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30 pages, 2099 KiB  
Article
SABE-YOLO: Structure-Aware and Boundary-Enhanced YOLO for Weld Seam Instance Segmentation
by Rui Wen, Wu Xie, Yong Fan and Lanlan Shen
J. Imaging 2025, 11(8), 262; https://doi.org/10.3390/jimaging11080262 (registering DOI) - 6 Aug 2025
Abstract
Accurate weld seam recognition is essential in automated welding systems, as it directly affects path planning and welding quality. With the rapid advancement of industrial vision, weld seam instance segmentation has emerged as a prominent research focus in both academia and industry. However, [...] Read more.
Accurate weld seam recognition is essential in automated welding systems, as it directly affects path planning and welding quality. With the rapid advancement of industrial vision, weld seam instance segmentation has emerged as a prominent research focus in both academia and industry. However, existing approaches still face significant challenges in boundary perception and structural representation. Due to the inherently elongated shapes, complex geometries, and blurred edges of weld seams, current segmentation models often struggle to maintain high accuracy in practical applications. To address this issue, a novel structure-aware and boundary-enhanced YOLO (SABE-YOLO) is proposed for weld seam instance segmentation. First, a Structure-Aware Fusion Module (SAFM) is designed to enhance structural feature representation through strip pooling attention and element-wise multiplicative fusion, targeting the difficulty in extracting elongated and complex features. Second, a C2f-based Boundary-Enhanced Aggregation Module (C2f-BEAM) is constructed to improve edge feature sensitivity by integrating multi-scale boundary detail extraction, feature aggregation, and attention mechanisms. Finally, the inner minimum point distance-based intersection over union (Inner-MPDIoU) is introduced to improve localization accuracy for weld seam regions. Experimental results on the self-built weld seam image dataset show that SABE-YOLO outperforms YOLOv8n-Seg by 3 percentage points in the AP(50–95) metric, reaching 46.3%. Meanwhile, it maintains a low computational cost (18.3 GFLOPs) and a small number of parameters (6.6M), while achieving an inference speed of 127 FPS, demonstrating a favorable trade-off between segmentation accuracy and computational efficiency. The proposed method provides an effective solution for high-precision visual perception of complex weld seam structures and demonstrates strong potential for industrial application. Full article
(This article belongs to the Section Image and Video Processing)
13 pages, 224 KiB  
Review
Cultural, Religious, and Spiritual Influences on Communication in Pediatric Palliative Care: A Narrative Review Focused on Children with Severe Neurological Conditions
by Francesca Benedetti, Luca Giacomelli, Simonetta Papa, Viviana Verzeletti and Caterina Agosto
Children 2025, 12(8), 1033; https://doi.org/10.3390/children12081033 (registering DOI) - 6 Aug 2025
Abstract
Pediatric palliative care (PPC) aims to enhance the quality of life of children with life-limiting conditions and their families through individualized, interdisciplinary support. Among this population, children with neurological diseases represent a substantial and growing group, often facing prolonged disease courses, cognitive impairment, [...] Read more.
Pediatric palliative care (PPC) aims to enhance the quality of life of children with life-limiting conditions and their families through individualized, interdisciplinary support. Among this population, children with neurological diseases represent a substantial and growing group, often facing prolonged disease courses, cognitive impairment, and high prognostic uncertainty. Effective communication is central to PPC; however, it remains deeply influenced by cultural, religious, and spiritual frameworks that shape family perceptions of illness, suffering, and decision-making. This narrative review explores communication strategies in PPC, with a specific focus on children with neurological conditions, highlighting conceptual foundations, cross-cultural variations, and emerging best practices. Key findings highlight the importance of culturally humble approaches, family-centered communication models, and structured tools, such as co-designed advance care planning and dignity therapy, to enhance communication. Additionally, the review highlights the presence of ethical and interdisciplinary challenges, particularly in neonatal and neurology settings, where misaligned team messaging and institutional hesitancy may compromise trust and timely referral to palliative care. Future research, policy, and clinical education priorities should advocate for models that are inclusive, ethically grounded, and tailored to the unique trajectories of neurologically ill children. Integrating cultural competence, team alignment, and family voices is essential for delivering equitable and compassionate PPC across diverse care settings. Full article
(This article belongs to the Special Issue Pediatric Palliative Care and Pain Management)
22 pages, 10285 KiB  
Article
Biophysical and Social Constraints of Restoring Ecosystem Services in the Border Regions of Tibet, China
by Lizhi Jia, Silin Liu, Xinjie Zha and Ting Hua
Land 2025, 14(8), 1601; https://doi.org/10.3390/land14081601 (registering DOI) - 6 Aug 2025
Abstract
Ecosystem restoration represents a promising solution for enhancing ecosystem services and environmental sustainability. However, border regions—characterized by ecological fragility and geopolitical complexity—remain underrepresented in ecosystem service and restoration research. To fill this gap, we coupled spatially explicit models (e.g., InVEST and RUSLE) with [...] Read more.
