Search Results (20)

Eye movement detection algorithms (e.g., I-VT) require the selection of thresholds to identify eye fixations and saccadic movements from gaze data. The choice of threshold is important, as thresholds too low or large may fail to accurately identify eye fixations and saccades. An inaccurate threshold might also affect the resulting visual scan path, the time-ordered sequence of eye fixations and saccades, carried out by the participant. Commonly used approaches to evaluate threshold accuracy can be manually laborious, or require information about the expected visual scan paths of participants, which might not be available. To address this issue, we propose two different computational approaches, labeled as “between-participants comparisons” and “within-participants comparisons.” The approaches were evaluated using the open-source Gazebase dataset, which contained a bullseyetarget tracking task, where participants were instructed to follow the movements of a bullseye-target. The predetermined path of the bullseye-target enabled us to evaluate our proposed approaches against the expected visual scan path. The approaches identified threshold values (220°/s and 210°/s) that were 83% similar to the expected visual scan path, outperforming a 30°/s benchmark threshold (41.5%). These methods might assist researchers in identifying accurate threshold values for the IVT algorithm or potentially other eye movement detection algorithms. Full article

Background: This study aims to provide a comprehensive overview of speckle tracking echocardiography (STE) findings in patients diagnosed with acromegaly, exploring a potential application for the differential diagnosis of cardiac hypertrophy and guiding clinicians in patient management. To our knowledge, this is the first review showcasing changes in the bull’s-eye pattern in myocardial function after acromegaly treatment, suggesting a possible pattern in this aetiology of left ventricular hypertrophy. Methods: A review of PubMed articles using the search term “speckle tracking echocardiography acromegaly” yielded 11 relevant papers published between 2017 and 2023. The final analysis evaluated each paper’s substantial value and summarised pertinent information. A clinical case of myocardial strain changes before and after pharmacological and neurosurgical treatment is also described. Results: The 11 analysed papers, with patient groups ranging from 19 to 50 individuals, revealed varying results in STE parameters between acromegalic and control groups. Left ventricular strain parameters were commonly assessed, showing discrepancies in different studies. Notably, the MAGYAR-Path Study emphasised left ventricular twist and radial strain abnormalities in acromegaly patients. Furthermore, the interplay between acromegaly and diabetes influenced myocardial function. Drug treatment with somatostatin receptor ligands demonstrated a favourable impact on left ventricular systolic function. The case study we describe in this manuscript showed changes in the posterior basal LV segment, which may be a specific pattern of acromegaly remodelling. Somatostatin therapy and neurosurgery led to the normalisation of global longitudinal strain (GLS) and improvement in myocardial work, as well as improved diastolic function, including enhanced left atrial strain (LAS) as well as a visible elastic recoil sign (ERS). Conclusions: While the available literature on STE in acromegaly is limited, our analysis suggests potential applications in differentiating hypertrophy aetiologies and monitoring cardiac function post-treatment. The results underscore the need for more interdisciplinary research to optimise patient management. The bull’s-eye pattern with posterior basal segment strain impairment we describe may be used to differentiate this entity. Full article

Two-dimensional leaky-wave antennas (LWAs) are a class of planar, traveling-wave radiators with attractive features of a low profile, ease of feeding, frequency reconfigurability of the radiation pattern, and polarization agility. Their use in conjunction with array feeders has been the subject of various investigations in recent decades, thanks to the additional degrees of freedom provided by the presence of multiple independent sources. Here, we provide a review of some of the most recent and promising array-fed two-dimensional (2-D) LWAs, selecting a couple of the most significant structures in application, namely Fabry–Perot cavity antennas and bull’s-eye antennas, and discussing some of their recently proposed advanced features. Full article

