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Keywords = Holoptelea integrifolia

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9 pages, 1255 KB  
Article
Patterns of Allergy-Related Healthcare Utilization and Medicine Consumption in Relation to Aeroallergen Exposure
by Rajat Prakash Singhal, Sumit Khandelwal and Akhilendra Bhushan Gupta
Aerobiology 2026, 4(1), 2; https://doi.org/10.3390/aerobiology4010002 - 22 Dec 2025
Viewed by 1077
Abstract
Allergic rhinitis and asthma remain major public-health challenges, with airborne pollen serving as a key environmental driver. This study investigates the temporal association between aeroallergen exposure, patient healthcare utilization, and allergy medicine consumption at the MNIT Jaipur dispensary from 2015 to 2020, focusing [...] Read more.
Allergic rhinitis and asthma remain major public-health challenges, with airborne pollen serving as a key environmental driver. This study investigates the temporal association between aeroallergen exposure, patient healthcare utilization, and allergy medicine consumption at the MNIT Jaipur dispensary from 2015 to 2020, focusing on Holoptelea integrifolia pollen as a primary allergen. Patient visit data and medicine issuance records were analyzed to evaluate seasonal co-trends using descriptive time-series and statistical tests, including Pearson correlation and Mann–Whitney U. The analysis revealed consistent peaks in both patient visit and medicine issuance during February–April, corresponding with H. integrifolia pollen release, and secondary peaks during August–September and October, coinciding with Amaranthus spinosus, Parthenium hysterophorus, and monsoon mold activity. A moderate positive correlation (r = 0.58, 95% CI: 0.22–0.79, p = 0.007) and significant differences between high- and low-patient months (U = 107.5, p = 0.043, 95% CI of difference: 1323–3620 units) indicating that increased healthcare utilization coincides with seasonal aeroallergen exposure. These findings highlight the potential of medicine consumption data as a cost-effective proxy for allergen surveillance, aiding early warning and preparedness for seasonal allergy management. Integration of such pharmaco-epidemiological insights with dispersion models may strengthen predictive frameworks for pollen exposure and public-health response. Full article
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13 pages, 2817 KB  
Article
Effect of Holoptelea integrifolia (Roxb.) Planch. n-Hexane Extract and Its Bioactive Compounds on Wound Healing and Anti-Inflammatory Activity
by Kanokwan Somwong, Pattawika Lertpatipanpong, Wutigri Nimlamool, Aussara Panya, Yingmanee Tragoolpua, Rujipas Yongsawas, Wandee Gritsanapan, Hataichanok Pandith and Seung Joon Baek
Molecules 2022, 27(23), 8540; https://doi.org/10.3390/molecules27238540 - 4 Dec 2022
Cited by 10 | Viewed by 4123
Abstract
The stem bark of Holoptelea integrifolia (Roxb.) Planch. has been applied for the treatment of human cutaneous diseases as well as canine demodicosis in several countries. However, no detailed mechanistic studies have been reported to support their use. In this study, thin-layer chromatography [...] Read more.
The stem bark of Holoptelea integrifolia (Roxb.) Planch. has been applied for the treatment of human cutaneous diseases as well as canine demodicosis in several countries. However, no detailed mechanistic studies have been reported to support their use. In this study, thin-layer chromatography and gas chromatography were used to screen phytochemicals from the fresh stem bark extract of H. integrifolia. We found the two major bioactive compounds, friedelin and lupeol, and their activity on wound healing was further investigated in keratinocytes. Both bioactive compounds significantly reduced wound area and increased keratinocyte migration by increasing matrix metalloproteinases-9 production. Subsequently, we found that the mRNA gene expressions of cadherin 1 and desmoglobin 1 significantly decreased, whereas the gene expression involved in keratinocyte proliferation and homeostasis (keratin-17) increased in compound-treated human immortalized keratinocytes cells. The expression of inflammatory genes (cyclooxygenase-2 and inducible nitric oxide synthase) and pro-inflammatory cytokine genes (tumor necrosis factor-alpha and interleukin-6) was reduced by treatment with n-hexane extract of H. integrifolia and its bioactive compounds. Our results revealed that H. integrifolia extract and its bioactive compounds, friedelin and lupeol, exhibit wound-healing activity with anti-inflammatory properties, mediated by regulating the gene expression involved in skin re-epithelialization. Full article
(This article belongs to the Special Issue A Feasible Approach for Natural Products to Treatment of Diseases)
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13 pages, 1177 KB  
Article
Analyzing the Effects of Urban Photopollution on Photosynthetic Efficiency of Certain Trees through Chlorophyll Fluorescence OJIP Transient
by Deepak Kumar, Hanwant Singh, Upma Bhatt and Vineet Soni
Stresses 2022, 2(4), 437-449; https://doi.org/10.3390/stresses2040030 - 23 Nov 2022
Cited by 13 | Viewed by 3814
Abstract
Trees in urban areas provide important ecosystem services and are an essential element of urban green space. The constant increase in artificial light from anthropogenic activities around the world creates photopollution that affects the phenology and physiology of plants. Here we conducted a [...] Read more.
Trees in urban areas provide important ecosystem services and are an essential element of urban green space. The constant increase in artificial light from anthropogenic activities around the world creates photopollution that affects the phenology and physiology of plants. Here we conducted a field study to investigate the anthropogenic impacts on six urban trees (Saraca asoca, Terminalia catappa, Bauhinia variegata, Holoptelea integrifolia, Ficus benjamina and Thevetia peruviana) using chlorophyll fluorescence analysis. OJIP curve, maximum quantum yield of primary photochemistry (ΦPo), quantum yield of electron transport (ΦEo), probability that an absorbed photon will be dissipated (ΦDo), photosynthetic performance index (PIcsm) and reaction center photochemistry were assessed. According to the results, various parameters of chlorophyll fluorescence showed significant and important effects on different tree species. T. peruviana and F. benjamina were found to be tolerant to street lighting, while on the other hand, S. asoca, T. catappa, B. variegata and H. integrifolia were found to be sensitive to artificial light induced by street lamps. This study clearly indicates that chlorophyll fluorescence analysis is a potent method for screening the tolerance of tree species to photopollution induced by artificial lights. Full article
(This article belongs to the Special Issue Physiological and Molecular Mechanisms of Plant Stress Tolerance)
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