Search Results (1,140)

Background: Previous research has linked hypertensive disorders of pregnancy (HDP) and long-term cardiovascular disease (CVD) with assisted reproductive technology (ART). It is not clear whether this reflects the background population cardiovascular profiles or whether ART independently increases the long-term risk for CVD and alters cardiovascular function. Furthermore, CVD has been associated with pathological cardiovascular function before and after the establishment of the disease. The aim of this study was to compare cardiac function in women attending for ART between those who had previous treatment and those who had not after controlling for demographic characteristics which have been shown to affect cardiovascular function. Methods: This was a prospective observational cohort study at a London fertility clinic. Women were consecutively enrolled between May 2021 and March 2022. Maternal demographics and cardiac function using transthoracic echocardiography were assessed before the current treatment cycle in the mid-luteal phase of the menstrual cycle. Maternal demographics included age, body mass index, smoking, race, and parity. Cardiovascular parameters included blood pressure and indices of left-ventricular systolic and diastolic function. Differences between cardiac variables after controlling for maternal demographics and history of previous ART were assessed by multivariate linear regression. Results: There were 232 healthy women who agreed to participate in the study; of those, 153 (58%) had undergone previous ART. After controlling for maternal demographic characteristics, previous assisted reproductive technology was not an independent predictor of cardiac function. Conclusions: Previous ART is not associated with significant changes in cardiac function. Full article

Precision oncology, also known as personalized oncology or precision medicine, is the tailoring of cancer treatment to individual patients based on the specific genetic, molecular, and other unique characteristics of their tumor. The goal of precision oncology is to optimize the effectiveness of cancer treatment while minimizing toxicities and improving patient outcomes. Precision oncology recognizes that cancer is a highly heterogeneous disease and that each patient’s tumor has a distinct genetic diversity. Precision medicine individualizes therapy by using information from a patient’s tumor in the context of clinical history to determine optimal therapeutic approaches and increasing numbers of drugs target specific tumor alterations. Several targeted therapies with approved companion diagnostics are commercially available, the haves of precision oncology, where predictive biomarkers guide clinical decision-making and improve outcomes. However, many therapies still lack clear biomarkers, the have nots, posing a challenge to fully realizing the promise of precision oncology. Herein, we describe the current state of the art for breast cancer precision oncology and highlight the therapeutic agents that require a more robust biomarker. Full article

Assessing the condition of artworks is a critical step in cultural heritage conservation that traditionally involves manual damage mapping, which is time-consuming and reliant on expert input. This study, conducted within the ChemiNova project, explores the automation of edge detection using both classical image processing techniques (Canny, Sobel, and Laplacian) and a deep learning model (DexiNed). The methodology integrates interdisciplinary collaboration between conservation professionals and computer scientists, applying these algorithms to artworks affected by environmental damage, including flooding. Preprocessing and post-processing techniques were used to enhance detection accuracy and reduce noise. The results show that while traditional methods often yield higher precision and recall scores, they are also sensitive to texture and contrast variations. These findings suggest that automated edge detection can support conservation efforts by streamlining condition assessments and improving documentation. Full article

The United Nations’ 2030 Agenda for Sustainable Development centers on the 17 Sustainable Development Goals (SDGs). Among these goals, two address climate change education: Goal 13, Climate Action, and Goal 4, Quality Education. In order to build a more sustainable future, climate change education is critical. In 2022, New Jersey became the first state in the US to integrate climate change into learning standards across subjects and grade levels K-12. In an effort to better understand the way in which teachers began to include climate change in their instruction, 50 teachers were observed implementing a lesson of their choosing that included climate change throughout the 2023–2024 academic year. Though most of the observed lessons featured science, many subject areas were included in the dataset, such as art, technology, history, and physical education. Teachers engaging in climate change instruction tended to use a variety of instructional practices. In nearly all cases, a multitude of methodologies were used in each lesson. However, small group instruction was featured in nearly all observed lessons. Quantitative descriptions of the findings are followed by three vignettes of exemplar instruction to provide a clearer understanding of the context of this work. These findings provide a scope for how climate change can be integrated in instructional settings at scale and suggestions for leveraging the experiences of early adopters of this innovation to support widespread implementation. Full article

