Search Results (5,516)

In this study, corn protein hydrolysates (CPT) were prepared via enzymatic hydrolysis using Alcalase and Protamex, and then fractionated by ultrafiltration into three molecular weight components: >5 kDa (CPT1), 3–5 kDa (CPT2), and <3 kDa (CPT3). The physicochemical, functional and in vitro antioxidant properties of each component were systematically compared. Subsequently, glutamine peptides were isolated and identified from CPT3 using LC-MS/MS technology, and the structural characteristics of the identified peptides were further analyzed. The results showed that the ultrafiltration fractionation effectively enriched peptides with lower molecular weights from the enzymatically hydrolyzed products, which may potentially enhance their bioavailability. In addition, CPT3 exhibited superior foaming ability, emulsifying ability, dispersibility, and zeta potential, along with lower particle size and viscosity. Moreover, CPT3 exhibited strong antioxidant activity, with IC₅₀ values for ABTS radical scavenging and hydroxyl radical scavenging of 0.042 ± 0.003 mg/mL and 0.807 ± 0.019 mg/mL, respectively. Finally, 205 glutamine peptides were further identified from CPT3, and their structural characterization revealed that the identified peptides were rich in hydrophobic amino acids and had a high affinity for membrane proteins, which could serve as potential ligands for regulating intestinal barrier dysfunction. In summary, CPT3 possesses excellent functional properties and antioxidant activity, indicating its potential for development and application in functional and health foods. Full article

Background: Nanotechnology, a multidisciplinary science, has diverse applications in biology, physics, and medicine. SeNPs have only recently been explored. Understanding how modifications to SeNPs affect toxicity is beneficial for therapeutic applications. This study involves a novel one-pot chemical synthesis of SeNPs using biodegradable precursors, sodium selenite and ascorbic acid, at predetermined molar ratios, followed by polymer modification. Results: All SeNPs were spherical with favorable sizes (<114 nm) and polydispersity indices (PDI < 0.4). Functionalization improved the zeta potential of the SeNPs (−34.4 to 91.1 mV), together with a smaller size and increased PDI. Cytotoxicity was size-, cell-, dose-, and time-dependent. Functionalized SeNPs showed good cell viability at low concentrations, with toxicity at higher concentrations compared to the unmodified SeNPs. SeNPs synthesized using excess sodium selenite exhibited enhanced toxicity, particularly in neuroblastoma cells. SeNPs induced a significant increase in reactive oxygen species, with G1/G0 cell cycle arrest and apoptosis in human embryonic kidney cells, and necrosis and apoptosis in neuroblastoma and cervical carcinoma cells. Conclusion: The physicochemical and toxicity profiles of SeNPs depend on precursor molar ratios and polymer concentration. Hence, studying the released ions and the polymer-core association will enable the personalized synthesis of SeNPs to achieve the desired therapeutic outcomes. Full article

This study investigates the effectiveness of using an interpolymer complex based on a synthetic polycation—Metacid (polyhexamethylene guanidine hydrochloride) and a natural biopolymer—chitosan for anti-erosion soil structuring in the Maktaaral district of the Turkestan region. Using the conical plastometry method, the critical concentration of structure formation in the soil suspension was determined to be 67.5%; for subsequent studies, the solid phase content was taken to be 70%. Rheological studies have revealed a pronounced synergistic effect of the combined use of Metacid and chitosan. If the initial soil–water system is characterized by low elastic moduli (E1, E2 ~ 10⁴ Pa), then the introduction of the “Metacid–chitosan” interpolymer complex leads to a sharp strengthening of the structure: The values of E1 and E2 increase to 3.26·10⁶–7.49·10⁶ Pa and 1.04·10⁶–1.46·10⁶ Pa, respectively. The mechanical stability limit increases by more than twofold, reaching 2000–2500 Pa. Analysis of the ζ-potential and electrical conductivity showed that the Metacid ensures a high positive charge of the complex (+21.76 … 28.69 mV), and chitosan acts as a spatial matrix. Experiments in a wind tunnel have confirmed that the “Metacid–chitosan” formulation, at an optimal concentration of 0.4%, provides effective protection of soil aggregates against wind erosion. The results obtained open up new prospects for using ecologically balanced interpolymer complexes to stabilize arable lands. Full article

