Search Results (4,453)

Women in resource-scarce communities navigate daily scarcity, structural neglect, and gendered violence, leaving profound but often invisible impacts on mental and reproductive health. Women play an active role in the Water–Energy–Food (WEF) space; they provide water, food, and household security daily. This study investigates how chronic deprivation across the WEF nexus shapes experiences of psychological distress, reproductive vulnerability, and social marginalization in South African settings: Lorentzville, a migrant urban informal settlement, and Mqanduli, a peri-urban Eastern Cape community. Using ethnographic methods, including in-depth interviews, focus group discussions, and participatory observation, and an analytical framework combining structural violence and feminist political ecology, we show that insecurity over water, energy, and food constrains reproductive autonomy, amplifies self-reported symptoms of anxiety and depression, and drives coping and adaptation strategies such as informal work, transactional sex, and fragile social support networks. These strategies, while mitigating immediate risks, cannot fully offset systemic harms. By foregrounding women’s lived experiences, this study extends the WEF nexus framework to include embodied, emotional, and reproductive dimensions, linking historical legacies of colonial and apartheid neglect to contemporary inequities. The findings offer critical insights for integrated health, social, and resource policy interventions that center on gender, care, and justice within environmental, wellbeing, and livelihood. Full article

Background/Objectives: Effective use of health services is essential for universal health coverage, yet many adults in Peru still forgo formal care despite illness. Evidence describing national trends and determinants of non-use of formal health services remains limited. This study aimed to estimate national trends from 2015 to 2024 and identify factors associated with non-use among Peruvian adults. Methods: We conducted a repeated cross-sectional analysis of annual secondary microdata from the Peruvian National Household Survey (ENAHO, 2015–2024). Adults aged ≥ 18 years who reported a health problem in the last four weeks were included. Non-use was defined as not seeking care at any public or private provider (IPRESS). Survey-weighted descriptive analyses and modified Poisson regression models estimated prevalence ratios (PRs) with 95% confidence intervals, adjusting for sex, age, education, marital status, health insurance, chronic illness, disability, area, and region. Results: Among 330,165 adults, 41.5% did not use formal health services. Non-use declined until 2019, rose sharply during 2020–2021, and partially recovered thereafter. In adjusted models, non-use was lower among women (PR = 0.92; 95% CI 0.91–0.93), those with higher education (PR = 0.88; 0.86–0.90), and participants insured by EsSalud (PR = 0.65) or SIS (PR = 0.76). It was higher in the Highlands (PR = 1.07) and lower in Metropolitan Lima (PR = 0.88). Conclusions: Non-use of formal health services in Peru remains high and unequal. Expanding effective coverage, strengthening primary care, and improving health literacy are essential to achieve equitable access. Full article

Background/Objective: Feminist theories and feminist economics have contributed to making visible the structural relevance of care work in sustaining capitalist societies and social reproduction, arguing that care must be addressed as a political phenomenon rather than a merely domestic issue. This perspective is particularly pertinent in contemporary healthcare, where chronic care represents one of the major public health challenges in a context of population ageing and increasing prevalence of chronic diseases. The aim is to contribute to a critical understanding that can support the development of public policies recognizing care as a fundamental pillar of socio-healthcare provision and as a matter of collective responsibility. Methods: A narrative literature review with a critical feminist approach was conducted using PubMed/MEDLINE, Scopus, and Web of Science. Results: A total of 299 records were identified, of which 30 studies were included following screening and eligibility assessment. Care is an essential element for sustaining life, although it has historically been rendered invisible, feminized, and relegated to the private sphere. Chronicity requires simultaneous consideration of the material dimension of care (as work), the subjective dimension (including emotional bonds and moral responsibility), and the political dimension (shaped by power relations). Global care chains reveal persistent inequalities related to gender, class, and race. Conclusions: Care is a structural, political, and transnational category that sustains life and healthcare systems. In the field of chronic care, the recognition, redistribution, and socialization of care are essential for achieving social justice and for safeguarding the dignity of both caregivers—predominantly women—and care recipients. Full article

