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Keywords = cephalization

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15 pages, 18289 KB  
Article
Mapping Dural and Periosteal SV2C, a Botulinum Toxin A Receptor, in the Mouse
by Anisa Dehghani, Agustin Melo-Carrillo, Andrew M. Strassman, Ron S. Broide, Aubrey Manack Adams, Brett Dabruzzo, Mitchell F. Brin and Rami Burstein
Toxins 2025, 17(10), 509; https://doi.org/10.3390/toxins17100509 - 17 Oct 2025
Viewed by 145
Abstract
Objectives: There has been a long-standing debate over the presence or absence of receptors for botulinum toxin A (BoNT/A) in cephalic areas relevant to migraine pathophysiology and onabotulinumtoxinA (onabotA) sites of action in migraine prevention. To address this issue, we sought to investigate [...] Read more.
Objectives: There has been a long-standing debate over the presence or absence of receptors for botulinum toxin A (BoNT/A) in cephalic areas relevant to migraine pathophysiology and onabotulinumtoxinA (onabotA) sites of action in migraine prevention. To address this issue, we sought to investigate for the first time whether synaptic vesicle protein 2C (SV2C), one member of the SV2 receptor family, is present in axons innervating the dura and periosteum. Methods: Single- and double- labeling immunohistochemical techniques were used to map and characterize the distribution of axons containing SV2C, the third isoform of the SV2 glycoprotein, in the mouse dura and periosteum. Results: Dense networks of axons containing SV2C receptors were distributed throughout all regions of the dura and periosteum. In the dura, SV2C-LIR axons were found in 43% of all peripherin-LIR fibers, 49% of all CGRP-LIR fibers, and 75% of all NaV1.8-LIR fibers. In the periosteum, SV2C-LIR was found in 38% of all peripherin-LIR fibers, 53% of all CGRP-LIR fibers, and 68% of all NaV1.8-LIR fibers. Conclusions: We interpret these findings as suggesting that many of the labeled axons are peripheral nerve axons (peripherin-positive) of unmyelinated sensory and possibly parasympathetic origin (CGRP-positive), and that some of these sensory axons are nociceptors (NaV1.8-positive). Clinically, these findings demonstrate an abundance of axons containing onabotA receptors in the vicinity of scalp structures commonly injected with onabotA for the treatment of chronic migraine. Dense labeling in the periosteum provides another rationale for the possibility that onabotA injections in this layer of the scalp may be advantageous. Full article
(This article belongs to the Section Bacterial Toxins)
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23 pages, 23896 KB  
Article
Two New Pseudochromadora Species (Nematoda: Desmodorida) from South Korea Based on Morphological and Molecular Evidence
by Hyeonggeun Kim and Raehyuk Jeong
J. Mar. Sci. Eng. 2025, 13(10), 1980; https://doi.org/10.3390/jmse13101980 - 16 Oct 2025
Viewed by 128
Abstract
During a survey of the west coast of South Korea, two new Pseudochromadora species were recorded from Yeongjongdo Island. Descriptions of two new species, an updated list of valid species within the genus, a tabular key, partial sequences of mtCOI, near full-length SSU, [...] Read more.
During a survey of the west coast of South Korea, two new Pseudochromadora species were recorded from Yeongjongdo Island. Descriptions of two new species, an updated list of valid species within the genus, a tabular key, partial sequences of mtCOI, near full-length SSU, and the D2–D3 region of LSU rDNA, together with phylogenetic analyses are provided. The two new species are classified as Pseudochromadora based on having a two-portioned cephalic capsule, unispiral amphidial fovea, lateral alae extending from the posterior end of the pharynx as far as the tail, and presence of copulatory thorns, as well as a short conical tail. The two species are distinguished from each other by their different types of labial regions of the cephalic capsule (round-shaped vs. hat-shaped). The two species, despite being found in the same locality, are morphologically and molecularly distinct from one another. Pairwise Kimura 2-parameter (K2P) distances between the two new species were 10.6% (18S) and 27.2% (28S), values consistent with interspecific divergence observed among congeners. Phylogenetic analyses showed both species as distinct lineages within Pseudochromadora. In the 28S rDNA tree, each was retrieved as a well-supported monophyletic clade with congeners, whereas in the 18S tree, all congeners including the two new species formed a single clade, except for P. plurichela, which branched outside the main group. These results highlight potential paraphyly within Pseudochromadora and suggest that overlooked morphological traits may hold phylogenetic significance, warranting further investigation. Full article
(This article belongs to the Special Issue Biodiversity and Population Ecology of Marine Invertebrates)
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10 pages, 1018 KB  
Article
Ultrasound Assessment of Breech Engagement: Breech Progression Angle and Prediction of External Cephalic Version Success
by Javier Sánchez-Romero, Rosa María Gallego-Pozuelo, Cristina Ortuño-Hernández, Ana Martínez-Zarco, Rocío Barroso-Linares, Fernando Araico-Rodríguez, José Eliseo Blanco-Carnero, Aníbal Nieto-Díaz and Catalina de Paco-Matallana
J. Clin. Med. 2025, 14(20), 7179; https://doi.org/10.3390/jcm14207179 - 11 Oct 2025
Viewed by 269
Abstract
Objectives: To evaluate the role of breech progression angle (BPA), a novel transperineal ultrasound parameter, as a predictor of external cephalic version (ECV) success, and to compare BPA between breech and transverse lie presentations. Methods: This prospective exploratory study was nested [...] Read more.
