Search Results (178)

The growing demand for natural and sustainable skincare products has driven interest in plant-based active ingredients, especially from in vitro cultures. This placebo-controlled study investigated the impact of a facial cream containing 2% Kickxia elatine (L.) Dumort cell suspension culture extract on various skin biophysical parameters. The cream was applied to the cheek once daily for six weeks on 40 healthy female volunteers between the ages of 40 to 49. The evaluated skin parameters including skin hydration, transepidermal water loss (TEWL), erythema intensity (EI), melanin intensity (MI), skin surface pH, and skin structure, wrinkle depth, vascular lesions, and vascular discolouration. The results indicated that significant improvements were observed in skin hydration (from 40.36 to 63.00 AU, p < 0.001) and there was a decrease in TEWL score (14.82 to 11.76 g/h/m², p < 0.001), while the skin surface pH was maintained (14.82 to 11.76 g/h/m², p < 0.001). Moreover, the K. elatine cell extract significantly improved skin structure values (9.23 to 8.50, p = 0.028), reduced vascular lesions (2.72 to 1.54 mm², p = 0.011), and lowered skin discolouration (20.98% to 14.84%, p < 0.001), indicating its moisturising, protective, brightening, and soothing properties. These findings support the potential use of K. elatine cell extract in dermocosmetic formulations targeting dry, sensitive, or ageing skin. Full article

Imaging technologies are widely used in surveillance, medical diagnostics, and other critical applications. However, under low-light conditions, captured images often suffer from insufficient brightness, blurred details, and excessive noise, degrading quality and hindering downstream tasks. Conventional low-light image enhancement (LLIE) methods not only require annotated data but also often involve heavy models with high computational costs, making them unsuitable for real-time processing. To tackle these challenges, a lightweight and unsupervised LLIE method utilizing a dual-stage frequency-domain calibration network (DFCNet) is proposed. In the first stage, the input image undergoes the preliminary feature modulation (PFM) module to guide the illumination estimation (IE) module in generating a more accurate illumination map. The final enhanced image is obtained by dividing the input by the estimated illumination map. The second stage is used only during training. It applies a frequency-domain residual calibration (FRC) module to the first-stage output, generating a calibration term that is added to the original input to darken dark regions and brighten bright areas. This updated input is then fed back to the PFM and IE modules for parameter optimization. Extensive experiments on benchmark datasets demonstrate that DFCNet achieves superior performance across multiple image quality metrics while delivering visually clearer and more natural results. Full article

Objectives: Sialic acid (SA), a naturally occurring compound abundantly found in birds’ nests, holds immense promise for skincare applications owing to its remarkable biological properties. However, its low bioavailability, poor stability, and limited skin permeability have constrained its widespread application. Methods: To overcome these challenges, SA was encapsulated within nanoliposomes (NLPs) by the high-pressure homogenization technique to develop an advanced and efficient transdermal drug delivery system. The skincare capabilities of this novel system were comprehensively evaluated across multiple experimental platforms, including in vitro cell assays, 3D skin models, in vivo zebrafish studies, and clinical human trials. Results: The SA-loaded NLPs (SA-NLPs) substantially improved the transdermal penetration and retention of SA, facilitating enhanced cellular uptake and cell proliferation. Compared to free SA, SA-NLPs demonstrated a 246.98% increase in skin retention and 1.8-fold greater cellular uptake in HDF cells. Moreover, SA-NLPs protected cells from oxidative stress-induced damage, stimulated collagen synthesis, and effectively suppressed the secretion of matrix metalloproteinases, tyrosinase activity, and melanin production. Additionally, zebrafish-based assays provided in vivo evidence of the skincare efficacy of SA-NLPs. Notably, clinical evaluations demonstrated that a 56-day application of the SA-NLPs-containing cream resulted in a 4.20% increase in L*, 7.87% decrease in b*, 8.45% decrease in TEWL, and 4.01% reduction in wrinkle length, indicating its superior brightening, barrier-repair, and anti-aging effects. Conclusions: This multi-level, systematic investigation strongly suggests that SA-NLPs represent a highly promising transdermal delivery strategy, capable of significantly enhancing the anti-aging, barrier-repair, and skin-brightening properties of SA, thus opening new avenues for its application in the fields of dermatology and cosmeceuticals. Full article

