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25 pages, 6180 KiB  
Article
Study on the Spatial Distribution Characteristics and Influencing Factors of Intangible Cultural Heritage Along the Great Wall of Hebei Province
by Yu Chen, Jingwen Zhao, Xinyi Zhao, Zeyi Wang, Zhe Xu, Shilin Li and Weishang Li
Sustainability 2025, 17(15), 6962; https://doi.org/10.3390/su17156962 (registering DOI) - 31 Jul 2025
Abstract
The development of the Great Wall National Cultural Park has unleashed the potential for integrating cultural and tourism development along the Great Wall. However, ICH along the Great Wall, a key part of its cultural identity, suffers from low recognition and a mismatch [...] Read more.
The development of the Great Wall National Cultural Park has unleashed the potential for integrating cultural and tourism development along the Great Wall. However, ICH along the Great Wall, a key part of its cultural identity, suffers from low recognition and a mismatch between protection and development efforts. This study analyzes provincial-level and above ICH along Hebei’s Great Wall using geospatial tools and the Geographical Detector model to explore distribution patterns and influencing factors, while Geographically Weighted Regression is utilized to reveal spatial heterogeneity. It tests two hypotheses: (H1) ICH shows a clustered pattern; (H2) economic factors have a greater impact than cultural and natural factors. Key findings show: (1) ICH distribution is numerically balanced north–south but spatially uneven, with dense clusters in the south and scattered patterns in the north. (2) ICH and crafts cluster significantly, while dramatic balladry spreads evenly, and other categories are random. (3) Average annual temperature and precipitation have the greatest impact on ICH distribution, with the factors ranked as: natural > cultural > economic. Multidimensional interactions show significant enhancement effects. (4) Influencing factors vary spatially. Population density, transport, temperature, and traditional villages are positively related to ICH. Elevation, precipitation, tourism, and cultural institutions show mixed effects across regions. These insights support targeted ICH conservation and sustainable development in the Great Wall cultural corridor. Full article
(This article belongs to the Collection Sustainable Conservation of Urban and Cultural Heritage)
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17 pages, 6856 KiB  
Article
Selection of Optimal Parameters for Chemical Well Treatment During In Situ Leaching of Uranium Ores
by Kuanysh Togizov, Zhiger Kenzhetaev, Akerke Muzapparova, Shyngyskhan Bainiyazov, Diar Raushanbek and Yuliya Yaremkiv
Minerals 2025, 15(8), 811; https://doi.org/10.3390/min15080811 (registering DOI) - 31 Jul 2025
Abstract
The aim of this study was to improve the efficiency of in situ uranium leaching by developing a specialized methodology for selecting rational parameters for the chemical treatment of production wells. This approach was designed to enhance the filtration properties of ores and [...] Read more.
The aim of this study was to improve the efficiency of in situ uranium leaching by developing a specialized methodology for selecting rational parameters for the chemical treatment of production wells. This approach was designed to enhance the filtration properties of ores and extend the uninterrupted operation period of wells, considering the clay content of the productive horizon, the geological characteristics of the ore-bearing layer, and the composition of precipitation-forming materials. The mineralogical characteristics of ore and precipitate samples formed during the in situ leaching of uranium under various mining and geological conditions at a uranium deposit in the Syrdarya depression were identified using an X-ray diffraction analysis. It was established that ores of the Santonian stage are relatively homogeneous and consist mainly of quartz. During well operation, the precipitates formed are predominantly gypsum, which has little impact on the filtration properties of the ore. Ores of the Maastrichtian stage are less homogeneous and mainly composed of quartz and smectite, with minor amounts of potassium feldspar and kaolinite. The leaching of these ores results in the formation of gypsum with quartz impurities, which gradually reduces the filtration properties of the ore. Ores of the Campanian stage are heterogeneous, consisting mainly of quartz with varying proportions of clay minerals and gypsum. The leaching of these ores generates a variety of precipitates that significantly reduce the filtration properties of the productive horizon. Effective compositions and concentrations of decolmatant (clog removal) solutions were selected under laboratory conditions