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Search Results (19,026)

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16 pages, 1554 KB  
Review
Explainable and Trustworthy Artificial Intelligence in Cardiology: A Narrative Review of Clinical Applications, Operational Integration, and Future Directions
by Mateusz Lucki, Ewa Lucka, Jacek Żak, Przemysław Mitkowski and Maciej Lesiak
J. Clin. Med. 2026, 15(13), 4885; https://doi.org/10.3390/jcm15134885 (registering DOI) - 23 Jun 2026
Abstract
Background/Objectives: Artificial intelligence (AI) is increasingly transforming cardiology through advanced analytical tools capable of identifying complex patterns across cardiovascular imaging, electrophysiology, and clinical datasets. Machine learning (ML) and deep learning (DL) algorithms are being integrated into echocardiography, cardiac computed tomography (CT), cardiac magnetic [...] Read more.
Background/Objectives: Artificial intelligence (AI) is increasingly transforming cardiology through advanced analytical tools capable of identifying complex patterns across cardiovascular imaging, electrophysiology, and clinical datasets. Machine learning (ML) and deep learning (DL) algorithms are being integrated into echocardiography, cardiac computed tomography (CT), cardiac magnetic resonance imaging (MRI), and electrocardiography (ECG), enabling earlier diagnosis and more personalized cardiovascular care. This narrative review summarizes current clinical and organizational applications of AI in cardiology and discusses emerging concepts related to explainable and trustworthy AI. Methods: A narrative review was conducted according to SANRA recommendations using the PubMed, MEDLINE, Web of Science, and Scopus databases, including peer-reviewed publications from 2015 to 2026 addressing clinical, organizational, and ethical applications of AI in cardiology, with particular emphasis on cardiovascular imaging, electrocardiography, heart failure, digital health, and explainable AI frameworks. Results: Substantial evidence demonstrates that AI-based tools can achieve expert-level performance in cardiovascular imaging interpretation, automated electrocardiographic analysis, and clinical risk prediction. Across multiple cardiovascular settings, AI has been associated with improved diagnostic accuracy, enhanced workflow efficiency, and earlier detection of cardiovascular disease. Predictive models support risk stratification in heart failure and ischemic heart disease, while chatbots and digital health platforms may facilitate patient engagement, remote monitoring, and continuity of care. Despite these advances, important challenges remain, including algorithmic bias, limited transparency, insufficient external validation, data heterogeneity, and barriers to routine clinical implementation. Emerging explainable AI approaches may improve model interpretability, clinician confidence, and the safe adoption of AI-driven decision support systems. Conclusions: Artificial intelligence is rapidly evolving from a research-oriented technology into a clinically relevant component of cardiovascular care. Current evidence indicates that AI can enhance diagnostic performance, improve risk prediction, streamline clinical workflows, and facilitate more personalized management across multiple cardiovascular domains. However, the successful translation of AI into routine practice will depend on robust external validation, transparent decision-making mechanisms, regulatory oversight, and clinician acceptance. The development of explainable and trustworthy AI frameworks represents a critical step toward the safe, ethical, and sustainable integration of AI into modern cardiology. Full article
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52 pages, 2139 KB  
Systematic Review
Machine Learning, Gamification, and Critical Thinking in Adaptive Educational Platforms: A Systematic Literature Review
by Darkhan Zhaxybayev, Madina Sambetbayeva, Azamat Dnekeshev, Aidar Igenov, Aizada Vakhitova and Tokabay Zhussip
Information 2026, 17(7), 619; https://doi.org/10.3390/info17070619 (registering DOI) - 23 Jun 2026
Abstract
Background: The convergence of machine learning (ML), gamification, and critical thinking assessment within adaptive educational platforms has accelerated since 2020, driven by large language models (LLMs) and graph neural networks (GNNs). No prior systematic review has jointly addressed all three dimensions, and Central [...] Read more.