In this study, zein–curdlan (CU) composite nanoparticles were fabricated via an anti-solvent precipitation method. The effects of preparation parameters, including the mass ratio, reaction pH, and temperature, on the physicochemical properties and emulsifying attributes of the composite particles were systematically investigated. Fourier-transform infrared (FTIR) and X-ray diffraction (XRD) analyses revealed changes in the local molecular environment and molecular organization following zein–CU association, while particle size, zeta potential, and surface hydrophobicity measurements further demonstrated fabrication-dependent changes in the physicochemical characteristics of the composite particles. As the CU ratio increased, the zeta potential decreased to −25.5 mV, accompanied by a reduction in surface hydrophobicity, suggesting a more hydrophilic CU-associated particle surface. At pH 8, the particles showed the smallest size among the pH series (244.6 nm), which may be related to enhanced zein deprotonation and interparticle electrostatic repulsion under the tested conditions. A preparation temperature of 40 °C produced the smallest particles and the most favorable emulsifying properties among the temperatures examined. Overall, this work provides evidence for the formation and emulsifying performance of zein/CU composite particles, broadening the application of plant protein–polysaccharide complexes in food-grade Pickering emulsion systems. Full article

The zinc oxide nanoparticles (ZnO NP) were synthesized from zinc acetate using potato starch as a capping agent through alkaline sol–gel precipitation, without calcination. The produced nanoparticles were characterized using various analytical techniques, including UV–visible absorption spectroscopy (UV-vis), zeta potential analysis, dynamic light scattering (DLS), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM). The ZnO NP exhibited an absorption maximum at 361 nm in the UV-vis spectrum, a z-average value of 138.1 nm and a zeta potential value of −23.8 mV as measured by DLS. The XRD pattern revealed distinctive diffraction peaks corresponding to the hexagonal wurtzite crystal structure characteristic of ZnO. FTIR analysis indicated that NP were capped with hydroxyl functional groups from the starch. The produced NP were quasi spherical, with sizes ranging from 20.7 to 38.1 nm and a mean particle size of 30.6 ± 5.1 nm. The potential application of ZnO NP as a photocatalyst was studied under UV light at 365 nm for the decolourization of tartrazine, a model azo food dye. The effects of varying concentrations of the catalyst (900–4500 µg/mL), tartrazine (2.5–10 µg/mL) and reaction time (30–120 min) on tartrazine removal were monitored using UV-vis at 426 nm. Under optimum conditions of 2700 µg/mL NP, 7.5 µg/mL tartrazine and a reaction time of 90 min, a 92% removal was achieved, with a rate constant (k) of 0.0135 min⁻¹. Additionally, the bactericidal activity of the NP against Escherichia coli and Bacillus subtilis was investigated using the resazurin broth method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values against E. coli and B. subtilis were 2700 and 1800 µg/mL and 3600 and 2700 µg/mL, respectively. Thus, the current study highlights the calcination-free, potato starch-capped sol–gel synthesis and the bifunctionality of ZnO NP as a recyclable photocatalyst and a bactericide for the decolourization of dyes and pigments, as well as for the bacterial disinfection of food industry wastewater effluents. Full article

