Search Results (1,181)

Background/Objectives: Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by pelvic pain, urinary symptoms, and reduced quality of life, with limited effective treatment options. Regenerative approaches using adipose-derived mesenchymal stromal cells (MSCs) have shown promising preclinical results. This study aimed to evaluate the feasibility, safety, and preliminary efficacy of transurethral implantation of autologous micronized adipose tissue (MAT) in patients with refractory IC/BPS. Methods: We conducted a single-center retrospective observational pilot study including 20 patients with refractory IC/BPS treated between April and October 2024. Adipose tissue was harvested via liposuction and mechanically processed using a closed system (Matrigen device) to obtain minimally manipulated micronized adipose tissue. The product was injected transurethrally into the bladder submucosa. Patients were evaluated at baseline and at 1, 3, and 6 months using validated questionnaires (ICSI/ICPI, SF-36, MOS Sexual Function), verbal rating scale (VRS) for pain and urgency, urodynamic parameters, and cystoscopic findings. Changes over time were assessed using paired non-parametric tests. Results: At 6 months, 65% of patients met responder criteria, defined as ≥50% improvement in pain and/or urgency or a positive global response. Significant improvements were observed in IC Problem Index, SF-36, MOS scores, and VRS urgency, while VRS pain improved significantly at 6 months. Urodynamic parameters showed increased bladder capacity (median 275 to 325 mL, p < 0.001) and reduced post-void residual volume (80 to 40 mL, p < 0.001). Cystoscopic findings demonstrated improvement in bladder mucosal appearance. The procedure was well tolerated, with no serious adverse events or immunological complications observed. Conclusions: In this exploratory pilot study, transurethral implantation of autologous micronized adipose tissue was associated with improvements in symptoms, bladder function, and cystoscopic findings in patients with refractory IC/BPS. These results support the feasibility and potential role of minimally manipulated adipose-derived therapies in this setting. Given the small sample size and absence of a control group, findings should be considered exploratory. Larger controlled studies are warranted to confirm efficacy and evaluate long-term outcomes. Full article

Background/Objectives: Recent studies have shown that GABA reduces visceral hypersensitivity and improves intestinal permeability in a post-inflammatory irritable bowel syndrome (IBS) rat model. We aimed to assess the efficacy of a GABA-based supplement in IBS patients with diarrhea (IBS-D), focusing on symptoms relief, quality-of-life improvement, mucosal barrier function, systemic microinflammation and gut microbiota. Methods: In this double-blind, placebo-controlled, crossover study, 20 IBS-D patients were randomized to receive GABA or placebo for two four-week treatment periods separated by a two-week washout. Efficacy was assessed using IBS Symptom Severity Score (IBS-SSS) and Short-Form Health Survey-36 (SF-36). Circulating levels of lipopolysaccharide-binding protein (LBP), Tumor Necrosis Factor-α (TNF-α) and interleukin (IL)-1β were measured before and after each treatment. Results: Eighteen patients completed the study. A clinical response (≥50-point reduction in IBS-SSS) was observed in 66.7% of patients during GABA treatment versus 33.3% with placebo. GABA produced a significant reduction in the IBS-SSS total score (p = 0.02) and in the bowel satisfaction item of the questionnaire (p = 0.02). Regarding quality of life, GABA significantly improved the “Emotional limitation” domain compared with placebo (p = 0.009). GABA treatment also led to a decrease in circulating LBP (p = 0.06) and IL-1β (p = 0.02) levels compared to placebo, although only the reduction in IL-1β reached statistical significance. In contrast, no substantial remodeling of the gut microbiota was observed. Conclusions: In this pilot study, GABA treatment led to a significant improvement in IBS-D symptoms compared with placebo and was also more effective in enhancing emotional wellbeing. GABA appeared to have a possible effect on intestinal permeability indirectly assessed through LBP, consistent with preclinical findings, and significantly reduced systemic inflammation. GABA may represent a promising therapeutic option for IBS, deserving further investigation in larger clinical trials. Full article

