Search Results (24)

Background: Cobras (Naja sp.) are medically important snakes in Thailand. Envenoming by the monocled cobra (N. kaouthia) often causes neurotoxicity, most notably ptosis, ophthalmoplegia, local tissue necrosis and progressive paralysis leading to respiratory failure. Early antivenom administration and respiratory support are medically significant for effective treatment. Methods: In this study, we determined the association between the time course of cobra envenoming and related neurotoxic outcomes using the clinical profiles of cobra envenomed patients. We also demonstrated histopathological changes in the neuromuscular junction of the diaphragm in experimentally envenomed rats. Results: A retrospective study of 69 cases of cobra envenoming in Central and Southern Thailand shows that delayed arrival beyond one hour at hospital was common among younger adults (47.0% aged 10–29) and associated with more severe neurotoxicity, including higher rates of ptosis (41.2%, p = 0.032) and referrals (41.2% vs. 15.4%, p = 0.040). Antivenoms (22 Monovalent and 1 Polyvalent) were administered to 23 (33.3%) envenomed victims and caused adverse reactions in 9 cases (39.1%). Neurotoxicity following cobra envenoming in the clinical section correlated with histopathological examination of envenomed rat diaphragms. Transmission electron microscopy (TEM) revealed degeneration of the neuromuscular junction and diaphragm within 1 h following experimental cobra envenomation, which worsened by 4 h. Intravenous administration of antivenom at recommended doses reduced diaphragmatic damage but failed to prevent presynaptic degeneration after 90 min of envenoming. Conclusions: Clinically, extraocular muscle paralysis was the earliest manifestation. Early monitoring and prompt administration of antivenom are essential to reduce neurotoxicity and relevant complications. Full article

The premetastatic niche (PMN) represents a specialized microenvironment established in distant organs before the arrival of metastatic cells. This concept has fundamentally altered our understanding of cancer progression, shifting it from a random event-driven process to an orchestrated one. This review examines the critical role of extracellular proteases in PMN formation, focusing on matrix metalloproteinases (MMPs), serine proteases, and cysteine cathepsins that collectively orchestrate extracellular matrix remodeling, immune modulation, and vascular permeability changes essential for metastatic colonization. Key findings demonstrate that MMP9 and MMP2 facilitate basement membrane degradation and the recruitment of bone marrow-derived cells. At the same time, tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes organ-specific hepatic PMN recruitment through neutrophil recruitment mechanisms. The plasminogen–plasmin system emerges as a master regulator through its broad-spectrum proteolytic activity and ability to activate downstream proteases, with S100A10-mediated plasmin generation providing mechanistic pathways for remote PMN conditioning. Neutrophil elastase and cathepsin G contribute to the degradation of anti-angiogenic proteins, thereby creating pro-metastatic microenvironments. These protease-mediated mechanisms represent the earliest interventional window in metastatic progression, offering therapeutic potential to prevent niche formation rather than treat established metastases. However, significant methodological challenges remain, including the need for organ-specific biomarkers, improved in vivo methods for measuring protease activity, and a better understanding of temporal PMN dynamics across different target organs. Full article

The dialogue between Christianity and Buddhism began during the Tang dynasty (618–907) when East Syrian Christian missionaries from Persia arrived in China in 635. At this time, Buddhism was prospering under the Tang Empire, and the “Church of the East” was established, known as the “Brilliant (or Radiant) Teaching” (Jingjiao 景教). Historical records and archaeological evidence indicate that the Jingjiao church employed the method of “matching concepts” (geyi 格義). This methodology, initially utilized in the early stages of Buddhism’s dissemination from India and Central Asia to China for the translation of Buddhist texts, was similarly applied to the translation of Christian texts and concepts. These translation efforts and dissemination activities represent the earliest documented encounters between Christianity and Buddhism in premodern times. Furthermore, recent archaeological discoveries reveal that the dialogue between the two religions in China transpired through textual and visual representations (iconography) in the form of “borrowing pictures”. This study investigates these interactions across disciplines, exploring the evidence of early cultural exchange between Buddhism and Christianity while reviewing the motivations behind the missionaries’ translation and dissemination activities. It addresses pivotal questions regarding these early dialogues by examining the proselytization strategies employed and analyzing the reasons why imperial authorities sanctioned Christian activities and facilitated their propagation during the Tang dynasty. Full article

