Search Results (1,653)

Animal protein production represents a complex system of lives transformed into nutrition, with profound ethical and environmental implications. This study provides a quantitative analysis of animal lives required to produce human-consumable protein across major food production systems. Categorizing animal lives based on cognitive complexity and accounting for all lives involved in production, including direct harvests, reproductive animals, and feed species, reveals dramatic variations in protein efficiency. The analysis considers two categories of animal life: complex-cognitive lives (e.g., mammals, birds, cephalopods) and pain-capable lives (e.g., fish, crustaceans). Calculating protein yield per life demonstrates efficiency differences spanning more than five orders of magnitude, from 2 g per complex-cognitive life for baby octopus to 390,000 g per life for bovine dairy systems. Key findings expose disparities between terrestrial and marine protein production. Terrestrial systems involving mammals and birds show higher protein yields and exclusively involve complex-cognitive lives, while marine systems rely predominantly on pain-capable lives across complex food chains. Dairy production emerges as the most efficient system. Aquaculture systems reveal complex dynamics, with farmed carnivorous fish requiring hundreds of feed fish lives to produce protein, compared to omnivorous species that demonstrate improved efficiency. Beyond quantitative analysis, this research provides a framework for understanding the ethical and ecological dimensions of protein production, offering insights for potential systemic innovations. Full article

The evidence for photobiomodulation in reducing postoperative pain after endodontic instrumentation is classified as low or very low certainty, indicating a need for further research. Longitudinal pain assessments over 24 h are crucial, and studies should explore these pain periods. Background/Objectives: This double-blind, randomized controlled clinical trial evaluated the effect of PBM on pain following single-visit endodontic treatment of maxillary molars at 4, 8, 12, and 24 h. Primary outcomes included pain at 24 h; secondary outcomes included pain at 4, 8, and 12 h, pain during palpation/percussion, OHIP-14 analysis, and frequencies of pain. Methods: Approved by the Research Ethics Committee (5.598.290) and registered in Clinical Trials (NCT06253767), the study recruited adults (21–70 years) requiring endodontic treatment in maxillary molars. Fifty-eight molars were randomly assigned to two groups: the PBM Group (n = 29), receiving conventional endodontic treatment with PBM (100 mW, 333 mW/cm², 9 J distributed at 3 points near root apices), and the control group (n = 29), receiving conventional treatment with PBM simulation. Pain was assessed using the Visual Analog Scale. Results: Statistical analyses used chi-square and Mann–Whitney tests, with explained variance (η²). Ten participants were excluded, leaving 48 patients for analysis. No significant differences were observed in postoperative pain at 24, 4, 8, or 12 h, or in palpation/percussion or OHIP-14 scores. Pain frequencies ranged from 12.5% to 25%. Conclusions: PBM does not influence post-treatment pain in maxillary molars under these conditions. These results emphasize the importance of relying on well-designed clinical trials to guide treatment decisions, and future research should focus on personalized dosimetry adapted to the anatomical characteristics of the treated dental region to enhance the accuracy and efficacy of therapeutic protocols. Full article

Air pollution is linked to childhood mortality and morbidity in low- and middle-income countries globally. There is growing evidence linking air pollution to asthma and other respiratory diseases in children. Studies have shown that children are likely to experience asthma due to their narrow airways and their heightened sensitivity to environmental irritants. This study aims to investigate the relationship between ambient air pollution and respiratory diseases in children under the age of 5. The study will be conducted in the informal township of Alexandra, north of Johannesburg, South Africa. A quantitative approach will be used in this cross-sectional analytical study. Data will be collected using different tools that include a questionnaire to determine the prevalence of asthma and respiratory disease and potential risk factors. While environmental air pollution will be measured using Radiello passive samplers and Gillian pumps. Data will be analyzed using the latest version of the STATANow/MP 19.5 software. Furthermore, health risk assessment will be conducted for lifetime non-carcinogenic and carcinogenic risk estimation following the USEPA framework. The study will identify environmental triggers that exacerbate asthma and other respiratory conditions in other similar community settings and will contribute to the body of knowledge in public health. Ethical approval was obtained from the Research Ethics Committee, Faculty of Health Sciences at the University of Johannesburg. Full article

