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22 pages, 303 KB  
Article
Investigating Early-Married Women’s Perceived Agency and Marital Quality in Rural Indonesia
by Cahya Haniva Yunizar and Zha Blong Xiong
Fam. Sci. 2025, 1(2), 15; https://doi.org/10.3390/famsci1020015 - 15 Dec 2025
Viewed by 191
Abstract
Early marriage remains a persistent issue in Indonesia, with significant implications for women’s well-being and societal dynamics. Despite efforts to reduce its prevalence, challenges persist due to the intersection of social, cultural, and economic factors. This study aimed to examine the phenomenon of [...] Read more.
Early marriage remains a persistent issue in Indonesia, with significant implications for women’s well-being and societal dynamics. Despite efforts to reduce its prevalence, challenges persist due to the intersection of social, cultural, and economic factors. This study aimed to examine the phenomenon of early marriage through the lens of women’s agency, focusing on their subjective experiences and perspectives within marital unions. Utilizing an interpretive phenomenological analysis (IPA), individual interviews were conducted with 17 early-married women in rural Indonesia to explore their lived experiences. Results highlighted early-married women’s definitions of happiness within marriage, their perceptions of agency and empowerment in marital relationships, and the role of agency in conforming to or resisting early marriage practices. The study provided insights into the complexities of early marriages in Indonesia and underscored the importance of understanding women’s agency in shaping marital outcomes and quality within a collectivist culture. Full article
14 pages, 715 KB  
Article
Vitamin D Status as a Late Pregnancy Biomarker of Perceived Stress
by Maya F. Andrade, Anjali G. Borsum, Mathew J. Gregoski, Myla D. Ebeling, Judith R. Shary, Martin Hewison, Bruce W. Hollis and Carol L. Wagner
Nutrients 2025, 17(22), 3553; https://doi.org/10.3390/nu17223553 - 14 Nov 2025
Viewed by 552
Abstract
Background/Objectives: Stress during pregnancy critically impacts maternal and fetal health. While prior research has linked sociodemographic and biological factors to stress levels, the role of specific biomarkers, such as vitamin D (VD), remains unexplored. This study examined the relationships among sociodemographic factors, [...] Read more.
Background/Objectives: Stress during pregnancy critically impacts maternal and fetal health. While prior research has linked sociodemographic and biological factors to stress levels, the role of specific biomarkers, such as vitamin D (VD), remains unexplored. This study examined the relationships among sociodemographic factors, VD status (as measured by serum 25-hydroxyvitamin D [25(OH)D] concentration), and perceived stress in pregnant women. We hypothesized that 25(OH)D concentration would be associated with perceived stress levels during pregnancy. Methods: A post hoc analysis of the Kellogg Pregnancy VD study was conducted on a cohort of 232 pregnant women with Perceived Stress Scale (PSS-10) scores at months 2, 5, and 7 with corresponding 25(OH)D concentrations. PSS-10 scores were classified into two groups: patients with scores of 0–13 were considered to have low stress, while those with scores of 14–40 were considered to have moderate-to-high stress. Logistic regression models identified factors associated with moderate-to-high stress. Results: At month 2, univariate analyses showed that being married (p = 0.002), having a college education (p = 0.0013), and lower BMI (p = 0.018) were associated with lower perceived stress, whereas Black race was associated with higher perceived stress (p = 0.027). By month 7, higher serum 25(OH)D concentration was the only significant predictor of perceived stress in univariate analysis (p = 0.002). In multivariate models at month 7, 25(OH)D approached significance (p = 0.053). Conclusions: Early in pregnancy, race, marital status, college education, and BMI were significantly associated with PSS-10 score. By month 7, 25(OH)D concentration over time emerged as a factor that was significantly associated in univariate analysis and showed a trend toward significance in multivariate models. VD status, as measured by 25(OH)D concentration, may act as a biomarker of stress during pregnancy. Results warrant further study in prospective intervention trials. Full article
(This article belongs to the Section Nutrition in Women)
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17 pages, 261 KB  
Article
Traumatic Symptoms Among Syrian Refugees in Host Countries: A Comparative Study of Jordan and Spain
by Dalia Al-Hourani, Mahmoud Al-Wriekat, Rocío Llamas-Ramos and Inés Llamas-Ramos
Societies 2025, 15(11), 295; https://doi.org/10.3390/soc15110295 - 27 Oct 2025
Viewed by 885
Abstract
Background: Displaced individuals endure challenges, including conflict, forced migration, family separation, human rights violations, limited access to essential services, and increased exposure to violence and abuse. These hardships significantly impact their mental health, often leading to heightened trauma-related symptoms. Methods: We used a [...] Read more.