The Western genre has traditionally been associated with American identity and male-dominated narratives. However, recent decades have seen increasing attention to female protagonists, particularly the European woman as a cultural mediator within the frontier context. This study aims to identify the archetypes of the European woman in the Western genre through a diachronic and comparative analysis of the visual language found in European painting from the late 17th to early 19th centuries and in 20th–21st century cinema. The research methodology combines narrative, visual, and semiotic analysis, with a focus on intermedial and intertextual parallels between visual art and film. The study identifies nine archetypal models corresponding to goddesses of the Greek pantheon and traces their transformation across different aesthetic systems. These archetypes, rooted in artistic traditions such as Baroque, Classicism, Romanticism, and others, reappear in Western films through compositional, symbolic, and iconographic strategies, demonstrating their persistence and ability to transcend temporal, medial, and geographical boundaries. The findings suggest that the woman in the Western genre is not merely a central character, but a visual sign that activates cultural memory and engages with deep archetypal structures embedded in the collective unconscious. Full article

The Buades Gallery (1973–2003) was not merely a commercial space in Madrid. In the history of art in Spain, it served as a professional and political node for Spanish conceptualism, an art form which, due to its idiosyncrasies, required its own channels of distribution. This article seeks to examine the trajectory of Mercedes Buades in alignment with this movement, re-evaluating her role from a feminist perspective and highlighting the importance of certain agents who have traditionally been invisibilised. To this end, a theoretical approach is adopted, following the sociology of art and the social history of art, paying particular attention to the contributions of Enrico Castelnuovo, Pierre Bourdieu and Núria Peist. These frameworks enable an analysis of the role of the gallerist as a structuring agent within the artistic field, capable of generating symbolic capital and establishing dynamics of production, circulation and consumption in the context of post-Franco Spain, a country that lacked a consolidated museum infrastructure at the time. Even so, Mercedes Buades established a model of gallery practice that, beyond its commercial dimension, contributed decisively to the symbolic configuration of contemporary art in Spain and formed part of a network of artistic visibility that promoted experimental art. Full article

The mosaic tesserae that are the topic of this study were found during an archeological excavation in a Roman villa at Aiano, in the municipality of San Gimignano, Tuscany (Italy). Many thousands of tesserae were found in the site in many different stratigraphic units (US). For this study, 392 tesserae mainly from three US (US 1095, US 5010 and US 5015 being the most consistent ones) were selected for non-invasive analyses. They might be tesserae coming from different places, collected to be reused or melted down to create new glass objects. The characterization of the tesserae, divided in various groups depending on their color, is an important tool in evaluating their compositional homogeneity/inhomogeneity. The presence of certain markers, such as the opacifiers based on Sb or Sn, could be helpful also in approximately dating the tesserae, since, as reported in the literature, various opacifiers were used in different periods. A well-established diagnostic protocol, based only on non-invasive techniques, allowed us to study a large number of tesserae, which certainly did not derive from a single mosaic and could have been of very different ages, compositions and origins. This procedure has proven to be a winning tool for this aim. Full article

This article examines the persistent conceptual and structural obstacles that pluralism faces within the Euro-United-Statesian art system, particularly in the fields of criticism, art history, and aesthetics. The study situates its inquiry within broader debates around the politics of difference and the decolonization of knowledge, aiming to understand how theoretical frameworks historically incorporated plurality in ways that ultimately neutralize its disruptive potential. Methodologically, the article combines philosophical analysis with a critical rereading of canonical texts by figures such as Clement Greenberg and Arthur Danto, juxtaposed with insights from Indigenous, Black, and decolonial thinkers. The findings suggest that pluralism, while rhetorically embraced, is frequently rendered compatible with a teleological and universalizing narrative that privileges Western aesthetic trajectories. As a result, forms of difference are tolerated only insofar as they can be translated into hegemonic terms. The article concludes by advocating for critical practices that sustain rather than resolve difference, calling for frameworks capable of embracing dissonance, incommensurability, and multiple ontologies without collapsing them into sameness. In doing so, it repositions the contemporary struggle over meaning in art not as a problem to be overcome, but as a necessary symptom of epistemic plurality. Full article

