Search Results (1,382)

Background: Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway represent an effective preventive treatment for chronic migraine, including in patients with multiple prior therapeutic failures. However, a substantial proportion of patients exhibit a suboptimal or delayed response. The role of personality traits in modulating treatment response remains poorly understood. Methods: In this prospective observational study, adults with chronic migraine received anti-CGRP monoclonal antibodies and were followed for 12 months. Monthly headache days (MHDs), monthly acute medication use (MAM), and disability scores (MIDAS and HIT-6) were recorded at baseline and at 3, 6, and 12 months. Responders were defined as patients achieving a ≥50% reduction in monthly headache days (MHDs) compared with baseline. Changes in disability measures were evaluated as secondary clinical outcomes. Personality traits were assessed using the Millon Clinical Multiaxial Inventory-III. Results: Thirty-eight patients were included, of whom 71% had medication overuse headaches. Responder rates increased over time (31.6% at 3 months and 39.5% at 12 months). Histrionic traits (37.5% vs. 6.7%, p = 0.048) and dysthymic features (21.4% vs. 0%, p = 0.046) were significantly more prevalent among non-responders. Conclusions: Histrionic and dysthymic personality features were associated with a lower likelihood of response to anti-CGRP therapy in patients with chronic migraine. Given the exploratory design, limited sample size, and absence of correction for multiple comparisons, these findings should be considered preliminary and hypothesis-generating. Further studies in larger cohorts are needed to confirm these observations. Full article

Background/Objectives: Developmental Language Disorder (DLD) is a persistent neurodevelopmental condition with an estimated prevalence of 7% in preschoolers. It is characterized by significant impairments in language acquisition and use, in the absence of an identified biomedical cause. The potential link between DLD and central auditory processing has encouraged the investigation of auditory evoked potentials as research tools; however, the existing literature remains notably dispersed and heterogeneous. To systematically synthesize evidence concerning auditory electrophysiological findings in children with DLD. Methods: Systematic searches were conducted in PubMed, Web of Science, and Scopus for studies published between January 2016 and March 2026. Keywords were combined using AND/OR operators. Two independent reviewers performed screening and data extraction, with discrepancies resolved through consensus. Risk of bias was assessed using the JBI tool for analytical cross-sectional studies. A structured narrative synthesis (SWiM) was applied to the findings. Results: Seven studies were included, with a combined total of 480 participants across all enrolled samples (including DLD, control, and other clinical subgroups), aged 2 years and 11 months to 10 years. The Frequency Following Response (FFR) appeared to show greater sensitivity, with alterations in both temporal components (waves C and D) and spectral components (F0 and F2), particularly under noise conditions. Findings for click-ABR were inconsistent across studies, suggesting limited sensitivity in cases of isolated DLD. Long-latency auditory evoked potentials (N2 and P300) exhibited prolonged latencies, potentially reflecting cortical immaturity and impaired attentional discrimination. The N400 potential suggested delayed or atypical semantic processing in a single investigation. Conclusions: The available evidence points toward a pattern of impairment in individuals with DLD that requires cautious interpretation, potentially encompassing subcortical, cortical, and linguistic encoding. Methodological heterogeneity across studies, combined with the absence of adolescent samples, highlights significant gaps in the current research regarding electrophysiology and DLD. FFR and Long-Latency Auditory Evoked Potentials (LLAEP/P300) assessments may warrant further investigation as auxiliary electrophysiological measures for the characterization of DLD, pending replication in larger and more homogeneous samples. Full article