Background: Displaced individuals endure challenges, including conflict, forced migration, family separation, human rights violations, limited access to essential services, and increased exposure to violence and abuse. These hardships significantly impact their mental health, often leading to heightened trauma-related symptoms. Methods: We used a cross-sectional correlational design in refugee camps, homes, and centers across Jordan and Spain. 200 refugees with confirmed status in the past ten years were recruited. Demographic data were collected via a demographic form, the PTSD-8 Inventory assessed traumatic symptoms, and data analysis included descriptive statistics, independent t-tests, one-way ANOVA, and Chi-square tests. Results: Most participants had a secondary education, were unemployed, and had low incomes. PTSD symptoms were prevalent, with rates of recurrent thoughts (63.5%), re-experiencing events (57.5%), nightmares (50.5%), sudden reactions (56.5%), activity avoidance (53.5%), avoidance of specific thoughts or feelings (56.5%), jumpiness (53.5%), hypervigilance (53.5%), feeling on guard (41.5%), and general avoidance (43.5%) rated from rarely to most of the time. All symptoms were significantly more frequent among refugees in Jordan than in Spain. Conclusions and Recommendations: Intrusive thoughts were more frequent among females, urban residents, and unemployed individuals. Avoidance behaviors were higher in married and unemployed individuals. Hypervigilance was more prevalent among females, married individuals, and those with lower incomes. Regionally, females and married individuals in Jordan exhibited more intrusive thoughts and avoidance. In Spain, intrusive thoughts and hypervigilance were more common among females and the unemployed. The findings highlight the urgent need for targeted mental health interventions, particularly in refugee camps like those in Jordan, where PTSD symptom rates were significantly higher. Programs should prioritize trauma-focused therapies, such as Cognitive Behavioral Therapy, while adopting gender-sensitive approaches to address the heightened vulnerability of women and unemployed individuals. Given the strong link between unemployment and symptom severity, livelihood support and vocational training should be integrated into psychosocial care. Policymakers in host countries like Jordan could benefit from adopting integration strategies similar to Spain’s, which may contribute to lower PTSD prevalence. Additionally, community-based awareness initiatives could improve early symptom recognition and access to care. Future research should explore longitudinal outcomes to assess the long-term impact of displacement and resettlement conditions on mental health. Full article
19 pages, 316 KB  
Article
Psychometric Validation of Trust, Commitment, and Satisfaction Scales to Measure Marital Relationship Quality Among Newly Married Women in Nepal
by Lakshmi Gopalakrishnan, Nadia Diamond-Smith and Hannah H. Leslie
Int. J. Environ. Res. Public Health 2025, 22(9), 1457; https://doi.org/10.3390/ijerph22091457 - 20 Sep 2025
Viewed by 2284
Abstract
Marital relationship quality significantly influences health outcomes, but validated measurement tools for South Asian populations remain limited. To validate scales measuring trust, commitment, and satisfaction as key components of marital relationship quality among newly married women in Nepal, we conducted a two-wave psychometric [...] Read more.