Deterministic transmission technology is a core key technology that supports deterministic real-time transmission requirements for industrial control in Time-Sensitive Networking (TSN). It requires each network node to have a deterministic forwarding delay to ensure the real-time end-to-end transmission of critical traffic streams. Therefore, when forwarding data frames, the switch nodes must consider the time-limited requirements of the traffic. In the input-queued switch system, an algorithm for clock-synchronized deterministic network traffic classification scheduling (CSDN-TCS) is proposed to address the issue of whether a higher-quality-of-service (QoS) performance can be provided under packet deadline constraints. First, the scheduling problem of the switch is transformed into a decomposition problem of the traffic matrix. Secondly, the maximum weight-matching algorithm in graph theory is used to solve the matching results slot by slot. By fully utilizing the slot resources, as many packets as possible can be scheduled to be completed before the deadline arrives. For two types of packet scheduling problems, this paper uses the maximum flow algorithm with upper- and lower-bound constraints to move packets from a larger deadline set to idle slots in a smaller deadline set, enabling early transmission, reducing the average packet delay, and increasing system throughput. When there are three or more types of deadlines in the scheduling set, this scheduling problem is an NP-hard problem. We solve this problem by polling the two types of scheduling algorithms. In this paper, simulation experiments based on the switching size and line load are designed, and the Earliest Deadline First (EDF) algorithm and the Flow-Based Iterative Packet Scheduling (FIPS) algorithm are compared with the CSDN-TCS algorithm. The simulation results show that under the same conditions, the CSDN-TCS algorithm proposed in this paper outperforms the other two algorithms in terms of success rate, packet loss rate, average delay and throughput rate. Compared with the FIPS algorithm, the CSDN-TCS algorithm has lower time complexity under the same QoS performance. Full article

Real-time performance and reliability are two critical indicators in cyber–physical production systems (CPPS). To meet strict requirements in terms of these indicators, it is necessary to solve complex job-shop scheduling problems (JSPs) and reserve considerable redundant resources for unexpected jobs before production. However, traditional job-shop methods are difficult to apply under dynamic conditions due to the uncertain time cost of transmission and computation. Edge computing offers an efficient solution to this issue. By deploying edge servers around the equipment, smart factories can achieve localized decisions based on computational intelligence (CI) methods offloaded from the cloud. Most works on edge computing have studied task offloading and dispatching scheduling based on CI. However, few of the existing methods can be used for behavior-level control due to the corresponding requirements for ultralow latency (10 ms) and ultrahigh reliability (99.9999% in wireless transmission), especially when unexpected computing jobs arise. Therefore, this paper proposes a dynamic resource prediction scheduling (DRPS) method based on CI to achieve real-time localized behavior-level control. The proposed DRPS method primarily focuses on the schedulability of unexpected computing jobs, and its core ideas are (1) to predict job arrival times based on a backpropagation neural network and (2) to perform real-time migration in the form of human–computer interaction based on the results of resource analysis. An experimental comparison with existing schemes shows that our DRPS method improves the acceptance ratio by $25.9\%$ compared to the earliest deadline first scheme. Full article

After the fall of Tenochtitlan in 1521, the first groups of friars arrived in Mexico to Christianize the native inhabitants of Mesoamerica. This task was anything but easy, as explaining Christian doctrine to the Indigenous people posed both a linguistic and a theological challenge. The need to learn Indigenous languages and to prepare doctrinal materials dedicated specifically to the Christianization of this land was a task that might have seemed almost impossible to conduct in a short period of time, yet by the 1540s, the first printed catechisms (doctrinas) in Nahuatl began to appear. One of the earliest and broadest of these works is the 1548 Dominican Doctrina Christiana en Lengua Española y Mexicana, in which the friars attempted to explain all of the principles of Catholic theology to the Indigenous people. This paper analyses how through highly detailed descriptions and a meticulous choice of vocabulary, the authors strove to impart the tenets of Christian doctrine to the Nahuas in such a way as to make it both fully understandable and as unlikely as possible to be misinterpreted. It points to the sources on which the friars relied while writing the text. The article formulates a theory that the creation of the Doctrina Christiana would not have been possible without the participation of the native speakers of Nahuatl in the project, even though their role in writing the catechism would have had to be hidden from the religious authorities. The Indigenous authors served as cross-cultural bridges in the process of preparing the doctrinal materials. On the one hand, they could therefore help to explain crucial parts of the doctrine to the Indigenous audience. On the other hand, allowing Indigenous concepts to permeate the Christian discourse often led to the creation of ambiguity and provided a space of contestation that could influence the understanding of the Catholic concepts by the Indigenous audience. Full article

