Search Results (12,383)

Ovarian cancer is a gynecological cancer, which, if metastasized and not detected early, can cause death among women. Therefore, accurate prediction of drug responses to ovarian cancer is needed. A gynecological pathologist inspects abnormality in tissues and provides a report for patients; however, this diagnostic process (1) is difficult to undertake; (2) requires experience; and (3) is time-consuming. Moreover, existing tools are imperfect. Hence, we present a computational pipeline to improve predictions of drug response pertaining to ovarian cancer. First, we downloaded digital pathology images pertaining to ovarian responses to bevacizumab from the Cancer Imaging Archive Repository. We employed a histogram of oriented gradients for images, constructed feature vectors, and used Fisher’s linear discriminant analysis to alter data representations through dimensionality reduction. This reduced-dimensionality data was used for regression analysis, employing support vector regression coupled with various kernels and calculating the area under the ROC curve (AUC). Experimental results were validated using transformer-based models (ViT and Swin) and other deep learning (DL) models (VGG16, ResNet50, InceptionV3, MobileNetV2, and EfficientNetB6). Our approach using a radial kernel (named SVRD + R) improved AUC performance by 17% compared to the best-performing transformer-based model (ViT). Likewise, AUC performance improved by 14.9% when compared against the best DL-based model (MobileNetV2). These results demonstrate feasibility, showing that induced models via the presented AI-based pipeline can lead to superior performance when investigating prediction problems pertaining to gynecologic cancer studies. Full article

Background: Cardiac point-of-care ultrasound (POCUS) is widely used in emergency and acute care settings. Still, broader use remains limited by operator dependence and variability in image acquisition and interpretation. Artificial intelligence (AI), including machine learning and deep learning methods, has been applied to cardiac POCUS to support image acquisition, automate quantitative measurements, and assist interpretation. Methods: We performed a narrative review of current applications of AI-assisted cardiac POCUS. A targeted literature search of PubMed and Google Scholar from 2018 to 2026 was conducted using terms related to AI, machine learning, deep learning, and cardiac ultrasound. Studies evaluating AI-assisted cardiac ultrasound in clinical, educational, or image-acquisition settings were included, with emphasis on recent, clinically relevant applications. Results: The most developed application of AI-assisted cardiac POCUS is an automated assessment of left ventricular systolic function, particularly the left ventricular ejection fraction (LVEF), where multiple studies report agreement with expert interpretation or formal echocardiography and improved performance among novice users. AI-assisted tools have also been evaluated for pericardial effusion detection, guidance for image acquisition, and education. More complex applications, including diastolic function assessment and hemodynamic measurements such as LVOT-VTI, remain less well validated and more dependent on image quality. Across studies, performance is closely linked to image acquisition quality and has often been evaluated under controlled rather than real-world conditions. Conclusions: Current evidence supports AI-assisted cardiac POCUS primarily as a decision-support tool, with the strongest data for automated assessment of LVEF. Other applications remain investigational. Full article

Artificial intelligence (AI) is reshaping the field of diagnostic radiology; however, its applications in interventional radiology and pediatric interventional radiology (PIR) remain limited despite clear clinical needs and the rich multimodal data environment characteristic of pediatric procedural care. In this narrative review, I summarize the current state of AI technologies relevant to PIR and outline future perspectives for their clinical integration. Peer-reviewed literature and position statements identified through MEDLINE/PubMed, Embase, Scopus, and major society publications up to the first quarter of 2026 are synthesized, focusing on AI applications across the PIR care pathway, including dose-sparing image acquisition and reconstruction, automated image interpretation and computer-aided diagnosis, data-driven procedural planning and navigation, and post-procedural risk prediction and monitoring. After briefly introducing core machine learning and deep learning concepts, pediatric-specific challenges are discussed, including radiation sensitivity, growth-related anatomical variability, regulatory constraints, and the scarcity of large, annotated datasets, as well as existing and emerging applications along the PIR care pathway: AI-assisted dose reduction and image reconstruction, automated image interpretation, segmentation, and computer-aided diagnosis; data-driven procedural planning, including three-dimensional modelling, augmented reality, AI-enabled/AI-adjacent robotics, and AI-directed procedural navigation; and post-procedural risk prediction and outcome monitoring. Finally, emerging paradigms, including explainable AI, federated learning, and multimodal integration, are highlighted, and research priorities, collaborative frameworks, and governance principles required to ensure safe, equitable, and effective AI deployment in PIR are outlined. In doing so, this review delineates the current evidence gaps and priority directions for clinically meaningful AI adoption in PIR. Although AI has the potential to improve patient care, it has not yet been specifically designed, validated, or deployed in children. Existing work demonstrates feasibility across the PIR workflow, but most tools remain weakly linked to pediatric clinical endpoints. Full article

