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38 Results Found

  • Review
  • Open Access
21 Citations
4,461 Views
26 Pages

Paracoccidioidomycosis Diagnosed in Europe—A Systematic Literature Review

  • Gernot Wagner,
  • Deddo Moertl,
  • Anna Glechner,
  • Verena Mayr,
  • Irma Klerings,
  • Casey Zachariah,
  • Miriam Van den Nest,
  • Gerald Gartlehner and
  • Birgit Willinger

23 February 2021

Paracoccidioidomycosis is a systemic mycosis that is endemic in geographical regions of Central and South America. Cases that occur in nonendemic regions of the world are imported through migration and travel. Due to the limited number of cases in Eu...

  • Review
  • Open Access
54 Citations
13,171 Views
21 Pages

Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment

  • Paulo Mendes Peçanha,
  • Paula Massaroni Peçanha-Pietrobom,
  • Tânia Regina Grão-Velloso,
  • Marcos Rosa Júnior,
  • Aloísio Falqueto and
  • Sarah Santos Gonçalves

18 October 2022

Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America caused by thermodimorphic fungi of the genus Paracoccidioides. In the last two decades, enhanced understanding of the phylogenetic species concept and molecular variations ha...

  • Systematic Review
  • Open Access
14 Citations
4,022 Views
11 Pages

Emergomycosis, an Emerging Thermally Dimorphic Fungal Infection: A Systematic Review

  • Kalaiselvi Vinayagamoorthy,
  • Dinesh Reddy Gangavaram,
  • Anna Skiada and
  • Hariprasath Prakash

23 October 2023

Emergomycosis is an endemic mycosis caused by the Emergomyces species. Infections due to this agent have been reported globally. Hence, the present systematic review on Emergomyces infections was conducted to study the disease epidemiology, underlyin...

  • Review
  • Open Access
1 Citations
3,249 Views
23 Pages

Talaromyces marneffei Outside Endemic Regions: An Overlooked Mycosis Under a One-Health Lens

  • Paulo Afonso,
  • Luís Cardoso,
  • Ana Sofia Soares,
  • Manuela Matos,
  • Hélder Quintas and
  • Ana Cláudia Coelho

Talaromyces marneffei is a zoonotic dimorphic pathogen endemic to Southeast Asia and reported in 33 countries, with an estimated 17,300 human cases and 4900 deaths annually. We aimed to identify the best available evidence regarding the epidemiologic...

  • Article
  • Open Access
5 Citations
4,091 Views
20 Pages

Development of a Multiplex qPCR Assay for Fast Detection and Differentiation of Paracoccidioidomycosis Agents

  • Breno Gonçalves Pinheiro,
  • Ana Paula Pôssa,
  • Giannina Ricci,
  • Angela Satie Nishikaku,
  • Ferry Hagen,
  • Rosane Christine Hahn,
  • Zoilo Pires de Camargo and
  • Anderson Messias Rodrigues

15 March 2023

Classic paracoccidioidomycosis (PCM) is a potentially deadly neglected tropical systemic mycosis caused by members of the Paracoccidioides brasiliensis complex (P. brasiliensis s. str., P. americana, P. restrepiensis, and P. venezuelensis) and P. lut...

  • Article
  • Open Access
25 Citations
6,213 Views
36 Pages

Immunoproteomic Analysis Reveals Novel Candidate Antigens for the Diagnosis of Paracoccidioidomycosis Due to Paracoccidioides lutzii

  • Anderson Messias Rodrigues,
  • Paula Helena Kubitschek-Barreira,
  • Breno Gonçalves Pinheiro,
  • André Teixeira-Ferreira,
  • Rosane Christine Hahn and
  • Zoilo Pires de Camargo

11 December 2020

Paracoccidioidomycosis (PCM) is a life-threatening systemic infection caused by the fungal pathogen Paracoccidioides brasiliensis and related species. Whole-genome sequencing and stage-specific proteomic analysis of Paracoccidioides offer the opportu...