Marital relationship quality significantly influences health outcomes, but validated measurement tools for South Asian populations remain limited. To validate scales measuring trust, commitment, and satisfaction as key components of marital relationship quality among newly married women in Nepal, we conducted a two-wave psychometric validation study in rural Nawalparasi district. The study included 200 newly married women aged 18–25 years, with 192 participants (96% retention) completing 6-month follow-up. We assessed factor structure, internal consistency, test-retest reliability, and criterion validity of trust (eight items), commitment (five items), and satisfaction (seven items) scales using exploratory and confirmatory factor analysis. Exploratory factor analysis identified single-factor solutions for trust and commitment scales and a two-factor model for satisfaction. Confirmatory factor analysis confirmed these structures, with satisfaction comprising marital conflict/dissatisfaction (four items) and general satisfaction (two items) subscales. All scales demonstrated good internal consistency (Cronbach’s α: 0.79–0.96) and significant criterion validity correlations with relationship happiness (r = 0.63–0.72, p < 0.001). Test-retest reliability showed moderate to low stability (r = 0.21–0.51), likely reflecting genuine relationship changes in early marriage. The validated scales provide reliable tools for assessing relationship quality in South Asian contexts, enabling research on marriage-health associations and evidence-based interventions. Full article
(This article belongs to the Section Behavioral and Mental Health)
36 pages, 5931 KB  
Article
Geospatial Impacts of Land Allotment at the Standing Rock Reservation, USA: Patterns of Gain and Loss
by Stephen L. Egbert and Joshua J. Meisel
ISPRS Int. J. Geo-Inf. 2025, 14(9), 363; https://doi.org/10.3390/ijgi14090363 - 19 Sep 2025
Viewed by 911
Abstract
Allotment—the division of Native American reservations into individually-owned plots of land—has been extensively studied; yet there exists a paucity of reservation-level studies at granular geospatial scales, i.e., at the level of examining the impacts of allotment on individuals, families, and clan or tribal [...] Read more.
Allotment—the division of Native American reservations into individually-owned plots of land—has been extensively studied; yet there exists a paucity of reservation-level studies at granular geospatial scales, i.e., at the level of examining the impacts of allotment on individuals, families, and clan or tribal groups. In previous research, we described a new semi-automated method for creating detailed GIS allotment databases and discussed the policies and processes that that lay behind allotment at the Standing Rock Reservation. In this study, we employed our Standing Rock database to map and explore allotment patterns in detail. We primarily focused on patterns of clustering versus dispersion of allotment parcels for individuals, families, and tribal groups by calculating median distance (and other descriptive statistics) and standard distance in GIS. Throughout, we used mapped representations of allotment patterns as visualization tools, both for confirming hypotheses and raising new questions. As anticipated, we discovered patterns of both gain and loss. On the one hand, as we had found earlier, the people at Standing Rock gained land through their insistence on allotments for married women and for children born after the beginning date of allotment (“later-born children”), land they otherwise would not have received. We also confirmed that married women only received half the land that their husbands received and that the early sale of “surplus” reservation lands deprived a future generation of children of the opportunity to receive their own land. Perhaps most importantly, however, we discovered that the belated timing of allotments to married women and later-born children caused their allotments to be located at some distance from those of their husbands or fathers, creating disjunct and dispersed patterns of family land holdings that would have significantly hampered the creation of viable farming and ranching operations. Full article
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17 pages, 740 KB  
Article
Natural vs. Assisted Conception: Sleep and Emotional Health from Pregnancy to Postpartum—An Exploratory Study
by Olympia Evagorou, Aikaterini Arvaniti, Spyridon Plakias, Nikoleta Koutlaki, Magdalini Katsikidou, Sofia Sfelinioti, Paschalis Steiropoulos and Maria Samakouri
J. Clin. Med. 2025, 14(17), 6310; https://doi.org/10.3390/jcm14176310 - 6 Sep 2025
Viewed by 1249
Abstract
Background/Objectives: Sleep plays a key role in female fertility. Sleep disturbances (SDis) during pregnancy are common and may negatively affect maternal health, contributing to an increased risk of perinatal depression and anxiety. Aim: The present prospective study aimed to examine the [...] Read more.