using a specially developed methodology and a TESCAN MIRA scanning electron microscope. Based on a scanning electron microscope analysis of the samples, the effectiveness of a decolmatizing solution based on hydrochloric and hydrofluoric acids (taking into account the concentration of the acids in the solution) was established for the destruction of precipitate formation during the in situ leaching of uranium. Geological blocks were ranked by their clay content to select rational parameters of decolmatant solutions for the efficient enhancement of ore filtration properties and the prevention of precipitation formation. Pilot-scale testing of the selected decolmatant parameters under various mining and geological conditions allowed the optimal chemical treatment parameters to be determined based on the clay content and the composition of precipitates in the productive horizon. An analysis of pilot well trials using the new approach showed an increase in the uninterrupted operational period of wells by 30%–40% under average mineral acid concentrations and by 25%–45% under maximum concentrations with surfactant additives in complex geological settings. As a result, an effective methodology for ranking geological blocks based on their ore clay content and precipitate composition was developed to determine the rational parameters of decolmatant solutions, enabling a maximized filtration performance and an extended well service life. This makes it possible to reduce the operating costs of extraction, control the geotechnological parameters of uranium well mining, and improve the efficiency of the in situ leaching of uranium under complex mining and geological conditions. Additionally, the approach increases the environmental and operational safety during uranium ore leaching intensification. Full article
(This article belongs to the Section Mineral Processing and Extractive Metallurgy)
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8 pages, 374 KiB  
Communication
Analyzing 8-Oxoguanine in Exhaled Breath Condensate: A Novel Within-Subject Laboratory Experimental Study on Waterpipe Smokers
by Natasha Shaukat, Tarana Ferdous, Simanta Roy, Sharika Ferdous, Sreshtha Chowdhury, Leonardo Maya, Anthony Paul DeCaprio, Wasim Maziak and Taghrid Asfar
Antioxidants 2025, 14(8), 929; https://doi.org/10.3390/antiox14080929 - 29 Jul 2025
Viewed by 124
Abstract
Introduction: This study aimed to analyze exhaled breath condensate (EBC) for 8-oxoguanine (8-oxoGua), an oxidative stress biomarker among waterpipe (WP) smokers. Methods: In a within-subject pre-post exposure design, thirty waterpipe smokers completed two 45 min laboratory sessions. EBC was analyzed for 8-oxoGua before [...] Read more.
Introduction: This study aimed to analyze exhaled breath condensate (EBC) for 8-oxoguanine (8-oxoGua), an oxidative stress biomarker among waterpipe (WP) smokers. Methods: In a within-subject pre-post exposure design, thirty waterpipe smokers completed two 45 min laboratory sessions. EBC was analyzed for 8-oxoGua before and after WP smoking. Median differences between time points (pre vs. post) were assessed using the Wilcoxon sign rank test, with significance defined as p < 0.05. Results: The analysis included 59 WP smoking sessions. Participants had a median age of 24 years (IQR: 21–25), with 62.1% being female. Most had a bachelor’s degree or less (62.1%), and over half were students (55.2%), while 34.5% were employed. The average age for first WP use was 18.6 years, with participants reporting a median of three WP smoking sessions per month. Results indicate a median increase in 8-oxoGua among participants from 5.4 ng/mL (IQR: 8.8) before the smoking session to 7.6 ng/mL after (IQR: 15.7; p < 0.001). Conclusions: This study is the first to examine 8-oxoGua in EBC. Findings provide strong evidence of WP smoking’s contribution to oxidative stress in the airways. It justifies the use of EBC to study the exposure to markers of oxidative stress with emerging tobacco use methods such as the waterpipe. Full article
(This article belongs to the Special Issue Cigarette Smoke and Oxidative Stress)
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16 pages, 1170 KiB  
Article
LoRA-Tuned Multimodal RAG System for Technical Manual QA: A Case Study on Hyundai Staria
by Yerin Nam, Hansun Choi, Jonggeun Choi and Hyukjin Kwon
Appl. Sci. 2025, 15(15), 8387; https://doi.org/10.3390/app15158387 - 29 Jul 2025
Viewed by 148
Abstract
This study develops a domain-adaptive multimodal RAG (Retrieval-Augmented Generation) system to improve the accuracy and efficiency of technical question answering based on large-scale structured manuals. Using Hyundai Staria maintenance documents as a case study, we extracted text and images from PDF manuals and [...] Read more.
