Search Results (14,649)

Gadolinium is a rare-earth element that is promising for the field of biomedicine due to its unique properties that enhance image quality, giving it high potential in targeted cancer therapy, antimicrobial treatments, etc. The disadvantage of Gd-containing materials is their high toxicity. In this work, ensembles of Fe and Al₂O₃ nanoparticles were fabricated by the electric explosion of wire and Gd ribbons using rapid quenching techniques. Stable Fe, Fe/Gd and Fe/Gd/Al₂O₃ aqueous suspensions with a Z-potential of about –54 mV were fabricated by the ball-milling mechanosynthesis of Fe (100%), Fe and Gd (70 and 30 wt. % accordingly) and Fe, Al₂O_3, and Gd (69, 30 and 1 wt.% accordingly). Fillers from suspensions were used for the synthesis of epoxy composites mimicking natural tissue with embedded magnetic particles. The concentration range for synthesized epoxy composites (0, 5, 10, and 15 wt.% of the filler) corresponded to the biomedical range of interest. Thin-film magnetoimpedance (MI) elements were prepared by a sputtering technique: conventional [FeNi/Cu]₅/Cu/[Cu/FeNi]₅ (NP) element and [FeNi/Cu]₅/Cu/[Cu/P{FeNi]₅} element with patterned top multilayer (SqP). They showed a maximum MI ratio of about 160% for NP and about 60% for SqP. MI sensor response was affected by the presence of filled magnetic composites in the shape of cylinders (5 mm × 4 mm) situated at about 1 mm due to the stray fields in the filler. MI response showed a linear dependence on the filler concentration for each selected position. These results open the possibility to develop new iron- and gadolinium-containing materials for simultaneous magnetic imaging and detection by magnetic field sensors, extending the functional properties of Fe/Gd materials for biomedical devices and therapies. Full article

Cardiovascular diseases remain the leading cause of mortality worldwide, highlighting the urgent need for more effective therapeutic strategies. Despite substantial advances in conventional biomaterials, their limited ability to support functional integration and dynamically interact with the biological microenvironment continues to hinder therapeutic outcomes. Native cardiovascular tissues rely on tightly regulated bioelectrical signaling to coordinate cellular communication, tissue homeostasis, and functional repair. Consequently, recreating these bioelectrical cues has emerged as a key design principle in cardiovascular tissue engineering. Electroactive biomaterials have gained increasing attention as a promising platform to address this challenge by enabling electrical modulation of cellular behavior and tissue function. In this review, we summarize the intrinsic bioelectrical properties of cardiovascular tissues and discuss the roles of electrical stimulation in regulating disease-relevant cellular responses. We further highlight recent advances in the development of conductive, piezoelectric, and other electroactive biomaterials for cardiovascular tissue engineering applications. Finally, we critically discuss the major challenges and future opportunities in the field, including tissue-specific responses, stimulation parameter optimization, long-term safety, and clinical translation. Collectively, electroactive biomaterials represent a promising and rapidly evolving frontier for the development of dynamic, responsive, and next-generation therapies for cardiovascular diseases. Full article

The efficiency of anaerobic digestion (AD) of lignocellulosic biomass is strongly determined by biomass yield, chemical composition, and bioavailability, all of which undergo substantial seasonal variation. However, integrated analyses linking these factors with AD performance, process kinetics, and energy-economic efficiency remain limited. This study aimed to evaluate the effect of seasonal variability in the chemical composition of Helianthus annuus biomass on AD efficiency from a technological and economic perspective. The novelty of this study lies in integrating seasonal changes in biomass composition with AD kinetics, CH₄ productivity per hectare, and CHP techno-economic performance to identify the optimal harvest window for Helianthus annuus. The experiments were conducted using biomass harvested from June to December. The results showed significant (p < 0.05) variability in biomass properties, including a progressive increase in lignocellulosic fractions over the growing season, with neutral detergent fiber (NDF) increasing from 30.58 ± 1.8 to 66.58 ± 3.1% TS and acid detergent lignin (ADL) from 5.13 ± 0.5 to 10.35 ± 0.9% TS, accompanied by a decline in substrate bioavailability. The maximum CH₄ yield of 258 ± 13 mL/g VS was obtained in August, with a process rate of 29.0 ± 3.4 mL/g VS·d and the highest utilization of methane potential, reaching 62.5 ± 3.8% (BMP_CH4/TBMP). Correlation and regression analyses indicated that ADL and NDF were the strongest empirical predictors of AD performance within the analyzed dataset, showing a negative association with both CH₄ production yield and kinetics (R² up to 0.86), whereas reducing sugars had a stimulatory effect. Multiple regression models showed high predictive performance, with R² = 0.889 for BMP_CH4. The highest energy and economic efficiency was achieved in summer. In August, CH₄ production reached 3214 ± 596 m³/ha, corresponding to 11.2 ± 2.1 MWh/ha of electricity and a net result of 1559 ± 417 EUR/ha. Increased lignification in the later part of the season led to reduced process efficiency and a deterioration of the economic balance. From a practical perspective, these results demonstrate that harvest scheduling should be based on the trade-off between biomass quantity and biodegradability rather than on biomass yield alone. Full article