Background/Objectives: Sleep plays a key role in female fertility. Sleep disturbances (SDis) during pregnancy are common and may negatively affect maternal health, contributing to an increased risk of perinatal depression and anxiety. Aim: The present prospective study aimed to examine the interplay of sleep, anxiety, and depression during the pregnancy and postpartum stages, comparing women who conceived naturally (NC) with those who conceived through assisted reproductive treatment (ART). Methods: The study included five timepoints: pre-pregnancy (t0), the end of each trimester (t1–t3), and the postpartum period (t4). SDis were assessed using the Pittsburgh Sleep Quality Index (PSQI), the Athens Insomnia Scale (AIS), the Epworth Sleepiness Scale (ESS), the Fatigue Severity Scale (FFS); perinatal depressive and anxiety symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Demographic and clinical characteristics were also collected. Given the imbalance in group size and the dispersion of values, a negative binomial regression model with robust variances and Satterthwaite approximation for the degrees of freedom was applied. Results: Compared to women with NC (N = 37), those undergoing ART (N = 57) were more likely to be older (p < 0.001), married (p < 0.001), unemployed (p < 0.001), and have a history of thyroid disease (p = 0.008). Significant differences between different time points were observed in both NC (N = 37) and successfully conceived ART groups (N = 9) in all sleep, fatigue, and well-being parameters. Notably, at the end of the first trimester (t1), the ART group reported more severe insomnia symptoms (p = 0.02). Conclusions: SDis are common in pregnancy, but more pronounced during the first trimester among women on ART. These findings highlight the need for early screening and targeted psychological support during perinatal care. Full article
(This article belongs to the Section Mental Health)
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11 pages, 475 KB  
Article
Association Between Screening Practices and Other Risks and Breast Cancer Among Indonesian Women: A Case—Control Study
by Primariadewi Rustamadji, Ratu Ayu Dewi Sartika, Pika Novriani Lubis, Edy Purwanto, Ismarulyusda Ishak, Amalia Ane Istamayu and Elvan Wiyarta
J. Clin. Med. 2025, 14(8), 2699; https://doi.org/10.3390/jcm14082699 - 15 Apr 2025
Viewed by 2217
Abstract
Breast cancer is the predominant cause of cancer in developing nations, and screening through breast self-examinations and mammograms is crucial in mitigating morbidity and mortality. Nonetheless, geographic disparities in screening methods persist, attributable to sociodemographic variation and healthcare accessibility. Background/Objectives: This study aimed [...] Read more.
Breast cancer is the predominant cause of cancer in developing nations, and screening through breast self-examinations and mammograms is crucial in mitigating morbidity and mortality. Nonetheless, geographic disparities in screening methods persist, attributable to sociodemographic variation and healthcare accessibility. Background/Objectives: This study aimed to analyze the influence of women’s screening practices for breast cancer and other risks, stratified by urban and rural areas in Indonesia. Methods: A case–control design was adopted, including all women who had breast cancer in 2014 as the study subjects. The Indonesian Family Life Survey data from 2007, with subjects aged at least 15 years, and from 2014 were used. Unconditional logistic regression was used to analyze the risk factors of breast cancer. Results: After controlling for confounders, the odds of breast cancer diagnosis were higher in women who performed breast self-examination (BSE) (aOR 10.22; 95% CI 1.04–50.81 and aOR 11.10; 95% CI 3.32–37.08) and those married before the age of 19 (aOR 4.81; 95% CI 1.93–6.05 and aOR 5.35; 95% CI 1.49–19.7), in urban and rural areas, respectively. In addition, women who had undergone mammography (aOR 48.04; 95% CI 10.33–83.45) had significantly higher odds of being diagnosed with breast cancer in urban areas. In rural areas, a paternal history of cancer-related death had higher odds of breast cancer (aOR 30.63; 95% CI 6.04–60.41) than those without a parental history of cancer. Conclusions: This study highlights the importance of intensifying national breast cancer screening, including BSE campaigns and expanding mammography infrastructure, particularly in rural areas, for improving breast cancer prevention and early diagnosis. Full article
(This article belongs to the Section Epidemiology & Public Health)
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12 pages, 833 KB  
Article
Quality of Life and Stress-Related Psychological Distress Among Patients with Cervical Cancer: A Cross-Sectional Analysis
by Razvan Betea, Mirabela Dima and Veronica Daniela Chiriac
Diseases 2025, 13(3), 70; https://doi.org/10.3390/diseases13030070 - 25 Feb 2025
Cited by 2 | Viewed by 2481
Abstract
Background and Objectives: Cervical cancer places substantial burdens on physical and psychosocial health. This study evaluated changes in quality of life (QoL) and perceived stress in patients with cervical cancer before and six months after initiating standard treatment. Four validated instruments were used: [...] Read more.