Background/Objectives: Total knee arthroplasty (TKA) is one of the most common surgeries among people over 60. Joint line restoration plays an important role in knee biomechanics, with joint line elevation or depression after TKA being associated with poorer postoperative outcomes, although there is no consensus regarding the threshold at which these variations become clinically relevant. The objectives of this study were to evaluate whether a joint line variation greater than 4 mm after primary TKA affects postoperative outcomes, and to assess the concordance between different radiographic methods used to measure joint line height. Methods: A retrospective study was conducted including patients over 60 who underwent primary TKA for knee osteoarthritis. Joint line height variations were evaluated preoperatively and postoperatively using three radiographic measurements: lateral femoral epicondyle–fibular head (LEFH) distance, adductor tubercle–joint line (ATJL) distance, and Blackburne–Peel index. Quality of life was assessed using the Short Form-12 (SF-12) questionnaire, and functionality using the Knee Society Score (KSS). Statistical analysis was carried out using R software. Results: Seventy-three patients were included. No statistically significant associations were found between joint line displacement and functional outcomes (KSS), quality of life (SF-12), or postoperative complications. Concordance analysis between radiographic methods showed a significant but weak correlation between the LEFH and ATJL measurements (ρ = 0.419; p < 0.001). Conclusions: Joint line displacement after primary TKA was not associated with poorer postoperative outcomes in this cohort. These findings suggest that its clinical impact may depend more on its magnitude than on its mere presence and may also be influenced by additional factors. The weak concordance observed between radiographic measurement methods highlights the need for standardized criteria. Full article

Background: Digital learning platforms increasingly leverage semantic web technologies to support interoperable and adaptive e-learning. However, the usability and cognitive impact of web-based authoring tools are still mainly assessed through subjective questionnaires and interaction logs, which provide limited time resolution and weak diagnostic power for identifying specific interface bottlenecks. Methods: We propose a multimodal evaluation of SOULSS, a semantic web-oriented platform for creating and optimizing digital learning contents. Eighteen participants completed an authoring workflow organized into three macro-segments (tutorial, initialization, module creation) while wearable electroencephalography, electrodermal activity, photoplethysmography, and eye tracking were recorded; objective metrics were analyzed both across macro-segments and within predefined micro-activities, whereas subjective engagement was collected after each macro-segment using the UES-SF. Results: Objective measures indicated increased EEG-derived mental workload and stress, higher tonic sympathetic arousal, and greater visual search and interaction effort during initialization and module creation, while UES-SF scores were lower during initialization. Fine-grained analyses localized critical elements to tutorial navigation options, the new course entry point, and spoiler-related controls. Repeated-measures correlations linked subjective scores with objective markers and supported an association between stress-related activation and delayed visual discovery. Conclusions: Integrating neurophysiological and eye tracking measures enables a more diagnostic assessment of semantic web-based authoring platforms than questionnaires alone, providing actionable evidence for iterative UX optimization and supporting a more user-centred design of digital educational tools. Full article

Background and Objectives: Overactive bladder (OAB) is frequently associated with impaired quality of life and sleep disturbances, particularly in women with refractory symptoms. Non-invasive neuromodulation targeting autonomic regulation has emerged as a potential therapeutic approach. The purpose of this pilot trial is to assess the efficacy and safety of NESA non-invasive neuromodulation in the treatment of patients with overactive bladder. Materials and Methods: Triple-blind, randomized, sham-controlled pilot trial. Women ≥ 18 years with refractory OAB were randomized to active NESA or sham using an identical protocol (10 sessions, 60 min, twice weekly). Outcomes were collected at baseline, after session 5, and after session 10. The primary outcome was mean daily micturitions, assessed using a 3-day voiding diary. Secondary outcomes included other diary variables, urinary questionnaires (ICIQ-UI SF, ICIQ-QoL, B-SAQ), and sleep measures (PSQI, ISI). Results: Per-protocol analysis included 43 women (NESA n = 24; sham n = 19). At session 10, mean daily micturitions decreased from 9.19 to 8.07 with NESA and increased from 10.56 to 11.03 with sham (between-group p = 0.043; d = −0.97). Sleep improved with NESA versus sham (PSQI p = 0.001; d = −0.63; ISI p = 0.001; d = −0.59). Between-group differences in urinary symptom questionnaires were not significant. No device-related adverse events occurred. Conclusions: In this pilot trial, NESA neuromodulation was safe and showed preliminary signals of benefit, particularly for mean daily frequency and sleep outcomes. However, given the exploratory design, small sample size, and per-protocol analysis, these findings should be interpreted cautiously and confirmed in larger adequately powered trials before clinical implementation. Full article

