Search Results (10,284)

Background: Traditional functional mobility assessments often fail to detect subclinical postural decline in active aging populations. This study introduces the Head–Sternum Dissociation Index as a novel digital biomarker to identify latent sensorimotor deficits before macroscopic balance failure occurs. Methods: Ninety-four participants (Young, Middle-Aged Civil, Middle-Aged Dancers, and Older Adults) performed instrumented limits of stability tasks, specifically functional and lateral reach tests, utilizing a three-sensor inertial measurement unit configuration. Postural strategies were quantified via the Head–Sternum Dissociation Index and the peak ratio of corrective micro-movements, validating the sensor output against a gold-standard force platform. Results: A significant kinematic breakpoint in postural control was identified at age 55 (p < 0.001). However, Middle-Aged Civilians exhibited early kinematic divergence despite maintaining normal Timed Up and Go test performance. Receiver operating characteristic analysis revealed distinct, sex-specific physiological limits: aging males predominantly adopted a rigid “Stiffness” strategy (peak ratio ≤ 1.15, head–sternum dissociation threshold > 0.63°), while females utilized a broader, more permissive “Continuous” strategy (head–sternum dissociation threshold > 0.31°). Notably, recreational rhythmic training (dance) completely neutralized this age-related decay, with middle-aged dancers maintaining highly efficient, youthful stabilization profiles (Cohen’s d = 2.20). Conclusions: The Head–Sternum Dissociation Index, combined with relative corrective frequency, successfully phenotypes early sensorimotor erosion. These findings advocate for the integration of sex-specific kinematic screening into primary care, allowing clinicians to prescribe targeted interventions well before clinical fall risk manifests. Full article

Background/Objectives: Artificial intelligence (AI)-assisted endoscopy has shown high sensitivity for early gastric cancer detection; however, false-positive diagnoses remain a clinical challenge. This study aimed to evaluate the real-world diagnostic performance of a commercially available AI system and to identify factors associated with false-positive diagnoses, focusing on repeated AI evaluations and confidence stratification. Methods: This single-center retrospective study included 47 patients with 89 localized gastric lesions evaluated between March 2024 and March 2025. Endoscopic examinations were performed under white-light, non-magnified observation with repeated AI assessments of each lesion. The rates of “Consider biopsy” (B) judgments were calculated. Lesions with a B judgment rate of ≥50% were defined as AI-positive and classified into four AI confidence categories. Diagnostic performance was assessed using sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Factors associated with false-positive diagnoses were analyzed using penalized logistic regression. Results: The AI system demonstrated a sensitivity of 97.6% and an NPV of 95.7%, with a specificity of 45.8%. Pathology-positive rates decreased stepwise across the four AI confidence categories (p < 0.001). Among AI-positive lesions, low regional reproducibility, lesion size ≥ 30 mm, scar, and erosion were independently associated with false-positive diagnoses. In analyses restricted to non-neoplastic lesions, lesion size ≥ 30 mm remained significantly associated with false-positive diagnosis. Conclusions: In real-world clinical practice, a commercially available AI system provides high sensitivity for early gastric cancer detection. Incorporating confidence stratification and regional reproducibility into clinical decision-making may enhance the effective use of AI-assisted endoscopic diagnosis beyond binary interpretations. Full article

The use of shotcrete is a critical support technique in ocean engineering structures. However, it often exhibits low chloride and salt erosion resistance under ocean environmental conditions and poor long-term durability. This study employed polypropylene fiber (PF) and basalt fiber (BF) to optimize the shotcrete mix design. Laboratory immersion and salt spray tests simulated chloride ion corrosion environments in the ocean’s underwater and atmospheric zones. The effects of different corrosion mechanisms and varying fiber volume fractions on shotcrete strength and durability were then analyzed. The results indicate that shotcrete demonstrates strong resistance to chloride-induced corrosion in both ocean underwater and atmospheric zones when the volume fractions of PF and BF are 0.2% and 0.1%, respectively. Based on test results from 3D digital microscopy (3D-DM), X-ray diffraction (XRD), and scanning electron microscopy (SEM), the chloride-induced degradation mechanism of hybrid fiber-reinforced shotcrete was analyzed from both mesoscopic and microscopic perspectives. This study offers theoretical support for applying hybrid fiber-reinforced shotcrete in ocean engineering environments. Full article