Almonds (Prunus dulcis; family Rosaceae) contain 18–25% protein (dry weight). They are an important plant-based protein source in dairy alternatives and other functional foods. The hard and dense nature of almond kernels and the localization of proteins with lipid bodies in the cotyledons of almond seeds make it challenging to recover protein from the seed efficiently and preserve its function. Therefore, this review evaluates the influence of pretreatments, including blanching, grinding, and defatting, on almond protein recovery and functionality, and compares conventional and emerging technologies for almond protein. Traditional protein extraction techniques such as alkaline extraction–isoelectric precipitation (AE–IEP), aqueous extraction, and salt extraction provide moderate-to-high protein yields, but harsh processing conditions denature the proteins, decrease solubility, and cause functional properties to be lost. On the other hand, emerging protein extraction technologies (including enzyme-assisted aqueous extraction (EAE) ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE), high-pressure processing (HPP), and pulsed electric field (PEF) treatment) improve protein recovery, resulting in protein extract with superior functional properties and reduced allergenicity. However, their application in industry remain challenging. This review reveals that pretreatment approaches and conditions/parameters significantly influence protein extraction efficiency and the functional and structural properties of almonds, and that no single method is universally optimal. This review concludes that controlled enzymatic hydrolysis combined with physical pretreatment may be the best approach for producing high-value-added almond protein ingredients with specific techno-functional properties for use in plant-based beverages, hypoallergenic products, or nutraceuticals. More research is needed to develop an efficient, applicable, sustainable and eco-friendly almond protein extraction process, optimizing processing conditions to achieve high protein recovery while retaining desirable functional properties, and reduce operating costs. Full article

In view of the fact that there are few reports on the preparation of NbC coating by high-power pulsed magnetron sputtering (HiPIMS) technology. In this study, the effects of NbC interlayer thickness on the microstructure, corrosion resistance and electrical conductivity of Nb/NbC/C multilayer coatings for proton exchange membrane fuel cell (PEMFC) bipolar plates were studied by using the high ionization characteristics of HiPIMS technology. A series of Nb/NbC/C multilayer coatings with varying NbC interlayer thicknesses was deposited via HiPIMS by modulating the deposition time (20, 40, and 60 min). The microstructure and properties of the coatings were characterized using scanning electron microscopy (SEM), Raman spectroscopy, interfacial contact resistance (ICR), and corrosion current, among other methods. The results indicate that as the NbC interlayer thickness increases, the total coating thickness increases from 0.43 μm to 1.42 μm. All coatings exhibit a uniform and dense microstructure lacking typical coarse columnar structures. Raman and XPS analyses show that the I_D/I_G ratio increases from 1.98 to 4.04, indicating an increase in sp²-hybridized bond content and a decrease in sp³ content. At a deposition time of 60 min, the coating achieved optimal performance, yielding a critical load (Lc1) of 31.9 N, the lowest average friction coefficient (0.27), the minimum corrosion current density, and an interfacial contact resistance of 7.5 mΩ·cm². These results demonstrate that the NbC interlayer thickness significantly governs the structure and properties of the Nb/NbC/C multilayer coatings. Specifically, an appropriate increase in the NbC interlayer thickness optimizes the sp²/sp³ hybrid bond ratio, thereby enhancing the overall coating performance. Full article