This study analyzed frost formation data provided by the Harbin Meteorological Bureau and considered geographic factors, temperature, and population density. Various analytical methods, including linear fitting, the Mann–Kendall mutation test, the Pettitt method, and the sliding t-test, were employed to identify the temporal and spatial changes as well as the effects of these factors on frost dates in Harbin. The study shows that the first FSD occurred on 18 August, in both 1966 and 1967, which was the 255th day. The latest FSD was observed on 10 October 2006, which was the 283rd day. The earliest occurrence of an FED was on 24 April 2015, which was the 114th day, and the latest was on 21 April 1974, which was the 141st day. The highest number of frost days occurred in 2012, with 161 days, whereas the shortest year was 1966, with only 123 frost days. Throughout the study period, the FSD increased by 7.8 days at a rate of −1.27d/10a, the FED increased by 10.9 days at a rate of 1.77d/10a, and the FFS increased by 18.9 days at a rate of 3.05d/10a. The propensity rates of the FSD and FFS at each location in Harbin indicate an upward trend, while for the FED, certain locations display an upward trend. In general, the FSD has exhibited a delayed trend, the FED has shown an earlier trend, and the FFS has experienced an extended trend. With one-way linear regression, the FSD exhibited an increasing trend at each site, while the FFS also indicated a similar trend, and the FED showed an overall decreasing trend. Throughout the study period, a change was observed in the FSD in 2000, resulting in an average arrival time of the 265th day, or 22 September, of that year. Subsequently, post mutation, the average arrival time of the FSD in the study area was the 272nd day, or 29 September, of that year. In 2006, the FED also underwent a change, with the average arrival time in the study area being the 128th day, or 4 April, of that year. After the change, the average arrival time of the FED in the study area was the 121st day, i.e., 8 April. In 1 April 2004 of that year saw a change in the FFS. Prior to the change, the FFS in the study area averaged the 137th day, whilst following the change, the FFS in the study area averaged the 150th day. The FSD and FFS within Harbin exhibit a negative correlation with latitude and a positive correlation with temperature. Additionally, the FED displays a positive correlation with latitude and a negative correlation with temperature. As the FSD, FED, and FFS in central Harbin are the earliest, latest, and longest, the Pearson correlation coefficient method and multiple regression cannot adequately reflect the effect of longitude. Full article

The eastern Baltic region represents the world’s most northerly limit of successful broomcorn millet (Panicum miliaceum) (hereafter, millet) cultivation in the past, yet this crop has been almost forgotten today. The earliest millet in the eastern Baltic region has been identified from macrobotanical remains which were directly dated to ca 1000 BCE. Between 800 and 500 BCE, millet was one of the major staple foods in the territory of modern-day Lithuania. Millet continued to play an important role in past agriculture up until the 15th century, with its use significantly declining during the following centuries. This paper analyses both the archaeobotanical records and written sources on broomcorn millet cultivation in Lithuania from its first arrival all the way through to the 19th century. The manuscript reviews the evidence of millet cultivation in the past as documented by archaeobotanical remains and historical accounts. In light of fluctuating records of millet cultivation through time, we present the hypothetical reasons for the decline in millet use as human food. The paper hypothesizes that the significant decrease in broomcorn millet cultivation in Lithuania from the 15th century onwards was likely influenced by several factors, which include climate change (the Little Ice Age) and the agricultural reforms of the 16th century. However, more detailed research is required to link past fluctuations in millet cultivation with climatic and historical sources, thus better understanding the roots of collapsing crop biodiversity in the past. Full article

In a production environment, scheduling decides job and machine allocations and the operation sequence. In a job shop production system, the wide variety of jobs, complex routes, and real-life events becomes challenging for scheduling activities. New, unexpected events disrupt the production schedule and require dynamic scheduling updates to the production schedule on an event-based basis. To solve the dynamic scheduling problem, we propose a multi-agent system with reinforcement learning aimed at the minimization of tardiness and flow time to improve the dynamic scheduling techniques. The performance of the proposed multi-agent system is compared with the first-in–first-out, shortest processing time, and earliest due date dispatching rules in terms of the minimization of tardy jobs, mean tardiness, maximum tardiness, mean earliness, maximum earliness, mean flow time, maximum flow time, work in process, and makespan. Five scenarios are generated with different arrival intervals of the jobs to the job shop production system. The results of the experiments, performed for the 3 × 3, 5 × 5, and 10 × 10 problem sizes, show that our multi-agent system overperforms compared to the dispatching rules as the workload of the job shop increases. Under a heavy workload, the proposed multi-agent system gives the best results for five performance criteria, which are the proportion of tardy jobs, mean tardiness, maximum tardiness, mean flow time, and maximum flow time. Full article