Background/Objectives: Following the LACC trial, the role of minimally invasive radical surgery for early-stage cervical cancer remains controversial. Robotic-assisted approaches have been proposed as a potential strategy to preserve the benefits of minimally invasive surgery while incorporating contemporary oncologic precautions. This study compared perioperative, pathological, and early oncologic outcomes between robotic and open radical surgical management in patients with FIGO 2018 stage IA2–IIA1 cervical cancer. Methods: Patients underwent robotic surgery (n = 20; da Vinci Xi), including robotic radical hysterectomy, compartment-based procedures, and fertility-sparing surgery when clinically indicated, or open abdominal radical hysterectomy (n = 22). Perioperative outcomes, histopathological parameters (including lymphovascular space invasion [LVSI], lymph node status, and margin status), and early oncologic outcomes were evaluated. Exploratory multivariable regression analyses were performed to adjust for baseline differences, including age and tumor size. Results: Patients in the open-surgery cohort were older (56.23 ± 15.87 vs. 45.67 ± 9.31 years; p = 0.012) and had significantly larger tumors (3.07 ± 1.10 vs. 1.4 ± 0.7 cm; p = 0.003). Robotic surgery was associated with longer operative time (178 ± 42 vs. 150 ± 38 min; p = 0.028), lower blood loss (112 ± 61 vs. 518 ± 98 mL; p < 0.001), and shorter hospital stay (4.2 ± 1.6 vs. 6.2 ± 1.4 days; p < 0.001). The robotic cohort also demonstrated a higher lymph node yield (median 18 vs. 9; p < 0.001). No statistically significant differences were observed between groups in lymph node metastasis (20.0% vs. 22.7%; p = 1.000), LVSI (33.3% vs. 63.6%; p = 0.121), or R0 resection rate (100% vs. 95.5%; p = 1.000). In exploratory adjusted analyses, surgical approach was not associated with adverse pathological features, whereas tumor size emerged as an independent predictor of both lymph node metastasis and LVSI. No recurrences were observed in the robotic cohort during the available follow-up period. Conclusions: In this exploratory comparative cohort study, robotic radical surgical management in carefully selected patients with predominantly small-volume disease was associated with favorable perioperative outcomes and no statistically significant differences in pathological parameters compared with open surgery. Tumor size, rather than surgical approach, emerged as the principal predictor of adverse pathological features. Given the limited sample size, baseline imbalances between cohorts, heterogeneous robotic procedures, and absence of mature survival data, these findings should not be interpreted as evidence of oncologic equivalence and require confirmation in larger prospective studies. Full article

With a low cement dosage and a well-formed skeleton-dense structure, super-large-particle-size cement-stabilized macadam (CTB-50, maximum particle size of 53 mm) can effectively reduce base course cracking and construction costs. Nevertheless, the existing literature lacks research on the strength design criteria for CTB-50, and the absence of dedicated strength specifications currently limits its practical application. This study investigates the mechanical properties of CTB-50 and the stress levels in the (sub)base course under construction vehicle loading, based on the vertical vibration compaction method (VCM) and Miner’s fatigue cumulative theory. Aiming to prevent ultimate failure under a single load during construction and fatigue failure under repeated loading during both construction and operation, this study proposes strength criteria for CTB-50 to control fatigue damage. The 7-day compressive strength of CTB-50 specimens prepared using the VCM is approximately 90% of that of field core samples, whereas that obtained using the static-pressing method is less than 70% of the field core sample value. The mechanical strengths of CTB-50 specimens prepared via the VCM are highly correlated with those of on-site core samples. Based on the strength criteria for controlling ultimate failure during construction and fatigue failure during service, this paper proposes strength criteria for controlling the fatigue failure of CTB-50. Specifically, the 7-day splitting and compressive strengths of the base course for expressways and first-class highways should exceed 0.77 MPa and 7.6 MPa, respectively, while those of the sub-base course should exceed 0.71 MPa and 7.0 MPa, respectively. Full article

As digital beauty filters have become widespread among young people, their links with self-image cognition and behavioral responses have attracted growing attention. However, existing studies largely focus on Western samples or linear approaches, leaving Chinese youth underexplored in their cultural context. Using mixed methods combining grounded theory and fsQCA, this study examines the mechanisms shaping self-image cognition and behavioral responses among Chinese youth in the context of digital beauty filter use. Semi-structured interviews and three-stage coding identified four core categories: Beauty Filter Use Habits, Beauty Filter Use Motivations, Beauty Filter Use Preferences, and Psychological Responses to Beauty Filter Use. Building on this, fsQCA identified five configurational pathways. The psychological-response–motivation and psychological-response–preference core coexistence configurations were linked to high Self-Image Cognition; the three non-high Self-Image Cognition pathways formed two patterns: dual absence of psychological responses and motivations, and motivational-core absence with coexisting habits and preferences. Different self-image cognition outcomes may relate to adaptive behaviors, such as moderate retouching and naturalized self-presentation, or risk-related behaviors, such as avoidance of original images and overdependence on beauty filters. This study offers a new perspective on youth authentic self-construction and technological adaptation in the digital visual era, with implications for media literacy education, platform design, and mental health intervention. Full article