Mental illness and related health inequities are disproportionately concentrated in economically disadvantaged urban neighborhoods. The COVID-19 pandemic has been associated with a rise in mental illness prevalence, with women generally at greater risk than men. Urban areas facing multiple structural and socioeconomic challenges may have limited capacity to meet the mental healthcare needs of residents, leading to increased reliance on emergency departments (EDs) for acute care. This ecological study uses data over four years (2018–2021) and examines spatial variations in ED utilization at the census tract level, focusing on geographic areas with women of reproductive age diagnosed with mental illness to compare patterns before and during the COVID-19 pandemic. Of the 22,565 ED visits in the four-year period, 12,832 occurred before COVID-19 and 9733 during COVID-19. Our findings highlight persistent structural disparities in mental healthcare access across census tracts characterized by high concentrations of vulnerable women of reproductive age. Understanding these spatial disparities allows for geographically targeted interventions and the prioritization of resources for neighborhoods identified as most underserved. Full article

Background: Exposure to environmental pollutants, especially endocrine-disrupting chemicals, disproportionately affects vulnerable populations like pregnant women, lactating mothers, and preterm infants. This study aimed to assess the detection patterns of DiNP-, DEP-, and DEHP-related metabolites in maternal urine and breast milk, examine agreement between matrices, and explore maternal factors associated with phthalate exposure. Methods: Fifty-five mothers who delivered at ≤32 gestational weeks and whose infants were hospitalized in the Neonatal Intensive Care Unit (NICU) were enrolled. Breast milk and urine samples were analyzed using a validated isotope-dilution LC–MS/MS method. Urinary phthalate metabolite concentrations were adjusted for specific gravity. Linear mixed-effects models with a random intercept for mother were used to examine associations between urinary and breast milk phthalate metabolite concentrations, assess temporal changes, and evaluate the influence of breast milk lipid content. Results: DEHP and DiNP metabolites were detected in nearly all maternal urine samples. Breast milk contained predominantly primary metabolites (MEHP and MiNP), while secondary oxidative metabolites were rarely detected. Urine concentrations consistently exceeded breast milk concentrations. Urinary and breast milk phthalate concentrations were not correlated across sampling periods, indicating limited matrix concordance. Conclusions: Mothers of very preterm infants experience sustained phthalate exposure in the postpartum period; however, limited metabolite transfer to breast milk indicates that maternal urine remains the preferred biomonitoring matrix for assessing systemic phthalate exposure. Breast milk phthalate profiles exhibit compound-specific temporal changes and appear largely independent of concurrent urinary exposure biomarkers. Full article

Background: POP surgery improves anatomical support and quality of life, but urinary, bowel, sexual, and pain issues are common after surgery. The role of rehabilitation in addressing these problems is recognized, though not yet clearly defined. Objective: This scoping review aims to map the clinical evidence on conservative rehabilitation interventions for urinary, bowel, and sexual dysfunction, and pelvic pain after POP surgery. Methods: In accordance with PRISMA-ScR guidelines, we included randomized controlled trials, cohort studies, observational studies, and systematic reviews relevant to post-surgical rehabilitation options frequently encountered in clinical settings, including pelvic floor muscle training (PFMT), physiotherapy, and multimodal programs. Meta-analysis was not conducted due to clinical and methodological heterogeneity across the studies. Results: PFMT demonstrates beneficial effects on symptom severity and pelvic muscle function in women with POP. Postoperative rehabilitation may improve urinary continence, sexual function, and pelvic pain, although the strength of current evidence remains limited. Many studies prioritize surgical revision over conservative management, and the effectiveness of rehabilitation for persistent or de novo symptoms is not well established. Conclusions: Conservative rehabilitation, especially PFMT, may aid recovery and improve function after POP surgery. More research is needed to define the optimal protocols and to determine how to incorporate them into post-surgical care. Full article