(1) Background and objectives: Large language models (LLMs) such as GPT, Mistral, and LLaMA exhibit strong capabilities in text generation, yet assessing the quality of their reasoning—particularly in open-ended and argumentative contexts—remains a persistent challenge. This study introduces Dialectical Agent, an internally developed modular framework designed to evaluate reasoning through a structured three-stage process: opinion, counterargument, and synthesis. The framework enables transparent and comparative analysis of how different LLMs handle dialectical reasoning. (2) Methods: Each stage is executed by a single model, and final syntheses are scored via two independent LLM evaluators (LLaMA 3.1 and GPT-4o) based on a rubric with four dimensions: clarity, coherence, originality, and dialecticality. In parallel, a rule-based semantic analyzer detects rhetorical anomalies and ethical values. All outputs and metadata are stored in a Neo4j graph database for structured exploration. (3) Results: The system was applied to four open-weight models (Gemma 7B, Mistral 7B, Dolphin-Mistral, Zephyr 7B) across ten open-ended prompts on ethical, political, and technological topics. The results show consistent stylistic and semantic variation across models, with moderate inter-rater agreement. Semantic diagnostics revealed differences in value expression and rhetorical flaws not captured by rubric scores. (4) Originality: The framework is, to our knowledge, the first to integrate multi-stage reasoning, rubric-based and semantic evaluation, and graph-based storage into a single system. It enables replicable, interpretable, and multidimensional assessment of generative reasoning—supporting researchers, developers, and educators working with LLMs in high-stakes contexts. Full article

This study empirically investigates the use of artificial intelligence (AI) tools within Hungarian religious communities, with a focus on Catholic respondents, to assess their awareness, application, and acceptance of AI in religious contexts. By religious communities, we do not mean monastic or priestly communities, but rather communities of lay religious people. Conducted between 10 February and 11 March 2025, the questionnaire-based research (N = 133) employs Campbell’s Religious Social Shaping of Technology (RSST) framework to analyze attitudes toward AI across 15 religious functions. Six hypotheses explore gender differences, religiosity types (church-based vs. self-defined), and the acceptability, authenticity, and ethicality of AI applications. Findings reveal high acceptance for administrative tasks (e.g., email list updates: 64.7%) and technical functions (e.g., live translation: 65.4%), but low acceptance for spiritual roles (e.g., spiritual leadership: 12.8%). Self-defined religious individuals are significantly more accepting, perceiving AI as more authentic and ethical compared to those adhering to church teachings. No significant gender differences were found. The study contributes to digital religion studies, highlighting the influence of religiosity on AI adoption, though its non-representative sample limits generalizability. Full article

Compassion is a critical competence for university students in the healthcare field when dealing with the suffering of patients and relatives. However, there are no tools that measure compassionate capacity during students’ training. Recently, the Compassion Capacity Scale (CCS) was developed for health professionals, exhibiting good psychometric properties. The aim of this study was to translate, culturally adapt, and validate the CCS for Portuguese university students in the healthcare field. The study was divided into two phases: (1) translation and adaptation of the CCS for Portuguese university students in the healthcare field; (2) validation and analysis of psychometric properties. The CCS-PHS showed good internal consistency (Cronbach’s α = 0.886), temporal stability (rho = 0.703), and content validity (CVI-i = 1). Criterion validity analysis showed strong correlations between all of the CCS-PHS’s dimensions and the chosen reference criteria scale. Construct validity analysis revealed that the CCS-PHS is composed of 17 items, classified into four factors. The differences found in the exploratory factor analysis in relation to the original scale may be due to the differences in the life experiences of healthcare professionals when compared to those of students. Our psychometric analysis suggests that the CCS-PHS is a reliable and valid tool to assess compassionate capacity in healthcare students. Knowing the compassionate competence of students is vital for guiding educational strategies, implementing compassion training programs and evaluating their effectiveness, as well as reinforcing key attitudes and behaviors for humanized and ethical healthcare. Full article

