Search Results (111)

Herpes simplex virus type 1 (HSV-1) is associated with eye infections. Specifically, the acute consequences of eye infections have been extensively studied. This review gathers information on possible collateral damage caused by HSV-1 in the retina, such as age-related macular degeneration (AMD), a neurodegenerative disease. The synthesis and accumulation of Amyloid-β peptide (Aβ) is a key hallmark in these types of pathologies. AMD is a disease of multifactorial origin, and viral infections play an important role in its development. It is known that once this virus has entered the eye, it can infect adjacent cells, thus having the ability to infect almost any cell type with great tropism. In the retina, retinal pigment epithelial (RPE) cells are primarily involved in AMD. This work reviews publications that show that RPE can produce Aβ, and once they are infected by HSV-1, the release is promoted. Also, all the information available in the literature that explains how these events may be interconnected has been compiled. This information is valuable when planning new treatments for multifactorial neurodegenerative diseases. Full article

Unmanned aerial vehicles (UAVs) have increasingly proven to be flexible tools for mapping mine terrain, offering expedient and precise data compared to alternatives. Photogrammetric outputs are particularly beneficial in open pit operations and waste dump areas, since they enable cost-effective and reproducible digital terrain models. Meanwhile, UAV-based LiDAR has proven invaluable in situations where uniform ground surfaces, dense vegetation, or steep slopes challenge purely photogrammetric solutions. Recent advances in machine learning and deep learning have further enhanced the capacity to distinguish critical features, such as vegetation and fractured rock surfaces, thereby reducing the likelihood of accidents and ecological damage. Nevertheless, scientific gaps remain to be researched. Standardization around flight practices, sensor selection, and data verification persists as elusive, and most mining sites still rely on limited, multi-temporal surveys that may not capture sudden changes in slope conditions. Complexity lies in devising strategies for rehabilitated dumps, where post-mining restoration efforts involve vegetation regrowth, erosion mitigation, and altered land use. Through expanded sensor integration and refined automated analysis, approaches could shift from information gathering to ongoing hazard assessment and environmental surveillance. This evolution would improve both safety and environmental stewardship, reflecting the emerging role of UAVs in advancing a more sustainable future for mining. Full article

In well drilling operations, interactions between drilling fluid water-based and the well-bore present significant challenges, often escalating project costs and timelines. Particularly, fractures (both induced and natural) and permeable zones at the wellbore can result in substantial mud loss or increased filtration. Addressing these challenges, our research introduces a novel coupled numerical model designed to precisely calculate fluid losses in fractured and permeable zones. For the permeable zone, fundamental variables such as filtration velocity, filtrate concentration variations, permeability reduction, and fluid cake growth are calculated, all based on the law of continuity and convection-dispersion theory. For the fracture zone, the fluid velocity profile is determined using the momentum balance equation and both Newtonian and non-Newtonian rheology. The model was validated against laboratory data and physical models, and adapted for field applications. Our findings emphasize that factors like mud particle size, shear stress, and pressure differential are pivotal. Effectively managing these factors can significantly reduce fluid loss and mitigate formation damage caused by fluid invasion. Furthermore, the understanding gathered from studying mud behavior in both permeable and fractured zones equips drilling personnel with valuable information related to the optimal rheological properties according to field conditions. This knowledge is crucial for optimizing mud formulations and strategies, ultimately aiding in the reduction of non-productive time (NPT) associated with wellbore stability issues. Full article

The damage to shipping containers during port handling operations continues to pose a significant challenge that adversely affects operational efficiency, equipment integrity, and supply chain accountability. This study utilises real-world measurement data gathered through accelerometers to examine the occurrence and dynamics of physical impacts, particularly side and rear collisions, during the handling of containers at Klaipėda City Port. The research prioritises two critical scenarios: side impacts during stacking operations with reach stackers and rear impacts during trailer loading procedures. Impact events are meticulously recorded and analysed to ascertain the magnitudes of acceleration across multiple axes. This reveals that side impacts produce significantly greater forces, particularly in the lateral direction, than rear impacts. This study employs sensor-based monitoring, advanced data visualisation techniques, and structured scenario analysis to delineate the variability and intensity of mechanical interactions during these operations. The findings emphasise the structural stress that containers experience and underscore the importance of embedded monitoring technologies for real-time event detection and damage prevention. The results contribute to the expanding body of knowledge that supports the digital transformation of container terminals and furnish actionable insights for enhancing handling protocols, informing insurance assessments, and improving safety measures within both automated and conventional port environments. Full article

