Search Results (26)

Background: Chronic pain is a leading contributor to disability worldwide, yet population-based data from rural and medically underserved settings remain limited. Evidence describing the biopsychosocial correlates of chronic pain in rural Filipino communities is particularly scarce. Methods: We conducted a secondary analysis of cross-sectional data from the I-HELP-FILIPINO community cohort, collected between January and June 2017. Participants included 909 adults aged 18–93 years who voluntarily attended barangay clinic days in rural Philippine communities. Pain severity was assessed with standardized self-report tools. Sociodemographic, psychosocial, sleep, and functional health factors were examined using bivariate analysis and hierarchical linear regression. Results are shown with 95% confidence intervals. Results: Chronic pain was very common, affecting 83.8% of participants, with 5.6% experiencing severe pain. In multivariable models, psychosocial distress, sleep issues, and reduced physical functioning were significantly linked to increased pain severity, while demographic factors contributed minimally to the variance. Most of the explained variance in pain outcomes was accounted for by psychosocial and clinical variables. Conclusions: In this rural Filipino cohort, chronic pain was strongly associated with modifiable psychosocial, sleep, and functional health factors. Focusing on community-based and culturally tailored interventions can inspire hope and empower healthcare professionals and policymakers to tackle these issues more effectively. Full article

Background: Health education is a vital component of preventative care; however, rural Filipino adults often face structural, linguistic, and access barriers to obtaining reliable health information. Designing equitable and culturally relevant health education programs requires understanding which sources are most significant and how context affects them. Objective: To identify preferred sources of health education among adults in rural Philippine communities and investigate the contextual factors that influence these preferences. Methods: A cross-sectional mixed-methods study included 1203 adults from disadvantaged Luzon and Visayas barangays. Participants completed a self-administered survey on the importance of neighborhood health fairs, native-language instructional tools, and social media. Descriptive statistics (mean ± standard deviation) were used to aggregate importance ratings, and exploratory comparisons were made using paired and independent-samples t-tests. A subsample of 60 semi-structured interviews was analyzed using thematic analysis to interpret qualitative data. Results: Community health fairs were identified as the primary source of health education, with a mean rating of 8.5 ± 1.6, followed by native-language educational materials, which received a mean rating of 5.5 ± 2.4. In contrast, social media was rated the lowest, with a mean of 3.5 ± 2.3. Preference patterns were consistent across regions and sociodemographic groups, with only slight variation in rating magnitudes. Qualitative analysis revealed four themes influencing source preferences: accessibility and proximity, cultural and linguistic relevance, confidence in local health providers, and structural obstacles to digital access. Conclusions: In rural Philippine communities, intimacy, confidence, and cultural congruence influence health education preferences more than online platforms do. Strengthening community-based, locally integrated health education strategies may enhance the reach and contextual relevance of preventive health communication in underserved settings. Full article

Background/Objectives: Poor nutritional status and cachexia have been well-documented as predictors of adverse outcomes in individuals with chronic heart failure (HF). However, despite obesity being a common observation in this patient population, a growing body of evidence indicates that these individuals may still suffer from nutrient deficiencies and malnutrition. This study aimed to characterize the food and nutrient intake of participants enrolled in the Pro-HEART clinical trial—a study evaluating dietary interventions in overweight and obese individuals with HF—and to compare their consumption patterns to national nutritional guidelines. Methods: A cohort of 92 overweight and obese individuals with chronic HF enrolled in the Pro-HEART trial. Baseline food consumption was assessed via a validated 3-day Food Record. The data were analyzed using descriptive statistics to evaluate adherence to recommended intake levels for energy, macronutrients (fat, carbohydrates, protein), and key micronutrients. Results: Among the 92 participants, 41% exceeded fat intake recommendations, 73% surpassed guidelines for saturated fat, and 95% consumed excessive sodium. Despite adequate caloric intake, many individuals failed to meet recommended levels for key micronutrients known to influence inflammation and metabolic regulation, including vitamin D, calcium, magnesium, and potassium. Conclusions: These findings suggest that overweight and obese individuals with HF, despite their excess body weight, exhibit dietary patterns that place them at risk of malnutrition. The results underscore the necessity of nutritional assessments and interventions in this population to address deficiencies that may contribute to the metabolic and inflammatory abnormalities associated with HF. Full article