Background/Objectives: Although biallelic pathogenic variants in different DNAH gene family members have been associated with infertility, the role of DNAH12 in this disorder is still incompletely understood. To date, few patients have been shown to have infertility due to biallelic variants in this gene. Here, we report two more unrelated patients with infertility who carry homozygous variants in DNAH12. Methods: This study included two male patients with primary infertility and oligoasthenoteratozoospermia (OAT). Patient 1 was a 32-year-old with 1.5 years of infertility and no chronic illnesses or prior assisted reproductive technologies (ARTs). Patient 2 was a 49-year-old with 24 years of infertility, a history of varicocelectomy, and the occasional use of PRN analgesics for bone pain. Using genome sequencing, we identified two homozygous variants: c.3757C>A, p. Pro1253Thr, and c.11086-1G>A, p.?, in patients 1 and 2, respectively. Results: Our findings add supportive evidence that DNAH12 is a gene implicated in rare cases of male infertility. The identification of these homozygous variants in two additional patients supports the association between DNAH12 variants and reproductive dysfunction. Conclusions: This study highlights the need for further research on the role of DNAH12, including functional studies to clarify the mechanisms contributing to infertility. Full article

Past archaeological practices have resulted in a distorted history of Native American cultures based upon western-biased research. This has been especially apparent in the rock art of the Klamath Basin in southern Oregon and northern California. In response to this, Native and non-Native scholars are striving to develop a counter-discourse that both challenges and replaces western constructs in research on Native American communities. The result of this approach is a growing trend within the discipline that has come to be called “Indigenous Archaeology.” Critical to this approach is that Native voices are transported from the margins of the research to its center, where they are intended to replace the Western colonialist narrative. Unfortunately, Native American tribal communities have been the targets of federal assimilation policies for the past few centuries, and as a result, much of their cultural knowledge unwittingly carries forward this distorted past. In this paper I explore a framework built upon ethnographic accounts of shamanism and rock art, along with a robust familiarity with local myth, and how this provides a foundation of traditional cultural knowledge against which to compare and evaluate the interpretive statements made in contemporary tribal members about rock art and other sacred material culture. Full article

Background: The perceived importance of physical practice and its contribution to students’ academic success have evolved considerably throughout the history of the modern educational system. Aim: The purpose of this study was to understand the relationship between physical fitness (measured as VO₂max) and cognitive abilities (attention and concentration) and academic performance in different subjects: sciences, letters, language, arts, and physical education. Method: Fifty Spanish male students who participated in extracurricular sports activities (mean age (SD): 11.59 ± 1.30; range: 9–15 years) were included in the analysis. The 6 min walk test was used to assess physical fitness (6MWT), while for selective attention and concentration, the students completed the D2 test, which is usually considered to analyse the visual ability to select the most relevant stimulus of an exercise and ignore precisely the most irrelevant stimuli. Results: Correlation the individual contribution analyses revealed no significant associations between VO₂max and academic performance in sciences (r = 0.04, p = 0.77), humanities (r = 0.00, p = 0.98), language (r = 0.03, p = 0.83), or arts (r = 0.04, p = 0.76). Similarly, no relationship was found between VO₂max and overall academic performance (r = 0.10, p = 0.46), or cognitive abilities. However, a small positive correlation was observed between VO₂max and physical education scores. Conclusions: Physical fitness showed no significant association with cognitive abilities or academic performance in most subjects, although a small positive correlation with physical education scores was observed. These findings emphasise the importance of promoting physical activity for its health and physical benefits. However, future research should explore broader cognitive outcomes and include more diverse and representative samples. Full article