Scour has been a topic of significant concern among coastal geotechnical engineers in recent years. The Shields number serves as a crucial parameter for erosion calculations, reflecting the balance between sediment particle conditions and hydrodynamic forces, derived from the mechanics of sediment particle equilibrium. Seepage flow, a common phenomenon driven by pressure in soil, further influences the movement of sediment particles. Building upon the classical three-dimensional two-slope angle erosion model, this study incorporates the vertical seepage force. It comprehensively considers slope angles, sediment response angles, incident current angles, and vertical seepage intensities to adjust the Shields number for sediment particles on slopes. The calculation encompasses both transverse and longitudinal slope configurations. Based on the derived formula and parametric analysis, the study draws the following conclusions: 1. The modified Shields number (${\theta }_{cr}/{\theta }_{cr0}$) decreases non-linearly with the increase of slope angle; 2. ${\theta }_{cr}/{\theta }_{cr0}$ is central and has axial symmetry about 180° incident current angles for transverse and longitudinal slopes, respectively; 3. ${\theta }_{cr}/{\theta }_{cr0}$ increases non-linearly with the increase of soil angle of response; 4. ${\theta }_{cr}/{\theta }_{cr0}$ decreases linearly with the increase of seepage intensity; 5. There exists an approximately zero ${\theta }_{cr}/{\theta }_{cr0}$ area when the response angle approaches the slope angle, and the area increases non-linearly as the seepage intensity becomes greater. Full article

The interaction between circular piers and turbulent open-channel flow generates complex three-dimensional structures, including horseshoe vortices at the pier base and wake vortices downstream. These structures increase vertical velocities, pressure fluctuations, and shear stresses, contributing to erosion and structural instability. Although these phenomena have been widely studied, limited attention has been given to surface geometric modifications as a flow-control strategy. This study employs Large Eddy Simulation (LES) to evaluate the influence of a hexagonal dimple pattern on circular piles in a free-surface channel. The dimples were defined by varying diameter, depth, and spacing to reduce vertical velocity and alter vortex formation. The computational domain represents a 0.40 m wide, 12 m long, and 1.2 m high rectangular channel, with an inlet mass flow of 9.4 kg/s and 0.10 m water depth. Model validation against particle image velocimetry (PIV) data showed 99% correlation, confirming numerical accuracy. Results demonstrate that textured surfaces modify flow dynamics by enhancing kinetic energy dissipation and generating micro-vortices that weaken dominant structures. The optimal configuration (6 mm diameter, 2 mm depth, 1 mm spacing) reduced downward vertical velocity by 42% and wake vortex shedding frequency by 24%, indicating improved hydraulic stability and erosion mitigation potential. Full article

Introduction: Bacterial multidrug resistance (MDR) drives treatment with expensive, toxic, or pharmacokinetically suboptimal antibiotics. Objectives: To assess the prevalence of MDR Gram-positive cocci among isolates from cardiac implantable electronic device (CIED) infections at a Polish reference center. Methods: Data come from the “EXTRACT” registry (ClinicalTrials.gov ID NCT05775783), which covers 702 transvenous lead extraction procedures. Blood samples and intraoperative swabs were collected from participants with CIED infection. Results: From 209 cases with isolated pocket infection (PI) (107, 51.2%) or systemic infections (102, 48.8%), 263 Gram-positive cocci were cultured. They were: coagulase-negative staphylococci (CoNS) (177, 67.3%), Staphylococcus aureus (62, 23.6%), enterococci (15, 5.7%), streptococci (8, 3.0%), and others (1, 0.4%). The highest MDR rate was among CoNS (46.9%). CoNS exhibited methicillin resistance (MR-CoNS) in 55.9% with co-resistance to macrolides (73.2%), lincosamides (51.0%), fluoroquinolones (56.1%), aminoglycosides (41.4%), tetracyclines (29.6%), and co-trimoxazole (29.3%). Resistance to daptomycin (5.3%) and linezolid (2.0%) in MR-CoNS was rare. The frequency of MDR S. aureus was 8.1%. Methicillin resistance in S. aureus (MRSA, 6.5%) co-occurred with resistance to macrolides/lincosamides and fluoroquinolones (100% for both) or linezolid (25.0%). All MDR staphylococci were vancomycin-susceptible. High-level aminoglycoside resistance (HLAR) in Enterococcus faecalis (53.8%) was accompanied by levofloxacin co-resistance (66.7%). Conversely, E. faecium HLAR (50.0%) strains showed 100.0% β-lactam resistance. Vancomycin-resistant enterococci (VRE) accounted for 6.7%; the VRE E. faecium strain was tigecycline- and linezolid-susceptible. Among viridans group streptococci, β-lactam and lincosamides resistance was common (40.0% for both), with 50.0% of co-resistance. Conclusions: Epidemiological data may improve the effectiveness of empirical antibiotic therapy for CIED-related infections. Full article