This study develops a domain-adaptive multimodal RAG (Retrieval-Augmented Generation) system to improve the accuracy and efficiency of technical question answering based on large-scale structured manuals. Using Hyundai Staria maintenance documents as a case study, we extracted text and images from PDF manuals and constructed QA, RAG, and Multi-Turn datasets to reflect realistic troubleshooting scenarios. To overcome limitations of baseline RAG models, we proposed an enhanced architecture that incorporates sentence-level similarity annotations and parameter-efficient fine-tuning via LoRA (Low-Rank Adaptation) using the bLLossom-8B language model and BAAI-bge-m3 embedding model. Experimental results show that the proposed system achieved improvements of 3.0%p in BERTScore, 3.0%p in cosine similarity, and 18.0%p in ROUGE-L compared to existing RAG systems, with notable gains in image-guided response accuracy. A qualitative evaluation by 20 domain experts yielded an average satisfaction score of 4.4 out of 5. This study presents a practical and extensible AI framework for multimodal document understanding, with broad applicability across automotive, industrial, and defense-related technical documentation. Full article
(This article belongs to the Special Issue Innovations in Artificial Neural Network Applications)
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26 pages, 2330 KiB  
Article
Enhanced Dung Beetle Optimizer-Optimized KELM for Pile Bearing Capacity Prediction
by Bohang Chen, Mingwei Hai, Gaojian Di, Bin Zhou, Qi Zhang, Miao Wang and Yanxiu Guo
Buildings 2025, 15(15), 2654; https://doi.org/10.3390/buildings15152654 - 27 Jul 2025
Viewed by 194
Abstract
The safety associated with the bearing capacity of pile foundations is intrinsically linked to the overall safety, stability, and economic viability of structural systems. In response to the need for rapid and precise predictions of pile bearing capacity, this study introduces a kernel [...] Read more.
The safety associated with the bearing capacity of pile foundations is intrinsically linked to the overall safety, stability, and economic viability of structural systems. In response to the need for rapid and precise predictions of pile bearing capacity, this study introduces a kernel extreme learning machine (KELM) prediction model optimized through a multi-strategy improved beetle optimization algorithm (IDBO), referred to as the IDBO-KELM model. The model utilizes the pile length, pile diameter, average effective vertical stress, and undrained shear strength as input variables, with the bearing capacity serving as the output variable. Initially, experimental data on pile bearing capacity was gathered from the existing literature and subsequently normalized to facilitate effective integration into the model training process. A detailed introduction of the multi-strategy improved beetle optimization algorithm (IDBO) is provided, with its superior performance validated through 23 benchmark functions. Furthermore, the Wilcoxon rank sum test was employed to statistically assess the experimental outcomes, confirming the IDBO algorithm’s superiority over other prevalent metaheuristic algorithms. The IDBO algorithm was then utilized to optimize the hyperparameters of the KELM model for predicting pile bearing capacity. In conclusion, the statistical metrics for the IDBO-KELM model demonstrated a root mean square error (RMSE) of 4.7875, a coefficient of determination (R2) of 0.9313, and a mean absolute percentage error (MAPE) of 10.71%. In comparison, the baseline KELM model exhibited an RMSE of 6.7357, an R2 of 0.8639, and an MAPE of 18.47%. This represents an improvement exceeding 35%. These findings suggest that the IDBO-KELM model surpasses the KELM model across all evaluation metrics, thereby confirming its superior accuracy in predicting pile bearing capacity. Full article
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39 pages, 10816 KiB  
Article
A Novel Adaptive Superb Fairy-Wren (Malurus cyaneus) Optimization Algorithm for Solving Numerical Optimization Problems
by Tianzuo Yuan, Huanzun Zhang, Jie Jin, Zhebo Chen and Shanshan Cai
Biomimetics 2025, 10(8), 496; https://doi.org/10.3390/biomimetics10080496 - 27 Jul 2025
Viewed by 319
Abstract
Superb Fairy-wren Optimization Algorithm (SFOA) is an animal-based meta-heuristic algorithm derived from Fairy-wren’s behavior of growing, feeding, and avoiding natural enemies. The SFOA has some shortcomings when facing complex environments. Its switching mechanism is not enough to adapt to complex optimization problems, and [...] Read more.