Objectives: To evaluate the role of breech progression angle (BPA), a novel transperineal ultrasound parameter, as a predictor of external cephalic version (ECV) success, and to compare BPA between breech and transverse lie presentations. Methods: This prospective exploratory study was nested within a randomized clinical trial (NCT06449430) at Virgen de la Arrixaca University Hospital, Murcia, Spain. Eligible participants were pregnant women ≥18 years with a singleton fetus in non-cephalic presentation at term, without contraindications to vaginal birth. BPA was measured transperineally following standardized methodology prior to ECV, performed under either spinal analgesia or propofol sedation. Logistic regression models adjusted for maternal and obstetric variables assessed the association between BPA and ECV success. Receiver operating characteristic (ROC) curves were generated to evaluate predictive accuracy. Results: A total of 117 women were included: 100 with breech and 17 with transverse lie presentations. Median BPA was significantly higher in breech compared with transverse lie (87.2° vs. 70.2°, p < 0.001). In the overall cohort, BPA was not significantly associated with ECV success (OR 0.97, 95% CI 0.94–1.00; p = 0.068). However, in breech presentations, BPA was independently associated with ECV success (adjusted OR 0.95, 95% CI 0.91–0.99; p = 0.015). The area under the ROC curve for BPA predicting ECV success in breech cases was 0.64 (95% CI 0.53–0.73). Predictive accuracy was poor for transverse lie (AUC 0.27, 95% CI 0.08–0.56). Conclusions: BPA measured by transperineal ultrasound does not provide clinically useful information for predicting the success of external cephalic version, either in breech or transverse lie. Full article
(This article belongs to the Special Issue New Perspectives in Maternal–Fetal Medicine)
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16 pages, 675 KB  
Article
Alterations in Gut Microbiota After Upper Gastrointestinal Resections: Should We Implement Screening to Prevent Complications?
by Urška Novljan, Žan Bohinc, Niko Kaliterna, Uroš Godnov and Tadeja Pintar Kaliterna
Medicina 2025, 61(10), 1822; https://doi.org/10.3390/medicina61101822 - 11 Oct 2025
Viewed by 145
Abstract
Background: Surgical procedures and alterations of the gastrointestinal (GI) tract increase the risk of small intestinal bacterial overgrowth (SIBO), which is associated with GI symptoms and complications that compromise postoperative recovery. However, the prevalence and clinical impact of SIBO after various upper [...] Read more.