Ecosystem restoration represents a promising solution for enhancing ecosystem services and environmental sustainability. However, border regions—characterized by ecological fragility and geopolitical complexity—remain underrepresented in ecosystem service and restoration research. To fill this gap, we coupled spatially explicit models (e.g., InVEST and RUSLE) with scenario analysis to quantify the ecosystem service potential that could be achieved in China’s Tibetan borderlands under two interacting agendas: ecological restoration and border-strengthening policies. Restoration feasibility was evaluated through combining local biophysical constraints, economic viability (via restoration-induced carbon gains vs. opportunity costs), operational practicality, and simulated infrastructure expansion. The results showed that per-unit-area ecosystem services in border counties (particularly Medog, Cona, and Zayu) exceed that of interior Tibet by a factor of two to four. Combining these various constraints, approximately 4–17% of the border zone remains cost-effective for grassland or forest restoration. Under low carbon pricing (US$10 t−1 CO2), the carbon revenue generated through restoration is insufficient to offset the opportunity cost of agricultural production, constituting a major constraint. Habitat quality, soil conservation, and carbon sequestration increase modestly when induced by restoration, but a pronounced carbon–water trade-off emerges. Planned infrastructure reduces restoration benefits only slightly, whereas raising the carbon price to about US$50 t−1 CO2 substantially expands such benefits. These findings highlight both the opportunities and limits of ecosystem restoration in border regions and point to carbon pricing as the key policy lever for unlocking cost-effective restoration. Full article
(This article belongs to the Special Issue The Role of Land Policy in Shaping Rural Development Outcomes)
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26 pages, 2126 KiB  
Systematic Review
Interlinking Urban Sustainability, Circular Economy and Complexity: A Systematic Literature Review
by Walter Antonio Abujder Ochoa, Angela Gabriela Torrico Arce, Alfredo Iarozinski Neto, Mayara Regina Munaro, Oriana Palma Calabokis and Vladimir A. Ballesteros-Ballesteros
Sustainability 2025, 17(15), 7118; https://doi.org/10.3390/su17157118 - 6 Aug 2025
Abstract
Urban sustainability challenges demand integrated frameworks capable of addressing the dynamic, non-linear nature of cities. This study explores how the principles of the circular economy and complexity theory intersect to support systemic transformation in sustainable urban planning. Through a systematic literature review of [...] Read more.