In this study, gravlax, a niche Scandinavian delicacy, was comprehensively investigated by producing it with combinations of two different fish species (tub gurnard (Chelidonichthys lucerna Linnaeus, 1758) and garfish (Belone belone Linnaeus, 1761)) and five herbs (dill (Anethum graveolens Linnaeus, 1753), sage (Salvia officinalis Linnaeus, 1753), mint (Mentha piperita Linnaeus, 1753), sweet (Ocimum basilicum Linnaeus, 1754), and purple basil (Ocimum basilicum var. purpurascens Bentham, 1830)). The nutritional composition, amino acids, color parameters, mineral substances, and heavy metal content, as well as physical characteristics, texture profile analysis, and extensive sensory analyses, were conducted, and the results were thoroughly evaluated using multivariate statistical methods. The influence of using different herbs on nutritional composition was found to be significant in gravlax made from both fish species (p < 0.05). Sensory analyses revealed that panelists identified mint as enhancing aroma and umami sensations, while dill improved overall acceptance. Gravlax with sage exhibited softer textures, but lower general acceptance due to perceived high saltiness. Color analyses revealed that purple basil transferred distinct pigments, causing darkening, whereas sweet basil had a brightening effect. Amino acid analyses revealed higher umami and sweet-tasting amino acids in herb-free gravlax, whereas proteolytic activity appeared to slow down in herb-containing gravlax samples. Full article

Large-scale magnetic flux ropes (MFRs) usually become visible during an eruption and are the core structures of coronal mass ejections, but the nature of MFRs is still a mystery. Here, we identify a large transequatorial MFR that spans across NOAA 13373 (in the Northern Hemisphere) and NOAA 13374 (in the Southern Hemisphere). Here, NOAA 13373 is a growing, newly emerging active region with a leading sunspot moving rapidly to the southwest, and it is surrounded by a highly dynamic moving magnetic feature (MMF), while NOAA 13374 is a decaying active region with a tiny leading negative sunspot and a large fading area. Recurrent reconnection, which occurs under the MFRs around the leading sunspot of NOAA 13373, results in local energy release, appearing as local EUV brightening, and it is related to the appearance of a transequatorial MFR. The appearance of this MFR involves several stages: EUV brightening, the slow rising and expansion of the MFR and its hosted filament, and, eventually, fading and shrinking. These observations demonstrate that a large-scale MFR can exist for a long-term period and that MMFs play a key role in building up free energy and triggering small-scale reconnections in the lower atmosphere. The energy released by these reconnection events is insufficient for triggering the eruption of an MFR but results in local disturbances. Full article

Caffeic acid (CA) is a naturally occurring polyphenol antioxidant found in coffee, tea, fruits, and vegetables, known for its strong antioxidant, anti-inflammatory, and anti-aging properties. However, its cosmetic application is limited because of poor dermal absorption due to its high polarity. This study aimed to evaluate the antioxidant and skin-brightening effects of a novel lipophilic CA derivative, CAD (caffeic acid-3,4-dihydroxyphenylpropanolester). CAD was synthesized by conjugating CA with 3,4-DHPEA, a lipophilic antioxidant derived from olive oil. In both DPPH and ABTS assays, CAD exhibited more potent antioxidant activity than CA. In B16F10 melanoma cells, CAD significantly inhibited melanin production without cytotoxicity at concentrations lower than those required for CA. Cellular assays using DCF-DA staining demonstrated that CAD effectively reduced intracellular ROS levels. Mechanistic studies revealed that CAD inhibited tyrosinase activity and downregulated the expression of TYR, TRP-1, and TRP-2. Additionally, CAD suppressed MITF phosphorylation, along with reduced phosphorylation of ERK and JNK, elucidating its anti-melanogenic mechanism. Importantly, CAD showed dose-dependent skin-brightening effects in the 3D human skin model Melanoderm™, as evidenced by increased lightness and histological evaluation. In conclusion, CAD demonstrates strong potential as a safe and effective antioxidant and skin-brightening agent for cosmetic applications. Full article