Integrating neural and muscular signals into wearable robotics enables adaptive assistance during real-world tasks. This study proposes a multimodal neural interface for passive exoskeletons that combines electroencephalography (EEG) and electromyography (EMG) signals to classify motor gestures and estimate real-time cognitive and muscular effort, supported by finite-element-based biomechanical modeling. The system was implemented on the Ottobock Shoulder X passive exoskeleton© and validated using synchronous EEG–EMG acquisition via the LiveAmp platform©, a commercially available platform that was not developed specifically for this study. A hybrid CNN–LSTM architecture with deep fusion was employed to enhance robustness and responsiveness under realistic operating conditions. This study proposes a multimodal neural interface for the software-level adaptive assistance of passive upper-limb exoskeletons. While the physical device maintains a static mechanical profile, the proposed digital framework achieves adaptation by interpreting the user’s physiological and motor states. Ten healthy participants performed three functional tasks (screwing, moving the box, and lifting the box) under five assistive conditions. Finite element modeling (FEM) was used to characterize the torque–angle relationship of the passive exoskeleton and to support the interpretation of experimentally observed assistive torque profiles. The FEM model, used as an offline biomechanical analysis tool to aid in the interpretation of experimental results, has not been integrated into the real-time control loop. Results showed an average classification accuracy of 90%, an F1-score of 0.85, and inference latency below 180 ms, confirming real-time applicability. Cognitive indices such as the Cognitive Load Index (CLI) and Frontal Asymmetry Index (FAI) enabled adaptive modulation of assistance strategies without requiring active actuation, thereby preserving the device’s intrinsic passive nature. Comparative torque analysis highlighted the ergonomic benefits of passive systems in mid-range postures, while Finite Element Method (FEM) supported analysis clarified their limitations under highly dynamic loads compared to active solutions. These findings advance multimodal brain–machine interfaces for wearable robotics by integrating physiological sensing, deep learning, and biomechanical modeling, offering a safe, energy-efficient, and adaptive approach with potential rehabilitation, occupational ergonomics, and human–robot applications. Full article

As tunnel engineering continues to advance toward deeper, longer, and more complex projects, the risks encountered during the construction phase have evolved into a combination of various disaster types and the accumulation of multiple contributing factors. Traditional empirical and semi-empirical risk management methods are increasingly revealing shortcomings in terms of timeliness, accuracy, and the ability to process multi-source data. In recent years, driven by advancements in computing power and sensor technology, artificial intelligence algorithms (AI algorithms) such as machine learning and deep learning have been rapidly adopted in tunnel construction risk management. This paper retrieved relevant literature from the Web of Science database covering the period from 2010 to 2025. After rigorous screening, 96 highly relevant papers were selected for bibliometric analysis. This paper systematically reviews research progress from two perspectives: algorithmic models and engineering applications. The review indicates that, in terms of algorithmic models, traditional machine learning, convolutional neural network, recurrent neural network, generative adversarial network, Transformer, and graph neural network constitute a multi-level technical framework encompassing feature representation, risk perception, and intelligent decision-making. In terms of applications, AI algorithms have been widely integrated into typical scenarios such as geological hazard identification and prediction, surrounding rock stability and deformation prediction, rock burst assessment and early warning, lining defect detection and structural safety assessment, construction-induced ground settlement prediction, and tunnel gas and fire hazard prediction, significantly enhancing risk identification and early warning capabilities. However, several challenges remain, including the scarcity of high-quality datasets, the prevalence of noisy, incomplete, and heterogeneous monitoring data, insufficient coupling between model interpretability and engineering mechanisms, limited cross-project transferability, and the lack of integrated management systems for multi-hazard lifecycle control. Based on this, this paper proposes future research directions in areas such as data infrastructure development, integration of mechanism constraints, and multi-hazard collaborative modeling, aiming to provide guidance for the further development of intelligent risk management in tunnel construction. Full article