Supracondylar humeral fractures are the most common type of elbow fractures in children. The treatment methods vary depending on the type of fracture (Gartland classification), which can be conservative or surgical. There is no clear consensus or guidelines to dictate the treatment of complicated supracondylar humeral fractures (Gartland types II and III). Gartland type II and III fractures are most frequently treated with closed reduction and percutaneous Kirchner-wire pinning or open reduction with K-wire pinning, depending on the degree of displacement and the orthopedic surgeon’s preference. Most studies recommend avoiding open reduction because of prolonged hospitalization and higher rates of complications. Orthopedic surgeons have different opinions regarding the Kirschner pin placement technique. Studies suggest that only lateral pinning is safe and effective, but medial and lateral pinning is proven to give more stability; there is always a risk of iatrogenic ulnar nerve damage during surgery. Modern treatment of supracondylar humeral fracture in children should focus on minimally invasive techniques and avoid open reduction, when possible, to ensure the best outcome for the patients. This scoping review’s purpose is to gather the available information on the topic in one place and to underline the lack of clear protocols. Full article

Background: The management of renal injuries in hemodynamically stable adult patients is moving toward more conservative methods, even in cases of severe grade and/or penetrating trauma. The objective of this study was to analyze the patterns of injury, management, and complications in renal trauma patients at a Polish trauma center. Methods: Patients diagnosed with renal trauma at the trauma center between January 2019 and December 2023 were identified based on the ICD-10 codes. The information was gathered from digitalized medical records, while imaging data were classified by Radiologists. Results: During a period of 4 years, a total of 81 patients with renal trauma were admitted to the trauma center. 76% of these patients were males, with a mean age of 44.61 ± 16.8 years. The most common concomitant conditions, both among men and women, included retroperitoneal hematoma, rib fractures, as well as chest and lung injuries. Surgical intervention within 8 h of admission was mainly performed on patients with grade IV and V kidney damage, which included a total of 22 people. In deferred treatment, 31 patients underwent surgical intervention. Conclusions: Hemodynamically stable patients, even with penetrating and/or high-grade blunt trauma, were mostly managed non-operatively, with a low rate of complications. Full article

Introduction: Pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD) are severe complications of patients with systemic sclerosis (SSc). Currently, there are a few tests for early identification of these conditions, although they are invasive and time-consuming. Extracellular vesicles (EVs) offer a promising possibility for gathering information on tissue health. This study aims to characterize EVs in cases of systemic sclerosis complicated by pulmonary hypertension and pulmonary fibrosis. Methods: A cohort of 58 patients with SSc was evaluated, including 14 with pulmonary hypertension, 17 with pulmonary fibrosis, and 27 without complications. Additionally, 11 healthy subjects, matched for sex and age, served as a control group. EVs were characterized by using a MACSplex kit to analyze the expression of 37 membrane markers. Results: After the overall analysis, we show that EVs from SSc patients had higher expression of CD146, CD42a, and CD29 (p = 0.03, p = 0.02 and p = 0.05) but lower expression of HLA-ABC with respect to the control patients (p = 0.02). Multivariate analyses demonstrated that only CD42a has a significant association with the disease (p = 0.0478). In group comparative analyses (PAH, ILD, uncomplicated systemic sclerosis (named SSc no PAH no ILD), and controls), CD3 and CD56 were higher in PAH patients, with respect to the controls, ILD, and the group SSc no PAH no ILD (CD3: p = 0.01, p = 0.003, p = 0.0005; CD56: p = 0.002, p < 0.0001, p = 0.0002). HLA-DR showed higher expression in PAH patients with respect to ILD patients (p = 0.02), CD25 showed higher expression in PAH patients with respect uncomplicated SSc (p = 0.02), and CD42a showed higher expression in PAH patients with respect to the controls (p = 0.03); nevertheless, multivariate analyses demonstrated that only CD3 retained its association with PAH. Conclusions: The expression of CD42a, a platelet-derived marker indicating endothelial damage, suggests its potential to provide information on the state of the microcirculation in systemic sclerosis. The higher expression of CD3 on the surface of the EVs in PAH patients might indicate increased T-cell activity in tissues, with a possible association with the development of pulmonary hypertension. Full article