Motoneurons are under strong pressure to maintain stable motor output throughout an individual life, through homeostatic regulation of their electrical properties. Dysregulated spinal motoneuron excitability has long been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). Recent work in SOD1^G93A mice suggests that the homeostatic response of motoneurons becomes dysregulated as cellular processes are disrupted by the disease, causing fluctuations in motoneuron electrical properties. Yet, few studies directly test whether ALS motoneurons respond differently than wild-type motoneurons to a common chronic perturbation. Here, we used in vivo electrophysiology to test whether motoneurons from pre-symptomatic SOD1^G93A mice modulate excitability differently than wild-type motoneurons in response to the same homeostatic perturbation: chronic inhibition exerted by the benzodiazepine diazepam. Using linear mixed-effects statistical models, we assessed whether diazepam treatment differentially modulated passive properties, firing behavior, spike properties, and/or synaptic inputs in SOD1^G93A versus wild-type motoneurons. We identified a significant genotype × treatment interaction effect selectively for properties related to passive membrane integration and spike initiation, including membrane time constant, peak input resistance, and recruitment current. In contrast, firing gain, spike waveform characteristics, and synaptic inputs were largely unaffected. These findings indicate that sustained inhibitory perturbation selectively triggered overactive intrinsic compensatory mechanisms in SOD1^G93A motoneurons rather than inducing widespread changes in firing or synaptic transmission. Together, our results provide direct evidence for over-active homeostatic control of motoneuron excitability and support a view of motoneuron dysfunction in ALS as a problem of altered feedback regulation rather than simply hyper- or hypo-excitability. Full article

Hybrid conductive materials have attracted increasing attention due to their combined electrical conductivity, mechanical flexibility, and sustainability. In this work, new hybrid materials based on polyaniline (PANI)-wrapped multi-walled carbon nanotubes (MWCNTs) and microfibrous cellulosic substrates were developed and assessed for photocatalytic degradation of a model dye pollutant. First, in situ oxidative polymerization of aniline in formic acid (FA) was conducted in the presence of MWCNTs to afford stable dispersions of carboxylated polyaniline-wrapped carbon nanotubes (c-PANI/MWCNTs). Next, the dispersions were used for affordable impregnation of microfibrous cellulosic filter paper. The influence of the initiator type—potassium peroxodisulfate (KPS) and hydrogen peroxide—on polymer–nanotube interactions, stabilization and surface deposition was emphasized. The structural, surface, morphological and thermal properties of the obtained dispersions and cellulose nanocomposites were systematically investigated using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, Raman spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy and thermal gravimetric analysis. The results revealed strong interfacial interactions between c-PANI and the pristine MWCNTs, resulting in improved dispersion stability and effective and even surface deposition of the conductive c-PANI/MWCNT hybrids into the cellulose fiber mesh. The photocatalytic degradation of 5 ppm methylene blue (MB) dye in the presence of the developed nanocomposite materials under UV-A illumination was studied. The results showed that the c-PANI@MWCNT-impregnated cellulose substrates exhibited enhanced photocatalytic ability (up to 83% degree of degradation of MB dye) in comparison with the pure c-PANI. Full article

Short circuits and subsequent fires resulting from objects impacting the bottom of vehicle power battery packs considerably jeopardize electric vehicle (EV) operations. This study investigated underbody impacts in EVs and the overall mechanical properties of battery cells. Key features of road debris were extracted and simplified to establish a geometric parameter structure model and determine realistic battery pack responses to debris impact. Quasi-static compression and dynamic impact tests on a prismatic lithium-ion battery (LIB) and power battery pack followed. Macroscopic mechanical responses, deformation failure modes, and internal jellyroll damage of cells and packs were evaluated, and constitutive equations and failure parameters were derived to develop a finite element model, whose effectiveness and reliability were verified by comparing simulation results with experimental data. Finally, a homogenized model of the prismatic LIB and power battery pack was constructed, which effectively predicted the macroscopic mechanical response and internal short-circuit failure under mechanical loading. However, simulation and test results revealed certain deviations in cell indentations under battery pack bottom impacts, presumably because the FEMs neglect the dynamic strain rate effects of electrolyte and cooling liquid. Overall, this study elucidates safety risks to cells and their key components under power battery pack bottom impacts. Full article

Polymeric materials face serious fire-safety challenges in construction, electrical and electronic devices, and aerospace because of their high heat release, melt-dripping tendency, and severe smoke and toxic emissions during burning. This review systematically summarizes the roles of nanofillers in the fire safety of polymer nanocomposites across three interconnected levels: functional mechanisms, regulatory factors, and macroscopic fire behavior. It focuses on four main mechanisms, namely physical barriers, catalytic charring, free-radical scavenging, and rheological network reconstruction, and further discusses how filler geometry, loading level, interfacial compatibility, dispersion state, and spatial orientation regulate fire-safety performance. By linking these factors to time to ignition, thermal stability, heat release, flame spread, and smoke emission and toxicity, the review clarifies the intrinsic structure–mechanism–property relationships. Current studies indicate that the fire-safety improvements provided by nanofillers do not arise from any single effect, but from their coupled regulation of heat transfer, mass transfer, radical reactions, and high-temperature rheology throughout thermal degradation, ignition, heat release, flame spread, and smoke and toxic-gas emission. Remaining challenges include the lack of unified evaluation criteria, limited in situ mechanistic evidence, and insufficient application-oriented rational design. Future work should establish verifiable, comparable, and predictive structure–mechanism–property relationships for polymer nanocomposites. Full article