Background: Tongue diagnosis is a fundamental diagnostic method in traditional medicine. Studies restricted to single ethnic groups may introduce bias and limit the clinical applicability of digital tongue diagnosis across diverse populations. Objectives: This study examined differences in tongue image features between Japanese and Brazilian (Caucasian ancestry) participants using digital tongue diagnosis technology and explored potential influencing factors. Methods: Tongue images were collected from 143 Japanese and 116 Brazilian participants attending traditional medicine clinics in Japan and Brazil. An independently developed tongue image analysis system (TIAS) was employed to extract shape, texture (gray level co-occurrence matrix), color (L*a*b color space), and deep-learning derived features (crack, prickle, tooth-mark, peel, greasy coating, stasis). Statistical analyses and machine learning models with SHAP explainability were used to compare features and identify key classification parameters. Results: Significant inter-group differences were observed in tongue shape, texture parameters (particularly at the root and tip), color parameters (especially middle-a-mean, middle-b-mean, tip-a-mean, and tip-b-mean), and deep features. The Japanese group showed a markedly higher prevalence of greasy coating (72.03% vs. 41.38%, p < 0.001) and stasis. Machine learning analysis revealed that the b value in the middle region of the tongue (middle-b-mean) contributed most strongly to the classification of greasy coating. Conclusions: The digital tongue image analysis system enables accurate and objective quantification of tongue features. Pronounced ethnic differences exist, particularly in the distribution of greasy coating. The middle-b-mean has the greatest impact on greasy coating classification. These findings underscore the importance of considering ethnic background when developing digital tongue diagnosis systems. Full article

The mean stand diameter at breast height (DBH) is a key indicator of stand structure and productivity and is widely used in forest resource inventory and management planning. When using regional inventory data, nonlinear interactions between plot-level conditions and predictor variables can undermine the stability of traditional empirical equations across varying site qualities and stand densities. To improve the accuracy and robustness of inventory-scale predictions of mean stand DBH, this study utilized data from 854 forest plots and employed stand age, site class index (SCI), and stand density index (SDI) as independent variables. The predictive performance of traditional growth equations, machine learning models (Random Forest, XGBoost, LightGBM, and support vector machine), and deep learning models (MLP and CNN, ResNet, RNN) was systematically compared, and ensemble learning strategies were further applied to optimize model performance. The results indicated that the Weibull model based solely on stand age achieved the best fit (R² = 0.669). Incorporating SCI and SDI greatly improved model explanatory capability with R² rising to 0.838. XGBoost and CNN further improved predictive performance (R² = 0.852 and 0.861, respectively), while the ensemble model exhibited the highest goodness-of-fit (R² = 0.893), outperforming all individual models. Compared with linear regression, machine learning models demonstrated superior predictive capability. A feature importance analysis indicated that stand age, site quality and stand density together drive mean stand DBH prediction, among which stand age and stand structural characteristics are the dominant influencing factors, whereas SCI and SDI have comparatively weaker effects. Overall, the ensemble model substantially enhanced the prediction accuracy of mean DBH in Pinus yunnanensis stands, thereby providing for precision forest management and ecological function assessment. Full article

Topological data analysis (TDA) has evolved into a flexible and robust paradigm for obtaining qualitative, geometry-inspired insights from high-dimensional, noisy, and complex data. Grounded in algebraic topology, geometry, statistics, and machine learning (ML), TDA provides multiscale descriptions through persistent homology, Mapper (a graph-based method that summarizes the shape of high-dimensional data), and related topological signatures that are often inaccessible to standard linear and metric methods. In recent years, and especially during 2024–2025, TDA has expanded rapidly across science, engineering, biomedical research, and socio-economic studies, while also being integrated with modern learning paradigms such as deep learning (DL) and graph learning. This survey summarizes recent developments in TDA using a carefully selected set of articles, with emphasis on 2024–2025. We first present the mathematical and computational foundations of TDA, covering simplicial complexes, filtrations, persistent homology, the Mapper algorithm, and computational advances such as data simplification, stability, and efficiency. We then review applications in time series and dynamical systems, biomedical imaging and precision medicine, engineering and physical sciences, finance and risk analysis, DL and interpretability, and security and critical infrastructure systems. Throughout, we highlight how TDA can extract informative features, function as a model component, and provide a conceptual lens for studying complex systems. However, the survey also emphasizes recurrent failure patterns: TDA performance is highly sensitive to filtration, embedding, and vectorization choices; aggressive simplification can dilute or remove informative topological signals; and integration into standard ML workflows still lacks uniform validation and reporting protocols. We conclude by outlining key challenges—including scalability, statistical foundations, interpretability, and compatibility with rapidly evolving artificial intelligence (AI) paradigms—and by identifying directions for future research. The survey also provides a unifying design perspective for TDA systems, highlighting methodological trade-offs and emerging research directions for integrating topology with modern ML. Full article

This review examines the evolving intersections of data analytics, machine learning, and artificial intelligence—terms that have been frequently conflated since 2016 during a period of increased hype and investment. Following recent reviews across areas such as open innovation, supply chain deep learning, strategic alliances, natural language processing, and big data streaming, we focus on the emerging field of Responsible Artificial Intelligence (AI). We apply descriptive analysis to identify trends, patterns, and gaps in the research through a review of academic literature from 2020 to 2025. Analysis reveals five distinct clusters of Responsible AI papers using five dimensions: fairness, cross-validity, transparency, accuracy–interpretability tradeoff, and drift detection. This review discusses patterns across the artificial intelligence literature and identifies future research opportunities with an emphasis on Responsible AI. Full article

