Search Results (476)

Panama, with nearly 3000 km of coastline and half its population living in coastal zones, faces high vulnerability to sea level rise, flooding, and extreme events. The most vulnerable areas include low-lying coastal provinces such as Panama, Colón, and Chiriquí. This review explores the use of sustainable concrete to address the effects of climate change in Panama towards coastal resilience. The methodology combined a bibliometric analysis using VOSviewer, a systematic literature review (2015–2025) of 99 sources including regulations and technical standards, and a socioeconomic SWOT analysis to assess adoption drivers and barriers. A 2050 permanent inundation map was examined to identify vulnerable areas, and an inventory of concrete-based protection structures was developed. The results highlight that concrete is already used in Panama for coastal resilience through structures such as breakwaters, dolos, and Xbloc units. However, as the country still needs to expand its coastal protection infrastructure, there is a crucial opportunity to implement lower-impact, sustainable concrete alternatives that minimize environmental burdens while ensuring long-term durability and performance. Sustainable options, including supplementary cementitious materials (SCMs), recycled aggregates, and CO₂ injection technologies, demonstrate strong mitigation potential, with national initiatives such as Vertua, Greentec, and Argos pozzolan offering early pathways. The conclusions emphasize the need to expand sustainable concrete applications, integrate nature-based solutions, and strengthen Panama’s regulatory and technical capacity to achieve resilient, low-carbon coastal infrastructure. Full article

Shallow landslide susceptibility assessment is an essential research activity for land management and risk assessment. In this study, a GIS-based approach was developed to assess rain-induced landslide susceptibility in the Municipality of Genoa, a Mediterranean anthropized area historically characterized by intense rainfall events that frequently trigger shallow landslides with high destructive power. Based on a detailed inventory of historical landslides, a semi-quantitative method was applied to assess the influence of seven causal factors of natural and anthropogenic landslides. The areas were categorized into five classes of rain-induced shallow landslide susceptibility, indicating slopes where newly triggered landslides may occur. The landslide susceptibility map was subsequently integrated with the map of gas and water utilities, whose features were used to assess their vulnerability. Finally, an early-stage risk assessment of the two utility networks was developed to serve as a decision support tool for strategic planning and integrated asset management in the context of climate change. The results show that about 9.8% and 6.8% of the total length of water and gas pipelines are exposed to higher risk classes 4 and 5. Full article

This study examines job performance among judo referees through the lens of personality traits during World Judo Tour events from 2018 to 2022. Sixty-three referees completed an online questionnaire including the Big Five Inventory (BFI) and the Conditions for Work Effectiveness Questionnaire (CWEQ-II). Data were analyzed using descriptive statistics, correlation analysis, and structural equation modeling (SEM). The measurement model showed acceptable validity and reliability, confirming the structural model. Support and resources emerged as the most influential factors affecting job satisfaction (JAS) and organizational role satisfaction (ORS). Incorporating refereeing experience at major events into the model indicated only partial model fit. Findings highlight the role of structural empowerment in mitigating job dissatisfaction among referees. Future research with larger samples should further strengthen the understanding of the relationship between personality traits, empowerment, and job performance. Full article

We investigated how nostalgia and declinism, two distinct forms of past-oriented reflection, differentially relate to personal growth. In preregistered cross-sectional Study 1 (N = 810, Chinese sample), we measured nostalgia using three instruments: the Southampton Nostalgia Scale (SNS), the Nostalgia Inventory (NI), and the Personal Inventory of Nostalgic Experiences (PINE). Although SNS- and NI-based nostalgia were positively associated with personal growth and uncorrelated with declinism, PINE-based nostalgia was positively linked to declinism and unrelated to growth. Canonical correlation analysis further indicated conceptual overlap between PINE items and declinism. In experimental Study 2 (N = 360, Chinese sample), we manipulated nostalgia and declinism with the Event Reflection Task to test their causal effects. Compared to a control condition, nostalgia increased personal growth, but declinism reduced it. Collectively, the findings highlight the importance of measurement in nostalgia research and underscore the psychological distinction between nostalgia and declinism. Accurately capturing the tone and function of nostalgic reflection is essential to understanding its influence on the self, motivation, and well-being. Full article

