Search Results (122)

Background: Childhood neglect is a pervasive yet often overlooked form of maltreatment that exerts profound and lasting effects on neurodevelopment. Unlike other types of abuse, neglect is characterized by the absence of essential stimuli and caregiving, which are critical for normal brain maturation, particularly in regions involved in executive function. Objective: This narrative review aims to critically explore the neurobiological mechanisms through which early-life neglect impairs the development of executive functions. Special emphasis is placed on alterations in brain structure and function, dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, and emerging epigenetic evidence. Methods: A comprehensive literature search (170 articles) was conducted across PubMed, Scopus, Web of Science, and PsycINFO, including studies published between 1 January 2000 to 31 March 2025. Relevant empirical and review articles were selected based on methodological rigor, relevance to executive functioning, and focus on child neglect. Results: Evidence reveals that neglect disrupts key neural circuits, particularly those involving the prefrontal cortex and amygdala, leading to deficits in attention, working memory, impulse control, and cognitive flexibility. Chronic stress associated with neglect also induces HPA axis dysregulation and elevated cortisol levels, which further compromise neural plasticity. Additionally, epigenetic modifications appear to mediate long-term cognitive and emotional consequences. Conclusions: Childhood neglect represents a distinct and critical risk factor for executive dysfunction. Understanding the neurodevelopmental consequences of neglect is essential for developing targeted prevention strategies and therapeutic interventions aimed at supporting cognitive resilience in affected populations. Full article

Although common, natural disasters (NDs) remain little studied, and their aggregate psychological impact is unknown. No aggregate measure of ND exposure could be located. This study reports the development and preliminary validation of the Natural Disaster Scale (NDS). In a sample of 131 US adults, disaster exposure was measured for NDs, for childhood and adult human disasters, for psychological flexibility, and for social support. Criteria included general distress, simple and complex PTSD, and life satisfaction. The NDS showed good internal consistency. Eleven of thirteen items loaded on a single factor. After controlling demographic factors, social support, and psychological flexibility, the NDS predicted general distress, simple PTSD, and satisfaction with life. In comparison, adult human adversity/disaster predicted general distress and simple PTSD, while childhood human adversity/disaster predicted complex PTSD and satisfaction with life. Similarly sized effects were found for human and natural disasters, except that only childhood adversity predicted complex PTSD. Demographic factors were insignificant except that age predicted life satisfaction. Because NDs may lead to distress, simple PTSD, and diminished life satisfaction, appraising lifelong exposure to NDs may be important for treatment. Those exposed to NDs may benefit from trauma-informed care. Fostering psychological flexibility, as proposed in the ACT therapy, is suggested as an important treatment focus for addressing the effects of human and natural disasters. Full article

Introduction: Childhood emotional maltreatment, which includes emotional abuse and neglect, has been identified as a significant risk factor for the development of disordered eating behaviors related to overeating and reduced dietary control. At the same time, the literature suggests that childhood emotional maltreatment appears to be linked to deficits in reflective functioning which, in turn, may increase vulnerability to dysregulated, impulsive, and addictive behaviors. However, to date, the role of a key factor, such as food addiction (FA), within this model has not yet been investigated. Therefore, the aim of this study was to test a mediation model in which emotional abuse and neglect predict overeating and reduced dietary control through deficits in reflective functioning and FA symptoms. Method: Using a cross-sectional design, a conventional non-clinical sample of 543 participants was recruited and completed a set of standardized questionnaires. A multiple mediation model with observed variables was specified (10,000 bootstrap resampling). Results: The multiple mediation model showed good results, confirming the initial hypotheses. Specifically, emotional abuse and neglect were associated with FA symptoms through deficits in reflective functioning. In turn, FA symptoms predicted overeating behaviors and poor dietary control. Discussion: These findings highlight the central role of FA in linking reflective functioning deficits to disordered eating patterns associated with excessive food consumption. This study advances our understanding of the psychological mechanisms underlying disordered eating behaviors and underscores the need for targeted interventions addressing reflective functioning deficits and food addiction in individuals with a history of childhood emotional maltreatment. Full article