Cannabis sativa L. has been traditionally used for its therapeutic properties, particularly in treating various skin conditions. This study explores the in vitro anti-aging potential of five distinct parts of C. sativa L. (inflorescence, seed, leaf, stem, and root) by analyzing their bioactive compounds and biological activities. Ultrasound-assisted extraction was employed using ethyl acetate as an extracting solvent, followed by chemical characterization via gas chromatography-mass spectrometry (GC-MS/MS) and liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS/MS) analyses. The biological assessment included antioxidant, anti-inflammatory, anti-tyrosinase activities, and cytotoxicity evaluations. The inflorescence extract demonstrated the antioxidant activity, with a half-maximal inhibitory concentration (IC₅₀) value of 3,849.01 ± 5.25 µg/mL against DPPH radicals and 31.19 ± 0.96% inhibition of NO radicals at 1.25 mg/mL. Notably, the stem extract exhibited the highest anti-tyrosinase activity, with an IC₅₀ value of 0.01 ± 0.00 mg/mL, and significantly inhibited 5-lipoxygenase (5-LOX) activity with an IC₅₀ value of <0.024 µg/mL. All extracts showed no cytotoxicity on HaCaT cells at a concentration of 10 µg/mL, indicating their potential safety for dermatological applications. The stem extract was abundant in phytosterols, triterpenoids, diterpenoids, unsaturated fatty acids, and phenolic compounds, which likely contribute to its anti-inflammatory and anti-tyrosinase effects. These findings suggest that the stem, traditionally considered as waste, could be a valuable raw material for developing dermatological treatments with strong anti-inflammatory and skin-brightening effects. Full article

Numerous existing methods demonstrate impressive performance in brightening low-illumination images but fail in detail enhancement and color correction. To tackle these challenges, this paper proposes a dual-branch network including three main parts: color space transformation, a color correction network (CC-Net), and a light-boosting network (LB-Net). Specifically, we first transfer the input into the CIELAB color space to extract luminosity and color components. Afterward, we employ LB-Net to effectively explore multiscale features via a carefully designed large–small-scale structure, which can adaptively adjust the brightness of the input images. And we use CC-Net, a U-shaped network, to generate noise-free images with vivid color. Additionally, an efficient feature interaction module is introduced for the interaction of the two branches’ information. Extensive experiments on low-light image enhancement public benchmarks demonstrate that our method outperforms state-of-the-art methods in restoring the quality of low-light images. Furthermore, experiments further indicate that our method significantly enhances performance in object detection under low-light conditions. Full article

Lysine carboxymethyl cysteinate (LCC) is a synthetic substance obtained via lysine salification of S-carboxymethyl-cysteine. LCC has emerged as a promising glutathione (GSH) precursor. In this study, we sought to determine whether LCC could boost GSH levels and protect skin against oxidative stress. Experiments utilizing primary human keratinocytes and skin tissue samples revealed that LCC significantly increased endogenous GSH levels. LCC was able to pass through the stratum corneum and reach deep into the epidermis, where it enhanced the production of key metabolites involved in GSH biosynthesis. Then, the efficacy of LCC on skin protection was explored. LCC demonstrated protective effects by shielding keratinocytes from blue-light-induced oxidative stress and preventing ultraviolet B (UVB)-induced barrier disruption and pigmentation in a pigmented living skin equivalent (pLSE) model. In addition to its antioxidant properties, LCC also reduced the production of inflammatory mediators. Together, these findings underscore the multifaceted role of LCC in bolstering the natural antioxidant defenses of skin and preventing the accumulation of irreversible damage from the environment, thereby positioning it as a promising candidate for advancing skin health. Full article