Dam collapse is a catastrophic event involving an artificial reservoir usually filled with water for hydropower or irrigation purposes. Several cases of dam collapses have overwhelmed entire valleys, reconfiguring their geomorphology, redesigning their landscape, and causing several thousand casualties. These episodes led to more careful regulations and the activation of more effective monitoring and mitigation strategies. A fundamental tool in defining appropriate procedures for alert and risk scenarios is the Dam Emergency Plan (PED), an operational document that establishes the actions and procedures required to manage potential hazards (e.g., geo-hydrological and seismic risk). The aim of this study is to describe a reference methodology for identifying geo-hydrological criticalities based on historical and geomorphological data, applied to civil protection activities. A further objective is to provide a structured inventory of Italian reservoirs, assigning each a potential risk index based on an analytical approach considering several factors (age and construction methodology of the dam, morphological and environmental settings, anthropized environment, and exposed population). The approach identifies that the most significant change in risk over time is not only the dam itself but also the transformation of the territory. This methodology does not incorporate probabilistic forecasting of flood or climate change; instead, it objectively characterizes the exposed territory, offering insights into existing vulnerabilities on which to base effective mitigation strategies. Full article

Background/Objectives: Diabetic neuropathy (DN) is a prevalent complication of diabetes mellitus, affecting up to 50% of long-term patients and causing significant pain, reduced quality of life, and healthcare burden. Conventional treatments, including anticonvulsants, antidepressants, and opioids, offer limited efficacy and are associated with adverse effects. Emerging evidence suggests that cannabis, acting via the endocannabinoid system, may provide analgesic and neuroprotective benefits. This study evaluates the long-term effects of inhaled cannabis as adjunctive therapy for refractory painful DN. Inhaled cannabis exhibits rapid onset pharmacokinetics (within minutes, lasting 2–4 h) due to pulmonary absorption, targeting CB1 and CB2 receptors to modulate pain and inflammation. Methods: In this prospective, observational study, 52 patients with confirmed painful DN, unresponsive to at least three prior analgesics plus non-pharmacological interventions, were recruited from a single clinic. Following a 1-month washout, patients initiated inhaled medical-grade cannabis (20% THC, <1% CBD), titrated individually. Assessments occurred at baseline and annually for 5 years, including the Brief Pain Inventory (BPI) for pain severity and interference; the degree of pain relief; Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) score; HbA1c; and medication usage. Statistical analyses used repeated-measures ANOVA, Kruskal–Wallis tests, Welch’s t-tests, and Pearson’s correlations via Analyze-it for Excel. Results: Of 52 patients (mean age 45.3 ± 17.8 years; 71.2% male; diabetes duration 23.3 ± 17.8 years), 50 completed follow-up visits. Significant reductions occurred in BPI pain severity (9.0 ± 0.8 to 2.0 ± 0.7, p < 0.001), interference (7.5 ± 1.7 to 2.2 ± 0.9, p < 0.001), LANSS score (19.4 ± 3.8 to 10.2 ± 6.4, p < 0.001), and HbA1c (9.77% ± 1.50 to 7.79% ± 1.51, p < 0.001). Analgesic use decreased markedly (e.g., morphine equivalents: 66.8 ± 49.2 mg to 4.5 ± 9.6 mg). Cannabis dose correlated positively with pain relief (r = 0.74, p < 0.001) and negatively with narcotic use (r = −0.43, p < 0.001) and pain interference (r = −0.43, p < 0.001). No serious adverse events were reported; mild side effects (e.g., dry mouth or euphoria) occurred in 15.4% of patients. Conclusions: Inhaled cannabis showed sustained pain relief, improved glycemic control, and opioid-sparing effects in refractory DN over 5 years, with a favorable safety profile. These findings are associative due to the observational design, and randomized controlled trials (RCTs) are needed to confirm efficacy and determine optimal usage, addressing limitations such as single-center bias and small sample size (n = 52). Future studies incorporating biomarker analysis (e.g., endocannabinoid levels) could elucidate mechanisms and enhance precision in cannabis therapy. Full article

Biomass burning in the Amazon region, especially during the dry season, generates aerosol dispersion events across the southern part of the continent, with impacts observable thousands of kilometers from the emission source. This study presents a long-range aerosol transport case from September 2024, in which smoke aerosols from forest fires in the central Amazon reached southeastern and southern Brazil, affecting the air quality in distant areas such as São Paulo and São Martinho. The event was simulated using the Weather Research and Forecasting model with Chemistry (WRF-Chem), configured with the MOZCART chemical mechanism, combined with MERRA-2 reanalysis data and by using the 3BEM biomass burning emission inventory. Satellite datasets from MODIS and MERRA-2 reanalysis were used to evaluate the model’s performance. The results indicate that the South American Low-Level Jet (SALLJ) played a key role in transporting carbonaceous aerosols over long distances. The model successfully captured the spatial and temporal evolution of the aerosol plume and its impacts, although it tended to underestimate aerosol optical depth (AOD) values compared with satellite observations. This study highlights the WRF-Chem’s capability to simulate extreme smoke transport events in South America and supports its potential application in forecasting and air quality assessments. Full article