Background: Although survival rates for patients with malignant bone tumors have improved significantly, complications following tumor resection and limb-sparing reconstruction remain a major clinical challenge, particularly in young individuals. Intercalary resection often results in large bone defects, necessitating complex reconstructions. Fibula grafts offer biological advantages; however, their long-term outcomes, especially regarding mechanical complications and comprehensive patient-reported well-being, require further detailed exploration, particularly in cohorts utilizing non-vascularized grafts. Objective: This retrospective study evaluated the complication rates, bone hypertrophy, limb function, and quality of life following non-vascularized fibular graft reconstruction for malignant bone tumors in a single-center cohort. This study offers insights into long-term success and patient well-being, with a particular focus on correlations with systemic therapy and defect size, factors that remain insufficiently explored in the current literature. Methods: In this single-center retrospective study, twenty-four non-vascularized fibular grafts were used to reconstruct intercalary bone defects following malignant tumor resection. Complications were categorized using the Clavien–Dindo classification. Graft hypertrophy was evaluated according to the method described by Weiland and de Boer. Functional outcomes were assessed using the MSTSs and TESSs, while quality of life was measured using the SF-36 questionnaire. Notably, the cohort analyzed represents a relatively large single-center series focusing exclusively on the outcomes of non-vascularized fibular grafts. Results: Our findings revealed significant rates of mechanical complications, with osteosynthesis material failure occurring in 50.0% of cases, pseudarthrosis in 47.6%, and fractures of the fibular grafts in 38.1% of cases. Importantly, there were significant correlations between mechanical complications and systemic therapy (p = 0.017), as well as between defect size and fractures (p = 0.013), identifying critical risk factors. Despite these considerable complication rates, patients achieved satisfactory limb function (MSTS: 74 ± 17; TESS: 83 ± 15) and quality of life scores comparable to national norms, with notably higher mental health indices, highlighting their psychological resilience. Conclusions: Non-vascularized fibular graft reconstruction, despite high mechanical complication rates, significantly facilitates long-term functional recovery and psychological well-being. These findings emphasize the necessity of risk-adapted surgical strategies and long-term follow-up protocols to mitigate complications, optimize long-term function, and ultimately advance patient-centered care. Full article

Background: Diabetes mellitus (DM) management is influenced by both physiological and psychosocial factors. Personality traits and psychiatric symptoms may affect glycemic control, but their exact relationship remains unclear. This study aimed to evaluate the association between glycemic control, personality traits, and psychological symptoms such as depression, anxiety, and stress in patients with DM. Methods: A total of 174 adult patients with Type 2 DM (T2DM) were included. Glycemic control was assessed via HbA1c values over one and five years. Personality traits were measured using the Personality Belief Questionnaire-Short Form (PBQ-SF), and psychiatric symptoms were evaluated with the Symptom Checklist-90-Revised (SCL-90-R). Patients were grouped based on HbA1c levels: good (<7%), moderate (7–9%), and poor (>9%) control. Results: Significant differences were found in several personality traits, including obsessive-compulsive, histrionic, paranoid, passive-aggressive, antisocial, and schizoid traits, between groups, with higher scores in patients with moderate glycemic control compared to those with poor control. No significant relationship was observed between psychiatric symptoms and glycemic control. The proportion of patients meeting the predefined HbA1c follow-up frequency threshold was lowest in the poor control group. Conclusions: General psychiatric symptoms did not show significant differences across glycemic control groups. Several maladaptive personality traits differed between groups in univariate analyses; however, after adjustment for potential confounders, only passive-aggressive personality traits remained independently associated with HbA1c levels. These findings indicate a possible association between specific personality characteristics and glycemic control, although no direct clinical utility can be inferred from the present data. Further longitudinal studies are required to clarify these relationships. Full article