The TOWCHED project explores how arts and heritage-based educational methodologies can support sustainable development by enhancing key transversal competencies in learners, particularly children and youth. In response to the global challenges outlined in the sustainable development goals (SDGs), this project promotes inclusive and participatory approaches to education that foster social cohesion, intercultural understanding, and civic engagement. Partnering with museums, TOWCHED develops cross-curricular pedagogical interventions, such as experiential, blended, and collection-mediated learning, that link cultural heritage with contemporary social and environmental concerns. These approaches aim to strengthen creativity, critical thinking, collaboration, and self-awareness. TOWCHED demonstrates that heritage collection-based education can play a vital role in transforming schools and other learning environments into hubs for sustainable, lifelong learning. By embedding cultural expression and heritage into educational practices, the project offers a compelling model for empowering individuals to navigate and shape a more equitable and interconnected world. This paper has two aims. First, we introduce TOWCHED, an interdisciplinary project recently funded by the Horizon Europe program of the European Union to preserve and promote education for sustainability in the heritage context. Second, we introduce a set of tools related to the project. Full article

We introduce a model to gauge the implementation of the Sustainable Development Goals (SDGs) in the course syllabuses of university degree programmes. The model, comprising four category systems, is designed to analyse curricula that are still at an early stage of this process. The model is tested in Spanish public universities that offer master’s degrees in Advanced Studies in Art History. A conventional content analysis is performed on 762 competencies across 82 subjects in five institutions. The results show that (a) 0.92% of competency codes were aligned with the SDGs, while 13.25% were merely related to them; (b) 48.02% were affected by repetitions of supposedly different competencies; (c) there was a mean value of 9.29 competencies per subject, and modal values of 1 and 4 subjects in which each competency was addressed; and (d) only 26.12% of the competencies were associated with high-level cognitive processes. In conclusion, a thorough reconceptualisation and reorganisation of curriculum maps is needed to adapt them for the SDG framework. The first steps are to promote high-level cognitive processes associated with competencies, eliminate repetition, reduce the number of competencies, increase the number of subjects addressing each competency, and organise the competencies into different performance levels. Full article

The digitisation of cultural heritage has transformed how GLAM (Galleries, Libraries, Archives and Museums) institutions manage and share collections. Digital catalogues are indispensable for documenting and granting public access to cultural assets. However, integrating spatial data remains challenging due to the ambiguity, uncertainty, granularity, and heterogeneity of historical data. This study addresses these issues through a case study on the Museo de América’s “Place of Provenance” data, proposing a methodology for data cleaning and evaluating geocoding accuracy using Nominatim, ArcGIS, and GeoNames APIs. We assess these APIs by quantifying geocoding errors through a “balance sheet” method, identifying instances of over-representation, under-representation, or neutral results for geographical regions. The effectiveness of each API is analysed using confusion matrices and interactive cartograms, offering insights into misallocations. Our findings reveal varying accuracy among the APIs in processing heterogeneous historical spatial data. Nominatim achieved a 40.91% neutral result in correctly geocoding countries, underscoring challenges in spatial data representation. This research provides valuable methodological experiences and insights for researchers and GLAM institutions working with cultural heritage datasets. By enhancing spatial dispersion visualisation, this work contributes to understanding cultural circulations and historical patterns. This interdisciplinary work was developed as part of the ClioViz project, integrating Data Science, data Visualisation, and art history. Full article

The first book of Kings succinctly evokes—in only thirteen verses—the mysterious figure of a queen who came from the distant land of Sheba to test Solomon’s wisdom (1 Kgs 10.1–13). Who would have predicted that this modest episode celebrating the glory of the ancient kings of Jerusalem would be so popular? The episode has spread far beyond the boundaries of the two Testaments, notably in painting. Piero della Francesca’s fresco cycle in Arezzo is a fine example in this respect. Inspired by the Golden Legend, the Florentine painter recreates the scenes of the discovery of the true Cross. Solomon and the Queen of Sheba meet against the backdrop of the fall of Constantinople in 1453. Whether intra- or extra-biblical, ancient or modern, rereading of the original episode reveals issues that are as much historical as they are theological. Full article