Aims: Morin is a flavonoid with potential neuroprotective and anti-inflammatory properties. This study evaluated the anticonvulsant and anxiolytic effects of morin-loaded PLGA-chitosan nanoparticles (Morin-PLGA-CS NPs) in male Wistar rats. Methods: Morin-PLGA-CS NPs were synthesized using a modified single emulsion-solvent evaporation method followed by CS coating. NPs were characterized by dynamic light scattering (DLS), scanning electron microscopy (SEM), and in vitro drug release analysis. Adult male Wistar rats received intraperitoneal injections of free morin (25 mg/kg), Morin-PLGA-CS NPs, diazepam (1 mg/kg), blank NPs, or vehicle. Behavioral assessments included the open-field test (OFT), elevated-plus maze (EPM), novel object recognition (NOR) test, and pentobarbital-induced sleep test. Anticonvulsant activity was evaluated using PTZ-induced seizure latency. Cytokine concentrations in cortical and hippocampal tissue lysates were quantified by ELISA at 12 h post-PTZ. Hippocampal relative mRNA expression of Nrf2, HO-1, GFAP, and Iba1 was quantified by quantitative real-time PCR (qRT-PCR). Results: Morin-PLGA-CS NPs demonstrated a hydrodynamic diameter of 221.6 nm, a zeta potential of +23.3 mV, and an encapsulation efficiency of 81%. FTIR spectroscopy showed spectral changes compatible with morin incorporation and possible hydrogen-bonding interactions. The NPs exhibited approximately 81.4% morin release over 72 h in vitro. Compared to free morin, Morin-PLGA-CS NPs increased center-zone exploration in the OFT and open-arm behavior in the EPM, but also reduced total distance traveled in the OFT, indicating that motor suppression or sedation may have contributed to the behavioral profile (p < 0.001). It also improved the discrimination index (DI) in the NOR test and elevated sleep duration in the pentobarbital test (p < 0.001). The NPs also prolonged seizure latency (137.2 s vs. 114.5 s for free morin; p < 0.001) and markedly reduced IL-1β, IL-6, and TNF-α levels in both the cortex and hippocampus. At the molecular level, Morin-PLGA-CS NPs were associated with significantly increased hippocampal Nrf2 and HO-1 mRNA transcript levels and decreased GFAP and Iba1 transcript levels relative to free morin and the PTZ-challenged vehicle control group. Conclusions: Morin-PLGA-CS NPs produced greater behavioral, anticonvulsant, inflammatory, and redox effects than free morin in male rats. Molecular data revealed changes in hippocampal mRNA expression, including increased Nrf2 and HO-1 transcripts and decreased GFAP and Iba1 transcripts. However, these transcript-level findings are preliminary and require protein-level validation. Full article

Background: Dimethyl fumarate (DMF) is an approved therapeutic agent for the treatment of multiple sclerosis, known for its anti-inflammatory and neuroprotective properties. However, its oral administration is often accompanied by gastrointestinal side effects, limiting its therapeutic potential. In the present study, a novel nanoemulsion (NE) formulation was developed and characterized with the aim of enhancing DMF exposure in the cerebrospinal fluid (CSF) following intranasal administration. Methods: The formulation was prepared via a self-emulsification method using geraniol (GER) as the oil phase, selected for its antioxidant properties, and chitosan oleate as a mucoadhesive stabilizer and absorption promoter. Physicochemical characterization, in vitro release, RPMI 2650 cell cytotoxicity, and permeability were evaluated. Finally, an optimized NE (1.08 ± 0.02 mg/mL DMF and 0.28 ± 0.01 mg/mL GER) was administered intranasally to adult male Sprague–Dawley rats to assess DMF and GER exposure in the CSF. Results: The NEs exhibited optimal physicochemical properties: a mean particle size of approximately 170 nm, a polydispersity index below 0.3, and a positive zeta potential (above 20 mV). Spectroscopic and thermal analyses confirmed GER and DMF compatibility and a reciprocal enhancement of stability. In vitro drug release studies revealed a fast release profile, with 81% of DMF released within 2 h, aligning with the rapid absorption expected from nasal administration. Cytotoxicity assays showed high biocompatibility (>86% viability up to 50 µM DMF), while permeability studies demonstrated significant absorption, with 60% of DMF and 90% of GER absorbed within 2–3 h, favored by smaller droplet size. In rats, intranasal delivery achieved maximum CSF concentrations of ~8 µg/mL for DMF and ~1.5 µg/mL for GER within 2 h. Conclusions: These findings provide pharmacokinetic proof-of-concept supporting further investigation of this intranasal formulation for CNS delivery of DMF. Full article