Background/objectives: Adolescent dating violence (ADV) is a serious public health concern affecting youth worldwide. Potential risk factors of ADV include child maltreatment (CM) and intimate partner violence exposure (eIPV), though existing research on ADV perpetration specifically is inconsistent. There is limited research on co-occurring eIPV and CM, despite co-occurrence in 30–60% of homes where there is one. This study aims to address these gaps by testing the impact of childhood violence exposure on ADV perpetration and assessing two potential, theory-informed mitigating factors—mental health and parent–youth relationship. Methods: This study utilizes moderated-mediation structural equation modeling with longitudinal data from a sample of 2354 U.S. adolescents (10–18) and one of their caregivers. Three models were tested: (1) childhood violence exposure (eIPV only, CM only, or co-occurring CM & EIPV) and ADV perpetration; (2) mediation by mental health quality on model 1; and (3) overall moderation by parent–youth relationship quality on model 2. Results: The final sample consisted of 961 youth with a history of dating. A significant direct effect between eIPV and ADV perpetration was found. There was a significant direct effect between co-occurrence (eIPV & CM) and ADV perpetration, which was mediated by mental health quality. Conclusions: This study further emphasizes the relation between eIPV and ADV and provides novel evidence of the impact co-occurrence has on ADV. Evidence of a trauma-informed mitigating factor, mental health quality, offers a potential point of intervention to be considered by mental health providers and ADV prevention/intervention programs. Full article

Background: Adverse childhood experiences (ACEs) have been identified as a major risk factor for physical and mental ill health in adulthood. So far, no studies have investigated whether ACEs during sensitive periods in infant development are associated with a higher likelihood of chronic pain (CP) in adulthood. Methods: Patients of the University Hospital of Innsbruck (Austria) completed questionnaires retrospectively assessing their ACEs as well as their current levels of CP, psychological distress, and trauma-related symptoms in this cross-sectional study. Dose-dependent associations of ACEs with CP were investigated through binary logistic regressions. To detect vulnerable developmental periods, a machine learning grid search was applied. Results: A total of n = 2577 patients were included in the analyses, with 31.5% reporting CP. Polytraumatization (i.e., four or more types of ACEs) was associated with a threefold increase for CP (OR: 3.01; 95% CI: 2.16–4.19; p < 0.001). The machine learning approach revealed maltreatment between 10 and 12 years to be the most predictive of CP (Ada Boost Classifier). Discussion: CP is a highly prevalent symptom among hospital patients and is clearly associated with ACEs. This is the first study to present evidence for a timing-dependent association of ACEs with CP. Early identification and appropriate psychosocial support for patients with ACEs is a crucial task for healthcare professionals. Full article

FKBP5 has been of special scientific interest in the behavioral sciences since it has been involved in the pathophysiology of several mental disorders. It is a gene with pleiotropic effects which encodes the protein FKBP5, a cochaperone that decreases glucocorticoid receptor (GR) affinity for glucocorticoids by competing with FKBP4, altering the GR chaperone complex, and impairing GR activation. As a key modulator of the stress response, FKBP5 plays a critical role in regulating cortisol levels in the organism. The FKBP5 gene is regulated through a combination of transcriptional, epigenetic, post-transcriptional, and environmental mechanisms, as well as genetic polymorphisms that influence its transcription and stress responsiveness. Notably, the rs1360780 T-allele in FKBP5 significantly affects FKBP5 regulation and has been linked to stress-related disorders by influencing transcription and stress responsiveness. In this narrative review, we aim to provide an overview of the role played by the single-nucleotide polymorphism rs1360780 in the FKBP5 locus in gene expression, its epigenetic regulation, and the impact of early stress in its functioning. We discuss some brain regions with differential expression of FKBP5 and some behavioral phenotypes linked to the locus. The T-allele of rs1360780 is considered a risk variant, as it leads to high FKBP5 induction, which delays negative feedback and increases GR resistance. This results in states of relative hypercortisolemia and brain morphofunctional alterations, particularly in regions sensitive to glucocorticoid activity during critical periods of neurodevelopment. Additionally, exposure to childhood maltreatment is associated with demethylation of the glucocorticoid response elements of FKBP5, further increasing its expression levels. Among the psychological dimensions analyzed in which FKBP5 is involved are neurocognition, aggression, suicidality, and social cognition. At the level of mental disorders, the gene may play a role in the pathogenesis of post-traumatic stress disorder, depression, and bipolar disorder. In psychotic disorders, its role is less clear. This knowledge enhances the understanding of disease mechanisms that operate through psychopathological dimensions, and highlights the need to design specific, person-centered psychopharmacological and environmental therapeutic interventions. Full article