Landslides are a persistent and destructive hazard in Angra dos Reis, located in the highlands of Rio de Janeiro State, southeastern Brazil, where steep slopes, intense orographic rainfall, and unregulated urban expansion converge to trigger recurrent mass movements. In this study, we applied Multiscale Geographically Weighted Regression (MGWR) to examine the spatially varying relationships between landslide occurrence and topographic, hydrological, geological, and anthropogenic factors. A detailed inventory of 319 landslides was compiled using high-resolution PlanetScope imagery after the December 2023 rainfall event. Following multicollinearity testing and variable selection, thirteen predictors were retained, including slope, rainfall, lithology, NDVI, forest loss, and distance to roads. The MGWR achieved strong performance (R² = 0.94; AICc = 134.99; AUC = 0.99) and demonstrated that each factor operates at a distinct spatial scale. Slope, rainfall, and lithology exerted broad-scale controls, while road proximity had a consistent global effect. In contrast, forest loss and land use showed localized significance. These findings indicate that landslide susceptibility in Angra dos Reis is primarily driven by the interaction of orographic rainfall, steep terrain, and geological substrate, intensified by human disturbances such as road infrastructure and vegetation removal. The study underscores the need for targeted adaptation strategies, including slope stabilization, restrictions on road expansion, and vegetation conservation in steep, rainfall-prone sectors. Full article

Background and Objectives: The COVID-19 pandemic has had severe and far-reaching repercussions for health systems and societies, creating a global mental health crisis that has persisted after the pandemic. This study examined differences in mental health (i.e., psychological distress and well-being) by gender and pandemic period (i.e., lockdown, second and third pandemic waves, the last year of the pandemic, and the post-pandemic period) among Spanish individuals in two stages of adulthood: established adulthood and midlife. The second objective was to identify the risk and protective factors for psychological distress and well-being during the post-pandemic period. Materials and Methods: The study design was repeated cross-sectionally. The non-probability sample included 3677 people (66.2% women) from the general Spanish population, aged 30 to 59 years. Participants were assessed between 1 June 2020 and 23 May 2024 using the following self-reports: the General Health Questionnaire-12 item version, the Scale of Positive and Negative Experience, the Brief Inventory of Thriving, the Satisfaction with Life Scale, the Rosenberg Self-Esteem Scale, the Social Support Scale, the Stressful Events Questionnaire, the Brief Resilience Scale, and the Perceived Vulnerability to Disease Questionnaire. Results: Although rates of psychological distress varied across pandemic periods, women consistently experienced higher rates than men. During the post-pandemic period, the rates of psychological distress were 47.5% for women in established adulthood and 34.7% for midlife women, compared to 28.6% and 22% for men, respectively. Low self-esteem was the main predictor of greater psychological distress and lower well-being for both genders and age groups in the post-pandemic period. Another significant predictor was lower stress resilience. Conclusions: The COVID-19 pandemic threatened women’s mental health and well-being more than men’s, and this threat persists after the pandemic, especially among women in established adulthood. The study’s findings are relevant for the design of policies, programs, and strategies to achieve better mental health and well-being among citizens and greater gender equality. Full article

Osteoarthritis is a prevalent and disabling condition in companion dogs, yet existing treatments are primarily symptomatic and limited by safety concerns. EF-M2, a defined derivative of vitamin D-binding protein, selectively biases macrophages toward an anti-inflammatory phenotype in vitro. We conducted a randomised, double-blind, placebo-controlled trial (IMPAWS-OA-1) in 60 client-owned dogs with naturally occurring hip or elbow osteoarthritis. Animals were allocated to subcutaneous EF-M2 (0.1 µg/kg) given thrice weekly or twice weekly, or to saline placebo for four weeks, followed by four weeks off-drug. The primary endpoint was change in Canine Brief Pain Inventory–Pain Severity Score (CBPI-PSS) at Day 28. EF-M2 produced dose–frequency-dependent benefits: LS-mean ΔPSS was −2.11 for thrice weekly, −1.42 for twice weekly, and −0.54 for placebo (arm effect p < 0.001). Objective measures showed parallel improvements in peak vertical force and accelerometery. Serum biomarkers confirmed macrophage repolarisation (ARG1/iNOS ratio, IL-10 increase, TNF-α decrease), correlating with clinical response. Adverse events were infrequent and mild, with no excess over placebo. In conclusion, EF-M2 achieved clinically meaningful pain relief, functional gains, and biomarker shifts without safety signals, establishing first-in-species proof that targeted macrophage modulation may be a viable disease-modifying approach for canine osteoarthritis. Full article