This paper presents the results of the photometric and spectral monitoring of the galaxy NGC 3516, which is an active galactic nucleus (AGN) of type Sy $1.5$ with a changing look. Observations were carried out at the Fesenkov Astrophysical Institute (FAI, Almaty, Kazakhstan) and the Shamakhy Astrophysical Observatory (ShAO, Shamakhy, Azerbaijan). Spectral monitoring of this galaxy in the wavelength range 4000–7000 Å began in 2020, while photometric observations have been conducted since 2014. During the observation period, estimates of the galaxy’s brightness in the B, V and $Rc$ filters were obtained, as well as measurements of the emission line and continuum fluxes. The light curve shows increased brightness of NGC 3516 in 2016 and 2019. The increase of emission line fluxes of H$\beta$ and H$\alpha$ and continuum began in 2019 and continued until spring 2020, when these characteristics reached their maximal values. A powerful X-ray flare took place on 1 April 2020. A new phase of brightening began in 2021 and has continued until 2025. After reaching their maxima in 2020, the emission fluxes of H$\beta$ and H$\alpha$ decreased by a factor of 1.5–2 and remained at a low level until 2022–2023, when they began to increase again. Medium-resolution spectra obtained on 20 April 2020, with the 1-meter “West” telescope (TSHAO) were used to study the broad components of the H$\beta$ and H$\alpha$ emission line profiles. Model calculations showed that the broad profile of the H$\alpha$ line consists of a central unshifted component and two (blue and red) components shifted symmetrically relative to the central component by a velocity of $v=980\pm 20$ km ${\mathrm{s}}^{-1}$. The H$\beta$ emission line was relatively weak, so the radial velocity of its components was determined with a large uncertainty: $900\pm 600$ km ${\mathrm{s}}^{-1}$. Full article

Fluorescent brighteners (FBs) are a class of chemicals extensively used in industrial and consumer products. Their environmental occurrences and potential health risks have raised significant concerns. However, the lack of analytical methods for FBs in human samples has hindered the accurate assessment of internal exposure levels. Addressing this gap, this study developed and validated a novel method for the simultaneous determination of 13 FBs at trace levels in human plasma using solid-phase extraction combined with HPLC-MS/MS. The method employed EMR-Lipid SPE columns, which can selectively adsorb phospholipids for plasma sample pre-treatment. Detection was achieved through positive ion electrospray ionization (ESI) in multiple reaction monitoring (MRM) modes. The results showed that all 13 FBs exhibited good linearity within their respective ranges, with correlation coefficients (R²) greater than 0.992. The method quantitation limits (MQLs) of the FBs ranged from 0.012 to 0.348 ng/mL, and the spiked recovery rates ranged from 61% to 98%. The method was successfully applied to analyze 10 adult plasma samples, detecting 10 FBs with total concentrations ranging from 0.221 to 0.684 ng/mL. This study provides a reliable analytical method for determining FBs in human plasma, providing a basis for further research on human internal exposure to FBs and associated health risk assessments. Full article

The aim of the study undertaken was to determine the effect of a marinade using unpasteurised fruit vinegars and spirit vinegar, on the quality of raw poultry meat fresh (F) and after thawing (S). The raw material for the study was chicken breast muscle fillets. The meat was divided into two batches (F and S). This study evaluated the potency of unpasteurized quince, apple, grape and cherry fruit vinegars. The effect of the type of fruit vinegar used in the marinating process on the pH value of the meat was shown. Meat (F) marinated in fruit vinegars had a lower pH (4.55–5.04 pH) compared to the control group (5.65 pH). When poultry meat (F, S) was marinated in fruit vinegars, there was a brightening of colour, as evidenced by the higher values of the (L*) component. The use of vinegar in marinating poultry affected the rheological characteristics: hardness, elasticity, chewiness, gumminess, adhesiveness, cohesiveness, stringiness and bumpiness (p < 0.05) depending on the type of fruit vinegar used. The type of poultry meat used (F) and (S) in the marinating process had an effect (p < 0.05) on hardness, springiness, chewiness adhesiveness, and bumpiness, but not on their (p > 0.05) gumminess, cohesiveness, stringiness. Using unpasteurized fruit vinegars to marinate poultry meat can be an attractive alternative to commonly used marinades. Full article