Superb Fairy-wren Optimization Algorithm (SFOA) is an animal-based meta-heuristic algorithm derived from Fairy-wren’s behavior of growing, feeding, and avoiding natural enemies. The SFOA has some shortcomings when facing complex environments. Its switching mechanism is not enough to adapt to complex optimization problems, and it faces a weakening of population diversity in the late stage of optimization, leading to a higher possibility of falling into local optima. In addition, its global search ability needs to be improved. To address the above deficiencies, this paper proposes an Adaptive Superb Fairy-wren Optimization Algorithm (ASFOA). To assess the ability of the proposed ASFOA, three groups of experiments are conducted in this paper. Firstly, the effectiveness of the proposed improved strategies is checked on the CEC2018 test set. Second, the ASFOA is compared with eight classical/highly cited/newly proposed metaheuristics on the CEC2018 test set, in which the ASFOA performed the best overall, with average rankings of 1.621, 1.138, 1.483, and 1.966 in the four-dimensional cases, respectively. Then the convergence and robustness of ASFOA is verified on the CEC2022 test set. The experimental results indicate that the proposed ASFOA is a competitive metaheuristic algorithm variant with excellent performance in terms of convergence and distribution of solutions. In addition, we further validate the ability of ASFOA to solve real optimization problems. The average ranking of the proposed ASFOA on 10 engineering constrained optimization problems is 1.500. In summary, ASFOA is a promising variant of metaheuristic algorithms. Full article
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19 pages, 429 KiB  
Article
Sustainability Views and Intentions to Reduce Beef Consumption: An International Web-Based Survey
by Maria A. Ruani, David L. Katz, Michelle A. de la Vega and Matthew H. Goldberg
Foods 2025, 14(15), 2620; https://doi.org/10.3390/foods14152620 - 26 Jul 2025
Viewed by 366
Abstract
The environmental detriments of the growing global production and overconsumption of beef, including greenhouse gas emissions, deforestation, and biodiversity loss, are well-documented. However, public awareness of how dietary choices affect the environment remains limited. This study examines sustainability views on beef consumption and [...] Read more.
The environmental detriments of the growing global production and overconsumption of beef, including greenhouse gas emissions, deforestation, and biodiversity loss, are well-documented. However, public awareness of how dietary choices affect the environment remains limited. This study examines sustainability views on beef consumption and the potential for behavioral change as a step toward more sustainable intake levels. An observational web-based survey was conducted (n = 1367) to assess respondents’ current beef intake frequency, views on beef consumption related to planetary health, tropical deforestation, greenhouse gas emissions, and climate change, and willingness to modify beef consumption behavior. Chi-square tests were used for group comparisons, and weighted average scores were applied to rank levels of resistance to reducing beef intake. Environmental concern related to beef consumption was associated with greater beef cutback intentions and lower long-term intake reduction resistance amongst beef eaters. Beef eaters who strongly agreed that global beef consumption negatively impacts the environment were considerably more likely to express intentions to reduce their long-term beef intake compared to those who strongly disagreed (94.4% vs. 19.6%). Overall, 76.6% of beef eaters indicated wanting to eat less beef or phase it out entirely (30.7% reduce, 29.4% minimize, 16.6% stop), with only 23.4% of them intending to keep their consumption unchanged. Compelling messages that help translate awareness into action, such as the #NoBeefWeek concept explored in this study, may support individuals in adopting more sustainable food choices. These cross-national findings provide evidence for a ‘knowledge–intent’ gap in sustainable diet research, with relevance for health communicators and policymakers. Future research could examine the factors and motivations influencing decisions to modify beef consumption, including the barriers to achieving sustainable consumption levels and the role of suitable alternatives in facilitating this transition. Full article
(This article belongs to the Special Issue Consumer Behavior and Food Choice—4th Edition)
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20 pages, 2537 KiB  
Article
Spatial Disparities in University Admission Outcomes Among Ethnic Hungarian Students: Regional Analysis in the Central European Carpathian Basin
by József Demeter, Klára Czimre and Károly Teperics
Educ. Sci. 2025, 15(8), 961; https://doi.org/10.3390/educsci15080961 - 25 Jul 2025
Viewed by 370
Abstract
This research investigates higher education admission outcomes at Hungarian universities for ethnic Hungarian minority students residing in countries within the Carpathian Basin. The region is distinguished by a variety of national policies that impact minority education. By analyzing extensive data on the availability [...] Read more.
