Search Results (52)

Although common, natural disasters (NDs) remain little studied, and their aggregate psychological impact is unknown. No aggregate measure of ND exposure could be located. This study reports the development and preliminary validation of the Natural Disaster Scale (NDS). In a sample of 131 US adults, disaster exposure was measured for NDs, for childhood and adult human disasters, for psychological flexibility, and for social support. Criteria included general distress, simple and complex PTSD, and life satisfaction. The NDS showed good internal consistency. Eleven of thirteen items loaded on a single factor. After controlling demographic factors, social support, and psychological flexibility, the NDS predicted general distress, simple PTSD, and satisfaction with life. In comparison, adult human adversity/disaster predicted general distress and simple PTSD, while childhood human adversity/disaster predicted complex PTSD and satisfaction with life. Similarly sized effects were found for human and natural disasters, except that only childhood adversity predicted complex PTSD. Demographic factors were insignificant except that age predicted life satisfaction. Because NDs may lead to distress, simple PTSD, and diminished life satisfaction, appraising lifelong exposure to NDs may be important for treatment. Those exposed to NDs may benefit from trauma-informed care. Fostering psychological flexibility, as proposed in the ACT therapy, is suggested as an important treatment focus for addressing the effects of human and natural disasters. Full article

This overview explores the complex relationship between environmental factors, particularly obesity, and the timing of puberty, with a focus on how hormonal and genetic interactions are influenced by external conditions. Puberty (gonadarche) is characterised by the activation of the hypothalamic–pituitary–gonadal (HPG) axis. The onset and progression of puberty vary significantly among individuals, primarily due to genetic factors, with key genes like kisspeptin 1 (KISS1) and makorin ring finger protein 3 (MKRN3) playing a crucial role. Cohesively, this paper emphasises that environmental factors, particularly obesity and exposure to endocrine-disrupting chemicals (EDCs), have become significant influences on the timing of puberty. Childhood obesity has risen significantly in recent decades and the age of pubertal onset has declined over the same period. Obesity greatly disrupts hormone regulation in pre-pubertal children. Leptin accelerates the onset of puberty in girls but not in boys. The underlying mechanism is proposed to be the increase in Kiss1/GnRH signalling. On the contrary, excess leptin in boys suppresses testosterone production by increasing oestrogen conversion. Low adiponectin in obese girls may contribute to earlier puberty due to a reduced inhibition of Kiss1/GnRH signalling. Low adiponectin in boys is linked to delayed puberty due to its role in maintaining insulin sensitivity and testosterone production. Hyperinsulinemia influences pubertal timing through central and peripheral mechanisms. Insulin acting synergistically with leptin promotes the earlier onset of puberty in girls but not in boys. The effects of exposure to certain EDCs—mostly obesogenic chemicals that mimic the action of natural hormones—on the timing of puberty remain unclear; hence, further research on this topic is needed. Addressing and preventing obesity in children could potentially mitigate these alterations in pubertal timing. Full article

This systematic review aims to synthesize key empirical findings to understand how various elements of the built environment influence the microbiome concerning children’s health and well-being. A comprehensive literature search was conducted across multiple databases, focusing on studies that examined the relationship between built environment factors and the microbiome aspects of childhood. A total of 42 studies were included in the final systematic review. We analyzed these studies from a range of different lenses, starting with basic research questions and variables to types of built environments, age groups of children, sampling strategy, bioinformatics, and the biological methods utilized. This review highlights a growing emphasis on children’s exposure to nature within built environments and its potential to beneficially alter the microbiome, with 38% of studies addressing this link. It also identifies a significant research gap in connecting built environment design features (landscape and/or architectural) to microbiome outcomes and associated health, behavioral, and mental health impacts on children. The findings indicate that interventions aimed at improving the built environment quality via design could foster healthier microbiomes in children’s environments. This review underscores the need for interdisciplinary research and policy initiatives that integrate microbiome science with built environment design to promote children’s health and well-being. Full article

Background and Objectives: Multiple sclerosis (MS) is a chronic autoimmune condition that impacts the central nervous system and has a rising incidence globally, especially in Saudi Arabia. Materials and Methods: This study examines environmental, lifestyle, and familial risk factors associated with MS in the Aljouf Region by a cross-sectional analysis of 155 clinically diagnosed MS patients. Data were gathered using structured questionnaires and medical record examinations to evaluate sociodemographic characteristics, sun exposure, smoking, obesity, eating habits, and childhood infections. Results: Logistic regression research found insufficient daily sun exposure (<15 min/day), smoking, obesity, and childhood measles infection as significant risk factors, but substantial weekend sun exposure (>4 h/day), exclusive breastfeeding, and regular fish consumption were deemed protective. While familial history of MS was statistically significant (5.5%, p = 0.04), parental consanguinity (38.7%) did not show a significant association with MS risk (p = 0.07). Conclusions: The findings underscore the complex nature of MS and the pressing necessity for preventive efforts, such as advocating for vitamin D supplementation, smoking cessation, obesity prevention, and dietary adjustments. Mitigating these controllable risk factors may alleviate the prevalence of MS in Saudi Arabia. Full article