Background and Objectives: Cervical cancer places substantial burdens on physical and psychosocial health. This study evaluated changes in quality of life (QoL) and perceived stress in patients with cervical cancer before and six months after initiating standard treatment. Four validated instruments were used: the 36-Item Short Form Survey (SF-36), the Perceived Stress Scale (PSS), the World Health Organization Quality of Life-BREF (WHOQOL-BREF), and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Methods: Ninety-six women (mean age: 48.3 ± 7.4 years) with histologically confirmed cervical cancer were enrolled. Baseline (pre-treatment) assessments included SF-36, PSS, WHOQOL-BREF, and EORTC QLQ-C30. Follow-up was conducted six months after initiating either surgery or chemoradiation. Paired t-tests (or Wilcoxon signed-rank for non-parametric data) compared baseline and follow-up scores. Subgroup analyses were performed by disease stage (early vs. advanced) and marital status (married vs. unmarried). Results: Post-treatment assessments showed significant improvements in SF-36 physical functioning (from 61.9 ± 11.6 to 66.7 ± 12.3, p = 0.015) and mental health (from 63.4 ± 12.2 to 68.1 ± 12.4, p = 0.022). PSS scores declined from 23.2 ± 5.7 to 20.6 ± 5.5 (p = 0.001). WHOQOL-BREF physical and psychological domains increased, with physical health rising from 56.4 ± 12.0 to 60.7 ± 12.5 (p = 0.032). EORTC QLQ-C30 global health improved from 61.4 ± 13.8 to 66.3 ± 14.2 (p = 0.014). Advanced-stage patients exhibited greater absolute QoL gains yet remained below the early-stage scores. Married patients reported sharper reductions in PSS and higher final QoL scores. Conclusions: Over six months of standard cervical cancer treatment, these patients demonstrated significant QoL improvements and reduced perceived stress. While advanced-stage disease remained associated with lower post-treatment scores, these individuals benefited from notable gains compared to baseline. Marital status emerged as a protective factor. Ongoing psychosocial support may amplify these beneficial effects, warranting further longitudinal studies to optimize integrative survivorship care. Full article
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14 pages, 283 KB  
Article
Effects of Mental Imagery on Quality of Life, Cognitive, and Emotional Status in Older Adults with Early-Stage Alzheimer’s Disease Dementia: A Randomized Controlled Trial
by Anna Christakou, Christina Bouzineki, Marousa Pavlou, George Stranjalis and Vasiliki Sakellari
Brain Sci. 2024, 14(12), 1260; https://doi.org/10.3390/brainsci14121260 - 16 Dec 2024
Cited by 2 | Viewed by 2384
Abstract
Background/Objectives: Dementia is a syndrome which involves cognitive and motor problems such as memory and motor control that impacts the individuals’ quality of life. In mental imagery (MI) technique, motor acts are mentally rehearsed without any overt body movements. The aim of this [...] Read more.
Background/Objectives: Dementia is a syndrome which involves cognitive and motor problems such as memory and motor control that impacts the individuals’ quality of life. In mental imagery (MI) technique, motor acts are mentally rehearsed without any overt body movements. The aim of this study was to investigate the effectiveness of MI on the quality of life, cognitive, and emotional status of older adults with an early stage of dementia. Methods: The present randomized controlled trial consisted of 160 participants. The sample from an Athens Day Care Center of the Alzheimer Association was randomized to (a) the MI and exercise group (intervention group, n = 55), (b) the only exercise group (1st control group, n = 52), and (c) the neither MI nor exercise group (2nd control group, n = 53). Participants engaged in a total of 24 physiotherapy sessions, each lasting approximately 45 min, scheduled twice weekly over a 12-week period. They performed three assessments: (a) one week prior to the program, (b) one and a half months, and (c) after the program. The intervention group performed a 30 min MI with exercise program content immediately following every physiotherapy exercise session. Walking While Talking Test (WWITT), the Euro-Qol 5-Dimensions 5-Level of severity scale (Euro-Qol 5D-5L scale), the Short-Form of Geriatric Depression Scale (SF-GDS), and the Short Anxiety Screening Test (SAST) were used to assess cognitive status, emotional status, and quality of life. Results: A total of 160 participants (43 men, 117 women, with MMSE M = 23.20 SD = 0.15) took part in this study in which most reported holding a university degree (n = 77), were married (n = 101), and had loss of memory as the 1st symptom of dementia (n= 117). The Friedman test revealed statistically significant differences across the three groups on (a) the WWITTmistakes (X2 = 14.95, df = 2, p = 0.001) and WWITTtime (X2 = 13.35, df = 2, p = 0.01), (b) the total Euro-Qol 5D-5L scale (X2 = 11.87.62, df = 2, p = 0.003) and quality of life on the measuring day (X2 = 25.59, df = 2, p = 0.00), (c) the SF-GDS (X2 = 6.54, df = 2, p = 0.038), and (d) the SAST (X2 = 39.907.62, df = 2, p = 0.00). The Friedman test with post hoc Wilcoxon analysis revealed that the mean scores for the intervention group and the 1st control were significantly better than the 2nd control group in many dependent variables. Conclusions: The results indicate that incorporating MI can positively influence cognitive status, emotional status, and the quality of life in older adults diagnosed with early-stage dementia. Full article