Urban sustainability challenges demand integrated frameworks capable of addressing the dynamic, non-linear nature of cities. This study explores how the principles of the circular economy and complexity theory intersect to support systemic transformation in sustainable urban planning. Through a systematic literature review of 71 peer-reviewed articles published between 2015 and 2025, we analyze conceptual, methodological, and practical articulations across multiple thematic axes, including circular governance, urban metabolism, regenerative design, adaptive planning, digital integration, and environmental justice. Bibliometric and content analyses were conducted using Scopus metadata, VOSviewer for thematic clustering, and the StArt software (Version 3.4) to structure article selection. The findings reveal that circular economy provides practical tools for resource efficiency and regeneration, while complexity theory offers an adaptive framework to navigate uncertainty, emergent behaviors, and feedback dynamics. The synthesis suggests that their integration enables a more holistic and resilient approach to urban transformation. However, gaps remain in social inclusivity, long-term assessment, and the operationalization of complexity-informed planning. This study contributes to advancing a transdisciplinary agenda for circular and adaptive urban futures, offering insights for scholars, planners, and policymakers aiming to reconfigure cities within planetary boundaries. Full article
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22 pages, 518 KiB  
Article
Staying or Leaving a Shrinking City: Migration Intentions of Creative Youth in Erzurum, Eastern Türkiye
by Defne Dursun and Doğan Dursun
Sustainability 2025, 17(15), 7109; https://doi.org/10.3390/su17157109 - 6 Aug 2025
Abstract
This study explores the migration intentions of university students—representing the potential creative class—in Erzurum, a medium-sized city in eastern Turkey experiencing shrinkage. Within the theoretical framework of shrinking cities, it investigates how economic, social, physical, and personal factors influence students’ post-graduation stay or [...] Read more.
This study explores the migration intentions of university students—representing the potential creative class—in Erzurum, a medium-sized city in eastern Turkey experiencing shrinkage. Within the theoretical framework of shrinking cities, it investigates how economic, social, physical, and personal factors influence students’ post-graduation stay or leave decisions. Survey data from 742 Architecture and Fine Arts students at Atatürk University were analyzed using factor analysis, logistic regression, and correlation to identify key migration drivers. Findings reveal that, in addition to economic concerns such as limited job opportunities and low income, personal development opportunities and social engagement also play a decisive role. In particular, the perception of limited chances for skill enhancement and the belief that Erzurum is not a good place to meet people emerged as the strongest predictors of migration intentions. These results suggest that members of the creative class are influenced not only by economic incentives but also by broader urban experiences related to self-growth and social connectivity. This study highlights spatial inequalities in access to cultural, educational, and social infrastructure, raising important questions about spatial justice in shrinking urban contexts. This paper contributes to the literature on shrinking cities by highlighting creative youth in mid-sized Global South cities. It suggests smart shrinkage strategies focused on creative sector development, improved quality of life, and inclusive planning to retain young talent and support sustainable urban revitalization. Full article
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28 pages, 10144 KiB  
Article
Decoding the Spatial–Temporal Coupling Dynamics of Land Use Intensity and Balance in China’s Chengdu–Chongqing Economic Circle: A 1 km Grid-Based Analysis
by Zijia Yan, Chenxi Zhou, Ziyi Tang, Hanfei Wang and Hao Li
Land 2025, 14(8), 1597; https://doi.org/10.3390/land14081597 - 5 Aug 2025
Abstract
Amid China’s national strategic prioritization of the Chengdu–Chongqing Economic Circle and accelerated territorial spatial planning, this study deciphered the synergistic evolution of Land Use Intensity (LUI) and Balance Degree of Land Use Structure (BDLUS) during rapid urbanization. Leveraging 1 km grid units and [...] Read more.
