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The learning equations of an ANN are presented, giving an extremely concise derivation based on the principle of backpropagation through the descendent gradient. Then, a dual network is outlined acting between synapses of a basic ANN, which controls the learning process and coordinates the subnetworks selected by attention mechanisms toward purposeful behaviors. Mechanisms of memory and their affinity with comprehension are considered, by emphasizing the common role of abstraction and the interplay between assimilation and accommodation, in the spirit of Piaget’s analysis of psychological acquisition and genetic epistemology. Learning, comprehension, and knowledge are expressed as different levels of organization of informational processes inside cognitive systems. It is argued that formal analyses of cognitive artificial systems could shed new light on typical mechanisms of “natural intelligence” and, in a specular way, that models of natural cognition processes could promote further developments of ANN models. Finally, new possibilities of chatbot interaction are briefly discussed. Full article

Preconception expanded carrier screening (PECS) informs prospective parents about the risk of conceiving a child with a heritable genetic condition. PECS will also, for many, become an important screening test, and websites will likely play a vital role in providing information on this practice. The aim of this article is to examine rationalities in the information on PECS on Dutch websites. The method used is multimodal critical discourse analysis. This method allows an examination of norms and assumptions in the descriptions, as well as of the positions that are discursively made available. The data consist of publicly available material on websites from two genetics departments in the Netherlands. In the results, we present the three main discourses and subject positions that were identified: risk and the couple as possible mediators of severe conditions; the focus on scientific facts and rational conceivers; and severity of the conditions and the responsible couple. In this study, we highlight the importance of acknowledging the interrelation between epistemology and ethics in the discourse on PECS. Finally, it is claimed that the focus on scientific facts in information on PECS risks making existential and ethical dilemmas and choices invisible. Full article

Life is based on a highly specific combination of atoms, metabolism, and genetics which eventually reflects the chemistry of the Universe which is composed of hydrogen, oxygen, nitrogen, sulfur, phosphorus, and carbon. The interaction of atomic, metabolic, and genetic cycles results in the organization and de-organization of chemical information of that which we consider as living entities, including cancer cells. In order to approach the problem of the origin of cancer it is therefore reasonable to start from the assumption that the sub-molecular level, the atomic structure, should be the considered starting point on which metabolism, genetics, and external insults eventually emanate. Second, it is crucial to characterize which of the entities and parts composing human cells may live a separate life; certainly, this theoretical standpoint would consider mitochondria, an organelle of “bacteria” origin embedded in conditions favorable for the onset of both. This organelle has not only been tolerated by immunity but has also been placed as a central regulator of cell defense. Virus, bacteria, and mitochondria are also similar in the light of genetic and metabolic elements; they share not only equivalent DNA and RNA features but also many basic biological activities. Thus, it is important to finalize that once the cellular integrity has been constantly broken down, the mitochondria like any other virus or bacteria return to their original autonomy to simply survive. The Warburg’s law that states the ability of cancers to ferment glucose in the presence of oxygen, indicates mitochondria respiration abnormalities may be the underlying cause of this transformation towards super cancer cells. Though genetic events play a key part in altering biochemical metabolism, inducing aerobic glycolysis, this is not enough to impair mitochondrial function since mitochondrial biogenesis and quality control are constantly upregulated in cancers. While some cancers have mutations in the nuclear-encoded mitochondrial tricarboxylic acid (TCA) cycle, enzymes that produce oncogenic metabolites, there is also a bio-physic pathway for pathogenic mitochondrial genome mutations. The atomic level of all biological activities can be considered the very beginning, marked by the electron abnormal behavior that consequently affects DNA of both cells and mitochondria. Whilst the cell’s nucleus DNA after a certain number of errors and defection tends to gradually switch off, the mitochondria DNA starts adopting several escape strategies, switching-on a few important genes that belong back at their original roots as independent beings. The ability to adopt this survival trick, by becoming completely immune to current life-threatening events, is probably the beginning of a differentiation process towards a “super-power cell”, the cancer cells that remind many pathogens, including virus, bacteria, and fungi. Thus, here, we present a hypothesis regarding those changes that first begin at the mitochondria atomic level to steadily involve molecular, tissue and organ levels in response to the virus or bacteria constant insults that drive a mitochondria itself to become an “immortal cancer cell”. Improved insights into this interplay between these pathogens and mitochondria progression may disclose newly epistemological paradigms as well as innovative procedures in targeting cancer cell progressive invasion. Full article

