Search Results (12,662)

In this paper, we propose a distributed admittance control framework for joint manipulation of objects by multiple robotic arms that addresses the challenges of human–robot interaction. The system is developed to control the joint transportation of an object by N Franka Emika Panda robots (validated with up to four in simulations) using external human force estimation in a distributed manner without relying on centralized computation or force sensors. We integrate a hybrid observer by combining a distributed force estimator with a nonlinear disturbance observer (NDOB) to achieve accurate human force estimation and minimize estimation errors in simulations. Adaptive radial basis function neural networks (RBFNNs) are employed to dynamically adjust the damping and inertia parameters, enhancing the system’s adaptability and stability. Event-based communication minimizes network bandwidth usage, while consensus protocols ensure synchronization of state estimates across robots. Unlike conventional methods, the proposed observer operates in a fully sensorless manner: no human-force measurements are required. The estimation relies solely on locally available robot states, maintaining high accuracy while reducing system complexity. The framework demonstrates scalability to multiple robots, enhancing robustness in distributed settings. Simulation results show superior performance in terms of path tracking, force estimation accuracy, and communication efficiency compared to centralized approaches. Specifically, the event-triggered strategy reduces communication messages by approximately 70% compared to always-connected mode while maintaining comparable RMSE in position $(9.97\times {10}^{-5}$ vs. $7.39\times {10}^{-5}$) and velocity $(2.52\times {10}^{-5}$ vs. $3.76\times {10}^{-5})$, outperforming periodic communication. Full article

This study examines customers’ continuance intention in metaverse services by integrating technological, content, and social-relational dimensions and assessing the role of immersiveness. Six focal antecedents are considered, namely, technological sophistication, security, content creativity, content richness, social interaction, and social presence. Survey data from 231 metaverse users in China show that technological sophistication, content creativity, social interaction, and social presence are positively associated with immersiveness, whereas security and content richness are not. In addition, continuance intention is positively associated with technological sophistication, security, content richness, social interaction, and immersiveness. Despite the absence of clear indirect effects via immersiveness, the results suggest that continuance intention reflects not only immersive experience but also post-adoption evaluations of assurance and usefulness. As metaverse services move toward broader adoption and commercialization, these findings distinguish experience-building drivers from retention-relevant factors and offer implications for service development, content strategy, and community experience design. Full article

The co-occurrence of microplastics (MPs) and cadmium (Cd) in agricultural soils poses ecological risks, yet their interactions in flooded rice paddies remain unclear. Therefore, this study investigated the individual and combined effects of polyethylene MPs (mPE) and Cd on rice (Oryza sativa L.) growth, Cd accumulation, and soil microbial communities. Combined stress (5 mg/kg Cd + 1% mPE) significantly reduced rice growth (4.1–13.8% in plant height) and increased Cd accumulation in roots, stems, and seeds, driven by MP-enhanced Cd bioavailability. MPs altered soil pH, organic matter (OM), and moisture content (MC), indirectly suppressing yield. Microbial analysis revealed decreased bacterial alpha diversity (0.86–8.36%), favoring Cd-tolerant taxa (e.g., Solirubrobacteraceae), while fungal responses were weaker under flooding. Structural equation modeling indicated that Cd exerted direct toxicity through tissue accumulation, whereas MPs acted indirectly by modifying soil properties and inducing oxidative stress. Under co-exposure, MPs intensified Cd-induced oxidative stress, enhancing both direct and indirect toxicity pathways. Mantel tests identified DTPA-extractable Cd (r = 0.70) and OM (r = 0.55) as key drivers of Cd uptake. These findings highlight the complex interplay of MPs and Cd in rice paddies, with implications for managing co-contaminated agroecosystems. Full article