This study investigates the determinants and predictability of stock return volatility by integrating firm-specific financial characteristics with advanced econometric and volatility modeling techniques. Using an unbalanced panel dataset comprising 1596 firms and 19,752 firm-year observations from MENA stock markets over the period 2010–2024, the analysis employs fixed-effects panel regression models, conditional volatility models, and machine learning-based forecasting approaches. Following extensive diagnostic testing, including tests for heteroskedasticity, serial correlation, cross-sectional dependence, and model specification, a two-way fixed-effects model with Driscoll–Kraay standard errors is adopted as the preferred estimation framework. The results indicate that liquidity ratio, cash ratio, sales growth, firm age, lagged volatility, and lagged returns are significant determinants of stock return volatility, whereas leverage, tangibility, board independence, firm size, Tobin’s Q, and profitability do not exhibit statistically significant effects after controlling for firm-specific and time-specific heterogeneity. The volatility analysis reveals substantial persistence in stock return volatility, with the EGARCH-t specification providing the best fit among the competing GARCH-family models according to the Akaike Information Criterion. The estimated asymmetry parameters indicate that volatility responds differently to positive and negative shocks, supporting the presence of asymmetric volatility dynamics and the suitability of asymmetric volatility models. The forecasting analysis shows that advanced machine learning and deep learning models achieve competitive predictive performance; however, differences in predictive accuracy across models are generally modest. Full article

Dipeptidyl peptidase-4 (DPP-4) is a key therapeutic target for type 2 diabetes (T2D). Several synthetic anti-DPP-4 drugs are currently available for the treatment of T2D; however, the need for safe and effective therapies remains unmet due to the side effects associated with existing DPP-4 inhibitors. This study aimed to integrate structure-based and machine learning (ML)-based virtual high-throughput screening to identify natural DPP-4 inhibitors. Random forest, logistic regression, support vector machine (SVM), and multilayer perceptron (MLP) models were trained on DPP-4 IC₅₀ datasets. Among these, the SVM and MLP models achieved high predictive performance, with areas under the curve of 0.928 and 0.923, respectively. Screening of a natural compound database identified 107 compounds for further analysis. Subsequent structure-based screening, using sitagliptin as a positive control, identified sennidin B and doxorubicin hydrochloride as promising candidates with strong binding affinity for DPP-4. Molecular dynamics simulations (200 ns) and MM-PBSA calculations confirmed stable interactions with DPP-4. Further, sennidin B and doxorubicin hydrochloride inhibited DPP-4 activity in a concentration-dependent manner, with estimated IC₅₀ values of 39.39 and 19.78 μM, respectively. Sennidin B also reduced DPP-4 mRNA and protein expression levels in Caco-2 cells. Overall, sennidin B shows promise as a natural DPP-4 inhibitor and warrants further investigation as a potential antidiabetic agent. Full article

Web service classification plays an important role in software reuse, service discovery, and automatic metadata organization. Although recent deep learning approaches have improved classification performance by using service names and natural-language descriptions, most existing methods still operate as black-box models and offer limited insight into how different metadata sources influence classification decisions. This lack of transparency reduces their practical usefulness for developers who need to verify predicted categories, analyze incorrect classifications, and improve service metadata quality. A well-trained interpretable model can not only help developers choose more appropriate and reliable categories for each web service, but also help write a more reasonable service name and description. In this paper, we present xServeNet, an explainability-oriented extension of ServeNet for transparent web service classification. xServeNet preserves the BERT-based representation and CNN–BiLSTM feature extractor of ServeNet and introduces (i) an instance-wise dynamic source-fusion mechanism that adaptively combines service-name and service-description features according to their semantic contribution, and (ii) model-internal importance indicators at both the source and word levels that support inspection of classification decisions without introducing additional trainable parameters. We benchmark xServeNet against eleven machine learning baselines on two real-world ProgrammableWeb datasets of 10,943 and 14,086 services covering 50 categories. xServeNet reaches 71.08% Top-1/91.35% Top-5 accuracy on the original dataset and 74.10% Top-1/92.95% Top-5 accuracy on the updated dataset, consistently improving Top-1 accuracy over ServeNet while remaining competitive on Top-5, and achieving the lowest per-category Top-5 standard deviation among all twelve compared methods. In practice, the importance indicators support three concrete activities at the service registry: helping developers verify predicted categories at registration time, iterating on description wording when the predicted category looks wrong, and supporting registry curators in flagging likely mislabelled services for review. Full article