(This article belongs to the Special Issue Aging-Related Changes in Memory and Cognition)
19 pages, 303 KB  
Article
Adult Children’s Marital Timing and Upward Intergenerational Financial Transfers: Variation across Gender, Race, and Ethnicity
by Xing Zhang and Anna M. Hammersmith
Soc. Sci. 2024, 13(10), 498; https://doi.org/10.3390/socsci13100498 - 24 Sep 2024
Viewed by 1638
Abstract
Marriage is a key adult milestone yet is also considered a greedy institution that monopolizes resources, jeopardizing adult children’s financial transfers to aging parents. As the age at which marriage shifts later into adulthood, this study examines whether marriage still operates as a [...] Read more.
Marriage is a key adult milestone yet is also considered a greedy institution that monopolizes resources, jeopardizing adult children’s financial transfers to aging parents. As the age at which marriage shifts later into adulthood, this study examines whether marriage still operates as a greedy institution, considering the role of marital timing on upward financial transfers to aging parents. Using data from Waves I–V of Add Health and Wave I of the Add Health Parent Questionnaire from 1994 to 2018, we examined whether timing of marriage (never, early, on time, and late) was associated with adult children’s upward financial transfers to their parents, accounting for variation across gender, race, and ethnicity. Adult children who never married were the largest group who gave upward financial transfers to their aging parents (33%). Results suggested that marriage or timing of marriage was a greedy institution among men, women, white, Hispanic, and Asian adults, but not Black adults, suggesting heterogeneity in the role of marriage on family support. Full article
(This article belongs to the Section Family Studies)
13 pages, 248 KB  
Article
“I Did Not Come to China for That!”: Intersections of Mission Work, Marriage, and Motherhood for Southern Baptist Women in China at the Turn of the 20th Century
by T. Laine Scales
Religions 2024, 15(8), 901; https://doi.org/10.3390/rel15080901 - 26 Jul 2024
Viewed by 1997
Abstract
The private writings of two Southern Baptist women missionaries in China are analyzed to deepen our understanding of women’s perspectives on their daily lives. After reviewing secondary research on married and single women’s work in China, the author uses primary source examples from [...] Read more.
The private writings of two Southern Baptist women missionaries in China are analyzed to deepen our understanding of women’s perspectives on their daily lives. After reviewing secondary research on married and single women’s work in China, the author uses primary source examples from family letters and diaries to illustrate differences in responsibilities and opportunities for single and married women, and how motherhood changed their relationship to their work even further. Requirements for “homemaking”, and a “civilizing mission” expected of married women, increased pressure on missionary wives. Single women, arriving in larger numbers in the early 20th century, were able to focus only on the mission work and accomplish more. The success and productivity of single women further marginalized married women, particularly those with children, who could not keep up with their single counterparts in the mission work. By exploring these two exemplars we can draw an even more nuanced picture of the many ways Baptist women missionaries negotiated their callings in light of their family status. Full article
(This article belongs to the Special Issue Reclaiming Voices: Women's Contributions to Baptist History)
11 pages, 1691 KB  
Article
Exome Sequencing to Identify Novel Variants Associated with Secondary Amenorrhea and Premature Ovarian Insufficiency (POI) in Saudi Women
by Ahmed M. Almatrafi, Ali M. Hibshi and Sulman Basit
Biomedicines 2024, 12(4), 785; https://doi.org/10.3390/biomedicines12040785 - 3 Apr 2024
Cited by 2 | Viewed by 2884
Abstract
Background and objectives: Post-pubertal disappearance of menstrual cycles (secondary amenorrhea) associated with premature follicular depletion is a heterogeneous condition. Patients with this disease have low levels of gonadal hormones and high levels of gonadotropins. It is one of the causes of female infertility [...] Read more.