Background and Objectives: Scleral lenses are widely used for visual rehabilitation in keratoconus patients, but their long-term effects on corneal tomography remain unclear. This study aims to evaluate the impact of 12-month scleral lens wear on corneal tomography in keratoconus patients through a case-controlled design. Materials and Methods: This retrospective study included 220 keratoconus patients, of whom 10 eyes were treated with SoClear (Brighten Optix Corporation, Taipei, Taiwan) mini-scleral lenses for over one year (SL group). A control group of 14 eyes was matched using Mahalanobis distance matching based on anterior maximum keratometry (K_max) and age. Both groups were evaluated at baseline and 12 months. Corneal tomography was assessed using the Pentacam HR (Oculus, Wetzlar, Germany), analyzing parameters such as anterior and posterior corneal curvature, thinnest corneal thickness (TCT), and higher-order aberrations. Generalized estimating equations (GEEs) were employed to assess the time-by-treatment effect between the two groups. Results: The SL group included 10 eyes from eight patients (seven males, one female; mean age 30.40 ± 6.52 years), while the control group included 14 eyes from 11 patients (three males, wight females; mean age 27.43 ± 8.11 years). Best corrected visual acuity with spectacles improved significantly with scleral lenses (p = 0.011) and remained stable (p = 0.044) at 12 months. Significant interaction effects were found in Ambrósio relational thickness (p = 0.006), posterior radius curvature (p = 0.047), posterior mean keratometry (p = 0.019), posterior flat keratometry (p = 0.023), and thinnest corneal thickness angle (p = 0.023); the SL group demonstrated less progression in these parameters compared to the control group. Conclusions: This case-controlled study highlights the 12-month impact of scleral lenses on keratoconus, showing improved visual acuity compared to spectacles, stabilized posterior corneal curvature, and maintained corneal thickness. Further prospective studies with larger cohorts are needed to assess scleral lens effect on keratoconus progression. Full article

Acne vulgaris is a dermatological condition characterized by the hyperkeratinization of sebaceous follicles, which can further lead to post-inflammatory hyperpigmentation. Considering the intricate pathophysiology of acne, it is essential to develop novel topical therapies that are capable of targeting multiple underlying mechanisms of acne. The objective of this study was to study the effect of products containing retinol, niacinamide, ceramides, and dipotassium glycyrriszinate on acne-related markers. A total of 43 women with acne skin (including sensitive skin) were enrolled. To evaluate the effect of test products on acne-related indicators following 4 weeks of use, this study combined clinical assessments of skin condition (acne lesion counts), instrumental assessments (skin gloss), and photo tracking using VISIA-CR and Primos CR systems, which encompass metrics such as a*, ITA°, skin area (%) covered by sebum spots, and the presence of sebum spots. Adverse reactions were also assessed. After 4 weeks of treatment, significant reductions were observed in both the inflammatory acne lesion count and non-inflammatory acne lesion count, while there was also a significant decrease in skin redness a* and skin area (%) covered by sebum spots and a significant increase in skin brightness ITA° and gloss. No adverse events occurred during the entire testing process. In summary, the daily application of products containing retinol, niacinamide, and ceramides not only improves acne-related symptoms but also alleviates post-inflammatory hyperpigmentation caused by acne, which suggests that such products have the potential to meet the dual needs of brightening and acne care. Full article

The catastrophic twin earthquakes that struck southern Turkey and northern Syria on 6 February 2023 caused massive casualties and extensive damage to infrastructure, with Hatay Province of Turkey bearing the brunt of the impact. To swiftly and thoroughly assess the damage caused by the earthquakes and the subsequent reconstruction efforts, this study initially investigated the application of light change ratios between the pre-earthquake monthly nighttime lights (NTLs) and the post-earthquake daily NTL data to identify earthquake damage in Hatay Province. Next, the monthly NTL data were employed to calculate the time series average lighting index (ALI). Subsequently, random noise and seasonal fluctuation were eliminated through data smoothing and seasonal decomposition techniques. Pre- and post-earthquake regression models were then utilised to establish a comprehensive framework for assessing economic recovery following the earthquake. The findings indicated that (1) the seismic damage identification method based on NTL data achieved an overall accuracy exceeding 71.55% in detecting building damage after a disaster. This method provided a swift and effective solution for rapidly assessing disaster-related destruction. (2) The reduced NTLs exhibited a strong correlation with the area of severely and moderately damaged buildings while showing a weaker correlation with areas of slightly damaged buildings. (3) The developed pre- and post-earthquake regression models demonstrated a high degree of fit, making them valuable tools for assessing regional economic recovery after the earthquake. At the county scale, such districts as Erzin and Kumlu exhibited promising signs of recovery, while such severely impacted areas as Antakya faced misconceptions of progress, primarily due to the brightening of NTLs caused by reconstruction efforts. Additionally, such districts as Dortyol and Samandag grappled with substantial short-term recovery challenges. Although the province experienced gradual economic recovery, achieving complete restoration has remained complex and time-intensive. The study offers valuable insights into earthquake damage assessment and economic recovery monitoring while serving as a scientific reference for disaster mitigation and post-disaster reconstruction efforts. Full article