Search Results (11)

The Sulu Sea has active internal tides (ITs) and basin-scale circulation. This study, for the first time, employs three-dimensional simulations to investigate the effects of the Sulu Sea circulation on IT generation and propagation. Results reveal that the cyclonic circulation can enhance the semi-diurnal and diurnal IT energy conversion in the Sulu Archipelago by approximately 17% and 77%, respectively, compared to those without circulation for semi-diurnal ITs (4.36 GW) and diurnal ITs (2.76 GW). This different increase portion between semi-diurnal and diurnal ITs is attributed to different influences of circulation on the positive and negative conversion rates for semi-diurnal and diurnal ITs. Energy budget analysis indicates that circulation increases the proportion of dissipation near source regions from 88% (90%) to 94% (93%) and reduces the proportion of energy flux radiation from 12% (10%) to 6% (7%) for semi-diurnal (diurnal) ITs. The ray-tracing results indicate that the cyclonic circulation induces significant westward refraction of IT rays by modulating IT speeds in counter-current/co-current regions. Further sensitive experiments reveal that circulation-induced stratification weakens the refraction, whereas the background currents strengthen it, with the latter dominating. These findings advance our understanding of the IT behaviors in the Sulu Sea under the modulation of circulation. Full article

The aim of this study was to investigate gene expression alterations associated with overall survival (OS) in glioblastoma (GBM). Using the Nanostring nCounter platform, we identified four genes (COL1A2, IGFBP3, NGFR, and WIF1) that achieved statistical significance when comparing GBM with non-neoplastic brain tissue. The four genes were included in a multivariate Cox Proportional Hazard model, along with age, extent of resection, and O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation, to create a unique glioblastoma prognostic index (GPI). The GPI score inversely correlated with survival: patient with a high GPI had a median OS of 7.5 months (18-month OS = 9.7%) whereas patients with a low GPI had a median OS of 20.1 months (18-month OS = 54.5%; log rank p-value = 0.004). The GPI score was then validated in 188 GBM patients from The Cancer Genome Atlas (TCGA) from a national data base; similarly, patients with a high GPI had a median OS of 10.5 months (18-month OS = 12.4%) versus 16.9 months (18-month OS = 41.5%) for low GPI (log rank p-value = 0.0003). We conclude that this novel mRNA-based prognostic index could be useful in classifying GBM patients into risk groups and refine prognosis estimates to better inform treatment decisions or stratification into clinical trials. Full article

A better understanding of responses to water limitation in woody species can help us to cope with the consequences of the progressing climate change. We focused on the putative transgenerational effects of water limitation in the maternal environment during reproduction. Water was restricted for cuttings of Frangula alnus Mill. in a common garden setting, with a Belgian (local), Italian and Swedish provenance, during the growing season of 2020 and mature berries were collected during the whole reproductive phase. Stones that were extracted from the berries were given a cold stratification. In the next spring, the germination percentage of the stones from the water restricted maternal environment was significantly higher than that of the stones from the normal maternal environment, for the three provenances, notwithstanding the fact that stone weight was not different. The timing of seedling emergence was advanced for the water-limited maternal environment, but only for the stones harvested when mature berry production was the highest (9th and 16th of July 2020). Population differentiation was observed for the timing of seedling emergence, which reflected population differentiation for bud burst of the mother plants in the common garden, including a counter-gradient effect for the Swedish provenance, and corroborating the suggestion that the timing of seedling emergence and leaf phenology may have a common genetic basis. In addition, the Swedish provenance displayed a somewhat more stable germination percentage over the whole berry collection period when the stones were harvested. A partitioning of variance analysis suggested that germination percentage is more genetically determined than timing of seedling emergence, probably reflecting the more important need to sense the environment for an adequate timing of emergence. Full article

Renal cell carcinoma (RCC) makes up the majority of kidney cancers, with a poor prognosis for metastatic RCC (mRCC). Challenges faced in the management of mRCC, include a lack of reliable prognostic markers and biomarkers for precise monitoring of disease treatment, together with the potential risk of toxicity associated with more recent therapeutic options. Glycosaminoglycans (GAGs) are a class of carbohydrates that can be categorized into four main subclasses, viz., chondroitin sulfate, hyaluronic acid, heparan sulfate and keratan sulfate. GAGs are known to be closely associated with cancer progression and modulation of metastasis by modification of the tumor microenvironment. Alterations of expression, composition and spatiotemporal distribution of GAGs in the extracellular matrix (ECM), dysregulate ECM functions and drive cancer invasion. In this review, we focus on the clinical utility of GAGs as biomarkers for mRCC (which is important for risk stratification and strategizing effective treatment protocols), as well as potential therapeutic targets that could benefit patients afflicted with advanced RCC. Besides GAG-targeted therapies that holds promise in mRCC, other potential strategies include utilizing GAGs as drug carriers and their mimetics to counter cancer progression, and enhance immunotherapy through binding and transducing signals for immune mediators. Full article