Introduction: Gestational diabetes (GD) screening remains limited in many low- and middle-income countries (LMICs) due to resource constraints, limited training, and low community awareness. Although community-centered approaches may improve access to screening in rural and Indigenous settings, the implementation processes through which such approaches are designed and operationalized are rarely documented. Methods: This study presents a community-based implementation process report describing the development, adaptation, and early implementation of a GD screening program in rural Guatemala, guided by the Exploration, Preparation, Implementation, and Sustainment (EPIS) implementation science framework. Using a participatory approach, international screening guidelines were systematically adapted to the local context through iterative protocol refinement, structured stakeholder engagement, and ongoing feedback from community health educators and partner institutions. Aggregate program data were used descriptively to characterize early screening uptake and feasibility. Results: Key implementation challenges included patient no-shows, community skepticism, and difficulties among health educators in interpreting screening procedures. Iterative adaptations were introduced to simplify protocols, reduce loss to follow-up, and strengthen community engagement. Over time, the program expanded from point-of-care screening to more comprehensive prenatal services and increased collaboration with the Ministry of Health and local community outlets. A total of 103 Indigenous Mayan Tz’utujil women were screened (mean age: 26.9 years; range: 15–46), of whom, 12 were diagnosed with GD. Conclusions: This implementation process report demonstrates the scientific value of systematically documenting real-world adaptation, feasibility, and stakeholder engagement when introducing GD screening in rural Indigenous LMIC settings. The implementation lessons described may inform similar maternal health initiatives in comparable contexts. Full article

Objective: To evaluate the effectiveness of a pharmacist-led educational intervention in reducing premenstrual syndrome (PMS) symptoms and improving self-care practices. Methods: A mixed-design study was conducted in community pharmacies in Spain between January and June 2025. First, a cross-sectional analysis determined PMS prevalence. Second, a longitudinal pre-post study was performed with women suffering from PMS. The intervention involved personalized guidance and an evidence-based educational infographic. Primary outcomes included symptom severity (measured by a numeric rating scale) and quality of life. Results: 350 women participated in the study. The mean age of participants was 23.7 ± 6.3 years (range: 17–51 years). At the six-month follow-up, the PMS group showed a significant reduction in mean pain intensity (from 6.86 to 3.26; p < 0.001) and a smaller reduction in the control group (from 4.82 to 2.88; p < 0.001), alongside improvements in irritability, insomnia, and fatigue. The proportion of women reporting a negative impact on quality of life decreased from 97.0% to 60.8% (p < 0.001). Oral contraceptive use was identified as a protective factor (OR: 0.33; 95% CI: 0.17–0.65). Conclusions: Educational interventions led by community pharmacists are effective in significantly alleviating PMS symptoms and enhancing women’s quality of life. Practice Implications: Community pharmacists are strategically positioned to identify women with PMS and provide evidence-based education. Implementing structured protocols and visual tools in pharmacies can optimize symptom management and promote self-care. Full article

Background: Malignant neoplasms are a leading cause of death among older adults, and population ageing is expected to further increase the cancer burden. Analysing long-term mortality trends is essential for evaluating the effectiveness of cancer prevention and oncological care. The aim of the study was to analyse long-term trends in mortality from malignant neoplasms among adults aged 65 years and older in Poland between 2000 and 2022. Methods: This nationwide population-based study analysed all deaths due to malignant neoplasms among Polish residents aged ≥65 years between 2000 and 2022 using national mortality data from Statistics Poland. Mortality trends were assessed separately for women and men in early (65–74 years) and late (≥75 years) old age. Standardised death rates (SDRs) were calculated using the European Standard Population. Joinpoint regression was applied to estimate annual (APC) and average annual percentage changes (AAPC). Results: Overall cancer mortality declined steadily among men in both age groups, while trends among women were heterogeneous. In men aged 65–74 years, SDRs decreased from 1140.1 to 1006.0 per 100,000 (AAPC = −1.7%), largely driven by declining lung cancer mortality (AAPC = −2.6%); similar patterns were observed in men aged ≥75 years. Among women aged 65–74 years, overall cancer mortality declined modestly (AAPC = −0.4%), but lung cancer mortality increased markedly, with SDRs nearly doubling between 2000 and 2022 (AAPC = 3.5%). Conclusions: Sustained declines among men contrast with less favourable trends among women, particularly for smoking-related cancers, highlighting the need for targeted prevention, screening, and age-adapted oncological care. Full article