  • Review
  • Open Access
36 Citations
6,837 Views
24 Pages

Molecular Tools for Detection and Identification of Paracoccidioides Species: Current Status and Future Perspectives

  • Breno Gonçalves Pinheiro,
  • Rosane Christine Hahn,
  • Zoilo Pires de Camargo and
  • Anderson Messias Rodrigues

18 November 2020

Paracoccidioidomycosis (PCM) is a mycotic disease caused by the Paracoccidioides species, a group of thermally dimorphic fungi that grow in mycelial form at 25 °C and as budding yeasts when cultured at 37 °C or when parasitizing the host tiss...

  • Review
  • Open Access
30 Citations
7,168 Views
26 Pages

Epidemiology of Systemic Mycoses in the COVID-19 Pandemic

  • María Guadalupe Frías-De-León,
  • Rodolfo Pinto-Almazán,
  • Rigoberto Hernández-Castro,
  • Eduardo García-Salazar,
  • Patricia Meza-Meneses,
  • Carmen Rodríguez-Cerdeira,
  • Roberto Arenas,
  • Esther Conde-Cuevas,
  • Gustavo Acosta-Altamirano and
  • Erick Martínez-Herrera

13 July 2021

The physiopathologic characteristics of COVID-19 (high levels of inflammatory cytokines and T-cell reduction) promote fungal colonization and infection, which can go unnoticed because the symptoms in both diseases are very similar. The objective of t...

  • Brief Report
  • Open Access
4 Citations
2,440 Views
8 Pages

Coccidioidomycosis in Immunocompromised at a Non-Endemic Referral Center in Mexico

  • Carla M. Román-Montes,
  • Lisset Seoane-Hernández,
  • Rommel Flores-Miranda,
  • Andrea Carolina Tello-Mercado,
  • Andrea Rangel-Cordero,
  • Rosa Areli Martínez-Gamboa,
  • José Sifuentes-Osornio,
  • Alfredo Ponce-de-León and
  • Fernanda González-Lara

18 June 2024

The incidence and distribution of coccidioidomycosis are increasing. Information scarcity is evident in Mexico, particularly in non-endemic zones and specific populations. We compared the treatment and outcomes for patients with isolated pulmonary in...

  • Article
  • Open Access
679 Views
11 Pages

16 November 2025

Background: Coccidioidomycosis is an endemic fungal infection in the southwestern United States that can present as solitary lung nodules, mimicking malignancy on imaging. Molecular testing, such as PCR, offers rapid diagnosis but its performance in...

  • Case Report
  • Open Access
13 Citations
7,255 Views
6 Pages

Uncommon Clinical Presentations of Sporotrichosis: A Two-Case Report

  • Erick Martínez-Herrera,
  • Roberto Arenas,
  • Rigoberto Hernández-Castro,
  • María Guadalupe Frías-De-León and
  • Carmen Rodríguez-Cerdeira

27 September 2021

Sporotrichosis is a subcutaneous endemic mycosis caused by species of the Sporothrix schenckii complex. The most common clinical form of the disease is lymphocutaneous, while the fixed cutaneous and disseminated cutaneous forms are rare. Moreover, it...

  • Case Report
  • Open Access
7 Citations
3,831 Views
4 Pages

Histoplasma capsulatum is an endemic mycosis with a widespread distribution, although it is infrequently reported in travellers. In April 2018, five television crew members developed an acute febrile illness after filming a documentary about vampire...

  • Review
  • Open Access
20 Citations
5,368 Views
23 Pages

25 April 2022

The ongoing COVID-19 pandemic has quickly become a health threat worldwide, with high mortality and morbidity among patients with comorbidities. This viral infection promotes the perfect setting in patients for the development of opportunistic infect...

  • Review
  • Open Access
146 Citations
16,123 Views
13 Pages

Antifungal Drug Resistance: An Emergent Health Threat

  • Antonio Vitiello,
  • Francesco Ferrara,
  • Mariarosaria Boccellino,
  • Annarita Ponzo,
  • Carla Cimmino,
  • Emilio Comberiati,
  • Andrea Zovi,
  • Salvatore Clemente and
  • Michela Sabbatucci

Fungal infections, named mycosis, can cause severe invasive and systemic diseases that can even lead to death. In recent years, epidemiological data have recorded an increase in cases of severe fungal infections, caused mainly by a growing number of...