War refugees are more likely to present psychological disorders, such as PTSD. Memory impairments often hinder their ability to recall and integrate traumatic events. This study investigated the memory capacity of 133 Syrian refugee children and adolescents in Lebanon and examined the moderating role of resilience in the relationship between exposure to negative events, post-traumatic stress reactions, and traumatic events recollection. Participants completed the Childhood War Trauma Questionnaire (CWTQ), Post-Traumatic Symptom Reactions Checklist for Children (PTSR-C), and Child and Youth Resilience Measure-28 (CYRM-28). They also performed a timeline exercise, part of Narrative Exposure Therapy, in which they organized and described their positive and negative life memories. Results showed that memories of traumatic events were lower than potentially traumatic events that participants had witnessed. This difference increased as post-traumatic stress increased. Moreover, potentially traumatic events experienced predicted post-traumatic stress reactions, and these predicted negative memories recalled. Participants’ resilience moderated the association between post-traumatic reactions and remembered traumatic memories showing that only for children and adolescents with higher resilience post-traumatic symptoms predicted trauma-related memories. The results highlight meaning making and sharing capacities of natural relational contexts (family, peers, etc.) as potential key processes to be promoted to overcome and process traumatic events. Full article

The rapid growth of unconventional natural gas development (UNGD), also known as hydraulic fracturing, has raised concerns of potential exposures to hazardous chemicals. Few studies have examined the risk of childhood cancer from exposure to UNGD. A case–control study included 498 children diagnosed with leukemia, lymphoma, central nervous system neoplasms, and malignant bone tumors during the period 2010–2019 identified through the Pennsylvania Cancer Registry. Cases were matched to controls using Pennsylvania birth records. For each subject, a new overall UNGD exposure metric was calculated which incorporates both spatial (proximity) and temporal (duration) aspects of well activity. Conditional logistic regression models were used to estimate the risk of combined and individual cancers by overall UNGD exposure, and well proximity. Children with a higher overall UNGD exposure (3rd/4th quartiles) had an increased risk for the four malignancies combined [OR] 1.69 (95% CI 1.01, 2.82) and 1.79 (95% CI 1.00, 3.19) compared to non-exposed children. Overall, individuals living within 0.5 miles of a UNGD site were 3.94 times (95% CI 1.66, 9.30) more likely to develop a malignancy compared to non-exposed children and the risk of lymphoma within 0.5 miles and 0.5–1 miles was also elevated [ORs of 5.05 (95% CI 1.09, 23.39) and 7.71 (95% CI 1.01, 59.00), respectively] compared to non-exposed. Our study found that overall UNGD cumulative activity as well as a proximity to UNGD wells were associated with an increased risk of childhood lymphoma and overall childhood cancers combined. Full article

Background: The manifestation of complex trauma results from exposure to severe and repetitive stressors occurring within the caregiver system. Frequently associated with child maltreatment, complex trauma can lead to impairments in multiple domains, including attachment, affect and behavioural regulation, and cognition. Treatments, including Trauma-Focused Cognitive Behavioural Therapy, have been shown to be efficacious, but high attrition rates point to the need for complementary methods that boost client retention and treatment efficacy. This systematic review examines whether dog-assisted therapy has beneficial impacts on the treatment of complex trauma and whether it can decrease treatment attrition among children presenting with complex trauma exposure. Methods: We followed PRISMA guidelines to locate relevant research reports. Seven published research reports matched the inclusion criteria. Results: Dog-assisted therapy may increase the efficacy of standard interventions for complex trauma, although only one study formally assessed treatment retention. Across most studies, there is an overall lack of detailed information on the nature of therapeutic activities involving the dog and how these activities may complement or enhance therapy as usual. Studies were of varying methodological quality, impacting the reliability of findings. Conclusions: Future studies should aim to better describe and justify dog-assisted therapy techniques and evaluate these in comparison with standard evidence-based approaches to the treatment of childhood complex trauma. Full article