Background: The convergence of machine learning (ML), gamification, and critical thinking assessment within adaptive educational platforms has accelerated since 2020, driven by large language models (LLMs) and graph neural networks (GNNs). No prior systematic review has jointly addressed all three dimensions, and Central Asian educational contexts remain underrepresented. Methods: Following PRISMA 2020 guidelines, we searched Scopus (n  =  4396) and OpenAlex (n  =  4152) for publications from 2016 to 2026. Quality assessment used the Mixed Methods Appraisal Tool (MMAT 2018; threshold ≥  2), yielding 82 papers. Five research questions addressed ML personalization (RQ1), gamification and engagement (RQ2), critical thinking assessment tools (RQ3), recommendation algorithms (RQ4), and regional applicability in Kazakhstan and Central Asia (RQ5). Results: Transformer-based and GNN models dominate the recent literature (52% of corpus from 2025), with an accuracy of 91–97% for dropout prediction and learning path recommendation under single-institution conditions. Gamification studies report up to 90% student satisfaction; LLM-based critical thinking assessment shows promise but faces validity concerns. Thirteen papers address Central Asian contexts. Conclusions: Significant gaps persist: no integrated gamification–critical thinking framework exists, recommendation systems lack explainability, and Kazakh-language datasets are severely underrepresented. Future research should prioritize multilingual adaptive systems, explainable algorithms, and privacy-preserving federated learning for low-resource contexts. Full article
(This article belongs to the Section Information Systems)
17 pages, 2596 KB  
Article
Intelligent Injection Molding: Machine Learning-Driven Optimization of Processing Parameters for Enhanced Mechanical Properties in Short-Fiber-Reinforced Thermoplastics
by Rafael Aguirre Flores, Francisco J. González, Felipe Avalos Belmontes and Jesús Francisco Lara Sánchez
Processes 2026, 14(13), 2037; https://doi.org/10.3390/pr14132037 (registering DOI) - 23 Jun 2026
Abstract
Optimizing the injection molding of short-fiber-reinforced thermoplastics (SFRTs) is a persistent challenge due to the complex interplay between processing parameters and final mechanical performance. To address this, we developed and validated a machine learning (ML) pipeline to maximize both the tensile strength and [...] Read more.
Optimizing the injection molding of short-fiber-reinforced thermoplastics (SFRTs) is a persistent challenge due to the complex interplay between processing parameters and final mechanical performance. To address this, we developed and validated a machine learning (ML) pipeline to maximize both the tensile strength and Charpy impact resistance in polyamide 6 with 30% glass fiber (PA6-GF30). Through a designed experimental campaign, we systematically varied four key process parameters—melt temperature (260–300 °C), injection pressure (600–1000 bar), packing pressure (400–800 bar), and cooling time (15–35 s). The resulting dataset was used to train and compare three different regression models: Random Forest (RF), Gradient Boosting (GB), and Support Vector Regression (SVR). Our findings indicate that the Gradient Boosting (GB) algorithm yielded the most reliable predictions, significantly outperforming the other evaluated models. Further analysis using SHAP (Shapley Additive exPlanations) identified packing pressure as the dominant factor influencing tensile strength (contributing approximately 40% to the prediction), while melt temperature emerged as the key driver for impact resistance (around 35% contribution). By integrating our best-performing GB model with a multi-objective genetic algorithm, we identified an optimal set of parameters that simultaneously enhances both mechanical properties. Among the evaluated models (Random Forest, Support Vector Regression, and Gradient Boosting), the Gradient Boosting algorithm achieved the highest predictive accuracy. Compared to the baseline condition (280 °C melt temperature, 800 bar injection pressure, 600 bar packing pressure, 25 s cooling time), experimental validation of these optimized settings demonstrated substantial improvement: tensile strength increased from 145 MPa to 171 MPa (an 18% enhancement), and impact resistance rose from 45 kJ/m2 to 55 kJ/m2 (a 22% gain). This work establishes that an integrated ML and optimization framework can serve as a transformative approach for high-precision manufacturing of advanced engineering polymers. The primary novelty of this work lies in the development of a fully integrated, bias-free methodological framework that explicitly couples physical interpretability with multi-objective optimization, bridging the critical gap between black-box predictions and actionable industrial insights. Full article
(This article belongs to the Special Issue Processing and Applications of Polymer Composite Materials)
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27 pages, 12626 KB  
Article
Local Surrogate Relationships Between Soil Texture Fractions and Near-Surface Hydro-Structural Properties for Hydrological Parameterization in High-Andean Catchments
by Christian Mera-Parra, Pablo Ochoa-Cueva, Jose Damian Ruiz Sinoga and Paola Duque Sarango
Soil Syst. 2026, 10(7), 68; https://doi.org/10.3390/soilsystems10070068 (registering DOI) - 23 Jun 2026
Abstract
For hydrological parameterization in high-Andean catchments, it is necessary to understand whether near-surface hydro-structural soil properties can provide a surrogate signal of particle-size composition when direct texture information is sparse. This study evaluated the extent to which sand, silt, and clay fractions can [...] Read more.