  • Article
  • Open Access
21 Citations
3,557 Views
14 Pages

Sporothrix spp. Biofilms Impact in the Zoonotic Transmission Route: Feline Claws Associated Biofilms, Itraconazole Tolerance, and Potential Repurposing for Miltefosine

  • Giulia Maria Pires dos Santos,
  • Luana Pereira Borba-Santos,
  • Taissa Vila,
  • Isabella Dib Ferreira Gremião,
  • Sandro Antonio Pereira,
  • Wanderley De Souza and
  • Sonia Rozental

3 February 2022

Sporotrichosis is the most prevalent subcutaneous mycosis globally, and it is typically caused by direct inoculation of the soil saprophytic fungus Sporothrix spp. into the patients’ skin. However, sporotrichosis has an important zoonotic trans...

  • Review
  • Open Access
78 Citations
18,238 Views
18 Pages

7 May 2021

Human activities have significantly impacted the environment and are changing our climate in ways that will have major consequences for ourselves, and endanger animal, plant and microbial life on Earth. Rising global temperatures and pollution have b...

  • Case Report
  • Open Access
7 Citations
6,708 Views
9 Pages

30 August 2023

Histoplasmosis is an endemic mycosis in the Americas. However, its diagnosis is challenging due to the complexity and limited availability of conventional laboratory techniques—antigen tests, culture, and staining. Microscopic preparations ofte...

  • Article
  • Open Access
6 Citations
3,368 Views
13 Pages

Environmental Screening of Fonsecaea Agents of Chromoblastomycosis Using Rolling Circle Amplification

  • Morgana Ferreira Voidaleski,
  • Renata Rodrigues Gomes,
  • Conceição de Maria Pedrozo e Silva de Azevedo,
  • Bruna Jacomel Favoreto de Souza Lima,
  • Flávia de Fátima Costa,
  • Amanda Bombassaro,
  • Gheniffer Fornari,
  • Isabelle Cristina Lopes da Silva,
  • Lucas Vicente Andrade and
  • Vânia Aparecida Vicente
  • + 3 authors

17 November 2020

Chromoblastomycosis is a chronic, cutaneous or subcutaneous mycosis characterized by the presence of muriform cells in host tissue. Implantation disease is caused by melanized fungi related to black yeasts, which, in humid tropical climates, are main...

  • Article
  • Open Access
9 Citations
2,683 Views
14 Pages

Trends in the Epidemiological and Clinical Profile of Paracoccidioidomycosis in the Endemic Area of Rio de Janeiro, Brazil

  • Eduardo Mastrangelo Marinho Falcão,
  • Dayvison Francis Saraiva Freitas,
  • Ziadir Francisco Coutinho,
  • Leonardo Pereira Quintella,
  • Mauro de Medeiros Muniz,
  • Rodrigo Almeida-Paes,
  • Rosely Maria Zancopé-Oliveira,
  • Priscila Marques de Macedo and
  • Antonio Carlos Francesconi do Valle

20 September 2023

Paracoccidioidomycosis (PCM) is a neglected endemic mycosis in Latin America. Most cases occur in Brazil. It is classified as PCM infection and PCM disease and is subdivided into chronic (adult type) or acute (juvenile type) disease, with the latter...

  • Article
  • Open Access
2,872 Views
12 Pages

Targeting the P10 Peptide in Maturing Dendritic Cells via the DEC205 Receptor In Vivo: A New Therapeutic Strategy against Paracoccidioidomycosis

  • Suelen S. Santos,
  • Eline Rampazo,
  • Carlos P. Taborda,
  • Joshua D. Nosanchuk,
  • Silvia B. Boscardin and
  • Sandro R. Almeida

10 May 2023

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis, a thermally dimorphic fungus, which is the most frequent endemic systemic mycosis in many Latin American countries, where ~10 million people are believed to b...

  • Article
  • Open Access
719 Views
15 Pages

Dendritic Cell-Based Therapeutic Immunization Induces Th1/Th17 Responses and Reduces Fungal Burden in Experimental Sporotrichosis

  • Juliana Aparecida Jellmayer,
  • Adriana Fernandes de Deus,
  • Matheus Ricardo Curti Gonçalves,
  • Lucas Souza Ferreira,
  • Francine Alessandra Manente,
  • Larissa Silva Pinho Caetano,
  • Fernanda Luiza Piccineli,
  • Thais Zamberço dos Reis Genari,
  • Beatriz da Cunha Saçaki and
  • Iracilda Zeppone Carlos
  • + 3 authors

Sporotrichosis is a globally distributed mycosis caused by thermally dimorphic fungi of the Sporothrix schenckii species complex. In Brazil, sporotrichosis is considered endemic and is usually acquired through zoonotic transmission from infected cats...