Background: Turner syndrome (TS) is a chromosomal disorder associated with considerable phenotypic variability and lifelong multisystem comorbidities. Beyond somatic manifestations, TS may substantially affect physical, psychological, and social functioning, highlighting the need for comprehensive assessment of quality of life in affected women. Methods: This observational comparative study included 30 adult women with genetically confirmed Turner syndrome and 43 age-matched healthy controls. Quality of life was assessed using the SF-36 questionnaire, with clinical, anthropometric, and psychosocial variables analyzed as potential predictors using correlation and multivariable regression analyses. Results: Women with Turner syndrome were significantly shorter than controls and more frequently affected by hypothyroidism, cardiac defects, and hearing impairment. They scored lower on SF-36 domains of general health, vitality, social functioning, and mental health, while exhibiting higher BDI-II depressive symptoms. Quality of life correlated negatively with comorbidity burden and depressive symptoms, positively with final height, and was lower in patients with hearing impairment, highlighting the multifactorial determinants of well-being in TS. Conclusions: Health-related quality of life in women with Turner syndrome is shaped by a complex interplay of somatic burden, psychological well-being, and social functioning. Depressive symptoms, comorbidities, stature, and hearing impairment significantly influence outcomes, emphasizing the need for holistic, multidisciplinary care that extends beyond medical management. Full article

Background/Objectives: Hypertensive disorders of pregnancy (HDP) remain a major contributor to maternal morbidity and mortality worldwide, yet early-life reproductive factors such as age at menarche have been insufficiently explored in relation to HDP. Therefore, we aimed to evaluate the association between age at menarche and the risk of HDP in a cohort of Mexican pregnant women. Methods: We conducted a retrospective cohort study among 1344 women with singleton pregnancies receiving care at a tertiary hospital in Mexico City in 2024. Age at menarche was categorized as <12, 12–14, and >14 years. HDP diagnoses were extracted from clinical records. Poisson regression with robust variance was used to estimate adjusted risk ratios (RRs). Sensitivity analyses included alternative menarche categorizations and restricted cubic spline models. Counterfactual mediation analyses assessed indirect effects through reconstructed prepregnancy BMI and gestational diabetes. Results: Both early (<12 years) and late (>14 years) menarche were associated with higher HDP risk than the 12–14-year reference (adjusted RR = 1.81; 95% CI 1.42–2.30, and 1.74; 95% CI 1.27–2.38, respectively). Spline models confirmed a U-shaped association. Mediation analyses indicated that prepregnancy BMI did not meaningfully mediate the association for either early or late menarche (<5% mediated). Gestational diabetes explained a modest proportion of the association for early menarche (≈14%), but not for late menarche. Conclusions: Age at menarche showed a robust U-shaped association with HDP, mostly independent of adiposity and gestational diabetes, within the limits of the available measurements. Incorporating pubertal timing into routine reproductive history taking may enhance contextual risk assessment for HDP. Full article

Introduction: Myasthenia gravis (MG) is a chronic autoimmune disorder in which fatigue represents one of the most burdensome symptoms. This multidimensional manifestation extends beyond neuromuscular fatigability and has a substantial impact on daily functioning, mental health, and quality of life. The present study aimed to evaluate the perception of fatigue in patients with MG, with particular emphasis on its interference with everyday activities and the extent to which it is understood by others. Methods: The study included 67 MG patients (61.2% women, mean age 53 years) treated at the Neurology Outpatient Department of the University Clinical Center in Gdańsk. Data were collected using an author-developed survey and standardized instruments: Chalder Fatigue Scale (CFQ), MG-ADL, MG-QoL15, HADS-M, Mini-COPE, and ACDS. Results: More than 70% of patients reported constant or frequent fatigue. Higher fatigue severity was positively associated with functional impairment (MG-ADL) and lower quality of life (MG-QoL15). More than 70% of patients reported constant or frequent fatigue. Higher fatigue severity was moderately associated with greater functional impairment and poorer quality of life. The extent to which fatigue interfered with daily life was associated with higher levels of depressive symptoms, poorer self-rated health, and less favorable disease-related perceptions (acceptance and influence). In contrast, perceiving fatigue as being better understood by others was associated with lower anxiety and depression and more favorable disease-related perceptions (acceptance, control, understanding), while it was not significantly related to fatigue severity, functional status, or quality of life. Conclusions: Fatigue in myasthenia gravis is a prevalent symptom, closely related to functional impairment and reduced quality of life. Different aspects of fatigue perception show distinct psychosocial correlates, highlighting the importance of considering subjective and social dimensions of fatigue alongside its severity. These findings support the relevance of psychosocial factors in the comprehensive care of patients with MG. Full article