Background/Objectives: Pediatric migraine is a prevalent neurological disorder that significantly impacts children’s quality of life, academic performance, and social interactions. Unlike migraines in adults, pediatric migraines often present differently and involve unique underlying mechanisms, making diagnosis and treatment more complex. Methods: This review discusses the clinical phases of pediatric migraine, key trigger factors, sex- and age-related differences, and the role of childhood maltreatment in migraine development. We also discuss episodic syndromes such as cyclic vomiting syndrome, abdominal migraine, benign paroxysmal vertigo, and benign paroxysmal torticollis, along with comorbidities such as psychiatric disorders, sleep disturbances, and epilepsy. Results: The underlying pathophysiological mechanisms for pediatric migraines, including genetic predispositions, neuroinflammation, and gut microbiota dysbiosis, are summarized. Current therapeutic strategies, including conventional and emerging pharmacological treatments, nutraceuticals, and non-pharmacological approaches, are evaluated. Non-pharmacological strategies, particularly evidence-based lifestyle interventions such as stress management, diet, hydration, sleep, exercise, screen time moderation, and cognitive behavioral therapy, are highlighted as key components of migraine prevention and management. The long-term prognosis and follow-up of pediatric migraine patients are reviewed, emphasizing the importance of early diagnosis, and tailored multidisciplinary care to prevent chronic progression. Conclusions: Future research should focus on novel therapeutic targets and integrating gut–brain axis modulation, with a need for longitudinal studies to better understand the long-term course of pediatric migraine. Full article

Background/Objectives: Pregnancy is a critical period marked by significant transformations that can trigger or exacerbate eating disorder symptoms. Childhood emotional maltreatment, including abuse and neglect, is a known risk factor for disordered eating, yet its specific impact during pregnancy remains unexplored. For this reason, this study aimed to examine the link between childhood emotional maltreatment and eating disorder symptoms in pregnant women, also focusing on the potential mediating and moderating variables involved in this association. Specifically, this study explored the mediating role of prenatal emotional distress, whereas prenatal social support was investigated as a protective factor able to moderate the effects of past trauma on disordered eating during this sensitive period. Methods: Participants were 272 Italian pregnant women (aged 18–48, M_age = 31.21, SD = 4.95) who were asked to respond to four self-report instruments: Childhood Trauma Questionnaire—Short Form; Eating Disorder Examination—Questionnaire Short; Perinatal Assessment of Maternal Affectivity; and Maternity Social Support Scale. Results and Conclusions: The results showed that prenatal emotional distress totally mediated the association between childhood emotional maltreatment and eating disorder symptoms in pregnant women (β = 0.20; SE = 0.06; 95% CI: 0.08, 0.33; p < 0.001). Moreover, moderation analysis showed that prenatal social support only moderated the direct link between childhood emotional maltreatment and disordered eating, so higher levels of childhood emotional maltreatment were predictive of higher levels of eating disorder symptoms only among pregnant women with low levels of prenatal social support (b = 0.17; SE = 0.06; t = 2.73; 95% CI: 0.05, 0.30; p < 0.01). The limitations and clinical implications are discussed. Full article