Background: This study sought to appraise health-related quality of life (HRQoL) one year after admission in persons with digestive cancer and chronic digestive diseases, stratified by nutritional status on hospital admission, and to identify clinical predictors of HRQoL. Methods: HRQoL questionnaires were completed on admission and after 12 months by a prospective cohort of 560 persons with digestive cancers and digestive chronic diseases. Between 2020 and 2021, among the 926 patients admitted to the study, a prospective cohort of 560 persons with digestive cancers or digestive chronic diseases completed HRQoL questionnaires at admission and after 12 months. Nutritional status was assessed using MUST and GLIM criteria. Multiple correspondence analyses were used to identify clinically meaningful subgroups of patients. Multivariate analyses were performed to identify HRQoL predictors. Results: Participants had a mean age of 63.4 years; 60.7% were male and 39.3% female. At baseline, 34.81% of participants were classified as malnourished. Scores for mental health (SF-36 MH), role-emotional (SF-36 ER), and vitality (SF-36 VT) were significantly lower among persons with severe malnutrition and colorectal cancer (CRC) (p = 0.001, p = 0.004 and p = 0.009, respectively). Regarding changes in HRQoL over one year, persons with severe malnutrition at baseline showed the greatest improvement in mental health (SF-36 MH) within the CRC group (p = 0.01). Among persons with cancer, polypharmacy was consistently associated with poorer outcomes, with significant negative associations across EuroQoL (p < 0.001), SF-36 Social Functioning (p < 0.001), and General Health (p < 0.001). In persons with digestive diseases, length of admission was inversely associated with Physical Role (p < 0.05) and Body Pain (p < 0.05). Finally, GLIM status displayed limited associations, only significant in the case of Vitality and Body Pain (p < 0.05 in both). Conclusions: HRQoL in patients with oncological and digestive diseases is shaped by a complex interplay of clinical and sociodemographic factors. Full article

Objectives: This cross-sectional study examined associations of lifestyle factors (physical activity (PA), diet, obesity, and smoking), age groups, and sex with the prevalence of non-communicable diseases (NCDs) in Saudi adults, including the World Health Organization (WHO) core NCDs (type 2 diabetes (T2DM), hypertension (HTN), chronic obstructive pulmonary disease (COPD) and NCD-associated conditions (osteoporosis (OP), chronic kidney disease (CKD)). Methods: A cross-sectional study was conducted across Saudi Arabia involving 2877 participants aged ≥30 years. Data were collected via an electronic survey using a standardized questionnaire. PA was assessed using the International PA Questionnaire (IPAQ-SF), diet using the Alternative Healthy Eating Index (AHEI), and smoking using the WHO Global Adult Tobacco Survey. Results: Prevalence estimates were: OP 22%, diabetes 21.8%, HTN 13.4%, COPD 4.3%, and CKD 5.1%. All conditions were more prevalent among inactive vs. active individuals (e.g., diabetes: 23.5% vs. 18.8%). An unhealthy diet was associated with higher prevalence (e.g., HTN: 16.3% vs. 10.8%). Obesity showed the strongest association with diabetes (37.1% in obese vs. 14.9% in normal-weight). Smoking was associated with higher prevalence (e.g., COPD: 7.9% vs. 3.7%). Women had higher prevalence than men for most conditions (e.g., OP: 23.4% vs. 19.7%), except COPD (5.1% in men vs. 3.8% in women). Prevalence increased with age (e.g., HTN: 7.2% at age 30–40 vs. 17.3% at age > 60). All comparisons were tested using chi-square tests (p < 0.05). Conclusions: The findings underscore an urgent need for targeted public health interventions to promote PA, improve nutrition, combat obesity, and reduce smoking. Full article