The hydropower plant, together with its reservoir, makes it possible to modify the natural flow regime. These changes can affect sediment transport dynamics and cause morphological changes in the river. If the river is also used as a waterway, the operational scenario of the hydropower plant can have a significant impact on sediment deposition, thereby reducing its navigable depths and increasing the risk of vessel–riverbed collisions. In this study, a 2D hydrodynamic model of the Danube River downstream of the Gabčíkovo Hydropower Plant (GHP) in Slovakia was developed to evaluate the influence of operational scenarios on maintaining the required navigable depths and to determine the most suitable scenario in terms of fairway maintenance costs. The operational scenario of the GHP influences the amount of sediment deposited downstream of the plant. The volume of deposition in the critical ford was approximately 50% smaller under hydropeaking than under run-of-river operation. The increase in riverbed elevation during hydropeaking was 33% to 64% lower than under run-of-river operation. The study results indicate that this reach of the Danube can remain navigable for a longer period without intervention (dredging), thanks to sufficient navigable depth maintained by erosion caused by hydropeaking, compared to run-of-river operation. Full article

This study presents a comprehensive 35-year (1990–2025) shoreline change assessment along the southeast coast of Ireland, integrating multi-decadal Landsat satellite archives with GIS-based Digital Shoreline Analysis System (DSAS) metrics to quantify both spatial and temporal coastal dynamics. Unlike previous studies that focus on shorter timeframes or localized sectors, this research provides a regional-scale, orientation-specific comparison between the eastern-facing (SE1; County Wexford) and southern-facing (SE2; County Waterford) shorelines. Shoreline evolution was quantified using four complementary DSAS indicators—Shoreline Change Envelope (SCE), Net Shoreline Movement (NSM), End Point Rate (EPR), and Linear Regression Rate (LRR), allowing robust discrimination between short-term variability and multi-decadal trends. The results reveal noticeable spatial variability in shoreline behavior with 57% accretion and 42% erosion across the eastern-facing coast (SE1) in County Wexford and the southern-facing coast (SE2) in County Waterford. SCE values ranging from 2.26 m to 663.83 m indicate considerable short-term shoreline variability, particularly within dynamic barrier and embayed systems. NSM values between −216.65 m and +663.83 m indicate erosional hotspots, particularly along soft-sediment coasts and exposed southern-facing sectors, whereas accretion is limited to embayments, sandy beaches, and zones of effective sediment trapping. Rate-based analyses show EPR values between −14.82 and +20.38 m/yr and LRR values between −5.27 and +20 m/yr, with LRR providing more reliable estimates of multi-decadal trends in highly dynamic environments. The findings highlight the strong influence of coastal orientation, sediment availability, geological controls, and human activities on shoreline change in southeastern Ireland. These findings provide valuable evidence to support coastal management, hazard mitigation, and climate adaptation planning, with the assistance of policymakers, to develop effective strategies that enhance the resilience and quality of life of coastal communities. Full article

To investigate the deterioration law of the mechanical properties of PVA-fiber-reinforced rubber concrete under the combined action of high-temperature and salt erosion, physical index tests, dynamic mechanical property experiments, and microstructural morphology observations were carried out on specimens subjected to different temperatures (ambient temperature, 100 °C, 300 °C) and various solution attacks (water, 5% NaCl, 5% Na₂SO₄, and 5% NaCl + 5% Na₂SO₄ mixture). The results show that, after exposure to 300 °C, the PVA fibers melt and the rubber pyrolyzes, since this temperature exceeds their melting points. A residual pore network is formed inside the matrix, and the damage degree of ultrasonic pulse velocity is about 2.3 times that of the 100 °C group. Although salt solution and its crystallization products can physically fill the pores and cause a partial recovery of pulse velocity, this change is mainly due to the alteration of the pore medium and does not represent a substantial restoration of the microstructure. The effects of different salt solutions on dynamic mechanical properties vary significantly: Sulfate erosion improves the dynamic performance significantly at ambient temperature by forming gypsum and ettringite to fill pores, but this strengthening effect disappears after 300 °C. Sodium chloride attack generates Friedel’s salt and consumes C₃A, leading to general strength deterioration. In composite salt erosion, the competitive and synergistic effects of Cl⁻ and SO₄²⁻ destabilize erosion products and weaken interfacial bonding, resulting in consistent decreases in dynamic compressive strength and elastic modulus under all temperatures and impact pressures. The strength reduction reaches 66.2% after 300 °C. Microscopic analysis confirms that composite salt erosion leads to the dissolution of ettringite and loose structure, which verifies the synergistic deterioration law of macroscopic properties. This study systematically reveals the damage evolution mechanism of PVA-fiber-reinforced rubber concrete under the coupled action of high-temperature and salt erosion, and provides a theoretical basis for the dynamic bearing capacity evaluation and durability design of concrete structures in such coupled environments. Full article