Current research on the effects of childhood trauma largely focuses on maltreatment. In the current study, we used diffusion tensor imaging (DTI) to determine the association between potentially traumatic exposures not related to maltreatment and fractional anisotropy (FA) in 184 youth aged 9–14 years. The Trauma History Profile was used to determine how many traumatic events in different categories were experienced and create low- and high-trauma groups. FA values were compared between groups in twelve a priori chosen regions of interest (ROIs). Five of the twelve regions showed significantly lower FA in the high-trauma groups when compared to the low-trauma groups, including the body of the corpus callosum, the total corpus callosum, bilateral posterior thalamic radiation, and the left cingulate gyrus projection of the cingulum bundle. Group differences were also observed across a range of behaviors. However, FA was not associated with posttraumatic stress symptomology. The results support the hypothesis that the high-trauma group had lower FA compared to the low-trauma group. The significant ROIs represent a subset of regions identified in studies of adults exposed to traumatic childhood events or children with a history of maltreatment. These results, obtained from typically developing youth, underline the importance of examining childhood trauma exposure in future developmental studies. Full article

Adverse childhood experiences (ACEs) represent one of the most critical factors contributing to the manifestation of psychiatric disorders later in life. Furthermore, such experiences are often associated with deficits in interpersonal relationships, manifesting as mistrust and violent behaviors, and are indicative of a fragmented personality. This study aimed to analyze the correlative relationships between personality deficits influenced by ACEs and the expression of reactive and appetitive aggression using self-report questionnaires in 53 male forensic psychiatric patients with a drug dependency background detained under §64 of the German Criminal Code between 2019 and 2022. Instruments included the Operationalized Psychodynamic Diagnosis Structure Questionnaire (OPD-SF), the Maltreatment and Abuse Chronology of Exposure Scale–German Version (KERF), and the Appetitive and Facilitative Aggression Scale (AFAS). Specifically, the OPD-SF used the following subscales: self-perception, self-regulation, the regulation of object relations, emotional communication inward/outward, internal/external attachment, and total score. The results demonstrate a significant relationship between childhood traumatic experiences, personality structure, attachment capacity, self-perception, and regulation and the expression of both reactive and appetitive aggression. While the association with reactive aggression is intuitively plausible, the findings notably reveal that the propensity to derive pleasure from violence is also associated with personality deficits caused by adverse childhood experiences. These findings have important implications for the treatment of offenders with personality disorders and should be considered in therapeutic interventions. Full article

The Adverse Childhood Experiences (ACEs) and Adverse Family Experiences (AFEs) frameworks have been employed extensively in research. However, to date, no such studies have considered both frameworks concurrently, nor have they explored the similarities and differences in resilience between siblings with ACE- and AFE-exposed parent(s). Doing so could, perhaps, establish the ways in which adversity is transmitted through generations and subsequently identify what trajectories to address in potential interventions. Thus, the objectives of this study were to examine the experiences of families with intergenerational ACE and AFE trauma, and to ascertain what influences similarities and differences in sibling resilience. The thematic analysis of two family case studies (n = 6) proposed a narrative encompassing fear, relationships and challenging trauma. Findings demonstrated the influence of neighbourhood violence which appeared to initiate this narrative. The fear associated with neighbourhood violence and maltreatment in early childhood appeared to influence both the parent–child bond and intimate relationships. Finally, participants demonstrated the protective properties of dissociation and sibling parentification, exhibiting their relationship with resilience. Investigators suggested neighbourhood violence be considered in the ACE questionnaire to inform current and future policies, and to safeguard the needs of families affected by intergenerational trauma. Full article

Adolescence is a phase characterized by reckless and risky behaviors, including the initiation and use of various illicit substances such as cannabis and alcohol. When ingested or administered, these substances affect mental processes by delivering pleasure, inner peace, and satisfaction. The aim of this study was to determine the prevalence and associated factors of psychoactive substance (PAS) use among adolescents. A cross-sectional study was conducted, including 300 participants surveyed using a structured questionnaire. Data were collected using the Mediterranean School Survey Project on Alcohol and Other Drugs (MedSPAD) to assess substance use, the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) to diagnose substance use disorders (SUDs), and the Early Trauma Inventory Self-Report Short Form (ETISR-SF) to identify childhood maltreatment, as well as socio-demographic characteristics. During the study period, 300 secondary school students participated. Their mean age was 17.92 ± 1.40 years, ranging from 15 to 22. There were slightly more males (56.7%) than females. A total of 40.67% of participants admitted to using at least one PAS at least once, while the prevalence of current use was 26%. Tobacco was the most commonly used substance (22.1%), followed by cannabis (7.33%). According to the DSM-5, 40.2% of users met the criteria for severe addiction. Factors associated with PAS use included the father’s level of education; place of use (e.g., home); poor relationships with parents, siblings, and teachers; and childhood maltreatment. Psychoactive substance use was found to be prevalent among adolescents in this study. Full article