This study evaluates landslide susceptibility in Hanang District, Manyara Region, Tanzania, using three approaches: Analytic Hierarchy Process (AHP), Frequency Ratio (FR), and Landslide Susceptibility Index. A total of 11 environmental and anthropogenic factors were analyzed, with 5879 landslide events identified from satellite imagery to create an inventory map for training and testing. Model performance was assessed using Area Under the Curve (AUC), Consistency Ratio, and Prediction Rate, while multicollinearity among factors was evaluated through Tolerance (TOL) and Variance Inflation Factor (VIF). Results indicate that the Analytic Hierarchy Process model outperformed Frequency Ratio and Landslide Susceptibility Index, achieving an Area Under the Curve of 0.88, demonstrating strong predictive capability. Slope, elevation, and geology were identified as the most influential factors. The susceptibility maps developed in this study aim to support policymakers and disaster management authorities in climate adaptation and risk reduction efforts, contributing to Sustainable Development Goal 13 (Climate Action). Limitations include reliance on remotely sensed data for landslide inventory, which may omit smaller events or introduce classification errors. Full article

Background and Objectives: The autonomic nervous system (ANS) orchestrates adaptation to stress; however, its reactivity is influenced by demographic, anthropometric, and psychosocial factors. While arterial stiffness and central adiposity are established cardiovascular risk markers, less is known about how maladaptive coping strategies, cumulative life stress, and quality of life influence short-term autonomic regulation. This study examined the age- and sex-specific associations between anthropometry, maladaptive coping, life stress, quality of life, and ANS adaptation in adults. Materials and Methods: In this cross-sectional study, 122 healthy adults aged 21–78 years underwent a standardized lay–stand–lay (LSL) protocol with pulse wave analysis. Hemodynamic outcomes included pulse wave velocity (PWVao), augmentation indices (AIxA and AIxB), and aortic blood pressures (SBPao and PPao). Anthropometric measures comprised BMI, waist and hip circumference, waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Psychosocial assessments included the Young Hypercompensation Inventory (maladaptive coping), Holmes–Rahe Life Events Inventory (life stress), and EQ-5D-3L (quality of life). Associations were analyzed using mixed-effects models adjusted for covariates, with false discovery rate correction. Results: Age was the strongest determinant of autonomic reactivity: older adults showed greater recovery of augmentation indices and central pressures after orthostatic challenge. Sex differences were evident, with women displaying consistently higher augmentation indices and men showing greater PWV responses. Central adiposity (WHR, WHtR, and waist circumference) predicted blunted augmentation index reactivity, while hip circumference was protective. BMI-defined obesity showed weaker associations. Maladaptive coping, life stress burden, and quality of life were not significantly associated with ANS indices after correction for multiple comparisons. Conclusions: ANS adaptation to postural stress is largely determined by age, sex, and visceral adiposity, whereas psychosocial measures showed limited influence in this healthy adult sample. These findings highlight the demographic and anthropometric determinants of cardiovascular adaptability, suggesting that psychosocial influences may primarily act through long-term behavioral and neuroendocrine pathways. Full article