Amid China’s national strategic prioritization of the Chengdu–Chongqing Economic Circle and accelerated territorial spatial planning, this study deciphered the synergistic evolution of Land Use Intensity (LUI) and Balance Degree of Land Use Structure (BDLUS) during rapid urbanization. Leveraging 1 km grid units and integrating emerging spatiotemporal hotspot analysis, BFAST, and geographic detectors, we systematically analyzed spatiotemporal patterns and drivers of LUI, BDLUS, and their Coupling Coordination Degree (CCD) from 2000 to 2022. Key findings: (1) LUI strongly correlated with economic growth, with core areas reaching high-intensity development (average > 2.96) versus ecologically constrained marginal zones (<2.42), marked by abrupt changes during 2011–2014; (2) BDLUS improvements covered 82.22% of the study area, driven by the Yangtze River Economic Belt strategy (21.96% hotspot concentration), yet structural imbalance persisted in transitional zones (18.81% cold spots); (3) CCD exhibited center-edge dichotomy, contrasting high-value cores (CCD > 0.68) with ecologically sensitive edges (9.80% cold spots), peaking in regulatory shifts around 2010; (4) terrain constraints and intensified human activities (the interaction effect between nighttime lighting and population density increased by 219.49% after 2020) jointly governed coupling mechanisms, with urbanization and industrial transition becoming dominant drivers. This research advances an “intensity–structure–coordination” framework and elucidates “dual-core resonance” dynamics, offering theoretical foundations for spatial optimization and ecological civilization. Full article
(This article belongs to the Special Issue Integration of Remote Sensing and GIS for Land Use Change Assessment)
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35 pages, 4098 KiB  
Article
Prediction of Earthquake Death Toll Based on Principal Component Analysis, Improved Whale Optimization Algorithm, and Extreme Gradient Boosting
by Chenhui Wang, Xiaotao Zhang, Xiaoshan Wang and Guoping Chang
Appl. Sci. 2025, 15(15), 8660; https://doi.org/10.3390/app15158660 (registering DOI) - 5 Aug 2025
Abstract
Earthquakes, as one of the most destructive natural disasters, often cause significant casualties and severe economic losses. Accurate prediction of earthquake fatalities is of great importance for pre-disaster prevention and mitigation planning, as well as post-disaster emergency response deployment. To address the challenges [...] Read more.
Earthquakes, as one of the most destructive natural disasters, often cause significant casualties and severe economic losses. Accurate prediction of earthquake fatalities is of great importance for pre-disaster prevention and mitigation planning, as well as post-disaster emergency response deployment. To address the challenges of small sample sizes, high dimensionality, and strong nonlinearity in earthquake fatality prediction, this paper proposes an integrated modeling approach (PCA-IWOA-XGBoost) combining Principal Component Analysis (PCA), the Improved Whale Optimization Algorithm (IWOA), and Extreme Gradient Boosting (XGBoost). The method first employs PCA to reduce the dimensionality of the influencing factor data, eliminating redundant information and improving modeling efficiency. Subsequently, the IWOA is used to intelligently optimize key hyperparameters of the XGBoost model, enhancing the prediction accuracy and stability. Using 42 major earthquake events in China from 1970 to 2025 as a case study, covering regions including the west (e.g., Tonghai in Yunnan, Wenchuan, Jiuzhaigou), central (e.g., Lushan in Sichuan, Ya’an), east (e.g., Tangshan, Yingkou), north (e.g., Baotou in Inner Mongolia, Helinger), northwest (e.g., Jiashi in Xinjiang, Wushi, Yongdeng in Gansu), and southwest (e.g., Lancang in Yunnan, Lijiang, Ludian), the empirical results showed that the PCA-IWOA-XGBoost model achieved an average test set accuracy of 97.0%, a coefficient of determination (R2) of 0.996, a root mean square error (RMSE) and mean absolute error (MAE) reduced to 4.410 and 3.430, respectively, and a residual prediction deviation (RPD) of 21.090. These results significantly outperformed the baseline XGBoost, PCA-XGBoost, and IWOA-XGBoost models, providing improved technical support for earthquake disaster risk assessment and emergency response. Full article
(This article belongs to the Section Earth Sciences)
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24 pages, 1464 KiB  
Review
An Overview of the Italian Roadmap for the Implementation of Circular Economy in the Energy Transition of Buildings
by Marilena De Simone and Daniele Campagna
Buildings 2025, 15(15), 2755; https://doi.org/10.3390/buildings15152755 - 5 Aug 2025
Abstract
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy [...] Read more.