Background: Adults hospitalized with COVID-19, influenza A/B, or respiratory syncytial virus (RSV) frequently receive empirical antibiotics, but antibiotic prescribing, confirmed bacterial co-infection, antimicrobial resistance (AMR), and outcomes have not been jointly synthesized across these infections. Methods: We conducted a PRISMA 2020 systematic review and meta-analysis of 39 studies including 839,531 hospitalized adults. Random-effects models with Freeman–Tukey double-arcsine transformation pooled prevalence estimates; sensitivity and publication-bias analyses were performed where appropriate. Results: Pooled antibiotic use was 62.56% (95% CI, 53.75–70.97%) for COVID-19, 57.48% (25.76–86.09%) for influenza A/B, and 76.03% (67.62–83.53%) for RSV, with very high heterogeneity. Confirmed bacterial co-infection was lower: 5.31% (3.43–7.56%), 18.66% (9.98–29.30%), and 24.36% (18.53–30.70%), respectively. Prescribing-to-confirmed infection ratios ranged from 3.0 to 46.2. AMR evidence was restricted to COVID-19 studies and was dominated by carbapenem-resistant Gram-negative organisms, mainly in secondary, ICU-associated, or healthcare-associated infections. Confirmed bacterial complications were associated with ICU admission, longer hospitalization, and higher mortality. Conclusions: Antibiotic prescribing exceeded confirmed bacterial infection across all viral groups, but estimates require cautious interpretation due to heterogeneity, diagnostic uncertainty, observational evidence, and the absence of low-risk-of-bias studies. The evidence base was dominated by COVID-19 cohorts, while influenza A/B and RSV data, especially virus-specific AMR evidence, remain limited. COVID-19-specific AMR findings should not be generalized to influenza A/B or RSV. Virus-specific stewardship should prioritize rapid diagnostics, systematic sampling, reassessment, and de-escalation when bacterial infection is not confirmed. Full article

Background: SARS-CoV-2 infection has been linked to an increased risk of hypertensive disorders during pregnancy, particularly preeclampsia (PE). As both conditions involve vascular and endothelial dysfunction, a mechanistic overlap has been proposed. This study examines the relationship between maternal COVID-19 and preeclampsia by analyzing inflammatory, endothelial, and angiogenic biomarkers in pregnancies with and without these complications. Methods: A case–control study was conducted, including four groups: healthy pregnancies before 2020 (n = 10), preeclampsia cases before 2020 (n = 10), COVID-19 cases without preeclampsia (n = 10), and COVID-19 cases with preeclampsia (n = 10). The groups were selected to be comparable in terms of gestational age at blood sampling. Biomarkers related to endothelial, inflammatory, and angiogenic pathways were measured. Results: Significant differences in biomarker levels were detected among the four groups. Regarding endothelial damage, sICAM1 levels were significantly higher in the COVID-PE group compared with the COVID-noPE group (p = 0.002). Additionally, vWF (p = 0.006), END1 (p < 0.001), and sVCAM1 (p = 0.030) levels varied significantly across groups. IL8 levels showed significant differences (p < 0.001), and were particularly elevated in preeclampsia cases (preCOVID-PE and COVID-PE groups) compared with controls (p = 0.005 and p < 0.001, respectively). Angiogenic markers sFlt-1, PLGF, and sFlt-1/PLGF exhibited significant group differences (p < 0.001). In contrast, maternal SARS-CoV-2 infection in the absence of preeclampsia was not associated with a significant alteration of the sFlt-1/PlGF ratio. Discussion: PE associated with SARS-CoV-2 infection preserved the classical angiogenic signature of preeclampsia, but showed additional endothelial and inflammatory biomarker alterations. These findings support an association between SARS-CoV-2 infection and a distinct endothelial and inflammatory biomarker profile in PE, warranting confirmation in larger prospective studies. Full article

Background: Perceived inequity in work allocation has well-documented consequences for nurse job satisfaction, organizational commitment, and patient safety. Despite this recognition, empirical research examining how nurses in Middle Eastern healthcare contexts conceptualize allocation justice remains limited. This qualitative study explored Saudi registered nurses’ perceptions of work allocation justice, identified the organizational factors shaping those perceptions, and examined their implications for nurse well-being and quality of care. Methods: A qualitative design employing reflexive thematic analysis was used, grounded in constructivism. Semi-structured individual interviews were conducted with 17 purposively sampled registered nurses from three Riyadh-based healthcare facilities. Credibility was established through data, method, and analyst triangulation; peer debriefing; and member checking (12 of the 17 participants were purposively selected for member checking to represent the full range of experiences; 11 of those 12 confirmed thematic plausibility). Thematic saturation was reached at interview 13. Results: Six interconnected themes emerged: (1) Understanding Work Justice; (2) Personal Experiences; (3) Influencing Factors; (4) Psychological and Professional Impacts; (5) Institutional and Administrative Support; and (6) Future Perspectives. Participants define fairness as contextual equity and relational respect rather than simple numerical equality. Inequities were driven by staffing constraints, leadership styles, and policy gaps, leading to burnout and reduced organizational commitment. Conclusions: Saudi nurses experience meaningful allocation inequities arising from structural constraints, leadership variability, and the absence of written allocation policies. Addressing these inequities requires coordinated action on policy transparency, objective criteria, and psychologically safe communication channels. These findings provide contextually grounded, evidence-informed guidance for developing equitable nursing work environments that support workforce retention and patient safety. Full article

