Search Results (321,191)

The transition to renewable energy is a central objective of the European Union’s energy and climate policies, yet adoption rates differ significantly across Member States. This study analyses the economic, structural, and energy determinants of renewable energy adoption in the EU-27 over the period 2008–2023, using panel data models with country and year fixed effects and clustered standard errors. The results indicate that the relationship between renewable energy and its main determinants is limited and heterogeneous across countries. Most explanatory variables do not exhibit consistent and statistically significant effects across model specifications. In particular, research and development expenditure does not show a robust impact, while GDP per capita is associated with negative coefficients in several specifications, suggesting the presence of structural constraints and path dependency. Energy-related variables also display weak and unstable relationships. The findings suggest that renewable energy adoption is shaped by context-specific and heterogeneous dynamics rather than by uniform drivers. The study contributes by highlighting the limited explanatory power of standard macroeconomic indicators and supports the need for differentiated policy approaches across Member States. Full article

Background: Emerging evidence highlights the importance of the MIF–sCD74 axis in health and disease, including its role in regulating cell death. While studies in routine cardiac surgery suggest perioperative relevance, its role in end-stage heart failure (ESFH) patients undergoing left ventricular assist device (LVAD) implantation remains unexplored. Moreover, although MIF and sCD74 induce necroptosis in neonatal cardiac myofibroblasts, the effects of MIF, its paralog D-DT, and sCD74 on adult cardiac myofibroblasts (CMFs) are unknown. Methods: Plasma concentrations of sCD74, MIF and D-DT were measured perioperatively in a small cohort of patients with ESHF undergoing LVAD implantation (n = 20). As a preclinical model of ESHF, primary adult CMFs were treated with recombinant MIF, D-DT and sCD74 to evaluate their effects on cellular viability and health. Results: In LVAD patients, sCD74 and D-DT levels were significantly increased 24 h postoperatively, whereas MIF levels were reduced compared to baseline. ROC curve analysis demonstrated a good discriminatory power of 24 h post-OP sCD74 (AUC = 0.83), sCD74/MIF ratio (AUC = 0.82), and D-DT levels (AUC = 0.88) for acute kidney injury, composite outcome, and right heart failure (RHF), respectively. In adult CMFs, MIF and sCD74 synergistically reduced viable cell counts (p = 0.0083), whereas D-DT reduced cell counts in an sCD74-independent manner (p = 0.0004). Yet, measures of metabolism, proliferation, apoptosis and necrosis along with inflammatory gene expression remained unchanged. Conclusions: Our findings indicate that the balance of MIF, D-DT, and sCD74 during LVAD implantation may be clinically relevant. In particular, an imbalance characterized by elevated sCD74 or D-DT and reduced MIF levels 24 h post-surgery was associated with unfavorable clinical outcomes. Yet, the current findings are exploratory and hypothesis-generating because of a small sample size. Thus, the prognostic value of plasma levels for postoperative complications after LVAD implantation, and the effects of MIF/D-DT/sCD74 imbalance on cardiac myofibroblasts, need to be validated in larger cohorts and in advanced human experimental models. Full article

Fluoroquinolones are known for their antibacterial properties, but recent research has revealed their potential to inhibit the growth and proliferation of cancer cells. Thus, this study aimed to emphasize the repositioning and potential of fluoroquinolones as possible therapeutic tools in the fight against cancer, opening up new perspectives for the field of oncology. Thus, this paper consists of a descriptive literature review of recent studies published between 2013 and 2023 on the use of fluoroquinolones in anticancer therapy. The results indicate that fluoroquinolones can interfere with the cell cycle, induce apoptosis and oxidative stress, and impact factors associated with tumorigenesis, such as the transcription of ectopic expression of SNAI1 for epithelial–mesenchymal transition. In addition, studies show that combining fluoroquinolones with other antineoplastic agents can increase their efficacy, and the possibility of encapsulating these drugs in controlled-release systems is also emerging as a promising antitumor strategy. In conclusion, repositioning fluoroquinolones in antitumor therapy presents an expanding field of research, offering new perspectives for cancer treatment. However, more studies are needed to fully elucidate their potential and establish effective clinical use protocols. Full article