Background: Heart failure (HF) is frequently associated with skeletal muscle wasting, reduced functional capacity, and malnutrition. High-protein diets offer a promising nutritional intervention to improve these outcomes in individuals with HF. Objective: This systematic review evaluated randomized controlled trials of high-protein dietary interventions in HF populations, with emphasis on intervention characteristics, quantitative benefits, and risk of bias. Methods: We conducted a comprehensive search in PubMed, MEDLINE, Embase, and Cochrane CENTRAL from inception to June 2025. Eligible studies enrolled adults (≥18 years) with HF, implemented high-protein regimens (≥1.1 g/kg/day or ~25–30% of energy), and reported on functional capacity, body composition, muscle strength, clinical outcomes, or biochemical markers. Two reviewers independently screened, extracted data, and assessed bias (Cochrane RoB 2). Heterogeneity in dosing, duration, and outcomes precluded meta-analysis; we therefore provide a narrative synthesis. Results: Ten trials (nine randomized controlled trials, one pilot) involving 1080 patients (median n = 38; range 21–652) were included. High-protein interventions yielded mean improvements in six-minute walk distance of +32 ± 14 m, lean body mass gain of +1.6 ± 0.9 kg, and 9 ± 4% enhancement in quality-of-life scores; muscle strength effects varied from −2% to +11%. Two studies reported an 18% reduction in HF readmissions (p < 0.05). The risk-of-bias assessment identified two low-risk, three moderate-risk, and one high-risk study. Key limitations include small sample sizes, varied protein dosing (1.1–1.5 g/kg/day), short follow-up (2–6 months), and outcome heterogeneity. Conclusions: High-protein dietary strategies appear to confer modest, clinically relevant gains in functional capacity, nutritional status, and HF readmission risk. Larger, well-powered trials with standardized dosing and longer follow-up are necessary to establish optimal protein targets, long-term efficacy, and safety. Full article

In environmental chemistry, photocatalysts for eliminating organic contaminants in water have gained significant interest. Our study introduces a unique heterostructure combining MIL-101(Cr) and bismuth oxyiodide (Bi₅O₇I). We evaluated this nanostructure’s efficiency in adsorbing and degrading tetracycline (TC) under visible light. The Bi₅O₇I@MIL-101(Cr) composite, with a surface area of 637 m²/g, prevents self-aggregation seen in its components, enhancing visible light absorption. Its photocatalytic efficiency surpassed Bi₅O₇I and MIL-101(Cr) by 33.4 and 9.2 times, respectively. Comprehensive analyses, including scanning electron microscopy (SEM) and transmission electron microscopy (TEM), confirmed the successful formation of the heterostructure with defined morphological characteristics. BET analysis demonstrated its high surface area, while X-ray diffraction (XRD) confirmed its crystallinity. Electron spin resonance (ESR) tests showed significant generation of reactive oxygen species (ROS) like h⁺ and·•O₂⁻ under light, crucial for TC degradation. The material maintained exceptional durability over five cycles. Density functional theory (DFT) simulations and empirical investigations revealed a type I heterojunction between Bi₅O₇I and MIL-101(Cr), facilitating efficient electron–hole pair separation. This study underscores the superior photocatalytic activity and stability of Bi₅O₇I@MIL-101(Cr), offering insights into designing innovative photocatalysts for water purification. Full article

Background: The existing literature has limited detail on theory-driven interventions, particularly in pain studies. We adapted Bandura’s self-efficacy framework toward a theory-driven, non-pharmacological intervention using auricular point acupressure (APA) and evaluated participants’ perceptions of this intervention on their pain self-management. APA is a non-invasive modality based on auricular acupuncture principles. Methods: We mapped our study intervention components according to Bandura’s key sources of self-efficacy (performance accomplishments, vicarious experience, verbal persuasion, and emotional arousal) to facilitate the self-management of pain. Through a qualitative study design, we conducted virtual interviews at one and three months after a 4-week APA intervention among 23 participants using purposive sampling to describe their experiences in managing their pain based on our theory-driven APA intervention. Results: Using thematic analyses, we found four themes: the enhanced self-management of pain, improved pain outcomes, the feasibility of technology, and the sustainability of APA. Conclusions: Describing how interventions are mapped according to the elements of theoretical frameworks can help to guide intervention development, advance science and knowledge development, and promote the implementation of interventions. As such, using Bandura’s self-efficacy theory as a foundation for the APA intervention, APA was found to be feasible and sustainable, improving self-management, pain intensity, and pain-related outcomes. Participants provided recommendations for the further improvement of this theory-driven intervention. Full article