Background/Objectives: Physical activity and sedentary behaviour represent related yet distinct movement behaviours with potentially different behavioural, psychosocial, and lifestyle correlates. However, multinational evidence examining these behaviours within the Mediterranean lifestyle framework remains limited. This study investigated correlates of physical activity and sedentary behaviour among adults from Mediterranean and neighbouring countries participating in the MEDIET4ALL survey. Methods: Data were collected from 4010 adults (37.2 ± 15.4 years; 59.5% female) across 10 Mediterranean and neighbouring countries using a standardized multilingual e-survey. Physical activity was assessed using the short International Physical Activity Questionnaire (IPAQ-SF; MET-min/week), and sedentary behaviour was assessed by daily sitting time. Hierarchical multiple linear regression analyses were conducted separately for physical activity and sedentary behaviour. Exploratory bootstrapped mediation analyses examined whether life satisfaction (SLSQ) or social participation (SSPQ) mediated associations between MEDLIFE dietary dimensions and sitting time. Results: Higher physical activity was associated with more rural living environments, lower body mass index, more favourable smoking status, higher alcohol consumption, stronger adherence to Mediterranean dietary habits, longer sleep latency, higher stress, and greater social participation (β ≈ 0.05–0.11), whereas female sex, longer sleep duration, and higher anxiety were associated with lower physical activity (β = −0.04 to −0.23); the positive association with alcohol consumption should be interpreted cautiously in light of potential residual confounding. By contrast, sedentary behaviour was positively associated with higher education, higher body mass index, and more favourable smoking-status (β ≈ 0.04–0.09) and inversely associated with better self-reported health status, Mediterranean dietary consumption patterns, life satisfaction, and social participation (β = −0.04 to −0.07). Mediation analyses showed significant but small-magnitude indirect effects for the pathways linking MEDLIFE dietary consumption patterns and MEDLIFE dietary habits with sitting time through social participation (indirect β = −0.0032 and −0.0045, respectively), which should be interpreted with caution, whereas no significant indirect effects were observed through life satisfaction. Conclusions: Physical activity and sedentary behaviour are associated with different, though partially overlapping, lifestyle and psychosocial correlates within the MEDIET4ALL framework. Social participation may represent a modest behavioural pathway linking Mediterranean dietary dimensions with lower sitting time. Given the cross-sectional design, these findings should be interpreted as associative rather than causal, but they nonetheless reinforce the importance of integrated and context-sensitive lifestyle promotion strategies. Full article