For hydrological parameterization in high-Andean catchments, it is necessary to understand whether near-surface hydro-structural soil properties can provide a surrogate signal of particle-size composition when direct texture information is sparse. This study evaluated the extent to which sand, silt, and clay fractions can be approximated from organic matter (OM), bulk density (ρb), and saturated hydraulic conductivity (Ksat) in the Zamora Huayco (ZH) and Irquis catchments, southern Ecuador. A harmonized dataset (n=44) was analyzed through exploratory statistics, compositional assessment, correlation analysis, PCA, fraction-wise regression, ILR-based modeling, AIC/BIC term reduction, sensitivity analysis excluding OM, nested LOOCV, and bootstrap-based uncertainty intervals. Among LULC classes, samples classified as paramo occupied a distinct high-Andean hydro-edaphic domain, characterized by a differentiated relationship between soil physical properties and hydrological behavior. PCA showed that the dominant covariance structure involved OM, ρb, Ksat, and the redistribution between sand and silt. The BIC-reduced ILR model provided the most balanced formulation, with positive nested LOOCV performance for sand, silt, and clay (RLOOCV2=0.147, 0.704, and 0.124, respectively) and exact 100% compositional closure after inverse transformation. Silt was the most stable predicted fraction, whereas sand and clay retained larger residual uncertainty, stronger tail departures, and partial compression of the observed variability. The proposed equations provide local hydro-pedotransfer support, although their predictive signal remains dependent on further refinement, uncertainty assessment, and external validation before regional application. Full article
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17 pages, 5457 KB  
Article
A Hybrid Ensemble System for Time-Series Anomaly Detection in Automated Quality Control of Medical Equipment
by Ziheng Zhang, Defeng Cai, Zhuo Deng, Zhicheng Du, Fuxing Zhang and Lan Ma
Diagnostics 2026, 16(13), 1953; https://doi.org/10.3390/diagnostics16131953 (registering DOI) - 23 Jun 2026
Abstract
Background/Objectives: The accuracy and reliability of automated clinical analyzers are fundamental to patient safety and effective medical decision-making. Traditional quality control (QC) methods, which rely on periodic manual calibration and reactive maintenance, are inherently limited by high latency and labor costs; furthermore, they [...] Read more.
Background/Objectives: The accuracy and reliability of automated clinical analyzers are fundamental to patient safety and effective medical decision-making. Traditional quality control (QC) methods, which rely on periodic manual calibration and reactive maintenance, are inherently limited by high latency and labor costs; furthermore, they fail to provide continuous, real-time monitoring. This paper introduces a novel hybrid ensemble learning framework for the automated quality inspection of medical devices through the analysis of time-series reaction curves. Methods: Our system integrates three heterogeneous anomaly detection paradigms: an Enhanced Dynamic Time Warping (DTW) detector for robust non-linear pattern matching, a Shape Template Matching (STM) detector that mimics expert clinical logic by analyzing morphological features in a normalized shape space, and a specialized Time-series Variational Autoencoder (TimeVAE) for deep representation learning. The outputs of these detectors are fused using a weighted ensemble strategy, which is specifically designed to prioritize the minimization of false negatives—a critical requirement in medical diagnostics. Results: We evaluate our framework on a comprehensive, multi-center real-world dataset comprising seven distinct biochemical assays. Experimental results demonstrate that our proposed method achieves superior performance, attaining a 0% false negative rate on CRE and DBIL assays and outperforming all baseline methods on the other five datasets. An ablation study confirms the model’s robustness even with limited training data, and a comparative analysis against eight state-of-the-art baseline methods further validates the effectiveness of our domain-optimized ensemble approach. Conclusions: The system provides a robust, interpretable, and highly automated solution for transitioning from reactive maintenance to proactive, real-time quality assurance in clinical laboratories. Full article
(This article belongs to the Special Issue Artificial Intelligence for Health and Medicine—2nd Edition)
20 pages, 8317 KB  
Article
Spatiotemporal Evolution of Meteorological Drought in Jiangxi Province During 1961–2022: A Comparative SPI–SPEI–EDDI Assessment for Sustainable Water-Resource Management
by Yahao Tu, Shuai Zou and Ennan Zheng
Sustainability 2026, 18(13), 6399; https://doi.org/10.3390/su18136399 (registering DOI) - 23 Jun 2026
Abstract
Under global warming, understanding regional drought evolution is essential for drought early warning, food security, climate adaptation, and sustainable water-resource management. This study analyzed meteorological drought in Jiangxi Province during 1961–2022 using SPI-12, SPEI-12, and EDDI-12 from the CHM_Drought high-resolution multi-index dataset. The [...] Read more.