Background: Surgical procedures and alterations of the gastrointestinal (GI) tract increase the risk of small intestinal bacterial overgrowth (SIBO), which is associated with GI symptoms and complications that compromise postoperative recovery. However, the prevalence and clinical impact of SIBO after various upper GI surgical procedures remain poorly understood. Objective: This study aimed to evaluate the prevalence of SIBO after different types of upper GI surgery and to investigate the associated clinical factors. Methods: We conducted an observational study involving 157 patients with a history of upper GI surgery: Roux-en-Y gastric bypass (RYGB), laparoscopic single-anastomosis gastric bypass (OAGB), subtotal (STG) or total gastrectomy (TG), subtotal (SP)or total pancreatectomy (TP), cephalic duodenopancreatectomy (WR), and small bowel resection for Crohn’s disease. A glucose–hydrogen breath test was performed, and demographic, clinical, and treatment-related data were collected. Statistical analyses included t-tests, non-parametric tests, ANOVA, and correlation analyses using R software. Results: At a median follow-up of 25.7 ± 18.1 months, 31% (48/157) of patients tested positive for SIBO. The highest prevalence was observed after RYGB and OAGB (43%), followed by TG (30%), STG (29%), TP/WR (28%), and Crohn’s disease bowel resection (19%). No cases of SIBO were observed after SP. SIBO positivity was significantly associated with bloating and flatulence (p = 0.002), lactose intolerance (p = 0.047), systemic sclerosis (p = 0.042), T2D (p = 0.002), and exposure to adjuvant chemotherapy (p = 0.001) and radiotherapy (p = 0.027). In addition, the risk of SIBO increased proportionally with the duration of GI resection or exclusion (p = 0.013). Conclusions: In our study, the prevalence of SIBO after upper GI surgery was 31%, with the highest incidence (43%) observed in metabolic surgery patients. Importantly, adjuvant radio/chemotherapy was associated with an increased risk of SIBO, and extensive small bowel resection or exclusion was strongly associated with an increased risk of SIBO. Furthermore, the limitations of current diagnostic methods, which lack sufficient sensitivity and specificity, highlight the importance of early screening and standardization of diagnostic techniques to improve patient management and outcomes. Full article
(This article belongs to the Special Issue Abdominal Surgery: Innovative Techniques and Challenges)
10 pages, 3509 KB  
Case Report
Dual Origin of the Cephalic Vein with Double Fenestration: A Case Report
by José Aderval Aragão, Guilherme Felício Matos, Gustavo Henrique Silva da Matta, Iapunira Catarina Sant’Anna Aragão, Felipe Matheus Sant’Anna Aragão, Rudvan Cicotti, Francisco Prado Reis and Deise Maria Furtado de Mendonça
Anatomia 2025, 4(4), 15; https://doi.org/10.3390/anatomia4040015 - 9 Oct 2025
Viewed by 177
Abstract
Background/Objectives: This article discusses the clinical–surgical relevance of vascular anatomical variations, such as fenestrations—the division of a vessel into multiple channels that subsequently rejoin distally. Although rare in peripheral veins, these variations, which originate from the incomplete condensation of the embryonic capillary plexus, [...] Read more.
Background/Objectives: This article discusses the clinical–surgical relevance of vascular anatomical variations, such as fenestrations—the division of a vessel into multiple channels that subsequently rejoin distally. Although rare in peripheral veins, these variations, which originate from the incomplete condensation of the embryonic capillary plexus, can predispose thrombosis and necessitate preoperative recognition to avert complications during routine procedures. This study aims to report a rare case of dual origin and double fenestration of the cephalic vein. Methods: During a cadaveric dissection, a variation of the cephalic vein was identified. Results: In this case, an origin of the cephalic vein was observed arising from the dorsal venous network of the hand. It exhibited a double fenestration in the forearm, where a branch of the medial cutaneous nerve of the forearm perforated it before draining into the brachial vein. The second, a proximal origin, arose from the convergence of two tributaries—one originating from the subcutaneous tissue lateral to the brachial muscle and the other from the biceps brachii muscle, forming a single trunk that drained into the subclavian vein. Conclusions: This rare variation of the cephalic vein (dual origin and fenestration) carries significant hemodynamic implications, including an increased risk of turbulence and thrombosis. The atypical anatomical relationship between the nerve and the fenestrated vein also heightens the potential for iatrogenic injuries. In-depth knowledge of such anomalies is crucial for healthcare professionals to minimize complications and optimize the success of procedures like venous access and arteriovenous fistulas, ultimately ensuring patient safety. Full article
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21 pages, 6976 KB  
Article
Pc-AIF1 Is Expressed in Hemocyte-Rich and Neural Tissues and Links Immune Response and Regeneration in the Snail Model Pomacea canaliculata
by Anita Ferri, Sandro Sacchi, Nicola Franchi, Umberto Rosani and Davide Malagoli
Int. J. Mol. Sci. 2025, 26(18), 9022; https://doi.org/10.3390/ijms26189022 - 16 Sep 2025
Viewed by 437
Abstract
Allograft inflammatory factor-1 (AIF1) is a conserved calcium-binding protein involved in inflammatory and neuro-immune responses and expressed in Pomacea canaliculata (Pc-AIF1) during cephalic tentacle regeneration. Here, we investigated the expression and distribution of Pc-AIF1 in control conditions and during cephalic [...] Read more.