Intracranial aneurysms are common vascular lesions with a highly variable natural history. While most unruptured intracranial aneurysms remain stable throughout life, a biologically aggressive subset progresses to growth and rupture, resulting in aneurysmal subarachnoid hemorrhage with substantial morbidity and mortality. Contemporary evidence demonstrates that aneurysm behavior is dynamic rather than static and reflects the interaction of hemodynamic forces, inflammatory vascular remodeling, genetic susceptibility, and environmental risk factors. Rupture risk is not constant over time and may be highest early after aneurysm formation, followed by a period of relative quiescence in selected lesions. Traditional population-based risk estimates have therefore evolved toward individualized risk stratification incorporating aneurysm size, location, morphology, growth, patient-specific factors, and emerging imaging and computational biomarkers. This chapter reviews the epidemiology, pathobiology, growth patterns, and rupture risk of intracranial aneurysms, integrating foundational observational studies with recent advances in genetics, vessel wall imaging, and predictive modeling. Understanding the natural history of brain aneurysms is essential for balancing the risks of observation against intervention and for guiding future innovations in aneurysm management. Full article

Variability in life cycle assessment (LCA) results for metal recycling technologies arises from multiple sources, including allocation methods, recycling route, regionality of impacts, and type of waste treated. Among these factors, waste composition is particularly critical, as it directly influences process performance by affecting auxiliary material consumption and emissions. This work investigates four waste categories: metals from incineration bottom ash (MBA), waste-printed circuit boards (WPCBs), industrial waste from gold refining (GRA), and spent automotive and industrial catalysts (SCs). The Climate Change (CC) for 1000 kg of waste was estimated at 3251 × 10³ kg CO₂eq for WPCBs, 3923 × 10³ kg CO₂eq for MBA, 1569 × 10³ kg CO₂eq for GRA, and 2101 × 10³ kg CO₂eq for SCs. A sensitivity analysis was performed to assess the influence of allocation methods on results for 1kg of recycled metal. The highest variability in CC across waste categories was observed for gold (up to 8477%) with the black-box economic allocation method, while different allocation methods reached 21,700% for WPCBs. These results highlight the strong influence of methodological choices and waste characteristics, emphasizing the need for transparent and consistent LCA reporting. Full article

Buildings represent 40% of the European Union’s energy consumption and 36% of its greenhouse gas emissions. Nursing homes are among the buildings that consume the most energy. The objective of this study was to make predictive models of Energy Consumption, Energy Costs, and CO₂ Emissions in nursing homes using different variables. To do this, data from 20 public nursing homes located in Extremadura (Spain) during the 2019–2023 period were analyzed. All the buildings were built or renovated between 1995 and 2009; the useful area and the number of residents were in the range of 1332–10,880 m² and 24–254 residents. A statistical analysis was performed using multivariable linear regression. During the research, equations that allow for the estimation of the annual Energy Consumption, Energy Costs and CO₂ Emissions of nursing homes, according to the useful area and number of residents, were found. The R_adj² was 0.9710, 0.9744 and 0.9742, respectively. The quality of the models obtained was contrasted using the mean absolute error (MAE), the relative error (RE) and the root mean square error (RMSE), together with the assessment of multicollinearity through the Variance Inflation Factor (VIF). The findings of this study may prove beneficial for stakeholders within the elder care sector. Full article

Behavioral parent training (BPT) is a front-line psychosocial treatment for childhood ADHD, yet its real-world effectiveness is often constrained by parents’ ability to consistently implement learned strategies. Parental ADHD is a prevalent and mechanistically important factor shaping both parenting behavior and child treatment response. Among parents with ADHD, deficits in executive functioning and emotion regulation, abilities essential for consistent and effective BPT implementation, often interfere with parents’ ability to apply learned strategies. Consequently, parental ADHD predicts reduced in-home skill use and attenuated child treatment gains, positioning it as a potentially critical, treatment-relevant risk factor. This narrative review synthesizes evidence on the intergenerational transmission of ADHD-related impairments, the impact of parental ADHD on parenting practices, and the role of parental ADHD as a moderator of BPT outcomes. We also examine existing approaches to addressing parental ADHD within the context of child BPT, including both pharmacological and psychosocial strategies, and evaluate their implications for parenting and child response. Building on this, we propose an intergenerational reconceptualization of psychosocial care for childhood ADHD in which parental functioning is routinely assessed and supported within BPT. Promising directions include integrating CBT-informed strategies to scaffold parents’ cognitive and regulatory processes, incorporating digital health tools that provide just-in-time guidance at the point of parenting performance, and tailoring BPT emphasis for families affected by multigenerational ADHD. Ultimately, embedding parent-focused supports within BPT may be essential for strengthening treatment impact, durability, and real-world effectiveness for many children and families. Full article