Under global warming, understanding regional drought evolution is essential for drought early warning, food security, climate adaptation, and sustainable water-resource management. This study analyzed meteorological drought in Jiangxi Province during 1961–2022 using SPI-12, SPEI-12, and EDDI-12 from the CHM_Drought high-resolution multi-index dataset. The Mann–Kendall (MK) test, Theil–Sen slope estimator, three-threshold run theory, Morlet wavelet analysis, wavelet coherence (WTC), and cross-wavelet transform (XWT) were used to examine drought trends, event characteristics, periodicity, and inter-index relationships. Results showed a widespread drying tendency. EDDI-12 exhibited a highly significant increase in 99.86% of valid resampled raster pixels, indicating enhanced atmospheric evaporative demand, while SPEI-12 and SPI-12 showed significant decreasing trends in 97.96% and 93.24% of valid pixels, respectively. Stronger drying signals were mainly distributed in central and northern Jiangxi. Run-theory analysis indicated longer-duration cumulative droughts in southern mountainous areas and frequent short-duration drought events in the Poyang Lake Plain and central-northern Jiangxi. Wavelet analysis identified a dominant interdecadal periodicity of approximately 20–21 years. WTC and XWT revealed strong in-phase coherence between SPI and SPEI, whereas SPI/SPEI and EDDI mainly showed anti-phase statistical phase relationships. From a sustainability perspective, these findings provide scientific support for multi-index drought monitoring, adaptive agricultural water allocation, drought early warning, and climate-resilient water-resource management in humid monsoon regions. Full article
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83 pages, 18053 KB  
Review
A Review of Wind Turbine Reliability and Long-Term Performance: Failure Mechanisms, Monitoring Strategies, and AI-Enabled Predictive Maintenance
by Sajid Ali, Muhammad Waleed and Daeyong Lee
Appl. Sci. 2026, 16(13), 6311; https://doi.org/10.3390/app16136311 (registering DOI) - 23 Jun 2026
Abstract
Wind turbines are increasingly deployed at larger scales and in harsher operating environments, leading to greater structural complexity, stronger load variability, and higher maintenance demands across both drivetrain and structural components. Reported field data indicate that gearboxes and bearings account for approximately 30–40% [...] Read more.
Wind turbines are increasingly deployed at larger scales and in harsher operating environments, leading to greater structural complexity, stronger load variability, and higher maintenance demands across both drivetrain and structural components. Reported field data indicate that gearboxes and bearings account for approximately 30–40% of total turbine downtime, while blade-related failures contribute roughly 20–25% of reported failure events, primarily through fatigue, delamination, leading-edge erosion, and lightning-induced defects. In parallel, large-scale and offshore turbines show increasing susceptibility to tower fatigue cracking, corrosion-assisted degradation, and flange joint bolt-preload loss under cyclic and environmental loading. This review provides a comprehensive applied-engineering synthesis of failure mechanisms, reliability challenges, and monitoring strategies for major wind turbine components, including gearboxes, bearings, blades, towers, and flange joints. A wide range of condition monitoring, structural health monitoring (SHM), and prognostics and health management (PHM) approaches is critically examined, including vibration analysis, acoustic emission, ultrasonic inspection, infrared thermography, impedance-based sensing, electromagnetic methods, machine vision, SCADA-based diagnostics, and artificial-intelligence-assisted fault classification. The review compares these techniques in terms of detectable damage types, spatial coverage, sensitivity, deployment practicality, and limitations under real operating conditions. In addition, statistical reliability methods and data-driven models are discussed to interpret failure trends and uncertainty. Recent AI-based studies have reported fault classification accuracies exceeding 90% under controlled or semi-controlled conditions; however, their field reliability remains constrained by data imbalance, domain shift, limited labeled failure datasets, model interpretability, and insufficient validation under realistic turbine operating environments. The main contribution of this review is an integrated applied synthesis that connects drivetrain and structural failure mechanisms with measurable monitoring indicators, diagnostic technologies, AI-enabled PHM limitations, and predictive-maintenance decision needs. The paper provides practical guidance for monitoring design, early fault detection, predictive maintenance, and long-term reliability improvement in next-generation wind turbine systems. Full article
(This article belongs to the Section Energy Science and Technology)
21 pages, 315 KB  
Review
Artificial Intelligence in Implant Dentistry: Clinical Validity, Diagnostic Performance, Surgical Planning, and Medico-Legal Implications—A Narrative Review
by Alfonso Acerra, Angelo Aliberti, Alessandra Amato, Anna Eccellente, Alessandro Santurro and Francesco Giordano
Dent. J. 2026, 14(7), 389; https://doi.org/10.3390/dj14070389 (registering DOI) - 23 Jun 2026
Abstract
Background: Artificial intelligence (AI) is increasingly being integrated into implant dentistry, where clinical decision-making depends on the interpretation of complex radiographic and patient-specific data. Although multiple applications have been proposed across diagnostic imaging, treatment planning, intraoperative support and outcome prediction, their clinical [...] Read more.
