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4 Results Found

  • Article
  • Open Access
8 Citations
6,033 Views
13 Pages

15 November 2016

Tissue-like phantoms are widely used as a model for mimicking the optical properties of live tissue. This paper presents the results of a diffusion reflection method and fluorescence lifetime imaging microscopy measurements of fluorescein-conjugated...

  • Article
  • Open Access
6 Citations
3,024 Views
13 Pages

Fluorescence Lifetime Changes Induced by Laser Irradiation: A Preclinical Study towards the Evaluation of Retinal Metabolic States

  • Svenja Rebecca Sonntag,
  • Eric Seifert,
  • Maximilian Hamann,
  • Britta Lewke,
  • Dirk Theisen-Kunde,
  • Salvatore Grisanti,
  • Ralf Brinkmann and
  • Yoko Miura

13 June 2021

Fluorescence Lifetime (FLT) of intrinsic fluorophores may alter under the change in metabolic state. In this study, the FLT of rabbit retina was investigated in vivo after laser irradiation using fluorescence lifetime imaging ophthalmoscopy (FLIO). T...

  • Article
  • Open Access
8 Citations
2,867 Views
21 Pages

Probing Polarity and pH Sensitivity of Carbon Dots in Escherichia coli through Time-Resolved Fluorescence Analyses

  • Gilad Yahav,
  • Shweta Pawar,
  • Anat Lipovsky,
  • Akanksha Gupta,
  • Aharon Gedanken,
  • Hamootal Duadi and
  • Dror Fixler

14 July 2023

Intracellular monitoring of pH and polarity is crucial for understanding cellular processes and functions. This study employed pH- and polarity-sensitive nanomaterials such as carbon dots (CDs) for the intracellular sensing of pH, polarity, and visco...

  • Article
  • Open Access
19 Citations
4,057 Views
15 Pages

Live-Cell Cardiac-Specific High-Throughput Screening Platform for Drug-Like Molecules That Enhance Ca2+ Transport

  • Tory M. Schaaf,
  • Evan Kleinboehl,
  • Samantha L. Yuen,
  • Lauren N. Roelike,
  • Bengt Svensson,
  • Andrew R. Thompson,
  • Razvan L. Cornea and
  • David D. Thomas

8 May 2020

We engineered a concatenated fluorescent biosensor and dual-wavelength fluorescence lifetime (FLT) detection, to perform high-throughput screening (HTS) in living cells for discovery of potential heart-failure drugs. Heart failure is correlated with...