Heavy and highly viscous oils account for a significant proportion of the world’s hydrocarbon reserves. The development of these reserves in harsh climates is associated with technological risks due to paraffin deposits and equipment corrosion. Ensuring reliable transportation requires operational monitoring of the physical and chemical properties of fluids directly at the wellhead. Traditional laboratory methods such as SARA fractionation and gas chromatography (GC) are time-consuming and can yield to distortions in the sample composition during transportation. Field optical methods, such as an infrared (IR) spectroscopy are complicated by the optical heterogeneity of crude oils due to emulsified water, supramolecular associations of resins, asphaltenes, and paraffins. In this paper, ultrasonic (US) sample preparation for high-viscosity oils is justified as a method for increasing the reliability and information content of field IR spectroscopic analysis by unmasking the diagnostic extrema of absorption bands that are initially distorted by emulsified water, baseline scattering, and radiation scattering from large resin–asphaltene–paraffin aggregates. The technique is based on cavitation-induced destruction of emulsion shells and disaggregation of the structural framework without volume thermal heating. Experimental data obtained from watered high-viscosity oil has shown that 9 min of the US exposure reduces the light scattering index $I_{\mathrm{t}\mathrm{r}\mathrm{s}}$ by 92.83%, bringing the system into a less heterogeneous state. Statistical correlation analysis confirmed that emulsions and aggregates are the main scattering centers, and their destruction correlates directly with the transparency of the medium. Stability of spectral indices $I_{{\mathrm{C}\mathrm{H}}_3/{\mathrm{C}\mathrm{H}}_2}$, $I_{\mathrm{f}\mathrm{o}\mathrm{c}}$ and $I_{\mathrm{C}=\mathrm{O}}$ indicates the absence of chemical degradation or oxidation at the US exposure intensity of 0.12 W/mL, confirming the physical nature of the effect. The proposed method makes it possible to implement automated monitoring of the properties of high-viscosity oil directly at the wellhead, minimizing logistic costs and risks of the sample degradation. The practical significance of the proposed method is to improve the reliability and information content of wellhead monitoring by reducing optical heterogeneity and making diagnostic significant IR absorption extremes more distinguishable for further interpretation. Full article

Background/Objectives: People aging with HIV (PAWHs) face distinct health challenges, including early onset of aging and heightened risk for chronic comorbidities despite effective antiretroviral therapy (ART). However, significant gaps persist in understanding the lived experience and how PAWHs perceive the interplay between their controlled HIV and the aging process. This study examined PAWHs’ illness perceptions of aging, health, and relationship of HIV to other health conditions. Methods: Semi-structured interviews were conducted with a convenience sample of 25 PAWHs (mean age 63.5; mean time living with HIV 22.3 years; 24 virally suppressed) recruited through an academic HIV specialty clinic. Demographic and clinical data were collected from Electronic Health Records (EHRs), and interviews were analyzed using inductive thematic analysis. Results: A central finding was the disconnect between participants’ illness perceptions of controlled HIV and other aging-related health concerns. Absence of acute somatic symptoms and sustained viral suppression fostered a view of HIV as chronologically remote, leading to an apparent unawareness of HIV’s systemic links to accelerated aging and comorbidities. Two primary themes around aging emerged: acceptance/disengagement and fear of future debility (prevalent among older, socially isolated individuals concerned about dementia and finances). Conclusions: This pervasive disconnect, understandable through the lens of the Common Sense Model of Self-Regulation, highlights a critical need to adjust health counseling strategies for PAWHs. Clinicians can leverage existing trusted provider relationships to explicitly address and refine PAWHs’ illness models, clarifying that viral suppression is not a cure and educating on HIV’s systemic links to chronic conditions (e.g., ‘inflammaging’). Tailored educational interventions are crucial for fostering shared decision-making, encouraging early screening, and improving health outcomes for this vulnerable and growing population. Generalizability may be limited by sample characteristics. Full article