Background: Informal caregivers of individuals with mild cognitive impairment (MCI) experience high levels of psychological and physical stress, with limited access to supportive interventions and time constraints. Virtual Reality (VR) technologies may provide brief and accessible opportunities to support caregiver well-being, particularly during waiting periods in clinical settings. This pilot study aimed to explore the potential of a semi-immersive VR intervention to enhance psychological well-being in informal caregivers. Methods: This non-randomized pilot study investigated the effects of a semi-immersive VR-based physical training program (K-HERO^®) on psychological well-being and coping strategies in informal caregivers. Participants were recruited from January to May 2025 at the IRCCS Centro Neurolesi “Bonino-Pulejo” (Messina, Italy), and the intervention was delivered individually in a dedicated room within the rehabilitation facility, while caregivers accompanied their relatives to treatment sessions. Ten caregivers completed six sessions (30–40 min each). The study was conducted in accordance with TREND reporting guidelines. Pre- and post-intervention assessments included the State-Trait Anxiety Inventory (STAI), Perceived Stress Scale (PSS), COPE Inventory, Caregiver Burden Inventory (CBI), and International Physical Activity Questionnaire (IPAQ). Visual Analog Scales and instrumental data from the VR system were used to monitor physical performance and user experience. Non-parametric statistics were applied. Results: Significant reductions were observed in avoidance (p = 0.033) and social support-based (p = 0.023) coping strategies. Differences emerged based on caregiver-patient relationships: parental caregivers showed increased anxiety, while offspring caregivers showed improvements. The intervention was well tolerated, with high usability and no adverse events reported. Conclusions: A short, structured, VR-based intervention delivered during clinical waiting periods may effectively reduce maladaptive coping strategies and support emotional well-being in informal caregivers. These findings highlight the potential of brief digital interventions in real-world care contexts. Larger randomized studies are needed to validate these preliminary findings and personalize interventions to different caregiver profiles. Full article

Underestimation of PM_2.5 emissions from the agricultural sector persists as a major difficulty for air quality studies, partly because of underutilization of high-resolution observation platforms for constructing a global emissions inventory. Coarse-resolution products used for such purposes often miss fine-scale burnt areas created by stubble-burning practices, which are primary sources of agricultural PM_2.5 emissions. For this study, we used the high-resolution Sentinel-2 observations to examine the spatiotemporal variability of burnt areas in Punjab, a major hotspot of agricultural burning in India, during the post-monsoon fire season (October–December) in 2022–2024. The results highlight the Sentinel-2 capability of detecting more than 34,000 km² of burnt areas (approx. 68% of Punjab’s total area) as opposed to the less than 7000 km² (approx. 12% of Punjab’s total area) detected by MODIS. The study also reveals, in unprecedented detail, multi-annual spatial and temporal shifting of burning events from northern to central and southern Punjab. This detection discrepancy has led to marked disparities in estimated monthly emissions, with approximately 217.3 million tons of PM_2.5 emitted in October 2022 compared to 8.7 million tons found by EDGAR v.8.1. This underscores higher-resolution observation systems intended to support construction of a global PM_2.5 emissions inventory. Full article

Introduction: Myotonic dystrophies (DM) are progressive genetic disorders with multisystemic involvement, particularly affecting the muscular, respiratory, and neuropsychological systems. Myotonic dystrophy type 1 (DM1), or Steinert’s disease, may lead to severe respiratory complications, including sleep-disordered breathing and hypercapnia, often requiring noninvasive ventilation to manage respiratory failure. However, adherence to NIV remains a major challenge, often influenced by cognitive and psychological factors such as apathy and depression. This study aims to investigate the presence of depression and SDB in patients with DM1 initiating NIV, and to evaluate factors influencing adherence to ventilatory support. Materials and Methods: We selected 13 adult patients (≥18 years) with diagnosis of Steinert’s disease with respiratory impairment who needed to start respiratory support. Dysphagia was assessed in all patients at baseline by a videofluoroscopic swallow study. Beck’s Depression Inventory II was administered for measuring the severity of depression. The Montreal Cognitive Assessment was used as a screening tool to detect signs of neurocognitive disorders. We evaluated adherence to NIV. Results: The study population presented with sleep-disordered breathing, as indicated by a median apnea–hypopnea index (AHI) of 24 events per hour (IQR: 14.2–34.5) and an oxygen desaturation index (ODI) of 25 events per hour (IQR: 18–33). Adherence to NIV was obtained in seven patients. No difference in baseline lung function was observed. Adherent subjects had moderate hypercapnia at baseline; pCO2 was 52 vs. 49 mmHg. Non-adherent patients showed a higher prevalence of depression with a median BDI-II score of 18 vs. 6 in adherent patients. The findings highlight that psychological factors, especially depression, play a crucial role in adherence to NIV. Interestingly, depression was not linked to initial respiratory measurements but showed a significant association with nocturnal oxygen desaturation. This suggests that relying solely on clinical and respiratory assessments may not be adequate to predict or improve treatment adherence. Conclusions: Incorporating psychological evaluations and addressing mental health issues, such as depression, are essential steps to enhance NIV compliance and overall DM1 patient outcomes. A multidisciplinary approach combining respiratory and psycho-emotional interventions is crucial for effective disease management. Full article