Nutrient inputs from human activities, such as agriculture and sewage discharge, influence algal blooms in water bodies. In Ecuador, the Daule River receives wastewater discharges. In addition, poor agricultural practices, including the unsuitable use of fertilisers in combination with soil erosion and surface runoff processes, increase the nutrient load to the river. Considering this, the objective of this study was to evaluate environmental and biological variables using statistical analysis to identify the parameters that influence algal blooms in the main stem of the Daule River. The methodology consisted of two phases: (i) data collection, including water sampling and laboratory work for the analysis of nutrients and phytoplankton, and (ii) statistical analysis, which includes univariate, bivariate, inferential and multivariate analysis (STATICO technique). The results showed that pH and dissolved oxygen were the main drivers of diatoms (Polymyxus coronalis and Aulacoseira granulate) and the charophyte Mougeotia sp. Similarly, ammonium-N was the main driver of the diatom Ulnaria ulna and the cyanobacteria Planktothrix cf. agardhii. The outcomes of this study identified the main environmental variables driving blooms of the five most abundant species, providing a basis for the development of ecological models in the context of land use and climate change. Full article

This study investigated the enhancement mechanisms and optimal mix proportion of basalt fiber (BF) in concrete for ship lock galleries. It focused on improving crack resistance, freeze–thaw resistance, impermeability, and abrasion–erosion resistance under complex hydraulic environments. Single-factor tests first determined the reasonable parameter ranges, which were subsequently used in a three-factor, four-level orthogonal experiment to analyze the effects of the water-to-binder ratio, fiber content, and fiber length on concrete’s mechanical properties. Range analysis of the orthogonal experiment indicated that the water-to-binder ratio was the most dominant factor (R = 57.4), followed by fiber content. Based on this, further durability tests were conducted, including ring restraint cracking, impermeability, freeze–thaw resistance, and abrasion–erosion resistance. Multi-objective optimization was performed using full factorial experiments and a comprehensive performance evaluation system. The final optimal mix proportion was determined as: a water-to-binder ratio of 0.35, a fiber content of 0.2%, and a fiber length of 12 mm. With this mix, the concrete’s ring cracking time was extended by 69.9%, the relative dynamic elastic modulus retention reached 73.0% after 100 freeze–thaw cycles, the relative permeability coefficient was 1.04 × 10⁻⁶ cm/h, and the abrasion–erosion resistance strength increased to 7.05 h·m²/kg, which achieved an optimal synergy among the mechanical properties, key durability indicators, and their workability. Mechanism analysis revealed that BF formed a three-dimensional, randomly distributed fiber network that comprehensively enhanced concrete performance through multi-scale mechanisms, including bridging, pore refinement, and energy dissipation. This research has provided systematic experimental evidence and mix proportion support for the durability design and engineering application of BF concrete in ship lock galleries. Full article

The asphalt industry, essential for the global transport infrastructure, requires substantial investments to increase the durability of production facilities. The quality of asphalt depends, essentially, on the degree of drying of mineral aggregates. Therefore, the rotary dryer is of major importance for ensuring the quality of asphalt. The rotary dryer flights are subjected to an erosive-abrasive wear process during operation, generated by the impact of abrasive aggregates. These phenomena lead to severe degradation of the flights. Experimental research, carried out by the authors, on-site, aimed at identifying solutions to improve the wear behavior of the flights, by hardfacing with four wear-resistant materials (FLUXOFIL 51, FLUXOFIL 56, SAFER R 400, SAFER R 600), using the GMAW and SMAW processes. The results revealed a decrease in the wear rate and a flattening effect of the wear curve along the profile of the flight. The research targeted the upper rear surface of the flights, which is predominantly affected by erosive-abrasive wear phenomena. The resistance to abrasive wear of the flights was improved by hardfacing with FLUXOFIL 51 wear-resistant tubular wire, resulting in the lowest wear rate, especially between the areas marked 14–26, which are the areas most affected during operation. Full article