  • Article
  • Open Access
17 Citations
3,329 Views
11 Pages

Clinical and Eco-Epidemiological Aspects of a Novel Hyperendemic Area of Paracoccidioidomycosis in the Tocantins-Araguaia Basin (Northern Brazil), Caused by Paracoccidioides sp.

  • Alessandra G. Krakhecke-Teixeira,
  • Danielle H. Yamauchi,
  • Alexsandra Rossi,
  • Herdson R. de Sousa,
  • Hans G. Garces,
  • Joaquim L. Júnior,
  • Antônio O. S. Júnior,
  • Maria Sueli S. Felipe,
  • Eduardo Bagagli and
  • Marcus de M. Teixeira
  • + 1 author

12 May 2022

Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Brazil. The disease is caused by dimorphic fungi nested within the Paracoccidioides genus. We described 106 PCM cases (47.1 cases/year) at the Tropical Diseases Public Hospital of...

  • Article
  • Open Access
2,054 Views
14 Pages

Paracoccidioides Species Circulating in the Endemic Area of Rio de Janeiro, Brazil: Updates into Their Genetic Diversity

  • Beatriz da Silva Motta,
  • Fernando Almeida-Silva,
  • Marcus de Melo Teixeira,
  • Andréa Reis Bernardes-Engemann,
  • Rodrigo Almeida-Paes,
  • Priscila Marques de Macedo and
  • Rosely Maria Zancopé-Oliveira

10 February 2025

Paracoccidiodomycosis (PCM) is the most important systemic mycosis in Brazil, and is usually associated with rural work. PCM is caused by inhalation of infective propagules of thermodimorphic fungi from the genus Paracoccidioides. In the past, it was...

  • Case Report
  • Open Access
5 Citations
112 Views

Mandibular Blastomycosis: A Case Report and Review of the Literature

  • Fritzie S. Albarillo,
  • Gotam T. Varma and
  • Stephen P.R. MacLeod

3 December 2018

Introduction: Blastomycosis is an endemic mycosis in the United States known to primarily cause pneumonia. However, dissemination to different organs including the musculoskeletal system has been described. Case report: We report a case of mandibula...

  • Review
  • Open Access
88 Citations
10,407 Views
23 Pages

Sporotrichosis In Immunocompromised Hosts

  • Flavio Queiroz-Telles,
  • Renata Buccheri and
  • Gil Benard

11 January 2019

Sporotrichosis is a global implantation or subcutaneous mycosis caused by several members of the genus Sporothrix, a thermo-dimorphic fungus. This disease may also depict an endemic profile, especially in tropical to subtropical zones around the worl...

  • Review
  • Open Access
27 Citations
12,708 Views
16 Pages

Blastomycosis—Some Progress but Still Much to Learn

  • Matthew F. Pullen,
  • Jonathan D. Alpern and
  • Nathan C. Bahr

7 August 2022

Blastomycosis, caused by Blastomyces spp., is an endemic mycosis capable of causing significant disease throughout the body. Higher rates of infection are seen in the Mississippi and Ohio River valleys, the Great Lakes region of the United States and...

  • Article
  • Open Access
2,932 Views
14 Pages

Prospective Uncontrolled Interventional Study of Itraconazole and β-Glucans (Euglena gracilis) to Assess Safeness and Clinical Effectiveness in Cats with Cutaneous and Mucosal Sporotrichosis

  • André Felipe Pedrazzi Chacon,
  • Anna Barreto Fernandes Figueiredo,
  • Jéssica Sepulveda Boechat,
  • Erica Guerino Reis,
  • Cindy Caroline dos Santos Honorato,
  • Maria Lopes Corrêa,
  • Sandro Antonio Pereira and
  • Isabella Dib Ferreira Gremião

28 August 2025

Brazil is an endemic region for both human and feline sporotrichosis, with Sporothrix brasiliensis being the main etiological agent. Currently, few effective antifungal agents are available for treating this mycosis in cats, and therapeutic studies r...

