1,196 Results Found

For many vaccines, multiple injections are required to confer protective immunity against targeted pathogens. These injections often consist of a primer administration followed by a booster administration of the vaccine a few weeks or months later. A...

Background: gemcitabine is a cytidine analog and major anticancer drug functioning as an antimetabolite. However, its administration by systemic route is accompanied by “burst” and side effects. To limit this, drugs are encapsulated in ma...

The main objective of this study is to develop a novel dual-purpose material based on carbon xerogel microspheres (CXMs) that permits the delayed release of cannabidiol (CBD) and the removal of aflatoxin. The CXMs were prepared by the sol-gel method...

An enteric coating plays a crucial role in preventing the disintegration of pharmaceutical dosage forms in the stomach. This is particularly important for drugs unstable at an acidic pH or designed to act in the small intestine. While conventional sy...

6-thioguanine (6-TG) is an antimetabolite drug of purine structure, approved by the FDA for the treatment of acute myeloid lesukemia, and it is of interest in treating other diseases. The interaction of drugs with matrices is of interest to achieving...

Background/Objectives: In this paper, we created enteric delayed-release granules that load Dendrobine (DNL) directly into the intestinal flora of hyperlipidemic mice, based on the relationship between intestinal flora and hyperlipidemia. Methods: We...

Many vaccines require multiple doses for full efficacy, posing a barrier for patient adherence and protection. One solution to achieve full vaccination may be attained with single-administration vaccines containing multiple controlled release doses....

Global warming leads to premature dormancy release and untimely flowering in southern highbush blueberry during winter, resulting in chilling injury and yield losses. However, effective strategies to delay flowering by modulating dormancy progression...

Oxidation processes can provide an effective barrier to eliminate cyanotoxins by damaging cyanobacteria cell membranes, releasing intracellular cyanotoxins, and subsequently oxidizing these toxins (now in extracellular form) based on published reacti...

Gemcitabine is a widely used antimetabolite drug of pyrimidine structure, which can exist as a free-base molecular form (Gem). The encapsulated forms of medicinal drugs are of interest for delayed and local drug release. We utilized, for the first ti...

Delayed sowing of wheat is a common problem in Punjab that exacerbates serious yield loss. However, individual or combined applications of seed rate and slow-release nitrogen fertilizer significantly impacted their efficacy in improving crop growth a...

Background: To investigate the potential synergistic effects of olive oil releasing 2-oleoylglycerol and hydrolyzed pine nut oil containing 20% pinolenic acid on GLP-1 secretion, glucose tolerance, insulin secretion and appetite in healthy individual...

Single-administration vaccine delivery systems are intended to improve the efficiency and efficacy of immunisation programs in both human and veterinary medicine. In this work, an osmotically triggered delayed delivery device was developed that was a...

Opacity, an important property of the information flow in discrete-event systems (DESs), characterizes whether the secret information in a system is ambiguous to a passive observer (called an intruder). Observation models play a critical role in the...

Currently, there is an increasing interest to apply pre-fusion (pre-F) protein of respiratory syncytial virus (RSV) as antigen for the development of a subunit vaccine. A pre-F-containing powder would increase the flexibility regarding the route of a...

Many health-promoting effects have been attributed to the intake of probiotic cells. However, it is important that probiotic cells arrive at the site of their activity in a viable state in order to exert their beneficial effects. Careful selection of...

Developing delayed-release formulations for acid-sensitive actives can be a costly and time-consuming process. However, ready-to-fill functional capsules, such as EUDRACAP^® can significantly mitigate these challenges. The in vitro performance of...

The search for alternative fuels for internal combustion engines is ongoing. Among the alternatives, plant-based fuels can also be mentioned. Alcohol is not a common fuel for diesel engines because the physical and chemical properties of the alcohols...

Mycobacterium (M.) bovis BCG vaccination is recommended for healthy babies after birth in several countries with a high prevalence of tuberculosis, including Ghana. Previous studies showed that BCG vaccination prevents individuals from developing sev...

Algicides, like hydrogen peroxide and copper sulfate, are commonly applied to recreational waters and drinking water sources to mitigate cyanobacterial blooms. In this work, the effects of hydrogen peroxide and copper sulfate were evaluated in two na...

An injectable delivery platform for promoting delayed bone healing has been developed by combining a thermosensitive polyurethane-based hydrogel with strontium-substituted mesoporous bioactive glasses (MBG_Sr) for the long-term and localized co-deliv...

In his “What Is Life?” Schrödinger poses three questions: (1) What is the source of order in organisms? (2) How do organisms remain ordered in the face of the Second Law of Thermodynamics? (3) Are new laws of physics required? He ans...

Progressive increase in bacterial resistance has caused an urgent need to introduce new antibiotics, one of them being oxazolidinones with their representative tedizolid. Despite the broad spectrum of activity of the parent tedizolid, it is character...

The eBooks market has been growing rapidly in recent years. At the same time, evidence shows that eBooks are cannibalizing the market for physical books. To alleviate the cannibalization effect between eBooks and physical books, publishers may choose...

One of the possibilities to reduce diesel fuel consumption and at the same time reduce the emission of diesel engines, is the use of alternative gaseous fuels, so far most commonly used to power spark ignition engines. The presented work concerns exp...