Background/Objectives: Canine superficial pyoderma is one of the most common dermatological diseases in dogs and is increasingly complicated by antimicrobial resistance. This study aimed to develop ethyl lauroyl arginate-integrated lipid-based nanoparticles (LAE-LBNs) as a non-antibiotic topical delivery platform and to evaluate their physicochemical stability, skin localization, and antimicrobial activity against clinically relevant canine skin pathogens. Methods: LAE-LBNs were prepared using high-shear homogenization followed by probe ultrasonication and characterized for particle size, polydispersity index, zeta potential, morphology, encapsulation efficiency, and storage stability. Antimicrobial activity was evaluated against methicillin-susceptible Staphylococcus pseudintermedius (MSSP), methicillin-resistant S. pseudintermedius (MRSP), and Malassezia pachydermatis. The ex vivo distribution of Nile Red-labeled formulations was assessed in porcine ear skin using fluorescence microscopy. Results: The optimized 5% LAE-LBN formulation exhibited a relatively small particle size, narrow size distribution, strongly positive surface charge (+46.49 mV), encapsulation efficiency exceeding 99%, and favorable physicochemical stability over two months. Fluorescence associated with the labeled LAE-LBN formulation was observed in the stratum corneum, viable epidermis, and hair follicles, whereas the aqueous control formulation was predominantly confined to the stratum corneum. LAE-LBNs exhibited bactericidal and fungicidal activity against MSSP, MRSP, and M. pachydermatis, with an MBC or MFC of 12.2 µg/mL. These endpoints were identical to those obtained for aqueous LAE, indicating that incorporation into the lipid-based nanocarrier preserved the antimicrobial activity of LAE. Conclusions: LAE-LBNs combined favorable physicochemical properties, follicular localization, and activity against bacterial and fungal canine skin pathogens. These findings support their further investigation as a non-antibiotic topical delivery platform for canine superficial pyoderma. Full article

The presence of polyvinyl chloride (PVC) micro/nanoplastics (MNPs) in water poses significant environmental and public health challenges, making their effective removal a pressing research problem. This study investigates the integration of air nanobubble pretreatment with conventional coagulation–flocculation–flotation as a strategy for PVC MNP remediation. The novelty of this study lies in validating nanobubbles as dual-function agents, serving simultaneously as chemical surface modifiers and physical flotation enhancers, within an integrated treatment process. Nanobubble exposure altered the physicochemical properties of PVC particles by reducing particle size, decreasing the magnitude of their negative zeta potential, and introducing oxygenated functional groups that enhanced surface reactivity and subsequent coagulation–flocculation. Among the tested coagulant/flocculant systems, polyaluminum chloride (PAC) combined with polyacrylamide (PAM) achieved the highest clarification efficiency, removing approximately 88–90% of turbidity. In comparison, Alum–PAM and ferric chloride (FeCl₃)–PAM systems exhibited lower removal efficiencies of 72–75% and 68–70%, respectively, under the tested flotation conditions. Flotation further promoted separation through nanobubble–particle and bubble–floc interactions. Fourier-transform infrared spectroscopy (FTIR) confirmed surface oxidation and changes in the interfacial chemistry of the recovered PVC-containing flocs. According to the results, the integrated process effectively combines physicochemical surface modification, electrostatic destabilization, polymer-assisted aggregation, and bubble-assisted flotation, with PAC–PAM under nanobubble pretreatment emerging as the most efficient configuration. Future research should focus on scaling to pilot/full-scale systems, testing real wastewater matrices, and evaluating long-term stability and energy efficiency. Full article

Liposomal drug-delivery systems can improve the formulation performance of poorly soluble compounds by enhancing aqueous dispersion, protecting encapsulated agents, and modifying release behavior. Co-encapsulation of pharmacologically distinct compounds may provide a formulation strategy for comparing combined delivery with a single agent nanoliposomal system. This study aimed to develop and characterize atorvastatin–rutin co-loaded nanoliposomes and to compare their antioxidant, anti-inflammatory, and SRB-based cytotoxic activity with the corresponding free-drug and single-loaded nanoliposomal formulations. Nanoliposomes were prepared by thin-film hydration and characterized by particle size, polydispersity index, zeta potential, encapsulation efficiency, lyophilization-associated retention of encapsulation efficiency, morphology, and in vitro release. A reverse-phase HPLC method was validated for simultaneous atorvastatin and rutin quantification, and lyophilized formulations were evaluated for retention of encapsulation efficiency. In vitro assays included DPPH radical scavenging, nitrite inhibition in LPS-stimulated RAW 264.7 macrophages, and SRB-based cytotoxicity screening across human cancer cell lines and normal periodontal ligament fibroblasts. The co-loaded nanoliposomes achieved encapsulation efficiencies of 88.46% for atorvastatin and 81.74% for rutin; after lyophilization, encapsulation efficiency decreased to 72.31% for atorvastatin and 76.63% for rutin. The nanoliposomal formulations showed measurable DPPH radical-scavenging activity, nitrite-inhibition activity in LPS-stimulated macrophages, and SRB-based antiproliferative activity in several cancer cell lines, while showing no detectable cytotoxicity toward PDL fibroblasts within the tested concentration range. With exquisite similarity to apoptogenic Anti-VEGF antiangiogenesis chemotherapeutic efficacies ofcisplatin; nanoliposomal atorvastatin and co-loaded atorvastatin with rutin were remarkable comparable (in descending order of human VEGF mitigations) in mammary T47D> uterine cervix HeLa> lung A549 adherent monolayers post 72 h incubations. These findings support further investigation of atorvastatin–rutin co-loaded nanoliposomes as an in vitro formulation platform; however, formal synergy analysis, cellular uptake studies, mechanistic assays, pharmacokinetic evaluation, and in vivo safety testing remain necessary. Further in vivo studies are required to determine pharmacokinetic behavior, tissue distribution, therapeutic relevance, and systemic safety. Full article