Allograft inflammatory factor-1 (AIF1) is a conserved calcium-binding protein involved in inflammatory and neuro-immune responses and expressed in Pomacea canaliculata (Pc-AIF1) during cephalic tentacle regeneration. Here, we investigated the expression and distribution of Pc-AIF1 in control conditions and during cephalic tentacle regeneration. A transcriptomic analysis of 315 RNA-seq datasets revealed maximal Pc-AIF1 expression in circulating hemocytes and hemocyte-rich tissues. Pc-AIF1 was also highly expressed in neural ganglia. Fluorescence in situ hybridization (FISH) evidenced Pc-AIF1 in circulating hemocytes and in the phagocytic hemocyte aggregates in the posterior kidney. qPCR showed the constitutive expression of Pc-AIF1 in cerebral ganglia. FISH experiments showed Pc-AIF1-positive cells within the cephalic tentacle blastema at 24 h post-amputation (hpa). Even if the amputation left them untouched, both the ipsilateral and contralateral cerebral ganglia increased Pc-AIF1 expression until 48 hpa. Immunocytochemical experiments evidenced positive cells to RCA120 (a microglial marker in mammals) among circulating hemocytes, in the connective tissue surrounding the cerebral ganglia, and within the regenerating tentacles. These findings suggest that Pc-AIF1 is a neuro-immune marker constitutively expressed in hemocyte populations and neural tissues; it is associated with the immediate hemocyte response to wounding and the neuro-immune interplay during the regeneration of sensory organs. Full article
(This article belongs to the Section Molecular Biology)
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10 pages, 1809 KB  
Case Report
Reconstruction of a Thrombosed Aneurysmal Radio-Cephalic Arteriovenous Fistula with a Tubular Bovine Pericardial Conduit
by Alexandru-Andrei Ujlaki-Nagi, Ludovic-Alexandru Szanto, Elena Florea, Nicolae-Alexandru Lazar, Suzana-Vasilica Șincaru, Adrian Vasile Mureșan, Eliza Russu, Réka Bartus, Eliza-Mihaela Arbănași, Ioan Hosu, Marius Mihai Harpa, Claudiu Constantin Ciucanu and Emil-Marian Arbănași
Kidney Dial. 2025, 5(3), 46; https://doi.org/10.3390/kidneydial5030046 - 13 Sep 2025
Viewed by 404
Abstract
We report the case of a 44-year-old man with end-stage kidney disease (ESKD) who has been on chronic hemodialysis via a radio-cephalic arteriovenous fistula (RC-AVF) for one year. The patient arrived at the emergency department due to an inability to continue dialysis through [...] Read more.
We report the case of a 44-year-old man with end-stage kidney disease (ESKD) who has been on chronic hemodialysis via a radio-cephalic arteriovenous fistula (RC-AVF) for one year. The patient arrived at the emergency department due to an inability to continue dialysis through the AVF. Clinical and ultrasound exams reveal an aneurysm in the cephalic vein, measuring 2.3 cm (cm) in diameter and 5 cm long, located in the middle third of the forearm, with intraluminal thrombosis. A surgical procedure is planned to exclude the aneurysmal segment and reconnect the vein, using a graft made from a bovine pericardium patch. Immediately after surgery, a thrill is detectable, and ultrasound shows a flow rate of 651 mL/min. On the second day, dialysis is performed through the distal cephalic vein segment under ultrasound guidance, avoiding the median forearm zone. At one month, the fistula remains functional, with no signs of thrombosis or stenosis. The bovine pericardium tubular graft has shown complete integration. This case supports the feasibility, safety, and potential advantages of using a tubularized bovine pericardial graft as an alternative conduit for RC-AVF reconstruction in select patients. However, further studies on larger cohorts and with extended follow-up are necessary to validate its reproducibility and long-term patency. Full article
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25 pages, 11592 KB  
Article
Pascua marecoralliensis, a New Species of Goby (Gobiiformes, Gobiidae) from the Central Coral Sea with Validation of the Genus Pascua
by Christopher H. R. Goatley, Andrea I. Varela, Javier Sellanes and Luke Tornabene
Fishes 2025, 10(9), 449; https://doi.org/10.3390/fishes10090449 - 4 Sep 2025
Viewed by 1098
Abstract
In this paper, we use molecular phylogenetics, micro-CT scanning, and morphological analyses to describe a new species of goby, Pascua marecoralliensis, and demonstrate that the genus Pascua is distinct from Hetereleotris, as supported by five diagnostic characters, including modified basicaudal scales [...] Read more.