Background/Objectives: Semaglutide and tirzepatide demonstrate substantial efficacy in obesity treatment, yet individual responses vary markedly. The incretin system—comprising glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)—is frequently dysregulated in obesity, but whether fasting incretin levels predict differential pharmacological responses remains unexplored. We investigated whether combinatorial fasting GLP-1/GIP tertile profiles predict the initial weight-loss response to semaglutide versus tirzepatide in patients with severe obesity. Methods: This prospective, parallel-group, open-label pilot study enrolled 90 treatment-naïve patients with BMI > 40 kg/m² (mean 42.5 ± 3.5 kg/m²) at the University of Catania, Italy. Fasting serum GLP-1 (0.8–50 pg/mL) and GIP (1–16 ng/mL) were measured by chemiluminescence immunoassay and distributed into tertiles, generating nine combinatorial profiles (P1–P9; n = 10 per profile). Within each profile, five patients were randomly assigned to semaglutide (escalated to 2.4 mg/week) or tirzepatide (escalated to 15 mg/week). Primary outcome was pharmacological response category at six months: low (<5% body weight reduction), intermediate (5–15%), or optimal (>15%). Results: Baseline characteristics were balanced across profiles (age 48 ± 8 years, BMI 42.5 ± 3.5 kg/m², waist circumference 134 ± 12 cm, HOMA-IR 8.5 ± 3.0; all p > 0.05). Tirzepatide achieved optimal response in profiles with low GIP tertile regardless of GLP-1 level (P1, P6, P8), while semaglutide achieved optimal response when GLP-1 was low and GIP was intermediate-to-high (P4, P5). Both drugs showed low response in the high GLP-1/high GIP profile (P3). Mean weight loss in optimal-response groups was 18.2 ± 2.1% for tirzepatide and 16.8 ± 1.9% for semaglutide. Waist circumference reductions paralleled weight loss patterns. HOMA-IR decreased significantly in all optimal-response groups (mean reduction 4.2 ± 1.1 units). Conclusions: In this hypothesis-generating pilot study, fasting GLP-1/GIP combinatorial profiling, obtained from a single fasting blood sample, was associated with differential pharmacological responses to semaglutide and tirzepatide in severe obesity. Low GIP levels were tentatively associated with optimal tirzepatide response; low GLP-1 with intermediate-to-high GIP was tentatively associated with optimal semaglutide response. These preliminary findings provide proof-of-concept for incretin-guided personalised obesity pharmacotherapy but require confirmation in larger, adequately powered randomised trials before any clinical recommendations can be made. The inability to discriminate incretin secretory deficiency from receptor resistance using fasting measurements alone, the absence of a placebo control, and the six-month follow-up (shorter than the 12–18 months at which maximal efficacy is typically observed) remain critical limitations. Full article

Background: Simultaneous pancreas–kidney (SPK) transplantation can restore renal function and insulin independence, but non-technical pancreas graft dysfunction remains difficult to anticipate. Methods: We conducted an exploratory single-centre retrospective biomarker-modelling study to determine whether day-zero recipient serum Fourier-transform infrared (FTIR) spectra are associated with subsequent loss of insulin independence after SPK transplantation. Results: Among 104 screened recipients, 51 met predefined sample-availability, spectral-quality, data-linkage and endpoint-adjudication criteria; 30 maintained pancreas graft function and 21 developed dysfunction. Cases dominated by early technical surgical failure were excluded. Clinical-only, FTIR-only and FTIR–clinical Naïve Bayes models were evaluated using leave-one-out cross-validation with Fast Correlation-Based Filter feature selection. In locked-feature internal validation, the best FTIR-only model used second-derivative spectra with vector normalization and nine selected wavenumbers, achieving AUC 0.997 (95% CI 0.985–1.000) and accuracy 0.961 (95% CI 0.902–1.000). A fixed-feature permutation analysis exceeded label-randomized performance (empirical p = 0.001). The secondary Group 1 versus Group 3 analysis suggested discrimination of pancreas dysfunction despite preserved kidney function (AUC 0.992; accuracy 0.930). Conclusions: Given the small cohort, high-dimensional input, non-nested feature selection, selection-bias risk and absence of external validation, serum FTIR should be considered a candidate risk-enrichment platform requiring prospective multicentre validation. Full article