Background: Central sensitization (CS) has been held responsible for both persistent pain and high disease activity scores in Spondyloarthritis (SpA). The Central Sensitization Inventory (CSI) is a questionnaire used to determine CS frequency: a score of at least 40 is associated with a high likelihood of CS. Objectives: To investigate the prevalence of CS in our cohort and its association with clinical characteristics of patients and their quality of life. Methods: Adult patients with a diagnosis of Psoriatic Arthritis (PsA) or Axial Spondyloarthritis (AxSpA) who were also classifiable according to ClASsification criteria for Psoriatic Arthritis (CASPAR) and Assessment of SpondyloArthritis international Society (ASAS) criteria respectively, and regularly followed at the SpA outpatient clinic of our Unit were consecutively enrolled from April to November 2023. Their epidemiologic, clinical and clinimetric data were collected, as well as patient-reported outcome measures (PROMs) [CSI, Health Assessment Questionnaire (HAQ), FACIT-Fatigue (FACIT-F), SHORT-FORM 36 (SF-36), and Hospital Anxiety and Depression Scale (HADS)]. Considering the definition of “difficult-to-treat” rheumatoid arthritis, we defined as “multi-failure” those patients who were treated with more than two biologic disease-modifying anti-rheumatic drugs (bDMARDs) with different mechanisms of action. Intergroup comparisons were assessed by using Chi-square, t-test and ANOVA. p-values < 0.05 were considered significant. Results: A total of 100 patients were enrolled, 46 male (46.0%) and 54 female (54.0%), with a mean age of 59.4 ± 9.8 years and a mean disease duration of 14.8 ± 10.1 years; 79 patients (79%) had a diagnosis of PsA and 21 (21%) of AS. Forty-two patients (42.0%) had a CSI score ≥ 40. Significant correlations were found between a CSI score ≥ 40 and female sex (p = 0.004), the occurrence of enthesitis (p = 0.05), DAPSA-CRP (p = 0.02) and ASDAS scores (p = 0.03), a multi-failure condition (p = 0.01), fibromyalgia (FM) (p = 0.004), thyroid disease (p = 0.016) and obesity (p = 0.047). Regarding PROMs, significant correlations were found between CSI and values of HADS (both anxiety and depression), FACIT-F, HAQ and all the domains of SF-36 (p-value < 0.0001). Conclusions: Our data confirmed that more than 40% of SpA patients had CSI values ≥ 40 and underlined how CS could widely impair their disease burden. A routinary evaluation of CS and a multifactorial biopsychosocial perspective in the diagnosis and management of chronic pain in patients with SpA could help rheumatologists in improving their quality of care. Full article

Background: Disruptions in social and circadian rhythms are increasingly recognized as key contributors to depressive symptomatology and impaired quality of life, particularly in older adults, for whom daily regularity represents a crucial determinant of psychological and functional stability. Understanding the interplay between rhythm dysregulation, mood disturbances, and perceived well-being may inform preventive strategies in aging populations. Objective: This study aimed to examine the association between social rhythm dysregulation, depressive symptoms, and perceived quality of life in a sample of community-dwelling older adults. Methods: A cross-sectional observational study was conducted among 119 older adults (mean age 72.26 ± 4.72 years) enrolled in an active aging program. Social rhythms were assessed using the Brief Social Rhythm Scale (BSRS), depressive symptoms with the Patient Health Questionnaire-9 (PHQ-9), and health-related quality of life with the SF-12 Health Survey. Pearson correlation analyses and multiple linear regression models were applied. Results: Greater social rhythm dysregulation was significantly associated with higher depressive symptom levels (r = 0.41, p < 0.001) and lower perceived quality of life (r = −0.39, p < 0.001). In multivariate analyses, both rhythm dysregulation (β = −0.1863, p < 0.001) and depressive symptoms (β = −0.2885, p = 0.037) independently predicted poorer quality of life. Conclusions: In community-dwelling older adults, irregular social rhythms and depressive symptoms are independently and jointly associated with reduced quality of life. These findings highlight social rhythm regulation as a relevant and potentially modifiable target for preventive and supportive interventions aimed at promoting mental well-being and resilience in later life. Full article

Background/Objectives: Urinary incontinence (UI) is a frequent condition in postmenopausal women and is associated with a substantial negative impact on quality of life. Conservative management can include pelvic floor muscle training (PFMT) and high-intensity focused electromagnetic stimulation (HIFEM); however, data regarding the potential benefit of combining these modalities remain limited. This study aimed to evaluate whether the addition of a structured Kegel exercise program to EMSELLA-based electromagnetic stimulation is associated with enhanced clinical outcomes in postmenopausal women with urinary incontinence. Methods: This prospective comparative study included 99 postmenopausal women with stress, urgency, or mixed urinary incontinence and an International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form (ICIQ-UI SF) score ≥ 6. Participants received either EMSELLA therapy alone (Group A, n = 49) or EMSELLA combined with a standardized Kegel exercise program (Group B, n = 50) over a three-month period. Symptom severity was assessed at baseline and at three months using the ICIQ-UI SF. Between-group comparisons were performed using analysis of covariance, adjusting for baseline scores. Results: Both therapeutic approaches were associated with clinically meaningful improvement in urinary incontinence symptoms. After adjustment for baseline severity, lower follow-up ICIQ-UI SF scores, greater mean symptom reduction, and higher response rates were observed in the combined-therapy group. Across all menopausal-duration subgroups, outcomes consistently favored the association of EMSELLA therapy with Kegel exercises. No treatment-related adverse events were reported. Conclusions: The association of EMSELLA electromagnetic stimulation with a structured Kegel exercise program was associated with greater symptom improvement than electromagnetic stimulation alone, suggesting an additive therapeutic effect of voluntary pelvic floor muscle training. This combined conservative approach was well tolerated and may represent a useful management strategy for postmenopausal urinary incontinence. Full article