Exploring how nitrogen deposition alters the competitive interactions between invasive plants and native plants is critical for predicting the invasion trends of invasive plants and for formulating their control strategies. In this study, the invasive plant Solanum rostratum and its native congener S. nigrum were selected as research subjects, and three different nitrogen (N) concentration treatments (N1: 50 mg·kg⁻¹, N2: 100 mg·kg⁻¹, N3: 150 mg·kg⁻¹) were set up to compare the two species in terms of growth and development, leaf nutrient utilization strategies, stress tolerance, and rhizosphere microbial community differences under competitive conditions. The results showed that the biomass of S. rostratum was 1.4 to 2.3 times that of S. nigrum; the former had a lower root–shoot ratio and a larger crown width, enabling it to seize more living space and light resources. Across all nitrogen treatments, the net photosynthetic rate of S. rostratum leaves was significantly higher than that of S. nigrum, reflecting a stronger carbon sequestration capacity. With the increase in soil nitrogen concentration, the malondialdehyde content in S. rostratum leaves showed a decreasing trend; meanwhile, its leaf soluble sugar and catalase contents were 3.5 to 4.3 times and 1.5 to 2.5 times those of S. nigrum, respectively, indicating a lower oxidative stress level and higher stress tolerance in S. rostratum. The leaf C/P and C/N ratios of S. rostratum increased with the rise in soil N, demonstrating a higher nutrient use efficiency, while the decrease in leaf phosphorus (P) content might be attributed to the element dilution effect caused by the rapid plant growth. In addition, the diversity and stability of the rhizosphere microbial community of S. rostratum gradually increased with increasing soil N and were significantly higher than those of S. nigrum. The rhizosphere-recruited microbes of the genera Comamonas and Chryseobacterium may help promote its root nutrient absorption and thus enhance its competitive ability. Collectively, our findings reveal that under exogenous N application, S. rostratum gains a significant growth advantage over S. nigrum, which is attributed to its stronger capacities for carbon assimilation and spatial resource acquisition, a nutrient strategy characterized by low acquisition and high utilization, as well as a stable and diverse rhizosphere microbial community. Full article

The mainstreaming of remote work has catalyzed the rise of the new tribe, the kinetic elite, a demographic comprising digital nomads and workationers who utilize technology to separate work from geography. Yet, this apparently free lifestyle often leads to a freedom trap, where the collapsing boundaries between work and leisure necessitate intense self-discipline within spaces originally architected for tourism. Drawing on an integrated framework of quality of destination features, service, and experience, this study investigates the antecedents of satisfaction and loyalty for this niche market of mobile workforce. Data were collected from 325 international digital nomads and workationers in Thailand using a purposive sampling approach. The proposed integrated model was empirically tested using Partial Least Squares Structural Equation Modeling (PLS-SEM). The analysis challenges the hardware-first paradigm of destination development. Findings indicate that while digital infrastructure (connectivity) and geoarbitrage (value) are non-negotiable baselines, they employ limited influence on ultimate satisfaction. Instead, human infrastructure, specifically the quality of staff and host–community interactions, emerges as the primary determinant in converting a location from a travel stop into a functional home base. These results advocate for a strategic plan toward precision niche marketing, moving beyond a homogenous view of the sector to target the community-seeking segment. Furthermore, the study frames community integration as a core practice of social sustainability, suggesting that for destinations to evolve into vibrant knowledge ecologies, Destination Management Organizations (DMOs) must prioritize community facilitation and smart policies that mitigate the social isolation inherent in nomadic life. Full article

Environmental health and biosecurity in pig farms and surroundings are increasingly threatened by pathogenic bacteria carried by fine particulate matter with an aerodynamic diameter of 2.5 μm or less (PM_2.5) in enclosed piggeries. However, limited attention has been given to these pathogens and their association with the respiratory microbiome of pigs. Using high-throughput sequencing, we investigated the overall and pathogenic bacterial communities attached to PM_2.5 in pig houses, as well as those in the upper (URT) and lower respiratory tracts (LRT) of healthy fattening pigs. Concentrations of PM_2.5, particulate matter with an aerodynamic diameter of 10 μm or less (PM₁₀), ammonia (NH₃), total volatile organic compounds (TVOCs), and hydrogen sulfide (H₂S) were significantly higher inside the piggery than in the surrounding environment. The composition of PM_2.5-associated bacteria varied with sampling height and showed greater similarity to the microbiota of the URT, particularly the oropharynx, than to that of the LRT. Additionally, 140 core potential bacterial pathogens were identified via Venn analysis in both PM_2.5 and respiratory tracts. Co-occurrence network analysis and community assembly patterns revealed that microbial communities in PM_2.5 and the respiratory tract exhibit distinct interaction and assembly characteristics. These findings highlight the potential role of PM_2.5 as a vector for respiratory pathogens and underscore the importance of air quality management in pig farming to safeguard environmental health. Full article