Shooting may impact the frequency of neuropathies in the upper extremity nerves or of cervical disc–root conflicts. This study was undertaken to assess whether shooting sports trained with a handgun by civilians may influence the risk factor for carpal tunnel syndrome (CTS) and other neuropathies of the brachial plexus nerve fibers. Neurophysiological studies using surface electromyography (rEMG at rest and mcEMG during maximal contraction), electroneurography (ENG), and motor-evoked potential recordings (MEPs) were performed in a select population of nine shooters, which were rigorously screened as positive through a clinical examination for carpal tunnel syndrome and other brachial plexus neuropathies among a population of forty-two subjects, to confirm the existence of pathologies in the upper extremities. Increased muscle tension in rEMG and a simultaneous decrease in motor unit activity in mcEMG were recorded both in the proximal and distal muscles of the upper extremities more frequently in the shooters than in the healthy controls—volunteers. An ENG examination confirmed CTS in the shooting hand of four subjects (4/42; 9.5%), additionally revealing a significantly decreased F-wave at the C6–C7 levels in the dominant extremities of the shooting group in comparison to the control population (p = 0.05). All the examined subjects had revealed brachial plexus pathologies on both sides according to the results of the MEP recordings upon stimulation at the C4–C8 levels (various significant differences between the shooters and control group were found), and two had ulnar neuropathy in the wrist on the shooting side. It was concluded that shooting sports are a moderate risk factor for carpal tunnel syndrome and that they significantly influence the development of other brachial plexus neuropathies. Full article

Phlyctema vagabunda is one of the main postharvest pathogens in late-harvest apples in Chile. The control of this pathogen is mainly through synthetic fungicides or copper-based compounds; however, there are concerns about the residues of these products in food and the environment. Therefore, there is a need for seeking alternative control strategies, in which propolis, a resinous substance collected by bees with antimicrobial properties, could be an environmentally friendly and safe alternative to control for P. vagabunda. The aim of this study was to characterize and determine the pathogenicity of Chilean isolates of P. vagabunda and to evaluate the antifungal activity of propolis against P. vagabunda in vitro and in vivo conditions. The Chilean isolates were identified as P. vagabunda through morphological and molecular characterization. The concentrations of propolis of 0.5% and 0.05% significantly decreased the mycelial growth and germination of conidia by 88.5% and 100%, respectively. The incidence and severity of the disease in apples also decreased by 57.2% and 61.3%, respectively. The use of propolis extract could be a promising alternative for the control of P. vagabunda in apples. Full article

This retrospective study investigated the toricity of dual-axis corneal refractive therapy (CRT) orthokeratology lenses and corneal parameters, including flat keratometry (FK), flat eccentricity (e), steep e, corneal astigmatism, and the difference in elevation at 8 mm chord length. We analyzed the right eyes of 143 adolescent patients who underwent ocular examinations, subjective refraction, and corneal topography before CRT lens fitting by trial lens evaluation. After orthokeratology treatment, all patients underwent a topography map with an intact plus power ring and decentration of <1 mm. The mean patient age was 10.7 ± 2.2 years old; 33% were male. The lens toricity range was 25–100 µm. Multiple linear regression analysis showed significant associations between CRT lens toricity and corneal astigmatism (β = 10.913, t = 3.012, p = 0.003) and the difference in elevation at 8 mm chord length (β = 0.681, t = 4.049, p < 0.001); no association was found between CRT lens toricity and FK, flat e, or steep e (all p > 0.05). Corneal astigmatism was positively associated with difference in elevation at 8 mm chord length (r = 0.743, p < 0.001, Pearson’s correlation), and corneal astigmatism and the difference in elevation at 8 mm chord length were positively associated with CRT lens toricity (r = 0.657 and r = 0.643, respectively; both p < 0.01, Spearman’s correlation). These results suggest that difference in elevation at 8 mm chord length can be used to conveniently estimate CRT lens toricity in clinical practice, using the equation Y (CRT lens toricity) = 1.02X (difference in elevation at 8 mm chord length) + 20.3. Full article

In order to quantitatively evaluate the degree of protection in protective layer mining and provide guidance for the design of a secondary outburst elimination scheme, a variable weight-projection gray target dynamic evaluation model for the effectiveness of protective layer mining is established. The improved order relation analysis method was used to determine the subjective weight of each index toward the decision-making goal based on numerical diversity characteristics, and the initial fixed-weight calculation for mixed multi-attribute metrics was processed through the degree of index action. The variable weight function was used to dynamically adjust the fixed weight through the penalty and incentive index methods. Four indexes (gas content, gas pressure, coal seam permeability coefficient, and expansion deformation) were selected, the outburst elimination and anti-reflection were taken as the guide, and the critical value of each index for eliminating burst and the critical value of pressure relief were taken as the positive and negative bullseyes. Based on the variable weight-projection gray target decision model, the distance between the two target centers of each scheme was calculated; at the same time, the variable weight vector changed dynamically with the evaluation scheme to achieve the dynamic quantitative evaluation of the degree of protection. Additionally, compared with the calculation results of fixed weights, it was found that the variable weight-projection bullseye distance can more accurately reflect the dynamic control effect of differences in numerical combinations of multi-attribute indexes in different decision schemes based on the degree of protection of protective layer mining. Taking a mine in PingMei as the engineering background, Ding protected the Wu area, and the degree of protection in the Wu group coal seam reached 116.29%, eliminating the outburst risk of the coal seam. The Wu protected the Ji group coal seam, with the degree of outburst risk in the Ji group being reduced by 14.27, and the Ding + Wu group protected the Ji group coal seam, with the degree of outburst risk of the Ji group being reduced by 20.71%, but not eliminated. The evaluation model quantifies the degree of protection of protective layer mining, and provides a theoretical basis for further assessing whether the working face should strengthen the enhancing permeability or whether it needs to be used in tandem with high-strength outburst elimination methods. Full article