The Singapore Stone was a large monolith present at the mouth of the Singapore River, clad with a faded inscription that was a point of interest for local and foreign antiquarians and other enthusiasts, as no person—native or otherwise—could decipher the meaning of its tongue. Tragically, the stone was blasted in 1848 by East India Company engineers as part of works to widen the mouth of the river. Only four fragments were saved; these were sent to Calcutta’s Asiatic Society of Bengal and later placed in the custody of the Indian Museum. Today, only one fragment remains, which was returned to Singapore in 1919 and at present is displayed in the National Museum of Singapore. Over the past century and a half, there has been great interest in the fate of the lost fragments and in the mysterious inscription that the fragments hold. There have been various attempts at deciphering the Stone, with a variety of suggested interpretations and languages. This research paper compiles and documents both the physical journey of the fragments and the various attempts at deciphering them, aiming to comprehensively detail the Stone’s origins and journey from its erection to its present residence while providing an analysis of the past attempts at decipherment and the future of this effort. Full article

Partial oxidation of methane (POM) is a prominent pathway for syngas production, wherein the hydrogen in syngas product can be recovered directly from the reaction system using a hydrogen (H₂)-permeable membrane. Enhancing the efficiency of this H₂ separation process is a current major challenge. In this study, Ce_0.8Y_0.2O_2-δ-BaCe_0.8Y_0.2O_3-δ (YDC-BCY) hollow fiber (HF) membranes were developed and characterized for their H₂ permeation fluxes. Firstly, YDC and BCY ceramic powders were synthesized using the sol-gel method, followed by the fabrication of YDC-BCY dual-phase ceramic HF membranes using a combined phase inversion–sintering process. Characterization using SEM, powder XRD, EDS, and electrical conductivity tests confirmed the phases of the prepared powders and HF membranes. Well-structured YDC and BCY powders with uniform particle sizes were obtained after calcination at 900 °C. With the addition of 1 wt.% Co₂O₃ as a sintering aid, the YDC-BCY dual-phase HF membrane achieved densification after sintering at 1500 °C. Subsequently, the influences of sweep gas composition and temperature on the hydrogen permeation of the YDC-BCY HF membranes with YDC/BCY molar ratios of 2:1, 3:1, and 4:1 were investigated. At 1000 °C and a sweep-gas flow rate of 120 mL·min⁻¹, the YDC-BCY HF membrane with a YDC/BCY molar ratio of 4:1 exhibited a peak hydrogen flux of 0.30 mL·min⁻¹ cm⁻². There is significant potential for improving the hydrogen permeation of dual-phase ceramic membranes, with future efforts aimed at reducing dense layer thickness and enhancing the membrane material’s electronic and proton conductivities. Full article

The Singapore Stone, discovered in 1819, was blown up in 1843 and remains an enigma today. Several studies have suggested the script to be Kawi, a Brahmic script used between the 8th and 16th centuries in Java and other parts of Southeast Asia. The language remains unknown but is thought to be Old Javanese, Sanskrit, or Tamil. There is great historical value in finding out what the script says, and it is the aim of this project to offer deeper insight into this undeciphered inscription. In this paper, an in-depth comparison of the Singapore Stone with the Calcutta Stone (1041 CE), a prominent example of a Later Kawi inscription, is performed. Brief comparisons of the Singapore Stone with other inscriptions are also conducted. Numerous characters on the Singapore Stone are matched to those on the Calcutta Stone. However, the Singapore Stone appears to have a much lower frequency of diacritics and clusters. Such a phenomenon is anomalous and could have hindered decryption efforts thus far. Nonetheless, an identification and comparison of such character signs are attempted. Overall, the two inscriptions are shown to share many stylistic similarities, suggesting that the Singapore Stone could be dated to the Later Kawi period. Full article