On 29 October 2024, Spain suffered the impact of an Isolated Depression at High Levels (DANA) that caused severe human and material damage. As seen in cases of natural disasters of similar magnitudes, the impact on children requires sustained interventions, with educational communities being key settings for providing protection and accompaniment. Although numerous studies highlight the role of schools in preventing and mitigating the socio-emotional impact of natural disasters on children, the literature on concrete educational actions to address the consequences of flood disasters is limited. This study analyses the co-creation process of six actions developed between researchers and teachers from 18 schools in the most affected areas of Valencia. For this purpose, a communicative research methodology was used. The techniques used to co-create actions were six dialogic focus groups, one dialogical scientific gathering and one WhatsApp community with teachers affected by the DANA. The results provide information on the redevelopment of the following six evidence-based actions and their impacts in the first weeks after the DANA: (1) the mapping of educational communities; (2) the planning of dialogic gatherings; (3) the creation of solidarity networks; (4) the creation of optimal learning environments; (5) the preservation of violence-free networks; and (6) the giving of specific support to vulnerable groups. The study offers guidelines for educational practises in flood-related disaster interventions, focusing on enhancing community resilience. Full article

As the human population has grown and expanded, increasing pressure is being put on natural habitats in Sri Lanka. This situation has led to a noticeable increase in human–primate conflicts. To understand the situation, we studied the interactions between humans and macaques in three administrative divisions of the Kurunegala District. Data was gathered from 875 informants through interviewer-administered questionnaires between 2020 and 2022. The monthly economic loss by commercial farmers due to macaque damage to fruits and vegetables doubled by 2022, amounting to approximately 5000 LKR. In non-fruiting seasons, losses from coconut damage increased, ranging from 3000 to 14,000 LKR/month, decreasing by over 50% during fruiting seasons. Property damage per household averaged between 850~4000 LKR/month. A cost of approximately 1200~3000 LKR was borne per household/month to deter monkeys from the fields. Macaques were the primary culprits for crop damage in this area, and were also responsible for property damage, surpassing that of other animals. The consensus among the community is that either relocating macaques to other forested areas or sterilizing them to control their population could mitigate the issue to some extent. An integrated management plan involving relevant stakeholders including the Forest Department, the Wildlife Conservation Department, the local agricultural agency, and local citizens is necessary to address the conflict arising from human–macaque crop utilization. Full article

Diabetes mellitus (DM), a global disease that significantly impacts public health, has become increasingly common over time. In this review, we aim to determine the potential benefits of St. John’s Wort (SJW) as an adjunct therapy for DM. We gathered information from studies conducted in vitro, in vivo, and in humans. In vitro studies investigated the concentrations of SJW extracts capable of inhibiting certain enzymes or factors involved in the inflammatory pathway, such as the β-signal transducer and activator of transcription 1, nuclear factor κB, methylglyoxal, and oxidative stress (OS). The extract was found to have positive effects on OS and anti-inflammatory properties in DM, suggesting it could serve as a protective agent against diabetic vascular complications, cell damage, and apoptosis. According to in vivo research, the essential components of the extract can stimulate thermogenesis in adipose tissue, inhibit several key inflammatory signaling pathways, and delay the early death of pancreatic β cells, all of which contribute to combating obesity. The extract may also help treat prediabetes and significantly reduce neuropathic pain. Human studies have also confirmed some of these results. However, some of the plant’s side effects need further investigation through clinical research before it can be used to treat DM. Full article

Overtopping phenomena and consequent floods cause significant damage to coastal communities. Morphological changes in front of structures during storms can influence their functionality, affecting their stability and leading to failures, impacting the population that are depending on those coastal interventions for their protection. The effect of climate changes, such as sea level rise and increase of the frequency and intensity of storms, can raise the number of overtopping events over defense structures, also increasing coastal morphological changes, challenging future managers, engineers and the scientific coastal communities. A review of morphological changes in front of coastal defense structures and in natural barriers due to overtopping, wave run-down and reflux was conducted. The objective of this review was to find and gather relevant information, sometimes dispersing, reflecting and grouping the concepts found in the literature. Additionally, the gaps in scientific research are addressed, focusing on topics that may be enhanced. Several keywords used in the research were presented, emphasizing the relationship between overtopping and models (physical and numerical), storms, defense structures and morphological changes, also related to wave run-down during storms. The results show that there is limited information available that is mainly related to morphological changes in front of coastal defense structures during storm events, showing an opportunity to develop knowledge. Full article

Technological advancements in mechanized food production have expanded markets beyond geographical boundaries. At the same time, the risk of contamination has increased severalfold, often resulting in significant damage in terms of food wastage, economic loss to the producers, danger to public health, or all of these. In general, governments across the world have recognized the importance of having food safety processes in place to impose food recalls as required. However, the primary challenges to the existing practices are delays in identifying unsafe food, siloed data handling, delayed decision making, and tracing the source of contamination. Leveraging the Internet of Things (IoT), 5G, blockchains, cloud computing, and big data, a novel framework has been proposed to address the current challenges. The framework enables real-time data gathering and in situ application of machine learning-powered algorithms to predict contamination and facilitate instant decision making. Since the data are processed in real time, the proposed approach enables contamination to be identified early and informed decisions to be made confidently, thereby helping to reduce damage significantly. The proposed approach also throws up new challenges in terms of the implementation of changes to data collection across all phases of food production, onboarding various stockholders, and adaptation to a new process. Full article