In this paper, we use molecular phylogenetics, micro-CT scanning, and morphological analyses to describe a new species of goby, Pascua marecoralliensis, and demonstrate that the genus Pascua is distinct from Hetereleotris, as supported by five diagnostic characters, including modified basicaudal scales and reduced sensory papillae patterns. Phylogenetic analysis places Pascua as sister to the Gobiodon group, while Hetereleotris forms a separate clade. The new species, P. marecoralliensis, differs from congeners in fin ray counts, cephalic pore patterns, and head morphology and exhibits unique live colouration. Additionally, we reclassify Hetereleotris readerae and H. sticta as Pascua readerae and P. sticta based on shared genus-specific traits. The distribution of Pascua spans the southern Pacific, suggesting a relict lineage or undiscovered diversity in the genus. This work underscores the importance of integrative taxonomic approaches for resolving cryptic diversity in gobioid fishes and highlights the need for further sampling in understudied regions. Full article
(This article belongs to the Section Taxonomy, Evolution, and Biogeography)
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15 pages, 877 KB  
Review
A Call for Conceptual Clarity: “Emotion” as an Umbrella Term Did Not Work—Let’s Narrow It Down
by Peter Walla, Angelika Wolman and Georg Northoff
Brain Sci. 2025, 15(9), 929; https://doi.org/10.3390/brainsci15090929 - 27 Aug 2025
Viewed by 1214
Abstract
To cut a long story short, the term “emotion” is predominantly employed as a comprehensive designation, encompassing phenomena such as feelings, affective processing, experiences, expressions, and, on occasion, cognitive processes. This has given rise to a plethora of schools of thought that diverge [...] Read more.
To cut a long story short, the term “emotion” is predominantly employed as a comprehensive designation, encompassing phenomena such as feelings, affective processing, experiences, expressions, and, on occasion, cognitive processes. This has given rise to a plethora of schools of thought that diverge in their inclusion of these phenomena, not to mention the discordance regarding what emotions belong to the so-called set of discrete emotions in the first place. This is a problem, because clear and operational definitions are paramount for ensuring the comparability of research findings across studies and also across different disciplines. In response to this disagreement, it is here proposed to simplify the definition of the term “emotion”, instead of using it as an umbrella term overarching an unclear set of multiple phenomena, which is exactly what left all of us uncertain about the question what an emotion actually is. From an etymological perspective, the simplest suggestion is to understand an emotion as behavior (from the Latin verb ‘emovere’, meaning to move out, and thus the noun ‘emotion’ meaning out-movement). This suggests that an emotion should not be understood as something felt, nor as a physiological reaction, or anything including cognition. Instead, emotions should be understood as behavioral outputs (not as information processing), with their connection to feelings being that they convey them. Consider fear, which should not be classified as an emotion, it should be understood as a feeling (fear is felt). The specific body posture, facial expression, and other behavioral manifestations resulting from muscle contractions should be classified as emotions with their purpose being to communicate the felt fear to conspecifics. The underlying causative basis for all that exists is affective processing (i.e., neural activity), and it provides evaluative information to support decision-making. The essence of this model is that if affective processing responds above a certain threshold, chemicals are released, which leads to a feeling (e.g., felt fear) if the respective organism is capable of conscious experience. Finally, the communication of these feelings to conspecifics is happening by emotion-behavior (i.e., emotions). In summary, affective processing guides behavior, and emotions communicate feelings. This perspective significantly simplifies the concept of an emotion and will prevent interchangeable use of emotion-related terms. Last but not least, according to the current model, emotions can also be produced voluntarily in order to feign a certain feeling, which is performed in various social settings. Applications of this model to various fields, including clinical psychology, show how beneficial it is. Full article
(This article belongs to the Special Issue Defining Emotion: A Collection of Current Models)
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25 pages, 2677 KB  
Article
Selection for Short-Nose and Small Size Creates a Behavioural Trade-Off in Dogs
by Borbála Turcsán and Eniko Kubinyi
Animals 2025, 15(15), 2221; https://doi.org/10.3390/ani15152221 - 28 Jul 2025
Viewed by 2656
Abstract
Brachycephalic head shape in dogs has been associated with behavioural traits that may enhance their appeal as companion animals, contributing to their popularity. However, it remains unclear whether these behavioural differences are directly linked to head shape or are mediated by factors such [...] Read more.