Background: The Callista Roy Adaptation Model posits that adaptation in later life emerges from the interaction among physical, psychological, and social dimensions. However, empirical evidence integrating these domains through predictive approaches remains limited. The aim of this study was to identify the main predictors of adaptive classification in older adult women using functional and subjective well-being measures. Methods: A predictive study was conducted in older adult women enrolled in community-based exercise programs. Assessments included the Senior Fitness Test and the SF-12 and WHO-5 questionnaires. Multiclass classification models were trained, with Random Forest selected due to superior performance. Model evaluation incorporated oversampling strategies and robustness analyses without oversampling, using metrics resilient to class imbalance (macro-F1 and balanced accuracy). Model interpretability was examined through variable importance analysis, partial dependence, and ICE plots. Results: Under the oversampling framework, the Random Forest model achieved an overall accuracy of 74% and a macro-F1 score of 0.73, with reduced performance observed in robustness analyses, particularly for the minority “High” class. The most influential predictors were the physical component of the SF-12, the 2 min step test, the mental component of the SF-12, and the chair sit-and-reach test. Conclusions: The findings highlight the joint contribution of physical and psychosocial factors to adaptive processes, in alignment with the Roy Adaptation Model. This study provides exploratory evidence supporting the integrated use of the SFT, SF-12, and WHO-5; however, external validation and longitudinal evaluation are required prior to clinical implementation. Full article

Background: Emerging evidence links the gut microbiome to chronic pain processing. Inulin, a prebiotic fibre, modulates the gut microbiome, while physiotherapy-supported exercise (PSE) improves pain and function. We evaluated the effects of inulin supplementation with and without PSE on knee osteoarthritis (OA) pain. Methods: In a 2 × 2 factorial RCT, 117 community-dwelling adults with knee OA received 6 weeks of: (A) 20 g/day inulin, (B) digital PSE (Joint Academy™), (C) inulin +PSE, or (D) 10 g/day maltodextrin. Primary outcome: pain (Numerical Rating Scale). Secondary: 30 s sit-to-stand (30-CST), timed up and go (TUG), grip strength, and quantitative sensory testing. Serum short-chain fatty acids (SCFAs) and glucagon-like peptide-1 (GLP-1) were measured. The study was not powered to detect synergistic interaction. Results: A total of 117 participants (58.1% female; mean ± SD age = 67.5 ± 9.4 years; BMI = 29.5 ± 5.3 kg/m²; NRS = 3.96 ± 2.67) completed the trial. Pain improved with inulin (baseline-adjusted between-group mean difference (Δ) = −1.11 [95%CI −2.18, −0.04], p = 0.045) and PSE (Δ = −1.55 [95%CI −2.52, −0.58], p = 0.002) compared to placebo, with no synergistic effect. PSE improved TUG (p = 0.02) and 30-CST (p = 0.0004), while inulin improved grip strength (p = 0.002), pressure pain thresholds (p = 0.009) and temporal summation (p = 0.025) compared to placebo and had significantly lower dropout rates (3.6%) compared with PSE (21% p < 0.01). Only inulin increased SCFA butyrate (p = 0.0248) and GLP-1 (p = 0.0109), and higher GLP-1 was associated with improved grip strength, suggesting a gut–muscle link. Conclusions: Inulin and PSE each produced meaningful pain reductions. Only inulin improved pain sensitivity and grip strength, the latter paralleled by increased GLP-1, and had much higher rates of retention compared to PSE. Full article