IBD98-M is a delayed-release formulation of mesalamine (mesalazine) and SH with a potential therapeutic role in ulcerative colitis (UC). A total of 51 patients with a modified Ulcerative Colitis Disease Activity Index (UCDAI) score of ≥4 and ≤1...

Neuronal timing with millisecond precision is critical for many brain functions such as sensory perception, learning and memory formation. At the level of the chemical synapse, the synaptic delay is determined by the presynaptic release probability (...

Polyacrylate/silica hybrid emulsions were prepared by blending aqueous silica nanoparticles with polyacrylate emulsion, which were used for coating urea granules. After incorporating 1.0 wt.% silica nanoparticles into polyacrylate emulsion, prelimina...

This study investigates whether financial markets efficiently incorporate information related to new product releases in industries where fundamental signals become available only after consumer engagement. Analyzing 49 commercial game launches by 13...

Background/Aim: Tooth avulsion and delayed replantation may cause inflammatory responses and root resorption of the tooth. The aim of this study is to investigate the effect of a doxycycline-loaded nitric oxide-releasing nanomatrix (DN) gel on the de...

Long COVID (LC) may involve endocrine dysfunction; however, the underlying mechanism remains unclear. To examine hypothalamic–pituitary responses in patients with LC, we conducted a single-center retrospective study of patients with refractory...

Garambullo is a plant with little industrial application. However, garambullo contains betalains, photosensitive phytochemical compounds, which through microencapsulation can be used in chitosan–polyvinyl alcohol (PVOH) films for application in...

Initial seizures observed in young rats during the 60 min after administration of pilocarpine (Pilo) were delayed and attenuated by pretreatment with a non-convulsive dose of methionine sulfoximine (MSO). We hypothesized that the effect of MSO result...

Intrinsically, enteric capsule shells offer several advantages compared to coating of dosage forms with enteric polymers. We undertook a systematic investigation to elucidate capsule-fill parameters that may result in premature gastric drug release f...

Leaching and nitrous oxide (N₂O) emissions can represent substantial nitrogen (N) losses from chemical fertilizers, and slow-release fertilizers (SRFs) can mitigate these effects. Thus, biochar can be an alternative from an agronomic and environmenta...

Gallic acid–Antarctic krill peptides (GA-AKP) nanocapsules (GA-AKP-Ns) were prepared using a dual delivery system with complex emulsion as the technical method, a high-pressure microjet as the technical means, polylactic acid–hydroxyaceti...

The on-plane rotations of the inclined axle-chain system on the functional swing plane (FSP) can represent the angular motions of the golfer–club system closely. The purpose of this study was to identify key performance factors in golf through...

Since their introduction to pharmacotherapy, proton pump inhibitors (PPIs) have been widely used in the treatment of numerous diseases manifested by excessive secretion of gastric acid. Despite that, there are still unmet needs regarding their availa...

Targeting celecoxib to the ileo-colonic region could be beneficial for the treatment and prevention of colon cancer. Ileo-colonic targeting can be achieved by using pH-dependent coating systems such as ColoPulse. Celecoxib has poor aqueous solubility...

The aim of the work is a comparison of two combustion systems of fuels with different reactivity. The first is combustion of the fuel mixture and the second is combustion in a dual-fuel engine. Diesel fuel was burned with pure ethanol. Both methods o...

Oral specially coated formulations have the potential to improve treatment outcomes of a range of diseases in distal intestinal tract whilst limiting systemic drug absorption and adverse effects. Their development is challenging, partly because of li...

Several nutraceutical products require gastric protection against the hostile environment in the stomach. Currently marketed synthetic and semi-synthetic coatings suffer from major shortcomings such as poor gastric protection, slow-release response t...

The ryanodine receptor (RyR2) has a critical role in controlling Ca²⁺ release from the sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple functional domains with specific roles, and four of these RyR2 protomers are re...

The use of sustainable carbon-free energy sources is becoming a priority in the field of transport so that it becomes sustainable. Sustainable transport can also be achieved with vehicles equipped with diesel engines fuelled by alternative fuels that...

Farmers are increasing the use of fertilizers in chestnut, the only cash crop produced in the mountainous areas of northeastern Portugal. This calls for more studies to guide them towards a more ecological intensification. The effects of three contro...

When order release is applied, jobs are withheld in a backlog from where they are released to meet certain performance targets. The decision that selects jobs for release is typically preceded by a sequencing decision. It was traditionally assumed th...

To facilitate the better use of RP-3 kerosene in compression ignition engines, the auto-ignition behaviors of RP-3 kerosene spray were experimentally investigated in an optical rapid compression machine. Results show that most of the tests have good...

We analyzed a sample of 21 solar energetic particle (SEP) events with clear signatures in both near-relativistic electrons and high-energy protons spanning over ∼2.5 solar cycles from 1997 to 2016. We employed velocity dispersion analysis (VDA) f...

Releasing Wolbachia-infected mosquitoes into the wild to suppress wild mosquito populations is an effective method for mosquito control. This paper investigates the finite-time contraction stability and optimal control problem of a mosquito populatio...

In this paper, based on the optical experimental platform of constant combustion and rapid compression expansion machines, the effects of spray characteristics and injection strategies of diesel in an atmosphere with ammonia on the ignition character...