Background: Artificial intelligence (AI) is increasingly being integrated into implant dentistry, where clinical decision-making depends on the interpretation of complex radiographic and patient-specific data. Although multiple applications have been proposed across diagnostic imaging, treatment planning, intraoperative support and outcome prediction, their clinical validity and real-world applicability remain incompletely defined and their use raises relevant medico-legal considerations. Methods: A narrative review was conducted through a structured search of PubMed/MEDLINE, Scopus, and Web of Science, including English-language studies published between 2010 and February 2026. Clinical and experimental studies, as well as relevant reviews addressing AI applications in implant dentistry, were included. A qualitative thematic synthesis was performed due to methodological heterogeneity. Results: AI applications are mainly concentrated in diagnostic imaging, particularly CBCT analysis, where high levels of performance are consistently reported. In treatment planning, systems support specific decision-making tasks rather than comprehensive strategies, while intraoperative applications are integrated into navigation and robotic systems to improve procedural accuracy. Predictive models for implant outcomes have been developed, although their reliability remains influenced by dataset variability and study design. Conclusions: AI currently represents a supportive tool in implant dentistry, with greater applicability in standardized tasks. Its integration into complex clinical decision-making remains limited, highlighting the need for clinically oriented validation and cautious implementation in practice. Full article
(This article belongs to the Special Issue Artificial Intelligence in Oral Rehabilitation)
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30 pages, 3719 KB  
Article
Nano-Encapsulated Black Bean-Cultivated Cordyceps militaris Attenuates PM- and LPS-Induced Airway Inflammation
by Hyo-Min Kim and Hye-Jin Park
Nutrients 2026, 18(13), 2043; https://doi.org/10.3390/nu18132043 (registering DOI) - 23 Jun 2026
Abstract
Background/Objectives: Exposure to particulate matter (PM) containing bacterial endotoxins triggers inflammation and oxidative stress in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-loaded Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food-derived ingredient against PM- and lipopolysaccharide [...] Read more.
Background/Objectives: Exposure to particulate matter (PM) containing bacterial endotoxins triggers inflammation and oxidative stress in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-loaded Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food-derived ingredient against PM- and lipopolysaccharide (LPS)-induced cellular damage in human lung epithelial cells. Methods: This study employed an integrative approach combining GCN analysis with bioinformatics methods using a PM- and LPS-induced pulmonary cellular inflammation model. Gene Expression Omnibus (GEO) transcriptomic datasets and Cytoscape-based network analysis were utilized to identify key hub genes and signaling pathways associated with PM- and LPS-induced pulmonary inflammation, which were subsequently validated by RT-PCR and Western blotting. Results: Nano-encapsulation significantly improved the antioxidant capacity and storage stability of the extract compared with non-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC). GCN markedly attenuated PM- and LPS-induced cytotoxicity and intracellular reactive oxygen species (ROS) production in a dose-dependent manner, resulting in a therapeutic index approximately 4.5-fold higher than that of GRC under PM and LPS co-exposure. Bioinformatics analysis identified inflammation-related genes and pathways associated with PM- and LPS-induced pulmonary responses, primarily enriched in tumor necrosis factor (TNF)-related inflammatory pathways, Toll-like receptor signaling, and cytokine signaling. Consistent with these findings, GCN suppressed the expression of C-X-C motif chemokine ligand 2 (CXCL-2) and tumor necrosis factor-alpha (TNF-α) mRNA and inhibited mitogen-activated protein kinase (MAPK)-mediated activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB) signaling pathways in human type II alveolar epithelial cells (A549). Conclusions: Collectively, nano-encapsulation enhanced the stability and bioactivity of Cordyceps militaris-based extracts, suggesting that GCN may have potential as a functional food-derived candidate ingredient to protect airway epithelial cells against inflammation and oxidative stress induced by PM and LPS. As this study was conducted using an in vitro A549 epithelial cell model, further validation in physiologically relevant systems is needed to confirm its translational applicability. Full article
23 pages, 5400 KB  
Article
A Gearbox Fault Diagnosis Method for Small-Sample Conditions Based on Physics-Informed and Multi-Scale Graph Learning
by Peng Chen, Yazhou Zhang and Jintao Xu
Processes 2026, 14(13), 2035; https://doi.org/10.3390/pr14132035 (registering DOI) - 23 Jun 2026
Abstract
Existing intelligent fault diagnosis methods ignore the influence of sensors at different positions on the model fault diagnosis performance. Furthermore, the lack of interpretability leads to insufficient reliability of the model fault diagnosis results. Therefore, a physics-informed multi-sensor information fusion method for gearbox [...] Read more.