Droughts are considered one of the major abiotic limitations constraining global plant productivity. Recent findings suggest that water-deficit responses in plants are largely mediated by associated microbial communities, instead of being purely genetically based in plants. Of these beneficial microbes, pink-pigmented, facultative, methylotrophic bacteria in the genus Methylobacterium have been recognized for their immense potential as plant-growth-promoting agents. These microbes have the ability to generate phytohormones, especially cytokinins and auxins, as well as manipulate host metabolic pathways. This review aims to compile available knowledge on hormonal and metabolic interactions in the plant holobiont mediated by Methylobacterium species, especially in relation to drought stress. Firstly, the review discusses the microbial production of phytohormones, specifically cytokinins (such as trans-zeatin) and auxins (like indole-3-acetic acid, or IAA), and their effects on plant roots and shoots. Next, the review aims to discuss metabolic priming approaches induced by Methylobacterium in plants exposed to drought, which include priming for osmolyte biosynthesis (proline, glycine betaine, trehalose, etc.) and activating antioxidant defenses. Furthermore, the review aims to explain how these interactions and responses collectively contribute to developing plant drought stress resilience via improved plant–water relations, postponing senescence, maintaining photosystem efficiency and elucidating mechanisms using omics approaches. Full article

Food insecurity is a considerable challenge for university students globally. While food pantries are a primary response, their impact on psychological well-being remains unclear. Here, we aimed to investigate effects of providing hot meals during community food-pantry events on participant satisfaction and self-reported loneliness among financially challenged university students in Tokyo. A non-randomized pre-post design was used to compare events with (n = 87) and without (n = 41) a hot meal. Participant satisfaction was assessed using a questionnaire; loneliness was measured using the University of California, Los Angeles (UCLA) Loneliness Scale. Hot-meal events had a 100% satisfaction rate. Notably, satisfaction with the café space was significantly higher in hot-meal events than in non-meal events (p = 0.003). However, analysis of covariance indicated that the adjusted mean difference in post-event loneliness scores was not statistically significant. Hot meals enhanced participant satisfaction and the perception of the venue, suggesting it is a key component of the food-utilization dimension of food security. Although a significant reduction in loneliness was not observed, the high appreciation of the dining environment suggests that future programs should integrate hot meals with strategies to maximize social interaction, aiming for a more holistic impact on student well-being. Full article

Female reproductive tract (FRT) disorders such as maternal conditions and gynecological cancers represent a significant global health burden. However, women’s health, and particularly locally acting therapies targeting the FRT, has historically been underprioritized in drug development and translational research. Developing safe and effective therapies requires a clear understanding of drug transport across FRT barriers. Conventional in vitro culture systems and animal studies fail to recapitulate the physiological complexity of the human FRT, including stratified mucosal architecture, functional mucus barriers, microbiome interactions, as well as dynamic hormonal regulation. Recently, organ-on-chip (OoC) microfluidic platforms, integrating human cells with precisely controlled perfusion, have emerged as advanced in vitro systems capable of recreating dynamic physiological microenvironments. This review summarizes the major anatomical and physiological barriers of the FRT, including the vagina, cervix, endometrium, and placenta, and discusses critical design considerations for the development of FRT-on-chip models. We highlight the advanced OoC developed to study infection, drug permeation, hormonal responses, and maternal–fetal interface dynamics. Finally, future perspectives are outlined, including the integration of immune components, vascularization strategies, and multi-organ systems to better simulate inter-organ communication. Collectively, these advances underscore the potential of FRT-on-chip models as predictive platforms for preclinical drug screening, toxicity evaluation, and personalized medicine. Full article

MicroRNAs (miRNAs) are essential post-transcriptional regulators of gene expression and have emerged as key modulators of host–pathogen interactions during bacterial infection. In this narrative review, we synthesize recent experimental and mechanistic evidence on how infection-responsive miRNAs shape innate and adaptive immunity, focusing on four representative pathogens: Salmonella, Listeria monocytogenes, Mycobacterium tuberculosis, and Helicobacter pylori. We highlight major miRNA-regulated signaling modules, including TLR/NF-κB, JAK–STAT, autophagy, immunometabolic reprogramming, and extracellular vesicle mediated intercellular communication, and summarize experimentally validated miRNA–target interactions that calibrate immune activation thresholds and inflammatory outcomes. Accumulating evidence indicates that miRNAs not only fine-tune host defense programs by controlling immune-related gene expression and immune cell activation, but can also be exploited by bacterial pathogens to suppress antimicrobial signaling and promote intracellular survival or persistent colonization. Collectively, these findings position miRNAs as a critical regulatory layer linking immune signaling networks to infection outcomes and underscore their translational potential as biomarkers and host directed therapeutic targets, while remaining grounded in current experimental evidence. Full article