An important task for the European Union is to transpose agreements and international standards in regulation and directives that are binding on member states. The resultant European action plans and directives identify priority areas in the building and energy sectors where circular economy principles can be applied. Italy records a general circular materials rate of 20.8%, surpassing the mean European value. But low recycling rates are still registered in the construction sector. This paper aims to assess the position of Italy with respect to the European regulatory framework on circularity in the energy transition of buildings. Firstly, the government’s initiatives and technical standards are introduced and commented upon. Secondly, the study illustrates the current Italian platforms, networks, and public and private initiatives highlighting opportunities and obstacles that the energy sector has to overcome in the area of circularity. It emerges that Italian policies still use voluntary tools that are not sufficiently in line with an effective circular economy model. Moreover, data collection plays a crucial role in accelerating the implementation of future actions. Italy should consider the foundation of a National Observatory for the Circular Economy to elaborate European directives, harmonize regional policies, and promote the implementation of effective practices. Full article
(This article belongs to the Special Issue Research on Sustainable Energy Performance of Green Buildings)
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20 pages, 10605 KiB  
Article
Network Analysis of Outcome-Based Education Curriculum System: A Case Study of Environmental Design Programs in Medium-Sized Cities
by Yang Wang, Zixiao Zhan and Honglin Wang
Sustainability 2025, 17(15), 7091; https://doi.org/10.3390/su17157091 - 5 Aug 2025
Abstract
With deepening global higher education reforms, outcome-based education has emerged as the core paradigm for teaching model innovation. This study investigates the structural dependencies and teaching effectiveness of the Environmental Design curriculum at Hubei Engineering University in medium-sized cities, China, addressing challenges of [...] Read more.
With deepening global higher education reforms, outcome-based education has emerged as the core paradigm for teaching model innovation. This study investigates the structural dependencies and teaching effectiveness of the Environmental Design curriculum at Hubei Engineering University in medium-sized cities, China, addressing challenges of enrollment decline and market contraction critical for urban sustainability. Using network analysis, we construct curriculum support and contribution networks and course temporal networks to assess structural dependencies and teaching effectiveness, revealing structural patterns and optimizing the OBE-based Environmental Design curriculum to enhance educational quality and student competencies. Analysis reveals computer basic courses as knowledge transmission hubs, creating a course network with a distinct core–periphery structure. Technical course reforms significantly outperform theoretical course reforms in improving student performance metrics, such as higher average scores, better grade distributions, and reduced performance gaps, while innovative practice courses show peripheral isolation patterns, indicating limited connectivity with core curriculum modules, which reduces their educational impact. These findings provide empirical insights for curriculum optimization, supporting urban sustainable development through enhanced professional talent cultivation equipped to address environmental challenges like sustainable design practices and resource-efficient urban planning. Network analysis applications introduce innovative frameworks for curriculum reform strategies. Future research expansion through larger sample validation will support urban sustainable development goals and enhance professional talent cultivation outcomes. Full article
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31 pages, 8580 KiB  
Article
TSA-GRU: A Novel Hybrid Deep Learning Module for Learner Behavior Analytics in MOOCs
by Soundes Oumaima Boufaida, Abdelmadjid Benmachiche, Makhlouf Derdour, Majda Maatallah, Moustafa Sadek Kahil and Mohamed Chahine Ghanem
Future Internet 2025, 17(8), 355; https://doi.org/10.3390/fi17080355 - 5 Aug 2025
Abstract
E-Learning is an emerging dominant phenomenon in education, making the development of robust models that can accurately represent the dynamic behavior of learners in MOOCs even more critical. In this article, we propose the Temporal Sparse Attention-Gated Recurrent Unit (TSA-GRU), a novel deep [...] Read more.