Brachycephalic head shape in dogs has been associated with behavioural traits that may enhance their appeal as companion animals, contributing to their popularity. However, it remains unclear whether these behavioural differences are directly linked to head shape or are mediated by factors such as body size, demographics, and dog-keeping practices. Drawing on two large-scale owner surveys (N = 5613) and cephalic index estimates for 90 breeds, we investigated the relationship between head shape and eight behavioural variables (four personality traits and four behavioural problems), while controlling for 20 demographic and dog-keeping characteristics, as well as body size. Our results show that behavioural differences among head shapes are only partly attributable to head shape itself; some are explained by confounding variables. Specifically, brachycephalic dogs appeared predisposed to positive behaviours (e.g., calmness, fewer behavioural problems), but these traits were often obscured by their small body size and low training experience. These findings highlight the complex interplay between morphology, behaviour, and environment, and emphasize the role of training and management in supporting the behavioural well-being of popular brachycephalic breeds. This has important implications for owners, breeders, and welfare professionals aiming to align aesthetic preferences with behavioural and welfare outcomes. Full article
(This article belongs to the Special Issue The Complexity of the Human–Companion Animal Bond)
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12 pages, 961 KB  
Article
Changes in the Position of Anatomical Points, Cranio-Cervical Posture, and Nasopharyngeal Airspace Dimensions in Complete Denture Wearers—A Cephalometric Pilot Study
by Andrea Maria Chisnoiu, Mihaela Hedeșiu, Oana Chira, Iris Bara, Simona Iacob, Andreea Kui, Smaranda Buduru, Mihaela Păstrav, Mirela Fluerașu and Radu Chisnoiu
Dent. J. 2025, 13(8), 335; https://doi.org/10.3390/dj13080335 - 22 Jul 2025
Viewed by 561
Abstract
Objectives: The objective of this study was to evaluate changes in anatomical point position, cranio-cervical posture, and respiratory dimensions following conventional bimaxillary total prosthetic rehabilitation. Methods: A prospective, longitudinal, observational, analytical study was conducted on 12 patients, aged 55 to 75 years, [...] Read more.
Objectives: The objective of this study was to evaluate changes in anatomical point position, cranio-cervical posture, and respiratory dimensions following conventional bimaxillary total prosthetic rehabilitation. Methods: A prospective, longitudinal, observational, analytical study was conducted on 12 patients, aged 55 to 75 years, at the Department of Dental Prosthetics at the University of Medicine and Pharmacy in Cluj-Napoca. All patients had complete bimaxillary edentulism and received removable dentures as treatment. Clinical and cephalometric analyses were performed before and after prosthetic treatment to compare changes. The cephalometric analysis was based on the guidelines of Tweed and Rocabado for evaluation. Quantitative data were described using the mean and standard deviation for normal distribution and represented by bar graphs with error bars. A paired samples t-test was used to determine differences between groups, with a significance threshold of 0.05 for the bilateral p-value. Results: When analyzing changes in cranial base inclination, the corresponding angles exhibited an increase, indicating cephalic extension. A statistically significant difference in the anteroposterior diameter of the oropharyngeal lumen with and without bimaxillary complete dentures was identified (p < 0.05). For hyperdivergent patients, modifications in the position of anatomical features on cephalometry slightly reduced the VDO and had a slight compensatory effect on skeletal typology. In contrast, for hypodivergent patients, modifications to the position of anatomical landmarks also had a compensatory effect on skeletal typology, increasing the VDO. Conclusion: Changes in the position of anatomical features on cephalometry generally have a compensatory effect on skeletal typology after complete denture placement. Complete prosthetic treatment with removable dentures can significantly influence respiratory function by reducing the oropharyngeal lumen and body posture by cephalic extension and attenuation of the lordotic curvature of the cervical spine. Full article
(This article belongs to the Special Issue Women's Research in Dentistry)
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12 pages, 1070 KB  
Article
Reproducibility of Breech Progression Angle: Standardization of Transperineal Measurements and Development of Image-Based Checklist for Quality Control
by Ana M. Fidalgo, Adriana Aquise, Francisca S. Molina, Aly Youssef, Otilia González-Vanegas, Elena Brunelli, Ilaria Cataneo, Maria Segata, Marcos J. Cuerva, Valeria Rolle and Maria M. Gil
Diagnostics 2025, 15(14), 1757; https://doi.org/10.3390/diagnostics15141757 - 11 Jul 2025
Viewed by 522
Abstract
Objectives: To evaluate the reproducibility of measurements of breech progression angle (BPA) by transperineal ultrasound (US) before and after its standardization by applying an image-based checklist. Methods: Eighteen 3-dimensional (3D) volumes of transperineal US from women at 36–40 weeks of gestation with a [...] Read more.