Traditional interpretations of Nietzsche’s The Genealogy of Morals (GM) argue that the work is a treatise on, or a straightforward account of, Nietzsche’s moral thinking. This is typically contrasted with what has become known as the postmodern reading, which holds that the core of GM is an attack on the very notion of the truth itself. These two interpretations are often taken to be non-coextensive and mutually exclusive. However, I argue, using a genetic form of argumentation that tracks the development of the text through archival evidence, that both are partially correct, since Nietzsche sees all fundamental problems hitherto as moral questions in service of the ascetic ideal and the will to truth. According to Nietzsche, all the hitherto fundamental questions of philosophy are not value-free but are deeply value-laden. To put this more precisely, Nietzsche rejects the fact-value distinction itself. Questions of morality are not separable from epistemology, questions of epistemology are not separable from morality, and both subjects have worked in service of the ascetic ideal. Further, I provide new evidence on the debate about the counter-ideal to the ascetic ideal. I claim that Amor Fati embodies that ideal. I argue for this using a section from the preface that was added but then removed. This section was removed because it gave away the conclusion of the work, that all fundamental problems, including questions of truth, are based on moral prejudices. Full article

Background: The Hospital-University Institute (IHU) Méditerranée Infection features a 27,000 square meter building hosting 700 employees and 75 hospitalized patients in the center of Marseille, France. Method: Previous preparedness in contagious disease management allowed the IHU to manage the COVID-19 outbreak by continuing adaptation for optimal diagnosis, care and outcome. We report here the output of this management. Results: From 5 March 2020, and 26 April 2021, 608,313 PCR tests were provided for 424,919 patients and 44,089 returned positive. A total of 23,390 patients with COVID-19 were followed at IHU with an overall case fatality ratio of 1.7%. Of them 20,270 were followed as outpatients with an overall CFR of 0.17%. We performed 24,807 EKG, 5759 low dose CT Scanner, and 18,344 serology. Of the 7643 nasopharyngeal samples inoculated in cell cultures 3317 (43.3%) yielded SARS-Cov-2 isolates. Finally, 7370 SARS-Cov-2 genomes were analyzed, allowing description of the first genetic variants and their implication in the epidemiologic curves. Continuous clinical care quality evaluation provided the opportunity for 155 publications allowing a better understanding of the disease and improvement of care and 132 videos posted on the IHU Facebook network, totaling 60 million views and 390,000 followers, and dealing with COVID-19, outbreaks, epistemology, and ethics in medicine. Conclusions: During this epidemic, IHU Méditerranée Infection played the role for which it has been created; useful clinical research to guarantee a high-quality diagnostic and care for patient and a recognized expertise. Full article

The aim of the current study was to examine the way in which preschool children deal with the concept of sound. For this purpose, a study was carried out in the context of detecting and categorizing the mental representations among young children of sounds which propagate through space from source to the receiver. Specifically, 91 preschool children aged 5–6 years voluntarily participated in individual semi-structured interviews which were carried out by three researchers in a special area of kindergartens. During these interviews, the children were asked to express their views on the three following axes: the concept of sound itself; the subjective characteristics of sound; and the phenomenon of the production and propagation of sound. The results of the research showed that while a small percentage of children recognized the propagation of sound in space, the vast majority of them associated sound with either the object that produced it or with the object that received it. Full article

Over the last 100 years, many studies have been performed to determine the biochemical and histopathological phenomena that mark the origin of neoplasms. At the end of the last century, the leading paradigm, which is currently well rooted, considered the origin of neoplasms to be a set of genetic and/or epigenetic mutations, stochastic and independent in a single cell, or rather, a stochastic monoclonal pattern. However, in the last 20 years, two important areas of research have underlined numerous limitations and incongruities of this pattern, the hypothesis of the so-called cancer stem cell theory and a revaluation of several alterations in metabolic networks that are typical of the neoplastic cell, the so-called Warburg effect. Even if this specific “metabolic sign” has been known for more than 85 years, only in the last few years has it been given more attention; therefore, the so-called Warburg hypothesis has been used in multiple and independent surveys. Based on an accurate analysis of a series of considerations and of biophysical thermodynamic events in the literature, we will demonstrate a homogeneous pattern of the cancer stem cell theory, of the Warburg hypothesis and of the stochastic monoclonal pattern; this pattern could contribute considerably as the first basis of the development of a new uniform theory on the origin of neoplasms. Thus, a new possible epistemological paradigm is represented; this paradigm considers the Warburg effect as a specific “metabolic sign” reflecting the stem origin of the neoplastic cell, where, in this specific metabolic order, an essential reason for the genetic instability that is intrinsic to the neoplastic cell is defined. Full article

The loss of genetic diversity of thousands of plants and crops has been well documented at least since the 1970s, and has been understood as a result of epistemological and political economic conditions of the Green Revolution. The political economic arrangement of the Green Revolution, alongside a post-war focus on economies of scale and export-oriented growth, replace high-yield single varieties of crops for a diverse array of varieties that may not have the same yield, but may be able to resist pests, disease, and changing climatic conditions. Also, the harvest does not flow in all directions equally: Whereas small holder subsistence farming uses a large variety of crops as a food source and small-scale trade, the industrial economic system requires simplified, machine harvested ship-loads of one variety of maize, for example. Diverse varieties of different crops confound the machines, whereas one variety of wheat can be harvested with one setting on a machine. However, none of this is new. The purpose of this article is to analyze how the twin concerns of lost varietals and lost cultures are bound together in the socio-political process of standardization, and to explain some areas of resistance. Full article