Research into auxetic foams—materials with a negative Poisson’s ratio— is expanding, yet their integration into orthotics for diverse neuropathic conditions remains largely unexplored. This pilot study evaluates the feasibility of fabricating custom auxetic foam insoles and characterizing vertical ground reaction force (vGRF) trends across a heterogeneous cohort. In collaboration with the NASA/Marshall Space Flight Center, six participants, including five representing varied neuropathic etiologies and one healthy control, performed randomized walking trials under three conditions: barefoot, over-the-counter (OTC) insoles, and custom auxetic prototypes. The healthy control was retained in the cohort-level analysis to preserve methodological symmetry across experimental conditions. To maintain physical rigor, vGRF data were mass-normalized (N/kg). A Friedman test (n = 6) evaluated global differences, supplemented by a dual-bootstrap analysis (1000 resamples) to quantify effect magnitudes (r) and numerical uncertainty. Although the Friedman test revealed no statistically significant global differences (Q = 0.333, df = 2, p = 0.846), a descriptively large effect size (r = 0.58) was observed for the auxetic material versus barefoot walking. However, wide 95% bootstrap confidence intervals prevent population-level inference, reinforcing the exploratory nature of these findings. Subject-specific observations showed descriptive differences in vGRF in three participants (0.17 to 1.18 N/kg), while increases in others occurred alongside confounding factors such as self-selected walking velocity. This work demonstrates the mechanical application of auxetic insole prototypes, providing a foundational rationale for future trials utilizing standardized walking velocity to isolate material performance. Full article

Objectives: Seawater-immersed burn wounds are highly susceptible to contamination, persistent inflammation, oxidative stress, and delayed healing, while current irrigation solutions remain suboptimal for such acute injuries. This study aimed to evaluate the therapeutic efficacy and underlying mechanisms of plasma-activated water (PAW) as a novel irrigation strategy for these complex wounds. Methods: The antibacterial efficacy of PAW against marine pathogens was first evaluated in vitro. Subsequently, a rat model of seawater-immersed burn injury was established in male Sprague-Dawley (SD) rats to assess the therapeutic effects of PAW irrigation on wound healing, infection control, and underlying biological mechanisms. Results: In vitro, PAW significantly eradicated two major marine pathogens, Vibrio vulnificus and Vibrio parahaemolyticus (p < 0.001). In vivo, PAW markedly accelerated wound closure, achieving complete healing in 23.60 ± 6.50 days vs. 38.67 ± 2.08 days (Normal saline group) and 58.33 ± 10.97 days (Model group) (p < 0.05). PAW significantly reduced bacterial burden, modulated inflammation by decreasing interleukin-6 and increasing interleukin-10, and alleviated oxidative stress, as evidenced by reduced malondialdehyde levels and enhanced superoxide dismutase activity. Histological evaluation demonstrated enhanced re-epithelialization, collagen deposition, and increased expression of vascular endothelial growth factor and platelet endothelial cell adhesion molecule-1. No adverse effects on serum biochemistry or major organ histopathology were observed. Conclusions: PAW may be a safe, promising, and multifunctional irrigation strategy that promotes seawater-immersed burn healing through coordinated antibacterial, anti-inflammatory, antioxidant, and pro-angiogenic effects, highlighting its strong potential for clinical translation. Full article

Severe and unpredictable wind conditions significantly disrupt flight safety, mission planning, and scheduling. Traditional wind forecasting methods rely on low-resolution mesoscale models or resource-intensive instrumentation. This study evaluates the accuracy of 40 m Large-Eddy Simulations (LESs), nested within a mesoscale framework, to better resolve hazardous wind phenomena over GrandSKY, North Dakota, the first large-scale commercial Uncrewed Aircraft System (UAS) test park in the United States, serving as a hub for UAS innovation and Beyond Visual Line of Sight operations. Using low-altitude airborne observations from Meteodrone flights, satellite data, and ground-based measurements, we assess the model’s accuracy in predicting wind speed and direction during both summer and winter. Results demonstrate that the 40 m LES provides improved predictions of wind gust variability compared to the 1 km forecast, and the impact on flight safety is quantified. The LES also reveals notable discrepancies in UAS flyability predictions, which result in up to a 17% reduction in operational windows during the summer. This study’s novelty lies in using a 40 m resolution LES nested within a 1 km WRF simulation, combined with multi-source observations, to resolve low-altitude turbulence and quantify its impact on UAS operations. A 10–18% correction factor can be applied to TKE (or derived wind variability) in coarser WRF runs to better estimate maximum wind speeds without LES. The findings highlight the potential of high-resolution LES modeling to support reliable UAS operations in weather-sensitive environments, laying the groundwork for broader integration of advanced simulation techniques in national airspace management systems. Full article