E-Learning is an emerging dominant phenomenon in education, making the development of robust models that can accurately represent the dynamic behavior of learners in MOOCs even more critical. In this article, we propose the Temporal Sparse Attention-Gated Recurrent Unit (TSA-GRU), a novel deep learning framework that combines TSA with a sequential encoder based on the GRU. This hybrid model effectively reconstructs student response times and learning trajectories with high fidelity by leveraging tthe emporal embeddings of instructional and feedback activities. By dynamically filtering noise from student interactions, TSA-GRU generates context-aware representations that seamlessly integrate both short-term fluctuations and long-term learning patterns. Empirical evaluation on the 2009–2010 ASSISTments dataset demonstrates that TSA-GRU achieved a test accuracy of 95.60% and a test loss of 0.0209, outperforming Modular Sparse Attention-Gated Recurrent Unit (MSA-GRU), Bayesian Knowledge Tracing (BKT), Performance Factors Analysis (PFA), and TSA in the same experimental design. TSA-GRU converged in five training epochs; thus, while TSA-GRU is demonstrated to have strong predictive performance for knowledge tracing tasks, these findings are specific to the conducted dataset and should not be implicitly regarded as conclusive for all data. More statistical validation through five-fold cross-validation, confidence intervals, and paired t-tests have confirmed the robustness, consistency, and statistically significant superiority of TSA-GRU over the baseline model MSA-GRU. TSA-GRU’s scalability and capacity to incorporate a temporal dimension of knowledge can make it acceptably well-positioned to analyze complex learner behaviors and plan interventions for adaptive learning in computerized learning systems. Full article
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22 pages, 6305 KiB  
Article
TOPSIS and AHP-Based Multi-Criteria Decision-Making Approach for Evaluating Redevelopment in Old Residential Projects
by Cheolheung Park, Minwook Son, Jongmyeong Kim, Byeol Kim, Yonghan Ahn and Nahyun Kwon
Sustainability 2025, 17(15), 7072; https://doi.org/10.3390/su17157072 - 4 Aug 2025
Abstract
This research aims to identify and prioritize key planning elements for the redevelopment of such housing complexes by incorporating perspectives from both experts (supply-side) and residents (demand-side). To achieve this, a hybrid multi-criteria decision-making framework was developed by integrating the Analytic Hierarchy Process [...] Read more.
This research aims to identify and prioritize key planning elements for the redevelopment of such housing complexes by incorporating perspectives from both experts (supply-side) and residents (demand-side). To achieve this, a hybrid multi-criteria decision-making framework was developed by integrating the Analytic Hierarchy Process (AHP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). A total of 25 planning elements were identified through Focus Group Interviews and organized into five domains: legal and institutional reforms, project feasibility, residential conditions, social integration, and complex design. The AHP was used to assess the relative importance of each element based on responses from 30 experts and 130 residents. The analysis revealed a clear divergence in priorities: experts emphasized feasibility and regulatory considerations, while residents prioritized livability and spatial quality. Subsequently, the TOPSIS method was applied to evaluate four real-world redevelopment cases. From the supply-side perspective, Seoul A District received the highest score (0.58), whereas from the demand-side perspective, Gyeonggi D District ranked highest (0.69), illustrating the differing priorities of stakeholders. Overall, Gyeonggi D District emerged as the most favorable option in the combined evaluation. This research contributes a structured and inclusive decision-making framework for the regeneration of public housing. By explicitly comparing and quantifying the contrasting preferences of key stakeholders, it underscores the critical need to balance technical feasibility with resident-centered values in future redevelopment initiatives. Full article
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37 pages, 1202 KiB  
Article
Exploring Service Needs and Development Strategies for the Healthcare Tourism Industry Through the APA-NRM Technique
by Chung-Ling Kuo and Chia-Li Lin
Sustainability 2025, 17(15), 7068; https://doi.org/10.3390/su17157068 - 4 Aug 2025
Abstract
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism [...] Read more.