Wildfire escalation is increasingly threatening ecosystems and communities in Khyber Pakhtunkhwa (KP), Pakistan, particularly in forest and rangeland landscapes where ecological flammability interacts with human activity. While environmental and climatic drivers are well studied, governance factors remain underexplored despite their decisive role in shaping how ecological risk translates into disasters. Regional forests show considerable ecological diversity, including chir pine-dominated stands, mixed temperate conifer forests, broadleaved oak-associated systems, and shrub rangeland mosaics, each differing in fuel structure and fire behavior. Dependence on fuelwood collection, grazing, and forest access further influences ignition probability and fire spread. This study examines how governance failures influence wildfire risk and severity through a Governance-Fire Risk Framework. Governance is treated as a determining institutional condition affecting prevention capacity, regulation of hazardous land use, fuel management, and emergency response effectiveness. A cross-sectional survey of 540 stakeholders from rural (Dir Lower, Dir Upper) and peri-urban districts (Swat, Mansehra, Abbottabad) was analyzed using SPSS (version 26) and AMOS (version 24) (CFA and SEM). Governance failure significantly escalates wildfire risk through delayed emergency response, regulatory non-compliance, political interference, and weak institutional coordination. Institutional preparedness and response capacity reduce risks, whereas corruption intensifies them. Corruption functions through illegal land conversion, diversion of fire management resources, procurement irregularities, nepotistic staffing, and selective enforcement, increasing ignition sources, fuel accumulation, and response delays. Rural districts show stronger governance-fire linkages. Wildfire escalation in KP is governance-driven in interaction with ecological conditions and community dependence on forest resources. Effective mitigation requires anti-corruption measures, rapid response systems, stronger enforcement, and improved preparedness. The study offers a transferable governance-focused framework for wildfire management in fire-prone developing regions. Full article

Facial neuromodulation with botulinum toxin has traditionally been approached from the perspective of wrinkle correction. However, facial expressions primarily arise from coordinated muscular interactions that convey both positive and negative emotional valence. A conceptual framework focused on muscular equilibrium rather than wrinkle severity may therefore offer a more comprehensive, reproducible, and clinically meaningful approach. In this article, we propose the Index of Muscular Equilibrium (IME) Framework, a conceptual model for aesthetic neuromodulation that integrates functional muscle mapping, validated severity scales, and a composite IME score to support personalized treatment planning and outcome assessment. The framework is derived from a narrative review of PubMed-indexed literature on facial muscle activity, emotional expression, and validated clinical assessment tools. It combines a Valence Map to classify positive- and negative-valence muscle groups, a standardized evaluation of static and dynamic hypertonus, a conceptual Plan Score to guide selective neuromodulation, and a feedback-based longitudinal workflow (the IME Loop). Together, these components enable structured assessment of muscular imbalance, integration of established wrinkle severity scales, and translation into individualized, function-oriented treatment strategies, with intended benefits including improved objectivity, reproducibility, and patient communication. By reframing treatment success from the duration of muscle blockade to the duration of expressive harmony, the IME Framework introduces testable constructs for future validation and offers a functional perspective on facial neuromodulation aligned with contemporary affective science. Full article

Quantum dots combine advantages such as strong processability via solution methods, wide color gamut coverage, and precise emission color coordinates, making them highly promising for applications in optoelectronic devices. However, they face limitations such as insufficient fluorescence intensity and low far-field extraction efficiency. Plasmonic nanocavities based on metallic nanostructures offer an efficient platform for regulating light–matter interactions. In this study, we constructed a tilted plasmonic nanocavity structure composed of a silver nanocube, CdSe/CdS nanorods, and a single-crystal silver microplate. An Al₂O₃ isolation layer prepared via atomic layer deposition was used to control the nanocavity gap, precisely matching the plasmonic resonance mode with the 620 nm fluorescence emission of the quantum dots. This coupling system significantly enhances the radiative rate in the emission band and the electric field strength in the excitation band, achieving a 187-fold luminescence enhancement of the quantum dot. Additionally, leveraging the nano-antenna effect, the fluorescence exhibits upward directional emission. Experimental and simulation results confirm the high-efficiency enhancement and directional control of quantum dot fluorescence by the tilted nanocavity, providing new insights for the integrated application of quantum dots in displays, quantum communication, and other fields. Full article