Background/Objectives: The World Health Organisation (WHO) recommends exclusive breastfeeding for the first six months of life, but exclusive breastfeeding (EBF) rates remain low in many countries, including Poland. Factors related to pregnancy, childbirth and the organisation of care can significantly affect the maintenance of lactation. There is a lack of representative data on these relationships in Poland, which makes it difficult to plan effective support measures. The aim of this study is to analyse the relationship between pregnancy and perinatal factors and exclusive breastfeeding in infants aged 6 to 12 months. Methods: This cross-sectional online survey was conducted between April and October 2025. A total of 557 women aged ≥18 years with infants aged 6–12 months participated in the research. Data were collected using a structured questionnaire covering sociodemographic characteristics, the course of pregnancy and childbirth, postpartum complications, early breastfeeding experiences and maternal birth satisfaction assessed using the Polish version of the Birth Satisfaction Scale—Revised (BSS-R). Multivariable logistic regression analysis was used to identify factors associated with exclusive breastfeeding up to six months. Results: Exclusive breastfeeding was significantly associated with vaginal delivery, the absence of postpartum complications and a lack of early breastfeeding problems in the first days postpartum, with initial lactation difficulties emerging as its strongest predictor. Most specific pregnancy-related conditions, maternal birth satisfaction and selected recommended hospital practices, including early skin-to-skin contact, were not independently associated with exclusive breastfeeding in the model. Conclusions: Exclusive breastfeeding up to six months is primarily determined by factors operating in the immediate perinatal and early postpartum period, particularly postpartum clinical stability and successful early lactation. Targeted support during this critical window may be key to improving exclusive breastfeeding outcomes. Full article

Primary ovarian insufficiency (POI) affects up to 3% of reproductive-aged women and is a critical yet underrecognized contributor to infertility and systemic accelerated aging. While most cases remain idiopathic, advances in genomics increasingly reveal a genetic basis, implicating pathways that govern DNA repair, meiosis, chromosomal stability, and folliculogenesis. This review synthesizes the multifactorial etiology of POI, integrating genetic contributions with emerging evidence on epigenetic dysregulation, mitochondrial dysfunction, and environmental influences such as toxins and lifestyle factors. These mechanisms converge on core cellular processes, driving premature follicular depletion and shortening reproductive lifespan. We also highlight racial and ethnic disparities in POI prevalence and research representation, alongside the profound psychosocial burden experienced by affected individuals. Addressing these challenges through integrative strategies that unite mechanistic insight with equity is essential, not only for improving POI care but also for advancing precision approaches to ovarian aging and safeguarding reproductive health across the lifespan. Full article

Population aging is a reality in Chile that affects the course of life, quality of life, and sexuality of older adults. The objective of this study is to identify the dimensions, characteristics, and underlying contents of sexuality in older adults participating in community-based organizations in Chile. A qualitative study was conducted using grounded theory, based on ten focus groups with N of 85 participants aged 60 and over. Groups of women, men, and mixed groups were organized in the northern, central, and south-central zones of the country. The data were entered and analyzed using MAXQDA 2023 software. The results identified 10 dimensions and 42 sub-dimensions related to the sexuality of older adults. A structural educational deficit in the subject was identified, characterized by a lack of training for health care personnel and care gaps at the primary health care level, among other issues. It is concluded that sexuality in older adults is an emerging issue and a human right subject to social discrimination, with limitations to its full experience which must be studied and addressed to improve sexuality as part of changes in quality of life. Full article