Background/Objectives: Binge eating (BE) is associated with physical and psychological consequences, such as obesity and reduced quality of life. The relationship between binge eating and childhood experiences of interpersonal trauma has been explored, yet few studies focus on the processes that may explain this association. In this regard, some personality traits and maladaptive cognitive-emotional regulation may help explain this relationship, as they have been associated, respectively, with BE and childhood interpersonal trauma. The purpose of this study is to explore the complex processes that link childhood interpersonal trauma and BE in a French-Canadian clinical adult population with obesity (BMI ≥ 30 kg/m²). Methods: This cross-sectional study included 148 participants aged 21 to 72, predominantly women of White ethnic background with a university degree, who were seeking treatment for eating or weight-related issues. They completed self-report questionnaires assessing maltreatment and bullying, BE, maladaptive cognitive-emotional regulation, and personality. Two multiple mediation models were tested to examine the indirect effects of personality and maladaptive regulation in the relationship between bullying and BE, as well as between maltreatment and BE. Results: The results revealed a significant indirect relationship between maltreatment and binge eating (BE), with personality traits and maladaptive cognitive-emotional regulation partially explaining this association. No direct effect was found for bullying, but a significant total indirect effect indicated that personality traits and maladaptive cognitive-emotional regulation play a mediating role in the relationship between bullying and BE. Finaly, self-directedness was found as a unique and significant contributor in both mediation models. Conclusions: This study draws attention to the multiple contributing factors in the relationship between interpersonal trauma and BE in adults with obesity. Further research is needed to gain a deeper understanding of the role of personality and maladaptive cognitive-emotional regulation in this relationship by focusing on individuals’ experiences. Full article

Child maltreatment is a worldwide issue with serious consequences throughout life. Maltreated children tend to be at greater risk of developing aggressive and antisocial behaviours (e.g., violent behaviour in adulthood). The present study aims to analyse how temperament mediates the relationship between childhood trauma and sexual violence perpetration in adolescence. The present cross-sectional study was conducted with 252 Portuguese adolescent students between ages 11 and 20 years (n = 126 boys), of whom 126 self-identified as perpetrators of sexual violence. Overall, the results show that temperament mediated the relationship between emotional abuse and the perpetration of sexual violence. Limitations and implications for future studies were discussed. This study will be crucial for the development of intervention programs on violence and will help to explore these practices in intimate relationships. A better understanding of violence through the identification of variables of interest will allow a better understanding of this phenomenon, deepening the relational dynamics between the different genders. Full article

The COVID-19 pandemic had a global impact on mental health. Identification of individuals at higher or lower risk of mental health problems may assist with targeting prevention, support and treatment efforts during future pandemics. Using a Canadian national mental health survey that collected data during the pandemic period (March 2022–December 2022), this study examined the vulnerability of participants reporting abuse during their childhood by examining the annual prevalence of mood, anxiety and substance use disorders. Psychiatric disorders were identified using a version of the Composite International Diagnostic Interview (CIDI). Because childhood adversities are well-known risk factors for mental disorders, the analysis focused on interactions between childhood adversities and pandemic-related stressors by estimating the relative excess risk due to interaction (RERI). RERIs provide evidence of synergy based on the occurrence of greater than additive interactions. Physical and sexual abuse interacted synergistically with pandemic-related stressors in predicting mood and anxiety disorders. No synergies were found for substance use disorders. Childhood adversities increase vulnerability to later stressors and may be useful for the identification of individuals more likely to have mental health needs during this type of public health emergency. Full article