Background: Long noncoding RNAs (lncRNAs) have emerged as critical regulators of hepatic metabolism and disease progression. The hepatocyte nuclear factor 1 alpha antisense 1 (HNF1A-AS1) lncRNA modulates liver-specific transcription factors; however, its physiological role in diet-dependent lipid homeostasis remains poorly defined. Methods: In this study, we investigated the mouse ortholog, Hnf1a opposite strand 1 (Hnf1aos1), using AAV-mediated knockdown in C57BL/6J mice fed either a chow diet (10% kcal from fat) or a high-fat diet (HFD; 60% kcal from fat) for 12 weeks. Metabolic phenotyping included hepatic lipid quantification, histological analysis, serum biochemistry, and quantitative gene expression profiling. Results: Loss of Hnf1aos1 produced distinct, diet-dependent alterations in hepatic lipid handling. Under chow conditions, knockdown mice exhibited selective hepatic cholesterol accumulation (6.10 ± 2.9 mg/g tissue vs. 3.51 ± 1.1 mg/g in controls), accompanied by dysregulation of cholesterol clearance pathways. In contrast, under HFD conditions, knockdown precipitated severe macrovesicular degeneration, with hepatic triglyceride levels approximately doubled relative to HFD-fed controls (51.72 ± 19.8 mg/g vs. 26.34 ± 11.9 mg/g) and a numerically elevated triglyceride-to-cholesterol ratio (TG:TC ≈ 6.1:1; p = 0.0621, trend). Chow/Kd mice gained significantly less weight than chow-fed controls, whereas HFD/Kd mice exhibited weight gain comparable to HFD controls despite severe hepatic steatosis. This paradoxical phenotype suggests impaired metabolic feedback at the post-transcriptional level, in which compensatory upregulation of Hnf1a mRNA is insufficient to suppress lipid-associated genes such as Cd36, despite profound lipid overload; however, HNF1A protein levels were not directly measured in this study. Conclusion: Collectively, these findings identify Hnf1aos1 as a regulator of hepatic lipid homeostasis whose loss produces a phenotype consistent with inappropriate lipid accumulation during nutrient excess, without defining the underlying molecular mechanism. Our results support a role for Hnf1aos1 in shaping hepatic metabolic plasticity and provide insight into lncRNA-associated MASLD phenotypes. Full article

Thaumasite sulfate attack (TSA) under elevated water pressure has important implications for the durability of deep underground concrete structures, yet the deterioration process and the coupled effect of water pressure and carbonate supply remain insufficiently understood. In this study, laboratory pressurized sulfate exposure tests were conducted to investigate the evolution of macroscopic performance and microstructure of cement mortars with different limestone powder contents (0%, 15%, and 30%) under water pressures of 0, 2.5, and 5.0 MPa. The results show that elevated water pressure promotes sulfate ingress into the mortar and accelerates later-stage strength loss; this interpretation is supported by the depth-dependent distribution of soluble SO₄²⁻ measured in mortars without limestone powder. Two-way ANOVA indicates that both water pressure and limestone powder content have significant effects on compressive strength, and their interaction becomes statistically significant at 120 d. XRD, FT-IR, and SEM/EDS results show that, under elevated water pressure and high limestone powder content, the corrosion products gradually evolve from gypsum-related products to ettringite- and thaumasite-related products, with a certain spatial differentiation. Specifically, the gray–white, mud-like surface products are consistent with thaumasite-rich assemblages, whereas the needle- and column-like crystals in the interior are consistent with ettringite-rich assemblages. Overall, elevated water pressure mainly promotes sulfate transport, while limestone powder mainly increases carbonate availability. These two factors may jointly intensify TSA deterioration in mortar through a pathway involving transport enhancement, carbonate supply, corrosion product evolution, and aggravated macroscopic damage. This study provides a reference for understanding the sulfate deterioration mechanism of limestone powder-containing cement-based materials in deep underground environments under elevated water pressure. Full article