Gas hydrate plugging remains a persistent flow-assurance challenge in offshore oil and gas operations. PVP, pectin, CMCS, and PASP were compared at 0.1–0.5 wt% in pure water, 3.5 wt% NaCl brine, pure water–sediment, and brine–sediment media using hydrate kinetics, Raman spectroscopy, CST, SEM/EDS, zeta potential, viscosity screening, and quantitative rheology. At 0.5 wt% and 3 °C, all sediment-containing formulations were shear-thinning. CSS ramps revealed continuous stress-dependent flow consistent with progressive yielding, while oscillatory measurements indicated weak elastic-dominant responses for polymer-containing suspensions. Pectin gave the highest storage modulus and the strongest salinity-induced increase in oscillatory flow-point stress (approximately 0.092 to 0.178 Pa), whereas PASP retained the most favorable multimetric KHI response and the highest 500 s recovery in brine–sediment. PVP shifted from an oscillatory flow point above 0.209 Pa in pure water–sediment to approximately 0.156 Pa in brine–sediment. These results show that small-deformation stiffness, steady yielding, oscillatory flow transition, post-shear recovery, and KHI performance are distinct but partially coupled material responses. The combined evidence supports weak, deformable polymer–sediment structuring rather than a single rheological strength mechanism governing hydrate inhibition. Full article

Phosphorus (P) contamination in agricultural runoff is a major environmental concern due to its contribution to eutrophication and deterioration of water quality. Ortho-phosphate extraction from aqueous model systems and agricultural runoff samples was investigated using cetyltrimethylammonium bromide-magnetic nanoparticles (CTAB-MNPs), sodium dodecylsulfate-magnetic nanoparticles (SDS-MNPs), and Mill scale. It was monitored using UV–visible spectroscopy based on the molybdenum blue method, while the adsorption mechanism of P on MNPs was evaluated through time-dependent studies, FTIR, zeta potential (ζ), X-ray photoelectron spectroscopy (XPS), and FESEM-EDS. CTAB-MNPs promoted P adsorption through favorable electrostatic interactions between positively charged quaternary ammonium groups and negatively charged phosphate ions, while SDS-MNPs enhanced P uptake by improving nanoparticle dispersion, colloidal stability, and accessibility of iron oxide active sites. Time-dependent studies revealed that the adsorption kinetics followed the order SDS-MNPs > Mill Scale > CTAB-MNPs. IR, XPS, FESEM-EDS and ζ analyses confirmed the presence of adsorbed P on the surface of MNPs. The results demonstrated that P removal was also governed by inner-sphere complexation with iron oxide active sites rather than electrostatic interactions alone, highlighting the potential of surfactant-modified MNPs and Mill scale as effective materials for P extraction from agricultural runoff. Full article