The complex nature of chronic bronchitis (CB) and changing definitions have contributed to challenges in understanding its aetiology and burden. In children, CB is characterised by persistent airway inflammation often linked to bacterial infections and is therefore termed “protracted bacterial bronchitis” (PBB). Longitudinal studies suggest that CB in childhood persists into adulthood in a subgroup. It can also be associated with future chronic respiratory diseases including asthma, bronchiectasis, and chronic obstructive pulmonary disease (COPD). Adult CB is traditionally associated with smoking, occupational exposures, and lower socioeconomic status. The interplay between risk factors, childhood CB, adult CB, and other chronic respiratory diseases is intricate, requiring comprehensive longitudinal studies for a clearer understanding of the natural history of CB across the lifespan. Such longitudinal studies have been scarce to date given the logistic challenges of maintaining them over time. In this review, we summarise current evidence on the evolution of the definitions, pathophysiology, risk factors, and consequences of childhood and adulthood chronic bronchitis. Full article

Child malnutrition remains a public health challenge in developing countries, but a comprehensive understanding of its burden and its determinants in specific local contexts is generally lacking. This study examined the prevalence of malnutrition and its determinants among children aged <5 years across contrasting agroecosystems in northwest Ethiopia. A community-based cross-sectional study involving 400 respondents was employed. Data were collected through semi-structured questionnaires and anthropometric measurements, complemented with focus group discussions and key informant interviews. The direct and indirect effects of the determinants of malnutrition were examined using structural equation modeling (SEM). The overall prevalence of child malnutrition, measured using the Composite Index of Anthropometric Failure, was 49%, with notable variation across agroecosystems (from 36.1% [midland with red soil] to 59% [lowland and valley fragmented]). Disease experience had significant positive direct effects on malnutrition. Dietary intake had negative and significant total (direct and indirect) effects on malnutrition, partially mediated through disease experience. Serial mediation in SEM analysis revealed significant indirect relationships between malnutrition and food security, feeding and care practices, household environment, health services, maternal diet, maternal empowerment, household wealth, and nutrition-sensitive agricultural practices. In conclusion, child malnutrition was highly prevalent and higher among children in the lowland and valley fragmented agroecosystem, characterized by unfavorable agro-climatic conditions, lower wealth status, poor health services access, and higher disease (particularly malaria) exposure. This study demonstrates the dynamics and multifaceted nature of malnutrition, highlighting the importance of considering geographical differences when planning interventions for childhood malnutrition and its determinants. Full article

Background: The intricate correlation between environmental exposures and mental health outcomes is increasingly acknowledged in psychiatric research. This study investigated the relationship between cumulative environmental risk factors, as represented by the exposome score (ES), and various domains of psychopathology within a non-clinical sample using a network analysis. Methods: We recruited 1100 participants (aged 18–35 years, 51.4% females) via a computer-assisted web interview, assessing psychopathological symptoms using standardized questionnaires. Environmental exposures, including season of birth, obstetric complications, advanced paternal age, childhood trauma, cannabis use, and urban upbringing, were self-reported to calculate the ES. Results: A network analysis revealed significant associations of the ES with psychotic-like experiences (PLEs) (weight = 0.113), manic (weight = 0.072), and attention-deficit/hyperactivity disorder symptoms (weight = 0.062). These connections did not differ significantly with respect to their weights. Depressive symptoms had the highest centrality and predictability. The mean predictability across all nodes included in the network was 0.344. Conclusions: These findings underscore the transdiagnostic nature of environmental exposures, aligning with previous research indicating broad associations between the ES and various facets of psychopathology. Our results suggest that the ES may not specifically correlate with PLEs but may indicate the risk of a broader psychopathology. Full article

Given our current knowledge and insights into the nature of nutrition, a simplistic approach to understanding the role of nutrition in relation to health outcomes appears insufficient as a scientific base for setting nutrition policies. To raise this issue, we performed a scoping review to evaluate the relationship between sugar intake, quality of life (QoL), and well-being in children and adolescents. Sugar was selected as it is an essential part of many different foods and dietary patterns. Its consumption is motivated by various aspects, such as social relationships, economic status, individual habits, and taste preferences. Childhood and adolescence are important periods in the life span influencing individual dietary habits and taste preferences but have been overlooked. We developed a framework and performed a structured literature search for articles published in English between 2001 and 2023 in three databases (Pubmed, Scopus, and Web of Science). This search resulted in 21 full-text eligible papers with highly heterogeneous exposure and outcome measures. Most studies found a negative association between the intake of sugar, sugar-sweetened beverages, or sweets, and various QoL outcomes, including food insecurity, sleep and sleep-related outcomes, and (oral) health-related QoL. This scoping review showed that the inclusion of more varied endpoints than only non-communicable diseases or caries could add more dimensions to the evidence underlying the association between sugar and health. The application of interdisciplinary approaches considering more aspects of sugar intake could give a more holistic view of nutrition when considering dietary recommendations or developing dietary policies, especially for children. Full article