Bull’s-eye rot, produced by Phlyctema vagabunda, is an important postharvest disease in apples. Current measures to control infection include synthetic fungicides, in addition to the application of copper hydroxide and potassium phosphite. However, growing public concern regarding fungicide residues in food has generated interest in developing non-chemical alternative control methods; biological control is one of the most promising alternatives. In this research, native endophytic yeasts were isolated and evaluated for the biocontrol of P. vagabunda in apples. The mechanisms of action involved were also determined. Our research found 2 isolates, Vishniacozyma victoriae EPL4.5 and EPL29.5, which exhibited biocontrol activity against P. vagabunda at 20 °C in apples, the incidence of bull’s-eye rot was reduced by 39% and 61%, respectively, and the severity of the disease was decreased by 67% and 70%, respectively, when apples were inoculated with these yeasts 24 h before applying the pathogen. The main mechanisms that could be involved in the observed biocontrol activity are the ability to form biofilms and the production of volatile organic compounds. Full article

A rogue wave is a huge wave that is generated by wave energy focusing. Rogue waves can cause critical damage to ships and offshore platforms due to their great wave energy and unpredictability. In this paper, to generate a rogue wave, a bull’s-eye wave, which is a focusing of multi-directional waves, was simulated in a numerical wave tank. A multi-directional wave generating boundary was developed using OpenFOAM, which is an open-source computational fluid dynamics (CFD) library. The wave height and profile of the generated rogue wave were compared to those of the regular wave. In addition, the pressure and velocity contours of water particles and velocity vectors at the free surface of the rogue wave were studied, along with the kinematic and dynamic effects of the rogue wave on a floating body. Full article

In this review, we collected 1765 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) M-pro inhibitors from the bibliography and other sources, such as the COVID Moonshot project and the ChEMBL database. This set of inhibitors includes only those compounds whose inhibitory capacity, mainly expressed as the half-maximal inhibitory concentration (IC₅₀) value, against M-pro from SARS-CoV-2 has been determined. Several covalent warheads are used to treat covalent and non-covalent inhibitors separately. Chemical space, the variation of the IC₅₀ inhibitory activity when measured by different methods or laboratories, and the influence of 1,4-dithiothreitol (DTT) are discussed. When available, we have collected the values of inhibition of viral replication measured with a cellular antiviral assay and expressed as half maximal effective concentration (EC₅₀) values, and their possible relationship to inhibitory potency against M-pro is analyzed. Finally, the most potent covalent and non-covalent inhibitors that simultaneously inhibit the SARS-CoV-2 M-pro and the virus replication in vitro are discussed. Full article

Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited treatment options and poor prognosis. MPM originates from the mesothelial lining of the pleura. Mesothelin (MSLN) is a glycoprotein expressed at low levels in normal tissues and at high levels in MPM. Many other solid cancers overexpress MSLN, and this is associated with worse survival rates. However, this association has not been found in MPM, and the exact biological role of MSLN in MPM requires further exploration. Here, we discuss the current research on the diagnostic and prognostic value of MSLN in MPM patients. Furthermore, MSLN has become an attractive immunotherapy target in MPM, where better treatment strategies are urgently needed. Several MSLN-targeted monoclonal antibodies, antibody–drug conjugates, immunotoxins, cancer vaccines, and cellular therapies have been tested in the clinical setting. The biological rationale underpinning MSLN-targeted immunotherapies and their potential to improve MPM patient outcomes are reviewed. Full article