Recently, Quzhou Aurantii Fructus Extract (QAFE) was reported to exert anti-inflammatory effects on different types of respiratory diseases; however, it is yet to be determined whether it is effective in patients with idiopathic pulmonary fibrosis (IPF). The purpose of this study is to explore the capacity of QAFE to fight fibrotic disease, in particular how it works in relation to the regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. QAFE was made with Quzhou Fructus Aurantii (QAF), and the content of four flavonoids in the samples prepared was analyzed by high-performance liquid chromatography (HPLC). The therapeutic effect of QAFE was experimented by establishing IPF models in mice and in cells. Identification of the mechanism of QAFE in IPF through knockout or knockdown of the Nrf2 gene. The experiments suggest that QAFE has the potential to prevent IPF-induced inflammation, collagen deposition, oxidative stress, and apoptosis of cells. Silencing Nrf2 by knockdown or knockout is enough to prevent the capacity of QAFE to inhibit the process of inflammation, oxidative stress, and collagen deposition to cause more serious lung injury and HO-1 expression downregulation. QAFE is a potential new antifibrotic drug in IPF with an effect on the Nrf2/HO-1 pathway that reduces inflammation and oxidative stress. Full article

This study analyzed the effect of forming temperature on the roller hemming process of AA6011-T4 aluminum alloy sheets, using a 2^K factorial design to also evaluate the influence of roller diameter and flange height. A total of 24 experimental tests were conducted, varying the forming temperature (23 °C and 50 °C), roller diameter (22 mm and 50 mm), and flange height (7 mm and 10 mm). The hemming process was performed using a six-axis industrial robot (FANUC 2000i, Fanuc Corporation, Oshino, Japan ) with roller tooling mounted o n a support fixture. The height of the flanged profile was measured using a coordinate measuring machine. ANOVA results, processed with MINITAB 18, showed that forming temperature, roller diameter, and flange height all have a statistically significant effect on the final profile height. No significant interactions were found among the factors, indicating their effects are independent. The most favorable configuration for maximizing profile height was the combination of the largest roller diameter and the highest flange height, under cold forming conditions. Additionally, a significant difference was observed between cold and warm forming processes in terms of the resulting profile height, highlighting the relevance of temperature control in the roller hemming of AA6011-T4 aluminum alloy. Full article

Background/Objectives: Radon exposure has recently been associated with asthma morbidity, including increased airway inflammation and school absenteeism in children, though limited data on underlying biological mechanisms exist. Interleukin-6 (IL-6), a pleiotropic cytokine implicated in both Type 2-low airway inflammation and radon-related lung carcinogenesis, may represent a key mechanistic link between radon exposure and asthma morbidity. We aimed to evaluate the association between indoor radon exposure and plasma IL-6 levels in children with asthma and whether this relationship differs by allergic sensitization status. Methods: We analyzed baseline data from the School Inner-City Asthma Study, a prospective cohort of children aged 4–13 years with persistent asthma. Monthly indoor radon concentrations at each participant’s residential ZIP Code Tabulation Area were estimated using a validated spatiotemporal prediction model. Plasma IL-6 was measured from baseline blood samples. Multivariable linear mixed-effects models with random intercepts for school were used to assess the association between radon exposure and IL-6, adjusting for demographic, clinical, and socioeconomic covariates. Effect modification by allergic sensitization was evaluated using an interaction term. Results: Among 144 participants, 62.5% were allergen-sensitized. The median home radon concentration was 46.6 Bq/m³ (range 30.7–99.9), and the mean plasma IL-6 was 0.22 pg/mL (SD 0.41). A significant interaction was observed between radon exposure and allergic sensitization status (β-interaction = –0.012; p = 0.014), indicating differential effects by phenotype. Among non-sensitized children, higher radon exposure was associated with increased IL-6 levels (β = 0.0088; p = 0.044), corresponding to a 0.32 pg/mL rise in IL-6 per 37 Bq/m³ increase in radon. No significant association was observed among sensitized children. Conclusions: Indoor radon exposure is associated with higher plasma IL-6 levels in non-sensitized children with asthma, suggesting a potential IL-6–mediated pathway linking radon exposure to asthma morbidity in the Type 2-low phenotype. These findings highlight heterogeneity in environmental asthma responses and support further investigation into radon mitigation as a modifiable factor to improve asthma outcomes. IL-6 may serve as a biomarker to identify children most susceptible to radon-related airway inflammation, guiding personalized mitigation strategies and targeted interventions to improve asthma outcomes. Future studies should incorporate direct home radon measurements, comprehensive endotyping panels, and longitudinal biomarker sampling to validate these findings and elucidate whether IL-6 trans-signaling pathways mediate radon-induced airway injury in non-allergic asthma. Full article