This study sought to examine the impact of air pollution on health in Africa. Air pollution is a major public health concern around the world. Exposure to air pollution has been linked to a slew of negative health consequences, ranging from subclinical effects, physiological changes in pulmonary functions and the cardiovascular system, to clinical symptoms, outpatient and emergency-room visits, hospital admissions, and finally to premature death. Health impact assessments indicate that sub-Saharan Africa suffers a high burden of disease and premature deaths, attributable to environmental pollution in the world. The health and economic repercussions of rapid pollution increases could jeopardize African efforts to enhance economic development, establish human capital, and achieve the Sustainable Development Goals (SDGs). Despite all these, literature on pollution and health is still scanty in the case of Africa. This study was quantitative in nature, and it used a difference GMM approach to estimate its model. The GMM results showed that children are negatively affected by pollution. Children under the age of five are especially at risk, and the effects are believed to be most severe in developing countries, where exposure to high levels of ambient air pollution throughout childhood is thought to lower total life expectancy by an average of 4–5 years. Based on the findings of this study, it is recommended that African countries must not overlook the pollution problem. They must promote and use low carbon technologies and services. In the absence of active intervention, pollution will soon raise morbidity and death. Full article

Multisystem inflammatory syndrome in children (MIS-C) is a potentially life-threatening childhood disease caused by SARS-CoV-2 infection, manifested by the persistence of fever and multi-organ dysfunction, elevated inflammatory markers, and the lack of an alternative diagnosis. It is still unknown if vaccination can precipitate or abrogate MIS-C or if a natural infection preceding or occurring at the time of vaccination plays any role. We present one case of MIS-C in a 16-year-old girl who was fully immunized against COVID-19 (Pfizer), with the second dose received three weeks prior to onset of the disease. She had no history of COVID-19 disease or contact with COVID-19 patients. At admission, she was somnolent, pale, and dehydrated, with cyanotic lips and cold extremities; she was hypotensive with tachycardia and poorly palpable pulses. Initial laboratory results revealed elevated levels of inflammatory markers, and high level of SARS-CoV-2 IgG spike antibodies, while testing for SARS-CoV-2 acute infection and other inflammatory etiologies were negative. Vaccine-related MIS-C was suspected in our case due to the development of MIS-C three weeks following the second dose of the COVID-19 mRNA vaccine, the absence of previous infection or exposure to SARS-CoV-2, and a positive result for IgG anti-spike (S) antibodies. Full article

Atopic dermatitis (AD) is a chronic inflammatory skin condition that affects more than 200 million people worldwide, including up to 20% of children and 10% of the adult population. Although AD appears frequently in childhood and often continues into adulthood, about 1 in 4 adults develop the adult-onset disease. The prenatal period, early childhood, and adolescence are considered critical timepoints for the development of AD when the exposome results in long-lasting effects on the immune system. The exposome can be defined as the measure of all the exposures of an individual during their lifetime and how these exposures relate to well-being. While genetic factors could partially explain AD onset, multiple external environmental exposures (external exposome) in early life are implicated and are equally important for understanding AD manifestation. In this review, we describe the conceptual framework of the exposome and its relevance to AD from conception and across the lifespan. Through a spatiotemporal lens that focuses on the multi-level phenotyping of the environment, we highlight a framework that embraces the dynamic complex nature of exposome and recognizes the influence of additive and interactive environmental exposures. Moreover, we highlight the need to understand the developmental origins of AD from an age-related perspective when studying the effects of the exposome on AD, shifting the research paradigm away from the per se categorized exposome factors and beyond clinical contexts to explore the trajectory of age-related exposome risks and hence future preventive interventions. Full article

Pregnancy and early childhood are two vulnerable times when immunological plasticity is at its peak and exposure to stress may substantially raise health risks. However, to separate the effects of adversity during vulnerable times of the lifetime from those across the entire lifespan, we require deeper phenotyping. Stress is one of the challenges which everyone can face with this issue. It is a type of feeling which contains mental pressure and comes from daily life matters. There are many research and investments regarding this problem to overcome or control this complication. Pregnancy is a susceptible period for the child and the mother taking stress can affect the child’s health after birth. The following matter can happen based on natural disasters, war, death or separation of parents, etc. Early Life Stress (ELS) has a connection with psychological development and metabolic and cardiovascular diseases. In the following research, the main focus is on Early Life Stress control during pregnancy of a healthy group of women that are at risk of future disease during their pregnancy. This study looked at the relationship between retrospective recollections of childhood or pregnancy hardship and inflammatory imbalance in a group of 53 low-income, ethnically diverse women who were seeking family-based trauma treatment after experiencing interpersonal violence. Machine learning Convolutional Neural Networks (CNNs) are applied for stress detection using short-term physiological signals in terms of non-linear and for a short term. The focus concepts are heart rate, and hand and foot galvanic skin response. Full article