Background: Worldwide, vitamin D deficiency is a public health issue and the prevalence of obesity and non-alcoholic fatty liver disease (NAFLD) are rapidly increasing. There are a limited number of studies assessing the association between serum levels of 25-hydroxyvitamin D (25(OH)D) and NAFLD risk in obese population. Objective: We evaluated the associations between serum 25(OH)D levels and risk of suspected NAFLD after stratification by obesity using data from the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2014. Methods: This study included 25,755 subjects without significant alcohol consumption for the serum alanine aminotransferase (ALT) and hepatic steatosis index (HSI) analyses (8922 subjects for the serum gamma-glutamyl transferase (GGT) and fatty liver index (FLI) analyses), based on a cross-sectional study design. Serum 25(OH)D levels were measured using a Gamma counter with radioimmunoassay. A survey logistic regression model was applied to estimate ORs and 95% CIs. Restricted cubic smoothing splines were applied to evaluate nonlinear associations. Results: The risk of suspected NAFLD was reduced per unit of natural log-transformed serum 25(OH)D concentration in obese individuals (OR [95% (CI)]; for ALT, 0.80 [0.67, 0.96]; for GGT, 0.70 [0.49, 0.99; for FLI, 0.68 [0.47, 1.01]; for HSI, 0.70 [0.56, 0.87]). The ORs [95% CI] of suspected NAFLD changed across the quartiles: for serum ALT, from 1.02 [0.85, 1.23] to 0.72 [0.59, 0.87]; for serum GGT, from 0.79 [0.56, 1.13] to 0.64 [0.44, 0.92]; for FLI, from 0.98 [0.67, 1.44] to 0.70 [0.48, 1.02]; and for HSI, from 0.91 [0.73, 1.14] to 0.65 [0.52, 0.81] with dose–response relationships (all p for trend < 0.01). Conclusions: This study suggests that vitamin D sufficiency for public health should be emphasized in order to prevent adverse health effects in obese populations. Full article

Meningioma is the most common tumor in central nervous system (CNS). Although most cases of meningioma are benign (WHO grade I) and curable by surgical resection, a few tumors remain diagnostically and therapeutically challenging due to the frequent recurrence and progression. The heterogeneity of meningioma revealed by DNA methylation profiling suggests the demand of subtyping for meningioma. Therefore, we performed a clustering analyses to characterize the progressive features of meningioma and constructed a meningioma progression score to predict the risk of the recurrence. A total of 179 meningioma transcriptome from RNA sequencing was included for progression subtype clustering. Four biologically distinct subtypes (subtype 1, subtype 2, subtype 3 and subtype 4) were identified. Copy number alternation and genomewide DNA methylation of each subtype was also characterized. Immune cell infiltration was examined by the microenvironment cell populations counter. All anaplastic meningiomas (7/7) and most atypical meningiomas (24/32) are enriched in subtype 3 while no WHO II or III meningioma presents in subtype 1, suggesting subtype 3 meningioma is a progressive subtype. Stemness index and immune response are also heterogeneous across four subtypes. Monocytic lineage is the most immune cell type in all meningiomas, except for subtype 1. CD8 positive T cells are predominantly observed in subtype 3. To extend the clinical utility of progressive meningioma subtyping, we constructed the meningioma progression score (MPscore) by the signature genes in subtype 3. The predictive accuracy and prognostic capacity of MPscore has also been validated in three independent cohort. Our study uncovers four biologically distinct subtypes in meningioma and the MPscore is potentially helpful in the recurrence risk prediction and response to treatments stratification in meningioma. Full article

The aim of this study is to explore whether and how school-based social capital (SSC) may increase or reduce inequalities in the academic achievement and well-being of students from different backgrounds (class, gender, and ethnicity). SSC here refers to those qualities of social relationships and the degree of interconnectedness between students, teachers, and parents that can support the educational attainment and social adjustment of young people. As the results of our ethnographic studies indicate, there is a significant association between SSC and school composition—i.e., the class and ethnic background of students in a school. The association indicates the stratification effect of social capital in schools as a predominant pattern. In a school with students from higher socio-economic backgrounds, we observed more qualified and motivated teachers, an intensive parental involvement, and, consequently, more constructive and friendly relationships among students. In contrast, in a school located in a disadvantaged area, the social relations were quite the reverse. We then found a third category. In a school with children from lower social class backgrounds placed in an immigrant-dense area, highly committed school staff were able to create an emotional closeness and trust between them, the pupils, and their parents. School-based social capital in this context introduced a sense of solidarity and created a pro-educational climate. Full article