The explosive demand for flexible wearable and portable devices imposes stringent requirements on the mechanical, energy storage, and sensing properties of functional materials. Although two-dimensional (2D) transition metal carbides and nitrides (MXene) possess high conductivity and pseudocapacitance, their severe self-restacking and intrinsic brittleness restrict their practical applications. Herein, a facile vacuum filtration and hot-pressing densification strategy is proposed to fabricate nacre-inspired MXene-based films. By incorporating one-dimensional (1D) high-aspect-ratio TEMPO-oxidized cellulose nanofibrils (TOCNFs), the self-restacking of MXene is effectively suppressed. The optimal M20F5 composite film exhibits a coordinated electromechanical balance, maintaining an electrical conductivity of 1.07 × 10⁶ S m⁻¹ while enduring 2124 folding cycles. For energy storage, the assembled symmetric supercapacitor delivers a specific capacitance of 828.92 F g⁻¹ at 0.5 mA cm⁻² and maintains an energy density of 13.75 Wh kg⁻¹ at a power density of 9500 W kg⁻¹. Furthermore, acting as a piezoresistive sensor, the film achieves reliable detection, spanning from bimodal gait recognition to subtle physiological pulses. This work establishes a viable material design strategy for next-generation supercapacitors and intelligent wearable systems. Full article

Sugarcane is a high-value crop in Egypt, yet weed communities in the understudied Upper Egypt region have not been systematically characterized. This study provides a comprehensive analysis of weed floristic composition, phytogeographical affinities, and the edaphic and canopy light factors governing vegetation structure across contrasting Nile Valley clay and reclaimed desert lands in Qena Governorate. Fourteen stands were surveyed during the 2024/2025 sugarcane growing season, recording 110 species from 33 families (68 annuals and 42 perennials), which were dominated by Poaceae, Asteraceae, Fabaceae, Euphorbiaceae, and Amaranthaceae (54.6% of the flora recorded). Therophytes were the most abundant life form (60.9%), and 51.8% of species belonged to Neotropical, Palaeotropical, Cosmopolitan, and Pantropical chorotypes. Diversity indices showed high and balanced species diversity, with no dominance by any single species. Seasonal variation showed that species richness peaked in spring, decreased through summer and autumn, and correlated with light intensity under the canopy. TWINSPAN identified four vegetation groups, which were merged into three primary vegetation groups (A, B, and C) via DCA and CCA ordinations and linked to microhabitats shaped by elevation and soil physicochemical properties. CCA revealed that Group C (stands in the Nile Riverbank lands) had the highest diversity, which was associated with organic matter, clay, and field capacity. In contrast, Group A (stands of reclaimed desert land) had low richness linked to high levels of Total Dissolved Solids (TDS), Electrical Conductivity (EC), Na, K, Mg, CaCO₃, and sandy soils. Group B (stands of Nile clay lands) was an intermediate transitional community between groups A and C. These findings establish edaphic factors as the primary determinant of weed community structure, with salinity as the critical constraint in reclaimed lands and seasonal light variation as a secondary diversity filter. Full article

Electronic textiles (e-textiles) have gained significant importance due to their potential to enable wearable electronic systems. Conductive pathways in textiles can be fabricated using various approaches; among these, printing technologies stand out for their cost-effectiveness and suitability for rapid design customization. In this study, conductive patterns were produced on 100% cotton woven fabrics using rotary screen printing with different conductive paste formulations and printing layer configurations. The electrical resistance, fabric thickness, microscopic surface morphology, tensile strength, elongation, and tearing strength of the printed e-textiles were evaluated. Results indicated that resistance decreased with increasing printed track width and number of printed layers, with samples A4 and A5 exhibiting the highest conductivity. Thickness measurements and microscopic surface images showed that repeated printing increased layer build-up and surface coverage, particularly for A3 and A4. Mechanical performance tests revealed reductions in tensile strength, elongation, and tear strength after printing, attributed to restricted fiber mobility caused by the conductive paste and curing process. Despite these reductions, the mechanical property losses remained within acceptable limits for wearable applications. To determine the most suitable conductive textile for use in electronic textile product design, the Multi-Objective Optimization on the Basis of Ratio Analysis (MOORA) method, a multi-criteria decision-making (MCDM) approach, was applied using mechanical performance criteria. Electrical resistance was evaluated separately as a functional performance indicator and interpreted together with the MOORA-based mechanical ranking. Considering both mechanical and electrical performance, sample A5 was identified as the optimal alternative. Overall, this study demonstrates that printed conductive textiles can be systematically evaluated and ranked using a multi-criteria decision-making approach for material selection in wearable electronics. Full article

