90-min classes. Outcomes were assessed at baseline, and then 6- and 12-months post-intervention. Primary outcome measures were the Geriatric Depression Scale-15 (GDS-15) and Wechsler Memory Scale-Revised. Walking speed, two-minute walking test scores, social network, life space, and subjective daily physical activity were secondary outcome measures. Compared with the control group, the exercise group obtained higher immediate and delayed recall logical memory scores, and the increase in immediate recall scores remained 12-months post-intervention. Two-minute walking performance improved in the exercise group, but not after 12 months. GDS-15 scores showed no significant improvements. The horticultural and control groups showed no differences. Exercise may improve memory, while horticultural activity may not. The effects of exercise and horticultural interventions on depressive symptoms remain unclear. Full article