This research investigates higher education admission outcomes at Hungarian universities for ethnic Hungarian minority students residing in countries within the Carpathian Basin. The region is distinguished by a variety of national policies that impact minority education. By analyzing extensive data on the availability of mother tongue education, the status of minority rights, advanced level examination performance, and types of settlement using a wide range of statistical methods, our study reveals significant cross-national differences in the distribution of admission scores and central tendencies. Compared to lower and more varied scores for students from Ukraine and Romania, ethnic Hungarian students from Serbia and Slovakia achieved high average admission scores. Performance was notably more consistent among students from EU member states compared to non-EU regions, strongly linking outcomes to the more robust implementation of minority rights and better access to mother-tongue education within the EU framework. A critical finding is the strong positive correlation (Pearson r = 0.837) between admission scores and advanced level examination results, highlighting the pivotal role of these exams for the academic progression of these minority students. The Jonckheere-Terpstra test (p < 0.05) further confirmed significant performance differences between ranked country groups, with Serbian and Slovak students generally outperforming their Ukrainian and Romanian counterparts. Counterintuitively, settlement type (urban vs. rural) exhibited a negligible relationship with admission scores (r = 0.150), explaining only 2% of score variability. This challenges common assumptions and suggests other factors specific to the Hungarian minority context are more influential. This study provides crucial insights into the complex dynamics influencing Hungarian minority students’ access to higher education, underscoring cross-country educational inequalities, and informing the development of equitable minority rights and mother-tongue education policies in Central Europe for these often-marginalized communities. Full article
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20 pages, 437 KiB  
Article
A Copula-Driven CNN-LSTM Framework for Estimating Heterogeneous Treatment Effects in Multivariate Outcomes
by Jong-Min Kim
Mathematics 2025, 13(15), 2384; https://doi.org/10.3390/math13152384 - 24 Jul 2025
Viewed by 379
Abstract
Estimating heterogeneous treatment effects (HTEs) across multiple correlated outcomes poses significant challenges due to complex dependency structures and diverse data types. In this study, we propose a novel deep learning framework integrating empirical copula transformations with a CNN-LSTM (Convolutional Neural Networks and Long [...] Read more.
Estimating heterogeneous treatment effects (HTEs) across multiple correlated outcomes poses significant challenges due to complex dependency structures and diverse data types. In this study, we propose a novel deep learning framework integrating empirical copula transformations with a CNN-LSTM (Convolutional Neural Networks and Long Short-Term Memory networks) architecture to capture nonlinear dependencies and temporal dynamics in multivariate treatment effect estimation. The empirical copula transformation, a rank-based nonparametric approach, preprocesses input covariates to better represent the underlying joint distributions before modeling. We compare this method with a baseline CNN-LSTM model lacking copula preprocessing and a nonparametric tree-based approach, the Causal Forest, grounded in generalized random forests for HTE estimation. Our framework accommodates continuous, count, and censored survival outcomes simultaneously through a multitask learning setup with customized loss functions, including Cox partial likelihood for survival data. We evaluate model performance under varying treatment perturbation rates via extensive simulation studies, demonstrating that the Empirical Copula CNN-LSTM achieves superior accuracy and robustness in average treatment effect (ATE) and conditional average treatment effect (CATE) estimation. These results highlight the potential of copula-based deep learning models for causal inference in complex multivariate settings, offering valuable insights for personalized treatment strategies. Full article
(This article belongs to the Special Issue Current Developments in Theoretical and Applied Statistics)
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19 pages, 5417 KiB  
Article
SE-TFF: Adaptive Tourism-Flow Forecasting Under Sparse and Heterogeneous Data via Multi-Scale SE-Net
by Jinyuan Zhang, Tao Cui and Peng He
Appl. Sci. 2025, 15(15), 8189; https://doi.org/10.3390/app15158189 - 23 Jul 2025
Viewed by 190
Abstract
Accurate and timely forecasting of cross-regional tourist flows is essential for sustainable destination management, yet existing models struggle with sparse data, complex spatiotemporal interactions, and limited interpretability. This paper presents SE-TFF, a multi-scale tourism-flow forecasting framework that couples a Squeeze-and-Excitation (SE) network with [...] Read more.