Conductive silicone interfaces are promising polymeric materials for wearable bioelectronic systems because they combine electrical continuity with elastomeric compliance, environmental durability, and moldability. In low-voltage wearable microcurrent interfaces, however, functional performance is governed not only by intrinsic material conductivity, but also by conductive network continuity, molded geometry, interfacial contact, and transient electrical response. In this study, we developed a spike-structured conductive silicone interface using a commercially available electrically conductive two-component silicone rubber and investigated its structure–electrical property relationships as a volume-resistive polymer interface. The interface consisted of a conductive silicone body with protrusions 7 mm in height and 3.6 mm in diameter, supported by a 1 mm base layer and electrically integrated through an Ag-paste-connected upper conduction region. Using a representative electrode-level resistance of 47.08 Ω, the geometry-derived apparent interfacial resistive response was estimated as 18.0 Ω·cm for the three-spike configuration and 24.0 Ω·cm for the four-spike configuration. The corresponding effective conductive areas were 0.305 cm² and 0.407 cm², respectively, giving analytical current-density amplification factors of 9.82 and 7.37 relative to a planar 3 cm² reference interface. Positional resistance mapping yielded an overall mean resistance of 47.80 ± 4.57 Ω, indicating acceptable electrical reproducibility across the structured conductive silicone interface. In addition, oscilloscope-based transient response analysis under a 5 V, 1 kHz square-wave input showed that the conductive silicone interface maintained the overall pulse waveform while showing a modest reduction in overshoot from 3.4 ± 0.1% to 2.7 ± 0.1%, with FFT traces used as qualitative waveform-monitoring displays. Formulation-dependent comparison further showed that increasing the silicone-rich fraction increased the measured resistance from 105 Ω to 145 Ω, whereas increasing conductive carbon loading reduced resistance but aggravated surface transfer. These results show that the conductive silicone interface functions not simply as a soft conductor, but as a volume-resistive, geometry-defined current-transfer medium whose behavior is governed by the coupled effects of conductive network formation, spike architecture, electrode-level resistance, and transient pulse response. This study provides a practical materials/interface design framework for spike-structured conductive silicone electrodes in wearable bioelectronic and electroceutical devices. Full article

In response to the harsh operating conditions of high-speed, high-temperature bearings in new energy vehicle drive motors, this study focuses on enhancing the performance of polyurea-based gel greases through the use of nano-additives. Using polyurea-based gel grease as the matrix, nano-composite gel greases with different CeO₂ loadings were prepared, and their tribological properties and rheological behavior were characterized using four-ball friction tests, rheological testing, and SEM analysis. The results indicate that adding 0.5 wt% CeO₂ increased the grease’s yield stress by approximately 75.4% and significantly raised its apparent viscosity. This rheological enhancement effect may be attributed to the physical adsorption of ultrafine particles onto the polyurea fiber network and potential interfacial interactions between the particles and the fiber surfaces. Compared to the original grease, the average coefficient of friction decreased by 10.4%, and the average wear scar diameter decreased by 12.7%. Meanwhile, the shear stress increased by 110.41 Pa, and the viscosity increased by 1102 Pa·s. This study provides experimental evidence and technical references for the development of high-performance gel lubricants suitable for motor bearings operating under high-temperature conditions. Full article

Polymers are increasingly used as structural materials in medical devices due to their lightweight, chemical resistance, and electrical insulation properties. High-density polyethylene (HDPE) is widely applied; however, the fabrication of large or thick components often requires extrusion welding. Since joint performance directly affects structural reliability, controlling welding quality is essential. In this study, the effects of preheating conditions on the mechanical performance of HDPE extrusion-welded joints were systematically investigated. Preheating temperature and hot-air movement speed were selected as key variables, and their influence on tensile, flexural, and elongation properties was evaluated experimentally. The results provide insight into the role of preheating in weld quality and offer guidance for process optimization in medical device applications. Full article