Objectives: To evaluate the reproducibility of measurements of breech progression angle (BPA) by transperineal ultrasound (US) before and after its standardization by applying an image-based checklist. Methods: Eighteen 3-dimensional (3D) volumes of transperineal US from women at 36–40 weeks of gestation with a singleton fetus in breech presentation were provided to eight operators from four maternity units in Spain and Italy. All operators measured the BPA using 3D US volume processing software, and interobserver reproducibility was evaluated using the intraclass correlation coefficient (ICC). Following an online live review of all measurements by the operators, and the identification of sources of disagreement, an image-based scoring system for BPA measurement was collaboratively developed. The checklist included the following: (1) acquisition in the midsagittal plane, avoiding the posterior shadow of the pubic ramus; (2) visualization of the complete “almond-shaped” pubic symphysis; (3) drawing a first line along the longitudinal axis of the symphysis, dividing it equally; (4) extending this line to the inferior edge of the bone; and (5) drawing a second line tangentially from the lower edge of the symphysis to the lowest recognizable fetal part. The BPA measurements were then repeated using this checklist, and reproducibility was reassessed. Results: Eighteen volumes were analyzed by the eight operators, achieving a moderate reproducibility (ICC: 0.70, 95% confidence interval (CI): 0.48 to 0.86). A score was developed to include a series of landmarks for the appropriate assessment of BPA. Subsequently, the same eighteen volumes were reassessed using the new score, resulting in improved reproducibility (ICC: 0.81, 95% CI: 0.66 to 0.92). Conclusions: The measurement of BPA is feasible and reproducible when using a standardized image-based score. Full article
(This article belongs to the Special Issue Advances in Gynecological and Pediatric Imaging)
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15 pages, 11003 KB  
Article
A New Holoplanktonic Nudibranch (Nudibranchia: Phylliroidae) from the Central Mexican Pacific
by Jeimy D. Santiago-Valentín, Eric Bautista-Guerrero, Eva R. Kozak, Gloria Pelayo-Martínez and Carmen Franco-Gordo
Diversity 2025, 17(7), 479; https://doi.org/10.3390/d17070479 - 11 Jul 2025
Cited by 1 | Viewed by 1929 | Correction
Abstract
Pelagic nudibranchs exemplify evolutionary convergences towards streamlined, transparent body forms adapted for life in the planktonic environment. Here, we describe a new genera and species, designated as Pleuropyge melaquensis gen. et sp. nov. This species belongs to the family Phylliroidae and is distinguished [...] Read more.
Pelagic nudibranchs exemplify evolutionary convergences towards streamlined, transparent body forms adapted for life in the planktonic environment. Here, we describe a new genera and species, designated as Pleuropyge melaquensis gen. et sp. nov. This species belongs to the family Phylliroidae and is distinguished by key diagnostic characters, including a laterally positioned anus approximately one-third of the body length from the head, the absence of a cephalic disc, and an anterior hepatic caecum that is longer than the intestine. The description of P. melaquensis contributes to the classification of a third genus and a fourth species within the Phylliroidae family. This study offers novel insights into the functional and structural traits that have enabled nudibranchs to transition from benthic to pelagic environments. Full article
(This article belongs to the Section Marine Diversity)
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13 pages, 824 KB  
Article
The Role of Guideline’s Threshold Vascular Diameters in Long-Term Radio-Cephalic Arteriovenous Fistula Failure
by Eliza Russu, Elena Florea, Alexandra Asztalos, Constantin Claudiu Ciucanu, Eliza-Mihaela Arbănași, Réka Bartus, Adrian Vasile Mureșan, Alexandru-Andrei Ujlaki-Nagy, Ioan Hosu and Emil-Marian Arbănași
J. Clin. Med. 2025, 14(13), 4667; https://doi.org/10.3390/jcm14134667 - 1 Jul 2025
Viewed by 822
Abstract
Background/Objectives: According to the guidelines established by the European Society of Vascular Surgery (ESVS), a minimum 2 mm diameter is advised for both the radial artery (RA) and cephalic vein (CV) to perform a radio-cephalic arteriovenous fistula (RC-AVF). However, studies have suggested [...] Read more.