  • Review
  • Open Access
34 Citations
6,060 Views
22 Pages

Histoplasmosis Diagnosed in Europe and Israel: A Case Report and Systematic Review of the Literature from 2005 to 2020

  • Spinello Antinori,
  • Andrea Giacomelli,
  • Mario Corbellino,
  • Alessandro Torre,
  • Marco Schiuma,
  • Giacomo Casalini,
  • Carlo Parravicini,
  • Laura Milazzo,
  • Cristina Gervasoni and
  • Anna Lisa Ridolfo

14 June 2021

Human histoplasmosis is a mycosis caused by two distinct varieties of a dimorphic fungus: Histoplasma capsulatum var. capsulatum and H. capsulatum var. duboisii. In Europe, it is usually imported by migrants and travellers, although there have been s...

  • Article
  • Open Access
13 Citations
3,686 Views
14 Pages

Protective Response in Experimental Paracoccidioidomycosis Elicited by Extracellular Vesicles Containing Antigens of Paracoccidioides brasiliensis

  • Ludmila Matos Baltazar,
  • Gabriela Fior Ribeiro,
  • Gustavo J. Freitas,
  • Celso Martins Queiroz-Junior,
  • Caio Tavares Fagundes,
  • Carlos Chaves-Olórtegui,
  • Mauro Martins Teixeira and
  • Daniele G. Souza

17 July 2021

Paracoccidioidomycosis (PCM) is a systemic disease caused by Paracoccidioides spp. PCM is endemic in Latin America and most cases are registered in Brazil. This mycosis affects mainly the lungs, but can also spread to other tissues and organs, includ...

  • Review
  • Open Access
40 Citations
7,683 Views
11 Pages

Paracoccidioidomycosis in Immunocompromised Patients: A Literature Review

  • João N. De Almeida Jr.,
  • Paula M. Peçanha-Pietrobom and
  • Arnaldo L. Colombo

26 December 2018

Paracoccidioidomycosis (PCM) is an endemic mycosis found in Latin America that causes systemic disease mostly in immunocompetent hosts. A small percentage of PCM occurs in immunocompromised patients where low clinical suspicion of the infection, late...

  • Article
  • Open Access
980 Views
36 Pages

Current Insights into Sporothrix schenckii: From Basic Biology to Virulence Mechanisms

  • Manuela Gómez-Gaviria,
  • Dario A. Baruch-Martínez,
  • Nathália Faria Reis,
  • Andréa Regina de Souza Baptista and
  • Héctor M. Mora-Montes

20 December 2025

Sporothrix schenckii is a thermodimorphic fungus and one of the main etiological agents of sporotrichosis, a globally distributed subcutaneous mycosis that primarily affects the skin, subcutaneous tissue, and lymphatic system. Historically regarded a...

  • Article
  • Open Access
3 Citations
2,444 Views
22 Pages

Proteomics of Paracoccidioides lutzii: Overview of Changes Triggered by Nitrogen Catabolite Repression

  • Vanessa Rafaela Milhomem Cruz-Leite,
  • André Luís Elias Moreira,
  • Lana O’Hara Souza Silva,
  • Moises Morais Inácio,
  • Juliana Alves Parente-Rocha,
  • Orville Hernandez Ruiz,
  • Simone Schneider Weber,
  • Célia Maria de Almeida Soares and
  • Clayton Luiz Borges

12 November 2023

Members of the Paracoccidioides complex are the causative agents of Paracoccidioidomycosis (PCM), a human systemic mycosis endemic in Latin America. Upon initial contact with the host, the pathogen needs to uptake micronutrients. Nitrogen is an essen...

  • Article
  • Open Access
16 Citations
3,755 Views
11 Pages

Performance of Two Commercial Assays for the Detection of Serum Aspergillus Galactomannan in Non-Neutropenic Patients

  • Rodrigo Almeida-Paes,
  • Marcos de Abreu Almeida,
  • Priscila Marques de Macedo,
  • Diego H. Caceres and
  • Rosely Maria Zancopé-Oliveira

18 July 2022

Besides the relevance of aspergillosis in neutropenic patients, this mycosis has gained significance among non-neutropenic patients in last years. The detection of Aspergillus galactomannan has been used for aspergillosis diagnosis and follow-up in n...