Winter frost injury is a major limiting factor for olive cultivation in temperate regions. The response of olive shoots to freezing stress can be used for selecting genotypes resistant to freezing. The electrolyte leakage (EL) and tetrazolium tests (TZ) are commonly used to evaluate dead tissues in cold stress studies. The temperature–response curve of dead tissues to lethal temperature (LT) is measured with models to calculate LT50 and LT90. In this study, we evaluated the accuracy and efficiency of eighteen nonlinear regression models (NLRs) in calculating LT50 and LT90 of freezing stress in different olive cultivars at various stages of dormancy. After evaluating the prediction performance of NLR models, it was found that only eight models were suitable for the purpose of this research out of the eighteen models examined. The 2p-logistic and Gompertz models were selected for modeling EL and TZ, respectively. Our research findings indicate that the Roughani, Kawi, and Zard varieties of olive trees exhibit the best performance under artificial temperature-controlled conditions. Our findings provide valuable insights into selecting frost-resistant cultivars and designing effective strategies for cold acclimation in olive cultivation. Full article

Novel polymers applied in economic membrane technologies are a perennial hot topic in the fields of natural gas purification and O₂ enrichment. Herein, novel hypercrosslinked polymers (HCPs) incorporating 6FDA-based polyimide (PI) MMMs were prepared via a casting method for enhancing transport of different gases (CO₂, CH₄, O₂, and N₂). Intact HCPs/PI MMMs could be obtained due to good compatibility between the HCPs and PI. Pure gas permeation experiments showed that compared with pure PI film, the addition of HCPs effectively promotes gas transport, increases gas permeability, and maintains ideal selectivity. The permeabilities of HCPs/PI MMMs toward CO₂ and O₂ were as high as 105.85 Barrer and 24.03 Barrer, respectively, and the ideal selectivities of CO₂/CH₄ and O₂/N₂ were 15.67 and 3.00, respectively. Molecular simulations further verified that adding HCPs was beneficial to gas transport. Thus, HCPs have potential utility in fabrication of MMMs for facilitating gas transport in the fields of natural gas purification and O₂ enrichment. Full article

Background: Despite the key role of optimized fasting in modern perioperative patient management, little current data exist on perioperative fasting intervals in routine clinical practice. Methods: In this multicenter prospective study, the length of pre- and postoperative fasting intervals was assessed with the use of a specifically developed questionnaire. Between 15 January 2021 and 31 May 2022, 924 gynecology patients were included, from 13 German gynecology departments. Results: On average, patients remained fasting for about three times as long as recommended for solid foods (17:02 ± 06:54 h) and about five times as long as recommended for clear fluids (9:21 ± 5:48 h). The average perioperative fasting interval exceeded one day (28:23 ± 14:02 h). Longer fasting intervals were observed before and after oncological or extensive procedures, while shorter preoperative fasting intervals were reported in the participating university hospitals. Smoking, treatment in a non-university hospital, an increased Charlson Comorbidity Index and extensive surgery were significant predictors of longer preoperative fasting from solid foods. In general, prolonged preoperative fasting was tolerated well and quality of patient information was perceived as good. Conclusion: Perioperative fasting intervals were drastically prolonged in this cohort of 924 gynecology patients. Our data indicate the need for better patient education about perioperative fasting. Full article