Existing intelligent fault diagnosis methods ignore the influence of sensors at different positions on the model fault diagnosis performance. Furthermore, the lack of interpretability leads to insufficient reliability of the model fault diagnosis results. Therefore, a physics-informed multi-sensor information fusion method for gearbox fault diagnosis is proposed. The method consists of a physics-informed shallow feature extraction module, a hierarchical multi-scale graph learning module, and an adaptive feature fusion module. The shallow feature extraction module is composed of Laplacian convolution. Multi-scale Laplacian convolution kernels are used to capture multi-frequency and multi-scale feature information, enriching fault representations. The hierarchical multi-scale graph learning module adopts graph convolutional neural networks to conduct deep multi-sensor fault feature extraction for generating high-level features. The adaptive feature fusion module realizes the weighting of important sensor data and the suppression of redundant information through attention scores. This method is validated on two gearbox datasets. The results show that when applied to the SEU dataset, the proposed method achieves a diagnosis accuracy 5.8% higher than that of the state-of-the-art method (MIFNet) under small-sample conditions. In noisy environments, the proposed method achieves an average diagnostic accuracy 1.8% higher than that of the state-of-the-art method (LiConvFormer). This indicates that the proposed method exhibits superior fault diagnosis performance and can effectively handle fault diagnosis tasks under small-sample conditions and in noisy environments. Full article
(This article belongs to the Special Issue Fault Diagnosis Technology in Machinery Manufacturing)
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41 pages, 5032 KB  
Article
A Hybrid Multi-Level Computational Framework for Latent Risk Modeling from Tabular Data
by Bigul Mukhametzhanova, Akgul Naizagarayeva, Gulbakyt Ansabekova, Shynar Turmaganbetova, Yermek Sarsikeyev, Akmaral Kassymova, Azamat Dnekeshev, Pavel Dunayev and Zhanat Manbetova
Computers 2026, 15(7), 402; https://doi.org/10.3390/computers15070402 (registering DOI) - 23 Jun 2026
Abstract
This study presents a hybrid artificial intelligence system for latent cardiovascular risk stratification based on publicly available clinical and laboratory data. The proposed system integrates data preprocessing, auxiliary target modeling, latent phenotyping using UMAP and Gaussian mixture models, fuzzy logic-based risk integration, and [...] Read more.
This study presents a hybrid artificial intelligence system for latent cardiovascular risk stratification based on publicly available clinical and laboratory data. The proposed system integrates data preprocessing, auxiliary target modeling, latent phenotyping using UMAP and Gaussian mixture models, fuzzy logic-based risk integration, and multilevel predictive modeling. The key contribution of the system is the construction of a proxy target reflecting latent risk progression by combining phenotypic structure, probabilistic indicators, and mortality-related anchor points. Experimental evaluation was conducted on the NHANES dataset. The final analytical cohort included 78,822 adult participants, and the modeling set was divided into training, validation, and test subgroups using a stratified 70/15/15 design. The proposed PhaseFuzzy Hybrid model achieved an accuracy of 0.8390, a balanced accuracy of 0.7302, an F1-score of 0.5225, an MCC of 0.4203, an ROC-AUC of 0.8489, a PR-AUC of 0.5014, and a best LogLoss value of 0.4290 on the test set. The latent phenotyping step also demonstrated acceptable internal validity with a silhouette coefficient of 0.4138 and a confidence of 0.8800. The results demonstrate that the proposed framework identifies hidden cardiometabolic risk factors and provides an interpretable, scalable, and calibration-aware framework for latent cardiometabolic risk stratification and population-level screening. Full article
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35 pages, 3804 KB  
Article
A Confound-Aware Framework for Multi-Class EEG Classification and Explainable Model Evaluation
by Ahmed Alqurashi and Abdullah Alharthi
Mathematics 2026, 14(13), 2239; https://doi.org/10.3390/math14132239 (registering DOI) - 23 Jun 2026
Abstract
Objective diagnosis in psychiatry remains challenging due to the lack of reliable biological markers and the presence of confounding variables in observational data. While EEG-based machine learning models have shown promising classification performance, their validity remains unclear when confounding factors such as age [...] Read more.