Background/Objectives: Reconstruction of full-thickness soft-tissue defects of the heel can be challenging due to the specific structural and functional demands of this region. Local flaps are often used due to their ability to provide durable and sensate coverage. This case series and systematic review aim to assess their surgical efficacy and reported outcomes, particularly in the context of the rhomboid flap. Methods: A systematic review was conducted in accordance with PRISMA guidelines, using PubMed, Cochrane and EBSCO. Studies published up to March 2026 evaluating local flaps were included, whereas distant pedicled and microvascular flaps were excluded. Defect size, flap types and surgical outcome were extracted and synthesized in a comparative table. In addition, we present four clinical cases of full-thickness soft-tissue heel defects reconstructed with a local rhomboid flap. This retrospective, single-center case series includes patients treated at our institution between January 2023 and March 2026, with initial debridement followed by flap coverage. Results: The four patients had a mean defect size of 4.1 cm². All defects ultimately healed, though one case demonstrated delayed wound healing. Eventually, neither donor-site morbidity, nor recurrence were observed during a mean follow-up of 7.4 months (range 1 to 17 months). Nine studies were included in the review, encompassing 56 patients. Despite the variety of the studies regarding design and flaps used, all focused on outcomes, including flap survival, complication rate, and functional recovery. Local flaps appear to be a feasible option for this type of soft-tissue defect; however, they seem to be limited to small defects. Conclusions: Local flaps may represent a valuable option for small full-thickness heel defects up to 6 cm² according to the “like-with-like” principle. They are associated with low surgical morbidity and do not compromise subsequent reconstructive options, making them a reasonable first-line approach. Limitations include the small sample size, retrospective design, the unequal follow-up time, as well as the absence of standardized functional outcome assessment. Full article

Background/Objectives: Alcohol-related frequent attenders (ARFAs) constitute a small but resource-intensive emergency department (ED) population. Methods: Following PRISMA-ScR guidelines, we searched MEDLINE, PsycINFO, CINAHL Complete, and EMBASE from inception to May 2025 for empirical studies examining ED frequent attendance with alcohol involvement. Definitions had high heterogeneity; therefore, narrative synthesis was conducted. Results: A total of 73 studies were included, most retrospective (57.5%), encompassing sample sizes from 14 to over 4.1 million participants: 59 frequent attender (FA) studies with alcohol subgroup analyses and 14 pure ARFA studies. Research was concentrated in North America and Europe (56/73, 76.7%), with limited Asia-Pacific representation (21.9%). Seven distinct definition threshold categories were identified (≥2 to ≥20 visits annually); 31.5% utilised different definitions. Qualitative studies (n = 6) identified push factors (dependence, mental health crises, housing instability, fragmented services) and pull factors (24/7 access, crisis care model, immediate service) driving frequent attendance. Eight studies evaluated interventions; all employed non-randomised designs examining case management, integrated pathways, and community-based treatments. Conclusions: Critical gaps include the absence of standardised definitions for comparison across studies, a concentration of research in Western settings limiting global applicability, and insufficient rigorous intervention evidence. Priorities include developing empirically validated definitions, expanding non-Western research, and conducting randomised controlled trials with adequate follow-up. Full article

Background/Objectives: Patients with breast cancer undergoing chemotherapy with taxanes or platin derivates often develop peripheral neuropathy (CIPN). Higher-grade CIPN generally affects the patient’s quality of life. Because the treatment options for CIPN are limited, early diagnosis is desirable to allow for timely modifications of the treatment. This may be facilitated with scoring tools that are ideally usable by the patients. A prospective study suggested that a recently developed self-assessment tool might be able to reveal the difference between the absence of CIPN and higher-grade CIPN. When CIPN has reached an advanced grade, alteration of the chemotherapy regimen may have only a limited effect. Therefore, it is important to know whether the new scoring tool can identify CIPN even when it is still mild. The current trial (NCT07604441) aims to identify the optimal cutoff point value for detecting mild CIPN. Given the limited sample size, the derived cutoff will be considered preliminary and will require validation in a larger independent cohort. Methods: The NEURO-BREAC-02 trial aims to identify the optimal cutoff point value of the new tool to distinguish between absent and mild CIPN after treatment with taxanes for breast cancer. Scores ranging between 0 and 44 points are reported via self-assessment supported by a neuropathy tracker. Secondly, the satisfaction of participants with the self-assessment tool is evaluated. Twenty-six participants (19 with mild CIPN and 7 without CIPN) are required, and 28 must be enrolled. Conclusions: The outcomes of the NEURO-BREAC-02 trial are considered crucial for the creation of a self-assessment tool to identify mild CIPN in patients with breast cancer and are a necessary addition to the preceding NEURO-BREAC study. Full article