Accurate and timely forecasting of cross-regional tourist flows is essential for sustainable destination management, yet existing models struggle with sparse data, complex spatiotemporal interactions, and limited interpretability. This paper presents SE-TFF, a multi-scale tourism-flow forecasting framework that couples a Squeeze-and-Excitation (SE) network with reinforcement-driven optimization to adaptively re-weight environmental, economic, and social features. A benchmark dataset of 17.8 million records from 64 countries and 743 cities (2016–2024) is compiled from the Open Travel Data repository in github (OPTD) for training and validation. SE-TFF introduces (i) a multi-channel SE module for fine-grained feature selection under heterogeneous conditions, (ii) a Top-K attention filter to preserve salient context in highly sparse matrices, and (iii) a Double-DQN layer that dynamically balances prediction objectives. Experimental results show SE-TFF attains 56.5% MAE and 65.6% RMSE reductions over the best baseline (ARIMAX) at 20% sparsity, with 0.92 × 103 average MAE across multi-task outputs. SHAP analysis ranks climate anomalies, tourism revenue, and employment as dominant predictors. These gains demonstrate SE-TFF’s ability to deliver real-time, interpretable forecasts for data-limited destinations. Future work will incorporate real-time social media signals and larger multimodal datasets to enhance generalizability. Full article
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15 pages, 2256 KiB  
Article
In Vivo Wear Analysis of Leucite-Reinforced Ceramic Inlays/Onlays After 14 Years
by Ragai-Edward Matta, Lara Berger, Oleksandr Sednyev, Dennis Bäuerle, Eva Maier, Werner Adler and Michael Taschner
Materials 2025, 18(15), 3446; https://doi.org/10.3390/ma18153446 - 23 Jul 2025
Viewed by 273
Abstract
Material wear significantly impacts the clinical success and longevity of dental ceramic restorations. This in vivo study aimed to assess the wear behavior of IPS Empress® glass-ceramic inlays and onlays over 14 years, considering the influence of different antagonist materials. Fifty-four indirect [...] Read more.
Material wear significantly impacts the clinical success and longevity of dental ceramic restorations. This in vivo study aimed to assess the wear behavior of IPS Empress® glass-ceramic inlays and onlays over 14 years, considering the influence of different antagonist materials. Fifty-four indirect restorations of 21 patients were available for comprehensive wear analysis, with complete follow-up data for up to 14 years. Three-dimensional measurements relied on digitized epoxy resin models produced immediately post-insertion (baseline) and subsequently at 2, 4, and 14 years. The occlusal region on the baseline model was delineated for comparative analysis. Three-dimensional superimpositions with models from subsequent time points were executed to assess wear in terms of average linear wear and volumetric loss. Statistical analyses were conducted in R (version 4.4.1), employing Mann–Whitney U tests (material comparisons) and Wilcoxon signed rank tests (time point comparisons), with a significance threshold of p ≤ 0.05. During the entire study period, an increase in wear was observed at each assessment interval, gradually stabilizing over time. Significant differences in substance loss were found between the follow-up time points, both for mean (−0.536 ± 0.249 mm after 14a) and integrated distance (−18,935 ± 11,711 mm3 after 14a). In addition, significantly higher wear was observed after 14 years with gold as antagonist compared to other materials (p ≤ 0.03). The wear behavior of IPS Empress® ceramics demonstrates clinically acceptable long-term outcomes, with abrasion characteristics exhibiting stabilization over time. Full article
(This article belongs to the Special Issue Advanced Dental Materials: From Design to Application, Second Volume)
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12 pages, 1751 KiB  
Article
Causal Inference of Adverse Drug Events in Pulmonary Arterial Hypertension: A Pharmacovigilance Study
by Hongmei Li, Xiaojun He, Cui Chen, Qiao Ni, Linghao Ni, Jiawei Zhou and Bin Peng
Pharmaceuticals 2025, 18(8), 1084; https://doi.org/10.3390/ph18081084 - 22 Jul 2025
Viewed by 230
Abstract
Objective: Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease. Adverse events (AEs) related to its drug treatment seriously damaged the patient’s health. This study aims to clarify the causal relationship between PAH drugs and these AEs by combining pharmacovigilance signal detection [...] Read more.