Background and objectives: Post-pubertal disappearance of menstrual cycles (secondary amenorrhea) associated with premature follicular depletion is a heterogeneous condition. Patients with this disease have low levels of gonadal hormones and high levels of gonadotropins. It is one of the causes of female infertility and a strong genetic component is attributed as an underlying cause of this condition. Although variants in several genes have been associated with the condition, the cause of the disease remains undetermined in the vast majority of cases. Methodology and Materials: Ten Saudi married women experiencing secondary amenorrhea were referred to a center for genetics and inherited diseases for molecular investigation. A family-based study design was used. Intensive clinical examinations, including pelvic ultra-sonography (U/S) and biochemical evaluations, were carried out. Karyotypes were normal in all cases and polycystic ovarian syndrome (PCOS) was excluded by using Rotterdam consensus criteria. Patients’ DNA samples were whole-exome sequenced (WES). Bidirectional Sanger sequencing was then utilized to validate the identified candidate variants. The pathogenicity of detected variants was predicted using several types of bioinformatics software. Results: Most of the patients have a normal uterus with poor ovarian reserves. Exome sequence data analysis identified candidate variants in genes associated with POI in 60% of cases. Novel variants were identified in HS6ST1, MEIOB, GDF9, and BNC1 in POI-associated genes. Moreover, a homozygous variant was also identified in the MMRN1 gene. Interestingly, mutations in MMRN1 have never been associated with any human disease. The variants identified in this study were not present in 125 healthy Saudi individuals. Conclusions: WES is a powerful tool to identify the underlying variants in genetically heterogeneous diseases like secondary amenorrhea and POI. In this study, we identified six novel variants and expanded the genotype continuum of POI. Unravelling the genetic landscape of POI will help in genetic counselling, management, and early intervention. Full article
(This article belongs to the Special Issue Molecular and Genetic Bases of Infertility)
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13 pages, 458 KB  
Article
Mothers’ Breastfeeding Satisfaction: Key to Environmental Sustainability
by Maria Teresa Murillo-Llorente, Adalberto Asins-Cubells, Javier Pérez-Murillo, Alma Palau-Ferrè, Maria Ester Legidos-García, Francisco Llorca-Colomer, Francisco Tomás-Aguirre and Marcelino Perez-Bermejo
Sustainability 2024, 16(5), 2041; https://doi.org/10.3390/su16052041 - 29 Feb 2024
Viewed by 3433
Abstract
Breastfeeding is the natural way to feed a baby in the first months of life. It is an option with a low environmental impact, as it is a natural and renewable food that does not pollute. It is the optimal food for the [...] Read more.
Breastfeeding is the natural way to feed a baby in the first months of life. It is an option with a low environmental impact, as it is a natural and renewable food that does not pollute. It is the optimal food for the infant, with nutritional and immunological advantages that reduce the prevalence of pregnancy disorders and provide benefits for the infant, the mother, and the environment. Its premature abandonment may have medium- and long-term consequences, as the use of formula milk is much more polluting. A descriptive, observational, cross-sectional study was carried out between December 2020 and January 2021, involving 96 breastfeeding women. Sociodemographic and obstetric variables were collected. A validated Spanish version of the Breastfeeding Self-efficacy Scale-Short Form (BSES-SF) was used. Factors that may lead to the early cessation of breastfeeding among the mothers that were studied are a high level of education, a lack of preparation for childbirth, a lack of security, a lack of confidence in preparation for childbirth, a lack of self-confidence, discomfort with breastfeeding in the presence of others, and a low level of maternal satisfaction. Married women and women whose partners support breastfeeding are significantly more satisfied with exclusive breastfeeding than single and divorced women. Adequate and protocolised care must be provided. Education and support for parents to allow for optimal breastfeeding and reduce the environmental impact of formula feeding is essential. Full article
(This article belongs to the Section Health, Well-Being and Sustainability)
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12 pages, 718 KB  
Article
Fertility and Pregnancy Outcomes after Fertility-Sparing Surgery for Early-Stage Borderline Ovarian Tumors and Epithelial Ovarian Cancer: A Single-Center Study
by Mu-En Ko, Yi-Heng Lin, Kuan-Ju Huang, Wen-Chun Chang and Bor-Ching Sheu
Cancers 2023, 15(22), 5327; https://doi.org/10.3390/cancers15225327 - 8 Nov 2023
Cited by 3 | Viewed by 3280
Abstract
This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18–45 [...] Read more.