Thermal energy storages (TES) are increasingly important for storing energy from renewable energy sources. TES that work with liquid storage materials are used in their most efficient way by stratifying the storage fluid by its thermal density gradient. Mixing of the stratification layers during stand-by periods decreases the thermal efficiency of the TES. Tank sidewalls, unlike the often poorly heat-conducting storage fluids, promote a heat flux from the hot to the cold layer and lead to thermal convection. In this experimental study planar particle image velocimetry (PIV) measurements and background-oriented schlieren (BOS) temperature measurements are performed in a model experiment of a TES to characterise the influence of the thermal convection on the stratification and thus the storage efficiency. The PIV results show two vertical, counter-directed wall jets that approach in the thermocline between the stratification layers. The wall jet in the hot part of the thermal stratification shows compared to the wall jet in the cold region strong fluctuations in the vertical velocity, that promote mixing of the two layers. The BOS measurements have proven that the technique is capable of measuring temperature fields in thermally stratified storage tanks. The density gradient field as an intermediate result during the evaluation of the temperature field can be used to indicate convective structures that are in good agreement to the measured velocity fields. Full article

This study examines the distribution and seasonal evolution of hydrographic, hydrodynamic, and nepheloid layers in Ushuaia Bay and the submerged glacial valley that connects it to the Beagle Channel. The hydrographic structure is highly seasonal, with a total mixing of the water column in winter and the appearance of a pycnocline between 50 and 70 m deep from spring to late autumn, mainly due to desalination. A counter-clockwise current sweeps the entire bay regardless of the season or phase of the tide. This current is at its maximum in the surface layer, allowing the rapid renewal of the bay’s waters, while deep currents are weak and imply a slow renewal of the valley’s waters. Turbid and oxygen-depleted structures are observed in summer in the valley. The combination of seasonal stratification, high organic matter inputs from planktonic production, oxygen consumption for remineralization, and sluggish circulation results in a decrease in near-bottom oxygen concentration in the glacial valley at the end of the stratified season, before mixing and re-oxygenation of the water column during the southern winter. The possible impact of dissolved oxygen depletion in the bottom waters of the valley on benthic organisms, like crustaceans, is discussed. Full article

Pheochromocytomas (PCCs) and abdominal paragangliomas (PGLs), collectively abbreviated PPGLs, are neuroendocrine tumors of the adrenal medulla and paraganglia, respectively. These tumors exhibit malignant potential but seldom display evidence of metastatic spread, the latter being the only widely accepted evidence of malignancy. To counter this, pre-defined histological algorithms have been suggested to stratify the risk of malignancy: Pheochromocytoma of the Adrenal Gland Scaled Score (PASS) and the Grading system for Adrenal Pheochromocytoma and Paraganglioma (GAPP). The PASS algorithm was originally intended for PCCs whereas the GAPP model is proposed for stratification of both PCCs and PGLs. In parallel, advances in terms of coupling overtly malignant PPGLs to the underlying molecular genetics have been made, but there is yet no combined risk stratification model based on histology and the overall mutational profile of the tumor. In this review, we systematically meta-analyzed previously reported cohorts using the PASS and GAPP algorithms and acknowledge a “rule-out” way of approaching these stratification models rather than a classical “rule-in” strategy. Moreover, the current genetic panorama regarding possible molecular adjunct markers for PPGL malignancy is reviewed. A combined histological and genetic approach will be needed to fully elucidate the malignant potential of these tumors. Full article

During the last decade there has been an essential development of wireless communication technologies for intelligent transportation system (ITS) applications for motor transport; these advanced infocommunication technologies are called vehicular ad hoc networks (VANET). VANET/ITS, in particular, inform and warn drivers about possible obstacles, and also the possibility of how to organize coordinated actions. Therefore, any violation of its functioning by cyber attacks automatically influences the safety of people and automotive engineering on the road. The purpose of this article is to provide an analytical overview of cyber attacks on VANET/ITS, presented in state-of-the-art publications on this topic by the prediction of its cyber resistance. We start with an analysis of the top 10 cyber threats, considered according to the following schemes: attack mechanism, vulnerability, damage, object of attack, and a counter measure. We then set out a synergistic approach for assessing the cyber resistance of the forward-looking VANET/ITS conceptual model, formed by the merger of the internet of vehicles and software-defined networking technology. Finally, we identify open issues and associated research opportunities, the main ones being the formalization of threats, vulnerability stratification, the choice of the level of network management centralization and, last but not least, the modeling and prediction of VANET/ITS cyber resistance. Full article