Background: The use of food supplements (FS) is rapidly increasing, particularly in Italy, which leads the European market. This trend is driven by various factors, including the pursuit of physical well-being, the influence of advertising, and concerns about disease prevention. This exploratory pilot descriptive study aimed to characterize FS use among patients attending general practitioner (GP) offices and examine potential patterns with psychophysical well-being. Methods: Two questionnaires were administered to participants: one on FS use and another on physical and mental health (SF-12 questionnaire). General information and anthropometric characteristics were also collected. Results: 230 questionnaires on FS use and 192 on psychophysical well-being were analyzed. The majority of participants (73.5%) reported using FS, primarily for general well-being (21.0%), immune system support (12.2%), and increased energy (11.4%). The most commonly consumed FS were vitamins (19.4%), minerals (16.9%), and probiotics (15.7%). Only 57.4% of patients reported informing their doctor about FS use, while 66.3% engaged in self-prescription. The SF-12 questionnaire revealed lower mental health scores (mood, energy, anxiety, and depression) in the studied population, while physical health remained unaffected. Importantly, no significant associations were observed between FS use and either physical or mental health scores, suggesting these patterns are independent of supplement consumption. Conclusions: FS use is prevalent among patients attending GP offices. The observed decrease in mental health scores may indicate psychological distress though this pattern was not associated with FS consumption. Given the exploratory nature of this study, findings should be interpreted with caution. This study highlights the need for improved health education and professional training to promote safer and more informed FS use. Further research is required to expand upon these initial findings. Full article

Background/Objectives: The Individualized Neuromuscular Quality-of-Life Questionnaire (INQoL) is a widely used measure of quality of life in patients with various neuromuscular diseases. This study aimed to adapt and test the validity and reliability of this measure in Hungarian patients with neuromuscular disease. Methods: According to the widely accepted method of validation, we first translated the original INQoL version into Hungarian, and then a native English speaker translated it back into English to test its validity. Following a pretest procedure, the INQoL was administered to 80 patients with various muscular diseases and 30 age-matched controls. The internal consistency and test–retest reliability were assessed. Concurrent validity was measured using the 36-item Short Form Survey (SF-36) questionnaire. Results: For all INQoL subscales, Cronbach’s alpha was above 0.7, demonstrating the reliability of the subscales. The highest Cronbach alpha value was for the Weakness subscale (0.983) and the lowest for the Treatment subscale (0.794). The intraclass correlation coefficient test values ranged from 0.810 (Treatment) to 0.988 (Pain), indicating excellent test–retest reliability. There was a strong correlation between the SF-36 Physical Function and multiple INQoL subscales, including Weakness (r = 0.754, p < 0.001), Fatigue (r = 0.704, p < 0.001), Activities (r = 0.744) p < 0.001, Independence (r = 0.791 p < 0.001), Body Image (r = 0.714 p < 0.001), and overall Quality of Life (r = 0.742 p < 0.001). Conclusions: Our findings indicate that the Hungarian-language adaptation of the questionnaire possesses adequate reliability and construct validity for assessing the quality of life in patients with muscular disorders. Full article