This study investigated the molecular characteristics and genetic diversity of Fowl adenovirus (FAdV) strains circulating in commercial broiler and layer flocks in the Southern Marmara and Aegean regions of Türkiye between January and December 2025. Liver samples (n = 120) collected from twelve flocks with increased mortality and clinical signs compatible with adenoviral infection were analyzed. Detection was performed using circular amplification technology and PCR targeting the hexon L1 region, and positive samples were sequenced for molecular characterization. BLAST analysis showed that all isolates belonged to Aviadenovirus hepatitidis and were identified as serotype 8b. Pairwise comparisons showed high nucleotide identity among isolates (97.4–100%) and 98.1–100% similarity with the Turkish reference strain MK937075. Only three isolates displayed nucleotide substitutions, while most sequences were identical within the analyzed region. Amino acid similarity ranged from 95.2% to 100%. Phylogenetic analysis revealed that all isolates clustered within a single monophyletic group together with previously reported Turkish FAdV-8b strains. Necropsy findings included hepatomegaly, multifocal hepatic pallor, petechial hemorrhages, gizzard erosion, and serous pericardial involvement. The detection of genetically closely related isolates across multiple provinces suggests regional circulation of a common viral lineage. These findings demonstrate that FAdV-8b is currently the predominant serotype associated with inclusion body hepatitis outbreaks in this major poultry production area and highlight the importance of molecular surveillance and targeted control strategies, including breeder monitoring and region-specific vaccine development. Full article

The progressive decline in functional β-cell mass in Type 2 Diabetes (T2D) is increasingly recognized not as a simple apoptotic loss, but as a complex erosion of cellular identity termed “dedifferentiation.” Central to this phenotypic shift is the metabolo-epigenetic axis, where mitochondria act as the primary sensing hub, transducing nutrient flux into biochemical signals that govern the chromatin landscape. This review synthesizes current evidence on how mitochondrial metabolites—including Acetyl-CoA, α-ketoglutarate, and NAD+—serve as obligatory co-factors for the epigenetic machinery. We explore how chronic metabolic stress triggers a “Systemic epigenetic destabilization,” leading to the loss of lineage-specific markers and the formation of persistent “metabolic scars.” Furthermore, we discuss the clinical implications of these changes, specifically regarding the phenomenon of metabolic memory and the molecular limits of β-cell reversibility. By integrating foundational transcriptional studies with emerging epigenomic data, we propose that targeting the mitochondrial–epigenetic axis offers a strategic window for re-differentiating failing β-cells and restoring glycemic homeostasis. Full article

Protein-losing enteropathy (PLE) is an uncommon and often underrecognized manifestation of lymphoproliferative disorders and may be difficult to diagnose when conventional gastrointestinal investigations are unrevealing. We present an 82-year-old woman with recurrent hospital admissions initially spanning six months for diarrhea, weight loss, peripheral edema, and persistent hypoalbuminemia. Initial upper gastrointestinal endoscopy was normal, and colonoscopy was deferred due to intercurrent infection. Despite extensive laboratory and radiologic evaluation, including routine biochemical testing and imaging, the etiology of PLE remained unclear. Peripheral blood flow cytometry subsequently identified a small kappa-restricted monoclonal B-cell population compatible with marginal zone lymphoma, later confirmed on bone marrow biopsy, raising suspicion for gastrointestinal involvement. Video capsule enteroscopy demonstrated diffuse erosive and ulcerative disease throughout the small intestine, providing an anatomical explanation for the patient’s protein loss. Following lymphoma-directed therapy, repeat capsule enteroscopy showed complete normalization of the small bowel mucosa. This case highlights the diagnostic value of combining peripheral blood flow cytometry and capsule endoscopy in unexplained protein-losing enteropathy, a rare and diagnostically challenging presentation of indolent lymphoma, and illustrates the role of capsule imaging in both disease localization and treatment monitoring. As a single-case report, these findings are not generalizable, and further studies are required to evaluate the broader applicability of this diagnostic approach. Full article