Traditional energy conservation policies have primarily relied on economic incentives and informational campaigns. However, recent insights from behavioral and social sciences indicate that subtle behavioral interventions, particularly social nudges, can significantly influence household electricity use. This paper presents a structured review of 23 recent field studies examining how social nudging strategies, such as peer comparison, group identity, and normative messaging, have contributed to measurable reductions in electricity consumption. By analyzing intervention outcomes across different regions and formats, we identify key success factors, limitations, and policy implications. Special attention is given to ethical considerations, fairness in implementation, and potential challenges in sustaining behavior change. This study offers a framework for integrating social nudges into future energy policies, emphasizing their role as low-cost, scalable tools for promoting sustainable energy behavior. Full article

Precision neurosurgery is rapidly evolving as a medical specialty by merging genomic medicine, multi-omics technologies, and artificial intelligence (AI) technology, while at the same time, society is shifting away from the traditional, anatomic model of care to consider a more precise, molecular model of care. The general purpose of this review is to contemporaneously reflect on how these advances will impact neurosurgical care by providing us with more precise diagnostic and treatment pathways. We hope to provide a relevant review of the recent advances in genomics and multi-omics in the context of clinical practice and highlight their transformational opportunities in the existing models of care, where improved molecular insights can support improvements in clinical care. More specifically, we will highlight how genomic profiling, CRISPR-Cas9, and multi-omics platforms (genomics, transcriptomics, proteomics, and metabolomics) are increasing our understanding of central nervous system (CNS) disorders. Achievements obtained with transformational technologies such as single-cell RNA sequencing and intraoperative mass spectrometry are exemplary of the molecular diagnostic possibilities in real-time molecular diagnostics to enable a more directed approach in surgical options. We will also explore how identifying specific biomarkers (e.g., IDH mutations and MGMT promoter methylation) became a tipping point in the care of glioblastoma and allowed for the establishment of a new taxonomy of tumors that became applicable for surgeons, where a change in practice enjoined a different surgical resection approach and subsequently stratified the adjuvant therapies undertaken after surgery. Furthermore, we reflect on how the novel genomic characterization of mutations like DEPDC5 and SCN1A transformed the pre-surgery selection of surgical candidates for refractory epilepsy when conventional imaging did not define an epileptogenic zone, thus reducing resective surgery occurring in clinical practice. While we are atop the crest of an exciting wave of advances, we recognize that we also must be diligent about the challenges we must navigate to implement genomic medicine in neurosurgery—including ethical and technical challenges that could arise when genomic mutation-based therapies require the concurrent application of multi-omics data collection to be realized in practice for the benefit of patients, as well as the constraints from the blood–brain barrier. The primary challenges also relate to the possible gene privacy implications around genomic medicine and equitable access to technology-based alternative practice disrupting interventions. We hope the contribution from this review will not just be situational consolidation and integration of knowledge but also a stimulus for new lines of research and clinical practice. We also hope to stimulate mindful discussions about future possibilities for conscientious and sustainable progress in our evolution toward a genomic model of precision neurosurgery. In the spirit of providing a critical perspective, we hope that we are also adding to the larger opportunity to embed molecular precision into neuroscience care, striving to promote better practice and better outcomes for patients in a global sense. Full article

Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Risk factors for EC include metabolic alterations (obesity, metabolic syndrome, insulin resistance), hormonal imbalance, age at menopause, reproductive factors, and inherited conditions, such as Lynch syndrome. For the inherited forms, several genes had been implicated in EC occurrence and development, such as POLE, MLH1, TP53, PTEN, PIK3CA, PIK3R1, CTNNB1, ARID1A, PPP2R1A, and FBXW7, all mutated at high frequency in EC patients. However, gene function impairment is not necessarily caused by mutations in the coding sequence of these and other genes. Gene function alteration may also occur through post-transcriptional control of messenger RNA translation, frequently caused by microRNA action, but transcriptional impairment also has a profound impact. Here, we review how chromatin modifications change the expression of genes whose impaired function is directly related to EC etiopathogenesis. Chromatin modification plays a central role in EC. The modification of chromatin structure alters the accessibility of genes to transcription factors and other regulatory proteins, thus altering the intracellular protein amount. Thus, DNA structural alterations may impair gene function as profoundly as mutations in the coding sequences. Hence, its central importance is in the diagnostic and prognostic evaluation of EC patients, with the caveat that chromatin alteration is often difficult to identify and needs investigations that are specific and not broadly used in common clinical practice. The different phases of the healthy endometrium menstrual cycle are characterized by differential gene expression, which, in turn, is also regulated through epigenetic mechanisms involving DNA methylation, histone post-translational modifications, and non-coding RNA action. From a medicolegal and policy-making perspective, the implications of using epigenetics in cancer care are briefly explored as well. Epigenetics in endometrial cancer is not only a topic of biomedical interest but also a crossroads between science, ethics, law, and public health, requiring integrated approaches and careful regulation. Full article

This article investigates the revolutionary potential of AI-powered virtual assistants in augmented reality (AR) and virtual reality (VR) environments, concentrating primarily on their impact on special needs schooling. We investigate the complex characteristics of these virtual assistants, the influential elements affecting their development and implementation, and the joint efforts of educational institutions and technology developers, using a rigorous quantitative approach. Our research also looks at strategic initiatives aimed at effectively integrating AI into educational practices, addressing critical issues including infrastructure, teacher preparedness, equitable access, and ethical considerations. Our findings highlight the promise of AI technology, emphasizing the ability of AI-powered virtual assistants to provide individualized, immersive learning experiences adapted to the different needs of students with special needs. Furthermore, we find strong relationships between these virtual assistants’ features and deployment tactics and their subsequent impact on educational achievements. This study contributes to the increasing conversation on harnessing cutting-edge technology to improve educational results for all learners by synthesizing current research and employing a strong methodological framework. Our analysis not only highlights the promise of AI in increasing student engagement and comprehension but also emphasizes the importance of tackling ethical and infrastructure concerns to enable responsible and fair adoption. Full article

This paper suggests a theoretical framework to summarise the empirical literature on the relationships between sports and both religious and secular ethics, and it suggests two interrelated theoretical models to empirically evaluate the extent to which religious and secular ethics, as well as sports policies, affect achievements in sports. I identified two national ethics (national pride/efficiency) and two social ethics (social cohesion/ethics) by measuring achievements in terms of alternative indexes based on Olympic medals. I referred to three empirical models and applied three estimation methods (panel Poisson, Data Envelopment, and Stochastic Frontier Analyses). I introduced two sports policies (a quantitative policy aimed at social cohesion and a qualitative policy aimed at national pride), by distinguishing sports in terms of four possibly different ethics to be used for the eight summer and eight winter Olympic Games from 1994 to 2024. I applied income level, health status, and income inequality, to depict alternative social contexts. I used five main religions and three educational levels to depict alternative ethical contexts. I applied country dummies to depict alternative institutional contexts. Empirical results support the absence of Olympic ethics, the potential substitution of sport and secular ethics in providing social cohesion, and the dependence of sports on politics, while alternative social contexts have different impacts on alternative sport achievements. Full article

Ensuring sustainable food systems is an urgent global priority as populations grow and environmental pressures mount. Technological innovations such as genetic engineering (GE) and nanotechnology (nano) have been promoted as promising pathways for achieving greater sustainability in agriculture and food production. Yet, the sustainability of these technologies is not defined by technical performance alone; it hinges on how they are perceived by key stakeholders and how well they align with broader societal values. This study addresses the critical question of how expert stakeholders evaluate the sustainability of GE and nano-based food and agriculture (agrifood) products. Using a multi-method online platform, we engaged 42 experts across academia, government, industry, and NGOs in the United States to assess six real-world case studies—three using GE and three using nano—across ten different dimensions of sustainability. We show that nano-based products were consistently rated more favorably than their GE counterparts in terms of environmental, economic, and social sustainability, as well as across ethical and societal dimensions. Like prior studies, our results reveal that stakeholders see meaningful distinctions between nanotechnology and biotechnology, likely due to underlying value-based concerns about animal welfare, perceived naturalness, or corporate control of agrifood systems. The fruit coating and flu vaccine—both nano-enabled—received the most positive ratings, while GE mustard greens and salmon were the most polarizing. These results underscore the importance of incorporating stakeholder perspectives in technology assessment and innovation governance. These results also suggest that responsible innovation efforts in agrifood systems should prioritize communication, addressing meaningful societal needs, and the contextual understanding of societal values to build trust and legitimacy. Full article