Objective diagnosis in psychiatry remains challenging due to the lack of reliable biological markers and the presence of confounding variables in observational data. While EEG-based machine learning models have shown promising classification performance, their validity remains unclear when confounding factors such as age are not explicitly controlled. In this work, we propose a confound-aware mathematical framework for supervised learning, where classification is formulated as a mapping f:RE×C×TY under the presence of a confounding variable A. Within this formulation, model performance is interpreted as a function of both predictive structure and confound dependence. The proposed framework integrates classification, regression, and feature selection into a unified evaluation pipeline. A central contribution is the Cross-Task Explanation Concordance (CTEC) index, a rank-based metric that quantifies the stability of feature importance across models and predictive tasks. Experimental results on a large-scale EEG dataset (N = 670) demonstrate that deep learning models outperform handcrafted approaches under standard evaluation. However, under confound-controlled settings, handcrafted models show a dual response to confound control: age residualization improves classification by removing feature-level noise (+20.3%), while age-matching collapses performance to chance (balanced accuracy, BA = 0.238) by eliminating demographic separability. Deep learning models retain partial robustness under both conditions. These findings highlight that conventional performance metrics may overestimate model validity in the presence of structured bias. The proposed framework provides a general mathematical approach for evaluating supervised learning models under confounding effects and is applicable to a wide range of data-driven systems beyond EEG. Full article
(This article belongs to the Special Issue Artificial Intelligence and Data Science, 2nd Edition)
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20 pages, 1348 KB  
Article
Auditory Brainstem Response Recorded with the NeuroAudio System in Children Under 3 Years of Age
by Milaine Dominici Sanfins, Diego Lourenço dos Santos Silva, Rhayane Vitória Lopes, Emilia Czaplicka and Piotr Henryk Skarzynski
Life 2026, 16(7), 1044; https://doi.org/10.3390/life16071044 (registering DOI) - 23 Jun 2026
Abstract
Background: The click-evoked Auditory Brainstem Response (ABR) is the gold standard electrophysiological tool for assessing auditory pathway integrity in infants and young children. As normative data are inherently equipment-specific, the absence of pediatric reference values for the NeuroAudio system (Neurosoft, Ivanovo, Russia) represents [...] Read more.
Background: The click-evoked Auditory Brainstem Response (ABR) is the gold standard electrophysiological tool for assessing auditory pathway integrity in infants and young children. As normative data are inherently equipment-specific, the absence of pediatric reference values for the NeuroAudio system (Neurosoft, Ivanovo, Russia) represents a significant gap in clinical practice, given that existing normative datasets for this system are restricted to adult populations. Objective: To establish normative data for click ABR recorded with the NeuroAudio system in children under three years of age, stratified by age group according to auditory maturation patterns. Methods: A prospective, cross-sectional study was conducted at the Electrophysiology Laboratory of the Department of Speech Therapy, Paulista School of Medicine, Federal University of São Paulo (UNIFESP/EPM), under the approval of the Research Ethics Committee (protocol 7.939.564). A total of 203 children (121 males, 82 females; age range: 2 weeks to 36 months) with confirmed normal peripheral auditory function were included. Click stimuli (0.1 ms, rarefaction polarity) were delivered monaurally via ER-3A insert earphones at 80 dB nHL and a repetition rate of 19.3/s. Two average runs of 2000 artifact-free sweeps were recorded per ear. Absolute latencies of waves I, III, and V, interpeak intervals I–III, III–V, and I–V, and amplitudes of waves I and V were analyzed. Results: Statistical modeling supported the consolidation of 12 initial age bins into three clinically and statistically validated categories: 0–3, 4–12, and 13–36 months. Wave I latency remained stable across age groups, whereas waves III and V and all interpeak intervals showed progressive shortening with increasing age. Wave V amplitude increased progressively with age, while wave I amplitude remained unchanged. Females presented shorter latencies than males for waves III and V and for all interpeak intervals. The right ear exhibited a shorter III–V interpeak interval than the left ear, with a significant ear × age interaction indicating that this asymmetry is modulated during early maturation. Age, sex, and ear-stratified normative values (two SD and three SD reference limits) are reported. Conclusion: This study provides the first pediatric normative dataset for click-evoked ABR acquired with the NeuroAudio system in children under three years of age. The proposed three age stratifications, together with sex- and ear-specific reference values for the III–V interpeak interval, offer a clinically actionable framework for the accurate interpretation of pediatric ABR recordings and for the early identification of auditory pathway abnormalities. Full article
(This article belongs to the Section Physiology and Pathology)
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18 pages, 4064 KB  
Article
Constitutive Analysis and Hot Processing Maps of As-Cast ZM6 Magnesium Alloys
by Hong Zhang and Jia Fu
Processes 2026, 14(13), 2034; https://doi.org/10.3390/pr14132034 (registering DOI) - 23 Jun 2026
Abstract
The constitutive analysis model and hot processing map of the ZM6 alloy across various deformation conditions were investigated during hot compression experiments. True stress-strain curves within 300–450 °C and 0.0001–0.1 s−1 were obtained from compression tests on a Gleeble-1500 platform. The results [...] Read more.