This study examined treatment outcomes, including preserved fertility, menstrual regularity, and pregnancy outcomes, in patients with stage I epithelial ovarian cancer (EOC) or borderline ovarian tumors (BOTs) who underwent fertility-sparing surgery (FSS). Patients with stage I EOC and BOTs who were aged 18–45 years and underwent FSS between 2007 and 2022 were retrospectively reviewed. Significant differences between various subgroups in terms of disease recurrence, menstrual irregularity due to the disease, and pregnancy outcomes were analyzed. A total of 71 patients with BOTs and 33 patients with EOC were included. In the BOT group, the median age was 30 (range, 19–44) years. Recurrence occurred in eight patients, with one case exhibiting a malignant transformation into mucinous EOC. Among the 35 married patients with BOTs, 20 successfully conceived, resulting in 23 live births and 3 spontaneous abortions. A higher pregnancy rate was observed in those without prior childbirth (82.4%) than in those who had prior childbirth (33.3%). In the EOC group, the median age was 34 (range, 22–42) years. Recurrence occurred in one patient. Menstrual regularity was maintained in 69.7% of the patients. Among the 14 married patients in this group, 12 achieved a total of 15 pregnancies (including 2 twin pregnancies), 16 live births, and 1 spontaneous abortion. The results of the study confirmed that FSS is a favorable surgical option for young women with early-stage BOTs or EOC who wish to preserve their fertility. However, additional investigations are needed to validate these findings. Full article
(This article belongs to the Section Cancer Epidemiology and Prevention)
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13 pages, 905 KB  
Article
Assessing the Level of Knowledge and Experience Regarding Cervical Cancer Prevention and Screening among Roma Women in Romania
by Septimiu Voidăzan, Alexandra Mihaela Budianu, Rozsnyai Florin Francisc, Zsolt Kovacs, Cosmina Cristina Uzun, Bianca Elena Apostol and Reka Bodea
Medicina 2023, 59(10), 1885; https://doi.org/10.3390/medicina59101885 - 23 Oct 2023
Cited by 1 | Viewed by 3382
Abstract
Background and Objectives: Romania ranks among the countries with a particularly high rate of mortality that can be prevented through prevention programs, screening, early detection, and prompt care. Cervical cancer (CC) is a major cause of these preventable deaths, affecting individuals from [...] Read more.
Background and Objectives: Romania ranks among the countries with a particularly high rate of mortality that can be prevented through prevention programs, screening, early detection, and prompt care. Cervical cancer (CC) is a major cause of these preventable deaths, affecting individuals from marginalized and rural regions, as well as the Roma population. The purpose of this article was to identify accurate and consistent information about the Roma population on the risk of CC, as well as the importance of understanding the causes of the disease and awareness of the available prevention methods. Materials and Methods: A cross-sectional study was conducted using a self-administered questionnaire applied only to Roma women in Romania. Results: We enrolled 759 patients in this study. These were divided into two groups: Group 1 comprised 289 (38.1%) women who had been tested for HPV infection, while Group 2 included 470 (61.9%) women who had never been tested for HPV infection. Characterization of women in Group 1: mostly aged between 25 and 54 years, with high school education, married, who started sexual activity under the age of 18 years, with only one sexual partner, and had over five pregnancies. Regarding contraceptive methods, 35.7% of women do not know or use any contraceptive method, and 32.2% use hormonal contraceptives. Two thirds of the women tested had heard of HPV, and 19.7% were vaccinated against HPV with at least 2–3 doses. A percentage of 8.7 had a diagnosis of CC, compared to those who were not tested (p-0.0001), whereas 63% of the tested women did not know much about CC, as opposed to 85.7% of the group of untested women. Conclusions: Cervical cancer (CC) continues to be a public health concern in Romania, particularly among vulnerable groups. Promoting campaigns to raise awareness for HPV vaccination and CC screening are necessary to reduce the associated mortality and morbidity. Full article
(This article belongs to the Section Epidemiology & Public Health)
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