The aim of this study was to identify the nature and cause of foxing spots in a historical manuscript. This manuscript was a Holy Quran from the beginning of the Qajar period and the end of the 18th century. Samples were incubated for 14 days and were evaluated for the presence of fungal activity. UV fluorescence photography, micro X-ray fluorescence spectroscopy and Fourier transform infrared spectroscopy were also used to investigate the characteristics and causes of foxing spots. The results showed that there was no fungal activity in the foxing spots of this manuscript. Based on the morphology of the stain in UV fluorescence photography, these foxing stains are of the Bullseye type, usually associated with metal ions. µXRF spectroscopy also showed a high accumulation of iron and copper at the site of these spots. This indicates abiotic foxing in this manuscript. Based on FTIR spectroscopy and peak deconvolution and fitting by Gaussian function, abiotic foxing increases the cellulose oxidation rate. Intensification of cellulose oxidation in foxing stains can be considered as one of the reasons for paper discoloration. Full article

Princess Merida, the “tomboy” princess in Disney/Pixar’s Brave, won praise for escaping the strictures of femininity and maternal demands for feminine propriety. In addition to her overt defiance of gender roles and demand for agency, Merida also enacts hegemonic masculinity by mocking her suitors during an archery contest in which she is the prize. The ridicule is the prelude to her dramatic, winning bullseye that feminizes the men, in a scene rich in symbolism about gender and power. In enacting the final phase of the tomboy paradigm, however, Merida reverses her trajectory as her rebellion against femininity ebbs. She then resolves conflict by displaying vulnerability rather than performing brave deeds. This marked shift to a more traditional gender role raises questions about her stature as a model of autonomy able to withstand the pressure to conform. Full article

Topological insulators, such as Bi₂Te₃, have been confirmed to exhibit plasmon radiation over the entire visible spectral range. Herein, we fabricate bullseye nanoemitters, consisting of a central disk and concentric gratings, on the Bi₂Te₃ nanoflake. Due to the existence of edge plasmon modes, Bi₂Te₃ bullseye nanostructures are possible to converge light towards the central disk. Taking advantage of the excellent spatial resolution of cathodoluminescence (CL) characterization, it has been observed that plasmonic behaviors depend on the excitation location. A stronger plasmonic intensity and a wider CL spectral linewidth can be obtained at the edge of the central disk. In order to further improve the focusing ability, a cylindrical Pt nanostructure has been deposited on the central disk. Additionally, the finite element simulation indicates that the electric-field enhancement originates from the coupling process between the plasmonic emission from the Bi₂Te₃ bullseye and the Pt nanostructure. Finally, we find that enhancement efficiency depends on the thickness of the Pt nanostructure. Full article

This study was conducted to examine plant biomass and phosphorus (P) accumulation and partitioning in response P availability and to determine the optimal P concentration during growth phases of two plant species with contrasting growth characteristics: geranium (Pelargonium × hortorum Bailey) “Bullseye Scarlet”, a flowering plant, and coleus (Solenostemon scutellarioides (L.) Codd) “Chocolate Mint”, a foliage plant. Plants were grown in inert media (1:1 mixture of perlite and vermiculite) with complete nutrient solutions containing a range of P concentrations considered low (3 and 5 mg/L), intermediate (10 and 15 mg/L), and high (20 and 30 mg/L). Higher P rates logarithmically increased shoot and root dry mass of geranium and coleus plants regardless of the growth phase, but linearly enhanced flower dry mass of reproductive geranium plants resulting from the accelerated flower development. During the vegetative phase, the intermediate-P increased the shoot biomass production of geranium plants, but high-P was more effective for coleus plants. During the reproductive phase, however, the intermediate-P increased shoot biomass production of both geranium and coleus plants to the level achieved by high-P. The change from vegetative to reproductive phase increased the relative biomass to flowers, roots, and shoots of reproductive geranium plants and roots and shoots of reproductive coleus plants in decreasing orders, resulting in an increased root-to-shoot ratio. The P content of all plant parts showed a logarithmical increase with higher P rates for reproductive geranium plants but a linear increase for reproductive coleus plants. During the reproductive phase, a higher proportion of acquired P was allocated to flowers of low-P geranium plants than the roots of high-P coleus. Our results demonstrate that geranium plants require intermediate-P throughout the growth phases, while coleus plants require high-P during the vegetative phase and intermediate-P during the reproductive phase. P-use efficiency (PUE) ranged from 5 to 15% in high-P, which was improved with intermediate-P by 36 to 70%. To further improve PUE, the application method also needs to be taken into consideration such that the fertigation volume is reduced during the vegetative phase and increased before the reproductive phase. Full article