The constitutive analysis model and hot processing map of the ZM6 alloy across various deformation conditions were investigated during hot compression experiments. True stress-strain curves within 300–450 °C and 0.0001–0.1 s−1 were obtained from compression tests on a Gleeble-1500 platform. The results showed that higher strain rates (e.g., 0.1 s−1) induced pronounced work hardening, whereas high temperatures (300–400 °C) combined with low strain rates (10−4 s−1) promoted conditions conducive to dynamic recrystallization (DRX), leading to a softening tendency of steady-state flow stress. Additionally, a modified strain-compensated constitutive model was built for flow stress prediction. Material constants were plotted as fifth-order polynomial functions of strain (0.025–0.80) for precise stress predictions. The derived activation energy (Q = 182.38 kJ/mol) falls within the typical range for Mg-RE alloys. Leave-one-temperature-out cross-validation showed average AARE values of 7.2–9.8%, demonstrating the model’s interpolation capability and its sensitivity to extrapolation. Cross-validation within the training dataset showed reasonable consistency between experimental and predicted stresses (R > 0.997, AARE < 4.35%). Using the dynamic materials model, hot processing maps identified safe deformation zones and instability zones of the ZM6 alloy. Flow instability was observed at strain rates >0.01 s−1, particularly at low temperatures (300–350 °C). Optimal processing windows appeared in high-energy dissipation (η > 30%) regions, e.g., 400–450 °C/10−4–10−3 s−1. Optical microscopy confirmed that at high temperatures (≥400 °C) and low strain rates (≤0.001 s−1), a uniform, fine-grained, fully recrystallized structure can be obtained, whereas low temperatures (350 °C) and high strain rates (0.1 s−1) produce coarse elongated grains with limited DRX, consistent with the instability regime predicted by the processing maps. Under intermediate conditions (e.g., 400 °C, 0.01 s−1), a bimodal grain distribution indicates incomplete recrystallization. Although EBSD analysis was not performed in this study, the optical microstructures directly validate the predicted safe and unstable windows. Together, all these findings provide preliminary model-based guidance for optimizing hot working parameters to balance microstructural stability and processing efficiency. Full article
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34 pages, 11399 KB  
Article
RSSI Data Augmentation Algorithm Based on Polynomial Regression and Stochastic Signal Fade Modeling
by Mateusz Sumorek, Adam Idźkowski and Krzysztof Konopko
Electronics 2026, 15(13), 2757; https://doi.org/10.3390/electronics15132757 (registering DOI) - 23 Jun 2026
Abstract
This article presents a simple, original data augmentation algorithm for Received Signal Strength Indicator (RSSI), dedicated to indoor localization systems. The aim of the research was to develop a synthetic data generation method to serve as a regularization technique, making models more robust [...] Read more.
This article presents a simple, original data augmentation algorithm for Received Signal Strength Indicator (RSSI), dedicated to indoor localization systems. The aim of the research was to develop a synthetic data generation method to serve as a regularization technique, making models more robust against measurement noise. The proposed approach combines propagation modeling using polynomial regression with the individual statistical characteristics of each Access Point (AP), accounting for signal fluctuations and a probabilistic signal outage mechanism. The effectiveness of the proposed solution was experimentally verified by evaluating K-NN and MLP neural network models in both classification and regression variants. The study was conducted on datasets with different measurement grid granularities, demonstrating the algorithm’s ability to improve the generalization properties of estimators, even with a limited number of samples in the training set. The results showed that the use of augmentation reduced the Mean Absolute Error (MAE) by an average of approximately 20% for the dense training set and about 17% for the sparse set. Within the evaluated test environment, models trained on the augmented sparse measurement grid, which contained 67% fewer physical calibration points (30 points compared to the dense grid’s 92), reached a precision comparable to models trained on the dense real-world dataset. Analysis of histograms and Cumulative Distribution Functions (CDF) of the error confirmed the preservation of the signal’s statistical integrity and the effective mitigation of gross errors. The proposed solution constitutes an efficient and easy-to-implement alternative to complex generative models (e.g., GANs). These findings serve as a successful proof-of-concept and pilot study, laying the foundation for further development and validation in larger, more complex spatial environments. Full article
(This article belongs to the Special Issue Recent Advance of Auto Navigation in Indoor Scenarios)
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