Background/Objectives: According to the guidelines established by the European Society of Vascular Surgery (ESVS), a minimum 2 mm diameter is advised for both the radial artery (RA) and cephalic vein (CV) to perform a radio-cephalic arteriovenous fistula (RC-AVF). However, studies have suggested that larger vein diameters, over 2.5 or 3 mm, or even smaller vessel diameters, above 1.6 mm, can yield satisfactory outcomes in both the medium and long term. This study aims to analyze how preoperative vascular mapping influences the long-term RC-AVF failure, considering adherence to guidelines. Methods: This retrospective, monocentric, and observational study enrolled 110 patients with ESKD who were admitted, between 2018 and 2024, to the Vascular Surgery Department at the Emergency County Hospital of Târgu Mureș for the creation of an RC-AVF. Demographic characteristics, comorbidities, preoperative vascular mapping data, and laboratory data were meticulously collected from the hospital’s electronic databases. Patients enrolled in the current study were categorized into two groups based on their adherence to guideline recommendations. Results: Patients whose RC-AVF was created outside guideline recommendations demonstrated smaller arterial (p < 0.001) and venous (p < 0.001) diameters. Additionally, a higher percentage of these patients were on hemodialysis via CVC at the time of RC-AVF creation (p = 0.041), as well as a higher incidence of 6-week AVF maturation failure (p = 0.012) and long-term AVF failure (p = 0.016). In ROC Curve analysis, a threshold of 2.75 mm was established for the RA (AUC: 0.647, p = 0.005) and 2.52 mm for the CV (AUC: 0.677, p = 0.001). Additionally, patients whose RC-AVF procedures adhered to guideline recommendations had a significantly lower risk of long-term RC-AVF failure (HR: 0.44, p = 0.012). This association lost significance after adjusting for cardiovascular risk factors and the presence of CVC at admission (HR: 0.69, p = 0.328). After full adjustment, only the CV remained an independent predictor of long-term successful RC-AVF (HR: 0.68, p = 0.026). In contrast, RA lost significance after adjusting for cardiovascular risk factors and the presence of CVC at admission (HR: 0.71, p = 0.086). Conclusions: In conclusion, this study reveals that only the diameter of the CV is correlated with the long-term failure of RC-AVF, independent of age, gender, diabetes, hypertension, active smoking, and the presence of a CVC at the time of AVF creation. Therefore, while adhering to the threshold diameters of the AR and CV, as recommended by the ESVS guidelines, facilitates the creation of a functional RC-AVF, we assert that additional cofactors, such as demographic data, usual cardiovascular risk factors, or CVC presence, must also be considered to achieve optimal long-term AVF. Full article
(This article belongs to the Special Issue Current Trends in Vascular and Endovascular Surgery)
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Article
Scale Sensilla in the Snakes of the Genus Natrix, and in the Old and New World Natricids
by Alessandro Paterna
Taxonomy 2025, 5(3), 34; https://doi.org/10.3390/taxonomy5030034 - 25 Jun 2025
Viewed by 1145
Abstract
Among European colubroids, scale sensilla—mechanoreceptors present in the head integument—are more expressed in natricids. The presence of protruded sensilla, observable with the naked eye, is found in the cephalic shields of all species belonging to the genus Natrix. The identification of these [...] Read more.
Among European colubroids, scale sensilla—mechanoreceptors present in the head integument—are more expressed in natricids. The presence of protruded sensilla, observable with the naked eye, is found in the cephalic shields of all species belonging to the genus Natrix. The identification of these sense organs in this genus determines its correlation in aquatic and semi-aquatic species, in which these traits are more developed and recognizable than in terrestrial species. As hypothesized for elapoids, this differentiation could be due to the fact that in natricids, like sea snakes, these can perform a hydrodynamic function in addition to the mechanosensory one. In support of this thesis, within the genus Natrix, the most aquatic species of the five, Natrix tessellata, features the most expressed sensilla. This specificity represents a further analogy in the evolutionary convergences involving the cephalic region that this species shares with marine elapids. Still in the genus Natrix, a second trait involving the shields has been identified, expressing itself in the opposite condition to the protruded sensilla, occurring as a pitting arranged mainly within the shields along the upper portion of the labial arches. In vivo examinations and microscopy were performed on different species of the Natrix genus, and comparative analyses have been carried out on other natricid taxa from the New and Old World, where the presence of protruded scale sensilla has been found in several species. Full article
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