This paper examines the effects of boundedly rational decision characteristics on travelers’ route choice behavior. The concept of boundedly rational confidence level (BRCL) is redefined, which is the probability that a trip arrives between the acceptable earliest arrival time and the acceptable latest arrival time on the shortest travel time budget (TTB). Mathematically, the acceptable boundedly rational arrival thresholds are proposed. Then, a reliability-based boundedly rational traffic equilibrium model (R-BRTE) considering both travel time reliability and acceptable arrival thresholds is developed. Moreover, the equivalent variational inequality problem and uniqueness of solution on the proposed model are proved. A route-based solution algorithm is used to solve the proposed R-BRTE model. Numerical results present the important decision ideas of the proposed model. The results demonstrate that travelers’ bounded rationality has a great impact on their route choice behavior and network performance. Full article

The dispersal of primitive elephantines and monodactyl equids in Eurasia has long been regarded as representative of a substantial turnover in mammal faunas, denoting the spread of open environments linked to the onset of cold and dry conditions in the Northern Hemisphere. During the 1980s, this event was named the “Elephant-Equus event” and it was correlated with the Gauss-Matuyama reversal, today corresponding to the Pliocene-Pleistocene transition and the beginning of the Quaternary, dated at ~2.6 Ma. Therefore, the Elephant-Equus event became a concept of prominent biochronological and paleoecological significance, especially in western Europe. Yet, uncertainties surrounding the taxonomy and chronology of early “elephant” and “Equus”, as well as conceptual differences in adopting (or understanding) the Elephant-Equus event as an intercontinental dispersal event or as a stratigraphic datum, engendered ambiguity and debate. Here, we provide a succinct review of the Elephant-Equus event, considering separately the available evidence on the “elephant” and the “Equus”. Elephantines dispersed out of Africa during the Pliocene (Piacenzian). Their earliest calibrated occurrences from eastern Europe date at ~3.2 Ma and they are usually referred to Mammuthus rumanus, although the allocation of several samples to this species is tentative. Available dating constraints for other localities do not resolve whether the dispersal of Mammuthus was synchronous across Eurasia, but this possibility cannot be ruled out. The spread of Mammuthus was part of an intercontinental faunal exchange between Africa and Eurasia that occurred during the Piacenzian, but in this scenario, Mammuthus is quite unique in being the only genus of African origin dispersing to western Eurasia. The arrival of monodactyl equids from North America coincides with the Pliocene-Pleistocene transition, with several occurrences dated or calibrated at ~2.6 Ma and no compelling evidence prior to this age. In Europe, early monodactyl equids are often aligned to Equus livenzovensis, but the material from the type locality of this species is chronologically time-averaged and taxonomically heterogeneous, and western European samples are seldom abundant or informative. Regardless, this does not diminish the biochronological significance of the “Equus event”. Indeed, while the term “Elephant-Equus event” should no longer be used, as the appearance of elephantines in the European fossil record markedly precedes that of monodactyl equids, we endorse the use of the “Equus event” as a valid alternative to refer to the intercontinental dispersal event that characterizes the middle Villafranchian faunal turnover, epitomized by but not limited to monodactyl equids. Full article