Background/Objectives: Advancements in neuroscience and machine learning have increasingly enabled brain pattern recognition based on bio-signal measurements, such as electroencephalography (EEG). These developments support next-generation technologies, including brain–computer interfaces (BCIs) and AI-assisted systems. However, volume conduction (VC) effects remain a major source of contamination in EEG recordings, affecting both univariate analyses and functional connectivity estimation. Methods: In this work, we propose a VC mitigation method that explicitly models and suppresses VC components in the observed functional networks. Specifically, the observed functional network is decomposed into a matrix capturing only VC-related components (i.e., components attributed to volume conduction) and a residual matrix, where the residual is regarded as a proxy for a VC-mitigated functional network that better reflects the underlying functional interactions. The VC component matrix is modeled using a decay function parameterized by the inter-electrode distance matrix, capturing the dominant spatial bias induced by VC. To estimate these parameters, we introduce supervised channel importance, quantified as the mutual information between experimental labels and channel signals, as a proxy for task-relevant neural activity. The parameters are optimized such that the unsupervised node importance derived from the VC-mitigated functional network, defined as the average node strength, aligns with the supervised channel importance. Results: Evaluation results using a deep-learning framework demonstrate that, compared with the observed functional network, the VC-mitigated functional network improves classification performance in brain pattern recognition tasks. Full article

Arthropathies are a major global health challenge because of their high prevalence, chronic progression, and significant impact on quality of life and health systems. Therefore, prompt and accurate diagnosis is critical for slowing disease progression and improving outcomes. Traditional imaging modalities, such as ultrasound and magnetic resonance imaging, suffer from significant limitations, including operator dependence, limited accessibility, high cost, and limited reproducibility. Infrared thermography has become a promising non-invasive imaging technique for identifying thermal variations linked to inflammatory and metabolic processes. Advances in quantitative thermography, automated segmentation, and artificial intelligence have greatly enhanced its clinical applicability. This review summarizes recent advances in thermography-based biomarkers, including region-of-interest-derived metrics, asymmetry indices, hotspot burden, spatial and texture descriptors, and composite thermographic scores. It discusses the role of machine learning and deep learning in prediction, phenotyping, and multimodal integration with clinical, laboratory, and imaging data. Heterogeneity of protocols, variability in measurements, domain shift, validation design, overfitting, and reporting quality are also addressed. Overall, thermography combined with AI is highly promising as an adjunct to early diagnosis, assessment of disease activity, and follow-up in arthropathies. However, clinical application at a large scale requires strict standardization, external validation, transparent reporting, and well-elucidated, reproducible analytical processes. Full article

Precision feeding is an important foundation for improving production efficiency in aquaculture, reducing feed waste, mitigating water pollution, and promoting the intelligent development of aquaculture. Conventional feeding practices remain heavily dependent on operator experience and are typically executed at predetermined times or fixed ration levels. Such approaches frequently result in extensive feeding management, poor adaptability, low feed utilization efficiency, and delayed responses to environmental changes. Advances in machine vision, the Internet of Things, machine learning, deep learning, and automatic control have progressively shifted aquaculture feeding research beyond standalone automatic feeders toward integrated systems encompassing demand perception, intelligent decision-making, precise control, and equipment coordination. This paper reviews the state of the art in precision feeding technologies and equipment in aquaculture. At the technical level, it summarizes advances in feeding demand perception, intelligent feeding decision-making, and precise control and execution. At the equipment level, it reviews the main types, design features, and field application status of precision feeding equipment in intensive aquaculture, pond aquaculture, and offshore aquaculture scenarios. Despite the considerable progress achieved, the practical deployment of precision feeding still faces several limitations. Environmental disturbances, water turbidity, illumination variation, and sensor drift may compromise the reliability of feeding demand perception. Existing decision-making models frequently exhibit limited generalizability across species, growth stages, and aquaculture scenarios. Moreover, insufficient integration of sensing, decision-making, and execution restricts the development of fully closed-loop feeding systems. High initial investment, maintenance costs, and the shortage of skilled personnel further constrain the adoption of precision feeding equipment, particularly in resource-limited regions. On this basis, the main challenges including sensing accuracy, model practicability, closed-loop control, equipment reliability, and standardization, are examined. Future development trends are also discussed, covering multi-source information fusion, synergy between mechanistic models and data-driven methods, system-level closed-loop control, equipment modularization, and industrial application. This review is expected to provide a reference for subsequent research and engineering applications. Full article