Studying consumers’ willingness to pay (WTP) for sustainable certification labels and preferences in consumption is a relevant issue for policymakers. Several studies have revealed a positive WTP a premium price for many certified products. The aim of this paper is to assess an overview of Italian consumers’ WTP for eight different sustainable certification labels and to collect information about their consumption preferences and perceptions in consumption. Participants were selected by stratified simple random sampling, using regional distribution, gender, and age as stratification criteria, to obtain a representative sample of n = 3600. Eight ordered logit models were estimated to understand how consumer sociodemographic characteristics influence the price premium. The results show important differences in WTP among different certification labels; a higher WTP emerged for ethical certifications than for environmentally focused labels. Younger individuals; women; and those with higher education, income and life satisfaction, as well as consumers in southern regions, were significantly more willing to pay premiums for certified products. However, a key finding for policymakers is that the stated price premium consumers are willing to pay falls significantly short of the actual higher costs of these products in supermarkets. Furthermore, insights into consumer perceptions and preferences revealed that quality and origin are perceived as key price drivers, while method of production holds less importance. It also emerged that consumers primarily seek a balance between quality and price, with only a small segment prioritizing certified products. Full article

What elements of nature do people involved in conservation projects seek to protect, and why? How do they identify and relate to nature? Answers to such fundamental questions are shaped by normative assumptions that can result in distinct conservation strategies and practices. Despite their importance, normative assumptions are rarely explicitly stated in conservation sciences, possibly because an epistemology of modern science suggests that normative backgrounds are not relevant to the production of objective knowledge, or because researchers and practitioners are unaware of the diversity of positions that exist. Using a combination of qualitative and quantitative methods, we created a catalogue of existing normative positions in conservation literature and described their key characteristics. We described 72 distinctive normative positions about human–nature relationships. Each position was characterized by unique combinations of value-states belonging to one or more of the following five dimensions: ontology (the positionality of human with respect to nature), axiology (value systems and ethical frameworks), pragmatism (extent of human interventions), epistemology (knowledge sources), and agency (agents of change). We then scored each position in terms of its alignment (support, opposition, or neutrality) with respect to all value-states within each dimension. A fuzzy correspondence analysis revealed that the field of conservation is heterogeneous beyond the conventional gradient of intrinsic–instrumental–relational values. The frequency and circumstances under which stakeholders adopt different normative positions are unknown, but the list of dimensions and associated values provided in this study may serve as a checklist for scoping this diversity. Consideration of values stemming from alternative normative positions may help broaden support for conservation actions. Full article

Caring for the lives and welfare of animals is central to veterinary and animal sanctuary work, yet the meaning remains a subject of complex debates. Different stakeholders negotiate what constitutes appropriate care, leading to conflicting demands and expectations from internal and external sources. This article is based on two qualitative studies: Study I explores the multifaceted aspects of death work in farm animal medicine, emphasising the practical, emotional and ethical challenges involved. Study II examines human–animal interaction in sanctuaries, which reveal tensions between instrumental and relational care in animal-centred work. Relational care represents a subjectifying approach with individual attention to animals, while instrumental care is a more objectifying perspective based on species representation. These demands can often be contradictory, complicating day-to-day decision making under pressure. To analyse these complexities, this study employs Clarke’s situational analysis (social worlds/arenas mapping), providing a means of comparing care work across different fields. This approach highlights how actor constellations, institutional settings, and structural constraints influence the negotiation of care. Addressing these issues provides a more nuanced understanding of the professional challenges of animal-centred care and the necessary skills to navigate its inherent contradictions. Full article