  • Article
  • Open Access
12 Citations
3,330 Views
10 Pages

Indoor Dust as a Source of Virulent Strains of the Agents of Cryptococcosis in the Rio Negro Micro-Region of the Brazilian Amazon

  • Fábio Brito-Santos,
  • Luciana Trilles,
  • Carolina Firacative,
  • Bodo Wanke,
  • Filipe Anibal Carvalho-Costa,
  • Marília Martins Nishikawa,
  • Jonas Pereira Campos,
  • Angela Cristina Veríssimo Junqueira,
  • Amanda Coutinho de Souza and
  • Wieland Meyer
  • + 1 author

Cryptococcosis, a potentially fatal mycosis in humans, is acquired via exposure to exogenous environmental sources. This study aimed to investigate the frequency, genetic diversity, and virulence of cryptococcal strains isolated from indoor dust in t...

  • Article
  • Open Access
3 Citations
3,039 Views
22 Pages

Drk1, a Dimorphism Histidine Kinase, Contributes to Morphology, Virulence, and Stress Adaptation in Paracoccidioides brasiliensis

  • Caroline Maria Marcos,
  • Haroldo Cesar de Oliveira,
  • Patrícia Akemi Assato,
  • Rafael Fernando Castelli,
  • Ana Marisa Fusco-Almeida and
  • Maria José Soares Mendes-Giannini

12 October 2021

P. brasiliensis is a thermally dimorphic fungus belonging to Paracoccidioides complex, causative of a systemic, endemic mycosis limited to Latin American countries. Signal transduction pathways related to important aspects as surviving, proliferation...

  • Article
  • Open Access
2 Citations
2,196 Views
13 Pages

Molecular Phylogenetic Analysis of Paracoccidioides Species Complex Present in Paracoccidioidomycosis Patient Tissue Samples

  • Luciana Bonome Zeminian de Oliveira,
  • Amanda Manoel Della Coletta,
  • Taiane Priscila Gardizani,
  • Hans Garcia Garces,
  • Eduardo Bagagli,
  • Luciana Trilles,
  • Ligia Vizeu Barrozo,
  • Sílvio de Alencar Marques,
  • Julio De Faveri and
  • Luciane Alarcão Dias-Melicio

Paracoccidioidomycosis (PCM) is the main and most prevalent systemic mycosis in Latin America, that until recently, it was believed to be caused only by Paracoccidioides brasiliensis (P. brasiliensis). In 2006, researchers described three cryptic spe...

  • Article
  • Open Access
1,081 Views
17 Pages

Acidic pH Modulates Cell Wall and Melanization in Paracoccidioides brasiliensis, Affecting Macrophage Interaction

  • Rafael de Souza Silva,
  • Wilson Dias Segura,
  • Rogéria Cristina Zauli,
  • Reinaldo Souza Oliveira,
  • Vitor Vidal,
  • Eduardo Correa Louvandini,
  • Patricia Xander,
  • Suzan Pantaroto Vasconcellos and
  • Wagner Luiz Batista

4 July 2025

Paracoccidioides brasiliensis is a thermally dimorphic fungal pathogen and the main etiological agent of paracoccidioidomycosis (PCM), a neglected systemic mycosis endemic in Latin America. The virulence of P. brasiliensis is closely associated with...

  • Article
  • Open Access
16 Citations
4,672 Views
12 Pages

Repeated Exposition to Mercury (II) Chloride Enhances Susceptibility to S. schenckii sensu stricto Infection in Mice

  • Alexander Batista-Duharte,
  • Damiana Téllez-Martínez,
  • Juliana Aparecida Jellmayer,
  • Deivys Leandro Portuondo Fuentes,
  • Marisa Campos Polesi,
  • Amanda Martins Baviera and
  • Iracilda Zeppone Carlos

25 May 2018

Sporotrichosis is a subcutaneous mycosis that has re-emerged in several tropical and subtropical regions over the last decades. Growing findings suggest that the interplay of host, pathogen, and environment has a determinant effect on the diversity,...