In a hyperproductive interactive environment, where speed and cost-effectiveness often overshadow accuracy, the media’s role is increasingly shifting towards an educational function, beyond its traditional informative and entertaining roles. This shift, particularly through the promotion of science and education, aims to bridge the gap between educational institutions and the labor market. In this context, the importance of 21st-century competencies—encompassing a broad range of knowledge and skills—becomes increasingly clear. Educational institutions are now expected to equip students with relevant, universally applicable, and market-competitive competencies. This paper proposes using a combination of principal component analysis (PCA) and fuzzy analytic hierarchy process (FAHP) to rank 21st-century competencies developed throughout the educational process to improve the system. The highest-ranked competency identified is the ability to manage information—specifically, gathering and analyzing information from diverse sources. It has been shown that respondents who developed “soft skills” and media literacy during their studies are better able to critically assess content on social networks and distinguish between credible and false information. The significance of this work lies in its focus on the damaged credibility of online media caused by user-generated content and the rapid spread of unverified and fake news. Denying such discourse or erasing digital traces is therefore futile. Developing a critical approach to information is essential for consistently identifying fake news, doctored images, and recordings taken out of context, as well as preventing their spread. Full article

Hypertensive nephropathy (HN) is a leading cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD), contributing to significant morbidity, mortality, and rising healthcare costs. In this review article, we explore the role of epigenetic mechanisms in HN progression and their potential therapeutic implications. We begin by examining key epigenetic modifications—DNA methylation, histone modifications, and non-coding RNAs—observed in kidney disease. Next, we discuss the underlying pathophysiology of HN and highlight current in vitro and in vivo models used to study the condition. Finally, we compare various types of HN-induced renal injury and their associated epigenetic mechanisms with those observed in other kidney injury models, drawing inferences on potential epigenetic therapies for HN. The information gathered in this work indicate that epigenetic mechanisms can drive the progression of HN by regulating key molecular signaling pathways involved in renal damage and fibrosis. The limitations of Renin–Angiotensin–Aldosterone System (RAAS) inhibitors underscore the need for alternative treatments targeting epigenetic pathways. This review emphasizes the importance of further research into the epigenetic regulation of HN to develop more effective therapies and preventive strategies. Identifying novel epigenetic markers could provide new therapeutic opportunities for managing CKD and reducing the burden of ESRD. Full article

Climate change is causing a range of environmental impacts, including increased flood frequency and intensity, posing significant risks to human populations and transportation infrastructure. Assessing flood risk under climate change is critical, but it is challenging due to uncertainties associated with climate projections and the need to consider the interactions between different factors that influence flood risk. Geographic Information Systems (GISs) are powerful tools that can be used to assess flood risk under climate change by gathering and integrating a range of data types and sources to create detailed maps of flood-prone areas. The primary goal of this research is to create a comprehensive GIS-based flood risk map that includes various climate change scenarios derived from the Coupled Model Intercomparison Project Phase 6 (CMIP6) models. This goal will leverage the Analytic Hierarchy Process (AHP) methodology to better understand the impacts of these climate change scenarios on the transportation network. Furthermore, this study aims to evaluate the existing flood risk map and assess the potential impacts of prospective climate scenarios on the levels of flood risk. The results showed that the northern and coastal regions of the United Arab Emirates (UAE) are at higher risk of flooding, with the majority of the population living in these areas. The projections for future flood risk levels indicate that under the SSP245 scenario, flood risk levels will generally be low, but some areas in the northern and eastern regions of the UAE may still face high to very high flood risk levels due to extensive urbanization and low-lying coastal regions. Under the SSP585 scenario, flood risk levels are projected to be significantly higher, with a widespread distribution of very high and high flood risk levels across the study area, leading to severe damage to infrastructure, property, and human lives. The recent publication of the CMIP6 models marks a significant advancement, and according to the authors’ knowledge, there have been no studies that have yet explored the application of CMIP6 scenarios. Consequently, the insights provided by this study are poised to be exceptionally beneficial to researchers globally, underscoring the urgent necessity for holistic sustainable flood risk management approaches for geography, planning, and development areas. These approaches should integrate both sustainable transportation infrastructure development and risk mitigation strategies to effectively address the anticipated impacts of flooding events within the study region. Full article