Objective: Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease. Adverse events (AEs) related to its drug treatment seriously damaged the patient’s health. This study aims to clarify the causal relationship between PAH drugs and these AEs by combining pharmacovigilance signal detection with the Bayesian causal network model. Methods: Patient data were obtained from the U.S. Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS), covering reports from 2013 to 2023. In accordance with standard pharmacovigilance methodologies, disproportionality analysis was performed to detect signals. Target drugs were selected based on the following criteria: number of reports (a) ≥ 3, proportional reporting ratio (PRR) ≥ 2, and chi-square (χ2) ≥ 4. Bayesian causal network models were then constructed to estimate causal relationships. The do-calculus and adjustment formula were applied to calculate the causal effects between drugs and AEs. Results: Signal detection revealed that Ambrisentan, Bosentan, and Iloprost were associated with serious AEs, including death, dyspnea, pneumonia, and edema. For Ambrisentan, the top-ranked adverse drug events (ADEs) based on average causal effect (ACE) were peripheral swelling (ACE = 0.032) and anemia (ACE = 0.021). For Iloprost, the most prominent ADE was hyperthyroidism (ACE = 0.048). Conclusions: This study quantifies causal drug–event relationships in PAH using Bayesian causal networks. The findings offer valuable evidence regarding the clinical safety of PAH medications, thereby improving patient health outcomes. Full article
(This article belongs to the Section Pharmacology)
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22 pages, 867 KiB  
Article
Occurrence of Potentially Toxic Metals Detected in Milk and Dairy Products in Türkiye: An Assessment in Terms of Human Exposure and Health Risks
by Burhan Basaran
Foods 2025, 14(15), 2561; https://doi.org/10.3390/foods14152561 - 22 Jul 2025
Viewed by 433
Abstract
This study investigated ten potential toxic metals (PTMs) in six milk and dairy product types and evaluated food safety (TDI, RDA), human exposure (EDI), non-carcinogenic risk (THQ, HI), and contamination levels (CF, PLI). Based on total PTM load, products ranked as: children’s milk [...] Read more.
This study investigated ten potential toxic metals (PTMs) in six milk and dairy product types and evaluated food safety (TDI, RDA), human exposure (EDI), non-carcinogenic risk (THQ, HI), and contamination levels (CF, PLI). Based on total PTM load, products ranked as: children’s milk > yogurt > protein milk > milk > ayran > kefir. Aluminum (Al) showed the highest average concentration in all products except ayran, where manganese (Mn) was dominant. Cadmium (Cd), mercury (Hg), and lead (Pb) were consistently at the lowest levels. Except for chromium (Cr) exposure from children’s milk, all average and maximum EDI values stayed below TDI and RDA thresholds. Children’s milk had the highest non-carcinogenic risk, while yogurt, kefir, milk, and ayran may also pose potential risks when maximum HI values are considered. Although CF values varied across products, PLI results showed all products had high levels of PTM contamination. Given the widespread consumption of dairy across all age groups, especially by sensitive populations like children, monitoring and controlling PTM levels is crucial alongside ensuring nutritional quality. Full article
(This article belongs to the Section Dairy)
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29 pages, 32010 KiB  
Article
Assessing Environmental Sustainability in the Eastern Mediterranean Under Anthropogenic Air Pollution Risks Through Remote Sensing and Google Earth Engine Integration
by Mohannad Ali Loho, Almustafa Abd Elkader Ayek, Wafa Saleh Alkhuraiji, Safieh Eid, Nazih Y. Rebouh, Mahmoud E. Abd-Elmaboud and Youssef M. Youssef
Atmosphere 2025, 16(8), 894; https://doi.org/10.3390/atmos16080894 - 22 Jul 2025
Viewed by 673
Abstract
Air pollution monitoring in ungauged zones presents unique challenges yet remains critical for understanding environmental health impacts and socioeconomic dynamics in the Eastern Mediterranean region. This study investigates air pollution patterns in northwestern Syria during 2019–2024, analyzing NO2 and CO concentrations using [...] Read more.