Background/Objectives: Ciprofloxacin (CIP) is a fluoroquinolone extensively used in hospital settings for the treatment of bacterial infections; however, this antibiotic requires multiple doses because it has poor absorption, rapid elimination, and is ineffective against resistant bacterial strains. Enhanced delivery efficiency could also be used in the dose-sparing techniques, resulting in better antibiotic efficacy. The aim of this study was to improve CIP-loaded chitosan nanoparticles (NPs) and to evaluate their capacity to enhance the antibacterial response in sensitive and resistant bacterial isolates. Methods: CIP-loaded chitosan nanoparticles were fabricated via ionic gelation using sodium tripolyphosphate (TPP) as a crosslinking agent. Formulation parameters, such as CIP concentration and polymer-to-crosslinker ratios, were optimized. The obtained nanoparticles were evaluated for particle size, polydispersity index, zeta potential, entrapment efficiency, morphology, stability, and in vitro release studies. Antibacterial efficacy was evaluated by determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values against standard and ciprofloxacin-resistant clinical isolates. Results: Successful optimization of these formulations allowed the preparation of stable nanoparticles that ranged from 38.39 to 115.07 nm, highlighting the role of both the formulation composition and polymer-to-crosslinker ratios on the size of the nanoparticles. The formulation exhibits a drug entrapment efficiency of 84.1% and uniform particulate size (38.39 ± 0.63 nm), which were optimized due to the polymer and crosslinker ratios. These nanoparticles showed a slow release of the drug over 220 h, and minimal size instability was noted after 28 days. Encapsulation of CIP resulted in enhanced antibacterial activity, yielding 2–4-fold reductions in MIC and MBC values against methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa resistant strains, compared with free CIP. Conclusions: Optimized CIP-loaded chitosan nanoparticles demonstrated improved antibacterial efficacy against resistant strains and good drug delivery properties. These findings highlight the potential of chitosan-based nanocarrier systems to improve the performance of CIP and antibiotic delivery dose-sparing antibiotic strategies. Full article

Kahweol is an active diterpene with anti-inflammatory, antioxidant, and anticancer properties; however, its use may be limited by unfavorable pharmacokinetic characteristics. This study aimed to develop kahweol-loaded poly(lactic-co-glycolic acid) (PLGA) and red blood cell membrane-coated PLGA (RBC-PLGA) nanoparticles and evaluate their in vitro release behavior and in vivo pharmacokinetic profiles. Kahweol-loaded PLGA nanoparticles were prepared using the emulsification-solvent evaporation method and subsequently coated with rabbit erythrocyte membranes, a type of blood cell membrane, to obtain RBC-PLGA nanoparticles. Particle size, zeta potential, morphology, and encapsulation efficiency were characterized. In vitro release studies were performed using the dialysis bag method. Pharmacokinetic profiles of free kahweol, kahweol-loaded PLGA, and kahweol-loaded RBC-PLGA nanoparticles were evaluated in rabbits following intravenous administration (0.5 mg/kg), and plasma kahweol concentrations were analyzed by LC-MS/MS. PLGA and RBC-PLGA nanoparticles showed high encapsulation efficiency (>90%) and sustained biphasic release compared with the rapid burst release of free kahweol. Pharmacokinetic analysis demonstrated that PLGA and RBC-PLGA nanoparticles reduced peak plasma concentrations and prolonged systemic exposure. Among the nanoparticles, RBC-PLGA exhibited the most prolonged pharmacokinetic profile, with delayed time to maximum plasma concentration (T_max), extended half-life, and increased overall exposure. The nanoparticles improved the pharmacokinetic profile of kahweol by enabling sustained release and prolonged systemic exposure, supporting their potential as delivery platforms for future applications. Full article

This work describes the formation of electrically charged nanobubbles and collective electrodynamical ordering in liquid water based upon the framework of the quantum electrodynamical theories of Del Giudice, Preparata, Vitiello and their co-workers. Nanobubbles with experimentally observed negative zeta potentials are predicted to generate interfacial electric fields on the order of 10⁵–10⁶ V m⁻¹, comparable to field strengths previously associated with collective vibrational coupling in electrically stressed water. The model addresses magnetic stabilization of the electrically induced vibronically coupled interfacial state, while the observed changes in nanobubble size and number are discussed within the broader framework, including a hypothesized preconditioning effect of the dynamically varying magnetic field on nanobubble formation. Under these conditions, regions of enhanced collective coupling of vibronic modes around a nanobubble with characteristic thicknesses of approximately 9.6–52.5 nm become physically plausible. Furthermore, a phenomenological Landau-type free-energy model is used to investigate the influence of external magnetic fields on the process. We suggest that magnetic fields primarily couple to the low-energy protonic and vibronic modes within this shell. These theoretical predictions are qualitatively consistent with recent experimental observations showing stronger negative zeta potentials, and higher nanobubble concentrations under the influence of magnetic fields, together with smaller characteristic nanobubble radii under an alternating field configuration. Our results support the interpretation that magnetic fields stabilize electrically induced mesoscopic coupling of vibronic modes that emerge transiently during cavitation-driven nanobubble formation. Full article