With the arrival of an aging society and the continuous extension of the human lifespan, the quality of life has not improved in a corresponding manner. People’s demand for happiness and health is increasing. As a result, a model emerged that integrates tourism and medical services, which is health tourism. This growing demand has prompted many service providers to see it as a business opportunity and enter the market. Tourism can help travelers release work stress and restore physical and mental balance; meanwhile, health check-ups and disease treatment can help them regain health. Consumers have long favored health and medical tourism because it helps relieve stress and promotes overall well-being. As people age, some consumers experience a gradual decline in physical functions, making it difficult for them to participate in regular travel services provided by traditional travel agencies. Therefore, this study aims to explore the service needs of health and medical tourism customers (tourists/patients) and the interrelationships among these service needs, so that health and medical tourism service providers can develop more customized and diversified services. This study identifies four key drivers of medical tourism services: medical services, medical facilities, tour planning, and hospitality facilities. This study uses the APA (attention and performance analysis) method to assess each dimension and criterion and utilizes the DEMATEL method with the NRM (network relationship map) to identify network relationships. By combining APA and NRM techniques, this study develops the APA-NRM technique to evaluate adoption strategies and identify suitable paths for health tourism services, providing tailored development strategies and recommendations for service providers to enhance the service experience. Full article
(This article belongs to the Special Issue Inclusive Tourism and Its Place in Sustainable Development Concepts)
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12 pages, 278 KiB  
Article
A Series of Severe and Critical COVID-19 Cases in Hospitalized, Unvaccinated Children: Clinical Findings and Hospital Care
by Vânia Chagas da Costa, Ulisses Ramos Montarroyos, Katiuscia Araújo de Miranda Lopes and Ana Célia Oliveira dos Santos
Epidemiologia 2025, 6(3), 40; https://doi.org/10.3390/epidemiologia6030040 - 4 Aug 2025
Abstract
Background/Objective: The COVID-19 pandemic profoundly transformed social life worldwide, indiscriminately affecting individuals across all age groups. Children have not been exempted from the risk of severe illness and death caused by COVID-19. Objective: This paper sought to describe the clinical findings, laboratory and [...] Read more.
Background/Objective: The COVID-19 pandemic profoundly transformed social life worldwide, indiscriminately affecting individuals across all age groups. Children have not been exempted from the risk of severe illness and death caused by COVID-19. Objective: This paper sought to describe the clinical findings, laboratory and imaging results, and hospital care provided for severe and critical cases of COVID-19 in unvaccinated children, with or without severe asthma, hospitalized in a public referral service for COVID-19 treatment in the Brazilian state of Pernambuco. Methods: This was a case series study of severe and critical COVID-19 in hospitalized, unvaccinated children, with or without severe asthma, conducted in a public referral hospital between March 2020 and June 2021. Results: The case series included 80 children, aged from 1 month to 11 years, with the highest frequency among those under 2 years old (58.8%) and a predominance of males (65%). Respiratory diseases, including severe asthma, were present in 73.8% of the cases. Pediatric multisystem inflammatory syndrome occurred in 15% of the children, some of whom presented with cardiac involvement. Oxygen therapy was required in 65% of the cases, mechanical ventilation in 15%, and 33.7% of the children required intensive care in a pediatric intensive care unit. Pulmonary infiltrates and ground-glass opacities were common findings on chest X-rays and CT scans; inflammatory markers were elevated, and the most commonly used medications were antibiotics, bronchodilators, and corticosteroids. Conclusions: This case series has identified key characteristics of children with severe and critical COVID-19 during a period when vaccines were not yet available in Brazil for the study age group. However, the persistence of low vaccination coverage, largely due to parental vaccine hesitancy, continues to leave children vulnerable to potentially severe illness from COVID-19. These findings may inform the development of public health emergency contingency plans, as well as clinical protocols and care pathways, which can guide decision-making in pediatric care and ensure appropriate clinical management, ultimately improving the quality of care provided. Full article
21 pages, 1369 KiB  
Article
Optimizing Cold Food Supply Chains for Enhanced Food Availability Under Climate Variability
by David Hernandez-Cuellar, Krystel K. Castillo-Villar and Fernando Rey Castillo-Villar
Foods 2025, 14(15), 2725; https://doi.org/10.3390/foods14152725 - 4 Aug 2025
Viewed by 27
Abstract
Produce supply chains play a critical role in ensuring fruits and vegetables reach consumers efficiently, affordably, and at optimal freshness. In recent decades, hub-and-spoke network models have emerged as valuable tools for optimizing sustainable cold food supply chains. Traditional optimization efforts typically focus [...] Read more.