Columbia River province magmatism is now known to include abundant and widespread rhyolite centers even though the view that the earliest rhyolites erupted from the McDermitt Caldera and other nearby volcanic fields along the Oregon–Nevada state border has persisted. Our study covers little-studied or unknown rhyolite occurrences in eastern Oregon that show a much wider distribution of older centers. With our new data on distribution of rhyolite centers and ages along with literature data, we consider rhyolites spanning from 17.5 to 14.5 Ma of eastern Oregon, northern Nevada, and western Idaho to be a direct response to flood basalts of the Columbia River Basalt Group (CRBG) and collectively categorize them as Columbia River Rhyolites. The age distribution patterns of Columbia River Rhyolites have implications for the arrival, location, and dispersion of flood basalt magmas in the crust. We consider the period from 17.5 to 16.4 Ma to be the waxing phase of rhyolite activity and the period from 15.3 to 14.5 Ma to be the waning phase. The largest number of centers was active between 16.3–15.4 Ma. The existence of crustal CRBG magma reservoirs beneath rhyolites seems inevitable, and hence, rhyolites suggest the following. The locations of centers of the waxing phase imply the arrival of CRBG magmas across the distribution area of rhyolites and are thought to correspond to the thermal pulses of arriving Picture Gorge Basalt and Picture-Gorge-Basalt-like magmas of the Imnaha Basalt in the north and to those of Steens Basalt magmas in the south. The earlier main rhyolite activity phase corresponds with Grande Ronde Basalt and evolved Picture Gorge Basalt and Steens Basalt. The later main phase rhyolite activity slightly postdated these basalts but is contemporaneous with icelanditic magmas that evolved from flood basalts. Similarly, centers of the waning phase span the area distribution of earlier phases and are similarly contemporaneous with icelanditic magmas and with other local basalts. These data have a number of implications for long-held notions about flood basalt migration through time and the age-progressive Snake River Plain Yellowstone rhyolite trend. There is no age progression in rhyolite activity from south-to-north, and this places doubt on the postulated south-to-north progression in basalt activity, at least for main-phase CRBG lavas. Furthermore, we suggest that age-progressive rhyolite activity of the Snake River Plain–Yellowstone trend starts at ~12 Ma with activity at the Bruneau Jarbidge center, and early centers along the Oregon–Nevada border, such as McDermitt, belong to the early to main phase rhyolites identified here. Full article

Recent work on automotive communications based on the Time-Sensitive Networking (TSN) standards proposed an approach to handle all the real-time frames in a uniform way regardless of their arrival pattern. According to such an approach, instead of binding all the frames of the same flow to a traffic class, each periodic or event-driven frame is scheduled based on its absolute deadline according to the Earliest Deadline First (EDF) algorithm. The approach does not impose additional frame overhead and does not require complex offline configurations that would be unsuitable for event-driven traffic. However, EDF scheduling cannot support time-driven communications. To solve this problem, this paper proposes a framework that combines the flexibility of online EDF frame scheduling for both periodic and event-driven traffic with the ability to guarantee temporal isolation to time-driven traffic. The paper describes the design of the proposed approach and the performance obtained using the OMNeT++ simulation environment. Full article

All stories vary depending on the channel through which they are presented. In the Late Middle Ages, the transmission of a single fact or event differed significantly according to the means of communication. Since at least 1408, Dominican preacher Saint Vincent Ferrer (c. 1350–1419) used to talk, in some sermons, about the vision experienced by a nameless friar who, being healed in extremis by Christ, preached the arrival of Antichrist afterward. In 1412, Ferrer wrote a letter addressed to pope Benedict XIII including the story of this ecstasy, though with some changes. In 1429, in the parish church of Santa Maria Assunta (frazione Stella, Macello, Piedmont) the earliest depiction of this legendary episode was made. Ferrer was explicitly identified for the first time as the unknown friar mentioned in his sermons from 1408. Extraordinarily, a picture of the friar’s figure appeared beside a literal copy of some passages from Ferrer’s letter to Benedict XIII, incorporated in the same frescoes. This rich documentation reveals the importance of interactions between sermons, texts and images in shaping the narrative of Vincent Ferrer’s vision and its later memory. Full article

Since the arrival of DNA nanotechnology nearly 40 years ago, the field has progressed from its beginnings of envisioning rather simple DNA structures having a branched, multi-strand architecture into creating beautifully complex structures comprising hundreds or even thousands of unique strands, with the possibility to exactly control the positions down to the molecular level. While the earliest construction methodologies, such as simple Holliday junctions or tiles, could reasonably be designed on pen and paper in a short amount of time, the advent of complex techniques, such as DNA origami or DNA bricks, require software to reduce the time required and propensity for human error within the design process. Where available, readily accessible design software catalyzes our ability to bring techniques to researchers in diverse fields and it has helped to speed the penetration of methods, such as DNA origami, into a wide range of applications from biomedicine to photonics. Here, we review the historical and current state of CAD software to enable a variety of methods that are fundamental to using structural DNA technology. Beginning with the first tools for predicting sequence-based secondary structure of nucleotides, we trace the development and significance of different software packages to the current state-of-the-art, with a particular focus on programs that are open source. Full article