Air pollution monitoring in ungauged zones presents unique challenges yet remains critical for understanding environmental health impacts and socioeconomic dynamics in the Eastern Mediterranean region. This study investigates air pollution patterns in northwestern Syria during 2019–2024, analyzing NO2 and CO concentrations using Sentinel-5P TROPOMI satellite data processed through Google Earth Engine. Monthly concentration averages were examined across eight key locations using linear regression analysis to determine temporal trends, with Spearman’s rank correlation coefficients calculated between pollutant levels and five meteorological parameters (temperature, humidity, wind speed, atmospheric pressure, and precipitation) to determine the influence of political governance, economic conditions, and environmental sustainability factors on pollution dynamics. Quality assurance filtering retained only measurements with values ≥ 0.75, and statistical significance was assessed at a p < 0.05 level. The findings reveal distinctive spatiotemporal patterns that reflect the region’s complex political-economic landscape. NO2 concentrations exhibited clear political signatures, with opposition-controlled territories showing upward trends (Al-Rai: 6.18 × 10−8 mol/m2) and weak correlations with climatic variables (<0.20), indicating consistent industrial operations. In contrast, government-controlled areas demonstrated significant downward trends (Hessia: −2.6 × 10−7 mol/m2) with stronger climate–pollutant correlations (0.30–0.45), reflecting the impact of economic sanctions on industrial activities. CO concentrations showed uniform downward trends across all locations regardless of political control. This study contributes significantly to multiple Sustainable Development Goals (SDGs), providing critical baseline data for SDG 3 (Health and Well-being), mapping urban pollution hotspots for SDG 11 (Sustainable Cities), demonstrating climate–pollution correlations for SDG 13 (Climate Action), revealing governance impacts on environmental patterns for SDG 16 (Peace and Justice), and developing transferable methodologies for SDG 17 (Partnerships). These findings underscore the importance of incorporating environmental safeguards into post-conflict reconstruction planning to ensure sustainable development. Full article
(This article belongs to the Special Issue Study of Air Pollution Based on Remote Sensing (2nd Edition))
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17 pages, 7542 KiB  
Article
Accelerated Tensor Robust Principal Component Analysis via Factorized Tensor Norm Minimization
by Geunseop Lee
Appl. Sci. 2025, 15(14), 8114; https://doi.org/10.3390/app15148114 - 21 Jul 2025
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Abstract
In this paper, we aim to develop an efficient algorithm for the solving Tensor Robust Principal Component Analysis (TRPCA) problem, which focuses on obtaining a low-rank approximation of a tensor by separating sparse and impulse noise. A common approach is to minimize the [...] Read more.
In this paper, we aim to develop an efficient algorithm for the solving Tensor Robust Principal Component Analysis (TRPCA) problem, which focuses on obtaining a low-rank approximation of a tensor by separating sparse and impulse noise. A common approach is to minimize the convex surrogate of the tensor rank by shrinking its singular values. Due to the existence of various definitions of tensor ranks and their corresponding convex surrogates, numerous studies have explored optimal solutions under different formulations. However, many of these approaches suffer from computational inefficiency primarily due to the repeated use of tensor singular value decomposition in each iteration. To address this issue, we propose a novel TRPCA algorithm that introduces a new convex relaxation for the tensor norm and computes low-rank approximation more efficiently. Specifically, we adopt the tensor average rank and tensor nuclear norm, and further relax the tensor nuclear norm into a sum of the tensor Frobenius norms of the factor tensors. By alternating updates of the truncated factor tensors, our algorithm achieves efficient use of computational resources. Experimental results demonstrate that our algorithm achieves significantly faster performance than existing reference methods known for efficient computation while maintaining high accuracy in recovering low-rank tensors for applications such as color image recovery and background subtraction. Full article
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