While timber harvesting has plateaued, repeat-logging and conversion into plantations (especially oil palm) are still active in the tropics. The associated hydrological impacts especially pertaining to enhanced runoff, flood, and erosion have been well-studied, but little attention has been given to water resource availability in the humid tropics. In the light of the increasing climate extremes, this paper compared baseflow values and baseflow recession constants (K) between headwater catchments of five differing land-uses in Sabah, Malaysian Borneo, namely primary forest (PF), old growth/virgin jungle reserve (VJR), twice-logged forest with 22 years regeneration (LF2), multiple-logged forest with 8 years regeneration (LF3), and oil palm plantation (OP). Hydrological and meteorological sensors and dataloggers were established in each catchment. Daily discharge was used for computing K via four estimation methods. Catchment ranks in terms of decreasing K were VJR (0.97841), LF3 (0.96692), LF2 (0.90347), PF (0.83886), and OP (0.86756). Catchment ranks in terms of decreasing annual baseflow were PF (1877 mm), LF3 (1265 mm), LF2 (812 mm), VJR (753 mm), and OP (367 mm), corresponding to 68%, 55%, 51%, 42%, and 38% of annual streamflow, respectively. Despite the low K, PF had the highest baseflow magnitude. OP had the fastest baseflow recession and lowest baseflow magnitude. Baseflow persistence decreased with increasing degree of disturbance. K showed strong association to catchment stem density instead of basal area. For dynamic catchments in this study, the K_b3 estimator is recommended based on its lowest combination of coefficient of variation (CoV) and root mean squared error (RMSE) of prediction. For wetter catchments with even shorter recession events, the K_b4 estimator may be considered. Regarding climate change, logging and oil palm agriculture should only be conducted after considering water resource availability. Forests (even degraded ones) should be conserved as much as possible in the headwaters for sustainable water resource. Full article

Objective: The goal of this study is to evaluate the feasibility and efficacy of an auricular point acupressure smartphone app (mAPA) to self-manage chronic musculoskeletal pain. Methods: A prospective, longitudinal, randomized, controlled pilot trial was conducted using a three-group design (self-guided mAPA (n = 14); in-person mAPA (n = 12); and control (n = 11)). The primary outcomes included physical function and pain intensity. Results: After a 4-week APA intervention, participants in the in-person mAPA group had improved physical function of 32% immediately post-intervention and 29% at the 1M follow-up. Participants in the self-guided mAPA group had higher improvement (42% at post-intervention and 48% at the 1M follow-up). Both mAPA groups had similar degrees of pain intensity relief at post-intervention (45% for in-person and 48% for the self-guided group) and the 1M follow-up (42% for in-person and 45% for the self-guided group). Over 50% of the participants in each group reached at least 30% reduced pain intensity at post-intervention, and this was sustained in the mAPA groups at the 1M follow-up. Approximately 80% of the participants in both mAPA groups were satisfied with the treatment outcomes and adhered to the suggested APA practice; however, participants in the self-guided group had higher duration and more frequency in APA use. The attrition rate was 16% at the 1M follow-up. No adverse effects of APA were reported, and participants found APA to be beneficial and the app to be valuable. Conclusions: The study findings indicate that participants effectively learned APA using a smartphone app, whether they were self-guided or received in-person training. They were able to self-administer APA to successfully manage their pain. Participants found APA to be valuable in their pain self-management and expressed satisfaction with the intervention using the app. Full article

There have been conflicting findings on hydrological dynamics in tropical montane cloud forests (TMCFs)—attributed to differences in climate, altitude, topography, and vegetation. We contribute another observation-based comparison between a TMCF (8.53 ha; 1906 m.a.s.l.) and a tropical lowland rainforest (TLRF) (5.33 ha; 484 m.a.s.l.) catchment in equatorial Sabah, Malaysian Borneo. In each catchment, a 90° v-notch weir was established at the stream’s outlet and instrumented with a water-level datalogger that records data at 10-min intervals (converted to discharge). A nearby meteorological station records rainfall at the same 10-min intervals via a tipping bucket rain gauge connected to a datalogger. Over five years, 91 and 73 storm hydrographs from a TMCF and a TLRF, respectively, were extracted and compared. Various hydrograph metrices relating to discharge and flashiness were compared between the TMCF and TLRF while controlling for event rainfall, rainfall intensity, and antecedent moisture. Compared to the TLRF, storm-event runoff in the TMCF was up to 169% higher, reflecting the saturated conditions and tendency for direct runoff. Instantaneous peak discharge was also higher (up to 6.6x higher) in the TMCF. However, despite high moisture and steep topography, stream responsiveness towards rainfall input was lower in the TMCF, which we hypothesise was due to its wide and short catchment dimensions. Baseflow was significantly correlated with API20, API10, and API7. Overall, we found that the TMCF had higher runoff, but higher moisture condition alone may not be sufficient to govern flashiness. Full article