Produce supply chains play a critical role in ensuring fruits and vegetables reach consumers efficiently, affordably, and at optimal freshness. In recent decades, hub-and-spoke network models have emerged as valuable tools for optimizing sustainable cold food supply chains. Traditional optimization efforts typically focus on removing inefficiencies, minimizing lead times, refining inventory management, strengthening supplier relationships, and leveraging technological advancements for better visibility and control. However, the majority of models rely on deterministic approaches that overlook the inherent uncertainties of crop yields, which are further intensified by climate variability. Rising atmospheric CO2 concentrations, along with shifting temperature patterns and extreme weather events, have a substantial effect on crop productivity and availability. Such uncertainties can prompt distributors to seek alternative sources, increasing costs due to supply chain reconfiguration. This research introduces a stochastic hub-and-spoke network optimization model specifically designed to minimize transportation expenses by determining optimal distribution routes that explicitly account for climate variability effects on crop yields. A use case involving a cold food supply chain (CFSC) was carried out using several weather scenarios based on climate models and real soil data for California. Strawberries were selected as a representative crop, given California’s leading role in strawberry production. Simulation results show that scenarios characterized by increased rainfall during growing seasons result in increased yields, allowing distributors to reduce transportation costs by sourcing from nearby farms. Conversely, scenarios with reduced rainfall and lower yields require sourcing from more distant locations, thereby increasing transportation costs. Nonetheless, supply chain configurations may vary depending on the choice of climate models or weather prediction sources, highlighting the importance of regularly updating scenario inputs to ensure robust planning. This tool aids decision-making by planning climate-resilient supply chains, enhancing preparedness and responsiveness to future climate-related disruptions. Full article
(This article belongs to the Special Issue Climate Change and Emerging Food Safety Challenges)
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13 pages, 2643 KiB  
Review
Primary Hyperparathyroidism: 18F-Fluorocholine PET/CT vs. 4D-CT for Parathyroid Identification: Toward a Comprehensive Diagnostic Framework—An Updated Review and Recommendations
by Gregorio Scerrino, Nunzia Cinzia Paladino, Giuseppa Graceffa, Giuseppina Melfa, Giuseppina Orlando, Renato Di Vuolo, Chiara Lo Cicero, Alessandra Murabito, Stefano Radellini, Pierina Richiusa and Antonio Lo Casto
J. Clin. Med. 2025, 14(15), 5468; https://doi.org/10.3390/jcm14155468 - 4 Aug 2025
Viewed by 41
Abstract
Introduction: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by excessive parathyroid hormone production, typically due to adenomas, hyperplasia, or carcinoma. Preoperative imaging plays a critical role in guiding surgical planning, particularly in selecting patients for minimally invasive procedures. While first-line imaging [...] Read more.
Introduction: Primary hyperparathyroidism (pHPT) is an endocrine disorder characterized by excessive parathyroid hormone production, typically due to adenomas, hyperplasia, or carcinoma. Preoperative imaging plays a critical role in guiding surgical planning, particularly in selecting patients for minimally invasive procedures. While first-line imaging techniques, such as ultrasound and 99mTc-sestamibi scintigraphy, are standard, advanced second-line imaging modalities like 18F-fluorocholine PET/CT (FCH-PET) and four-dimensional computed tomography (4D-CT) have emerged as valuable tools when initial diagnostics are inconclusive. Methods: This article provides an updated review and recommendations of the role of these advanced imaging techniques in localizing parathyroid adenomas. Results: FCH-PET has shown exceptional sensitivity (94% per patient, 96% per lesion) and is particularly useful in detecting small or ectopic adenomas. Despite its higher sensitivity, it can yield false positives, particularly in the presence of thyroid disease. On the other hand, 4D-CT offers detailed anatomical imaging, aiding in the identification of parathyroids in challenging cases, including recurrent disease and ectopic glands. Studies suggest that FCH-PET and 4D-CT exhibit similar diagnostic performance and could be complementary in preoperative planning of most difficult situations. Conclusions: This article also emphasizes a multimodal approach, where initial imaging is followed by advanced techniques only in cases of uncertainty. Although 18F-fluorocholine PET/CT is favored as a second-line option, 4D-CT remains invaluable for its high spatial resolution and ability to guide surgery in complex cases. Despite limitations in evidence, these imaging modalities significantly enhance the accuracy of parathyroid localization, contributing to more targeted and minimally invasive surgery. Full article
(This article belongs to the Section General Surgery)
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