97 Results Found

The success of the first approved kinase inhibitor imatinib has spurred great interest in the development of type II inhibitors targeting the inactive DFG-out conformation, wherein the Phe of the DFG motif at the start of the activation loop points i...

Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the th...

Candida albicans is an oral mucosal commensal fungus that transforms into an opportunistic pathogen under specific conditions, including immunosuppression. It causes oral and systemic candidiasis, which results in a significant health burden. Further...

In this paper we report an in situ electrochemical Sum-/Difference Frequency Generation (SFG/DFG) spectroscopy investigation of the adsorption of nitrile and CN⁻ from the ionic liquid 1-butyl-1-methyl-pyrrolidinium bis(trifluoromethylsulfonyl) amide...

The tropomyosin receptor kinases (TRKs) have been validated as effective targets in anticancer drug discovery. Two first-generation TRK inhibitors have been approved into market and displayed an encouraging therapeutic response in cancer patients har...

We report a diode-pumped solid-state (DPSS) laser used for intracavity pump-enhanced difference frequency generation (DFG) to create a 3.5-micron laser. Using a 50 mm-long periodically poled lithium niobate (PPLN) crystal inside the cavity of an Nd:Y...

Since the 2010s, various national and pan-European public infrastructures have been emerging around aggregation, viewing, and 3D heritage model collection. The purpose of this article is to focus on the current state and ecosystem for 3D models in Eu...

Protein glycosylation requires dolichyl phosphate as a carbohydrate carrier. Dolichols are α-saturated polyprenols, and their saturation in S. cerevisiae is catalyzed by polyprenyl reductase Dfg10 together with some other unknown enzymes. The a...

RAF (Ras activating factor) kinases are important and attractive targets for cancer therapy. With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-ba...

Protein kinases and phosphatases are key signaling proteins and are important drug targets. An explosion in the number of publicly available 3D structures of proteins has been seen in recent years. Three-dimensional structures of kinase and phosphata...

Photovoltaic (PV) models’ parameter extraction with the tested current-voltage values is vital for the optimization, control, and evaluation of the PV systems. To reliably and accurately extract their parameters, this paper presents one improve...

High nonlinearity, wide transparency range and optical quality allowed potassium titanyl phosphate (KTiOPO₄, KTP) crystals to be used in a wide range of nonlinear applications. The success of KTP usage in the visible and infrared (IR) ranges drives i...

Functionally Graded Materials (FGMs) are designed for use in high-temperature applications. Since the mass production of FGM has not yet been made, the determination of its thermo-mechanical limits depends on the compositional gradient exponent value...

Terahertz (THz) sources, ranging from 0.1 THz to 10 THz, between microwaves and infrared waves, have important applications in spectral detection, medical imaging, communication, etc. Difference frequency generation (DFG) is an effective method for g...

Background: Glioblastoma (GBM) uses Glut3 and/or Glut14 and the Leloir pathway to catabolize D-Galactose (Gal). UDP-4-deoxy-4-fluorogalactose (UDP-4DFG) is a potent inhibitor of the two key enzymes, UDP-galactose-4-epimerase (GALE) and UDP-Glucose 6-...

We report on the development of an ultrawideband and high-resolution THz spectroscopic system, which operates over a frequency range of 2–13.5 THz. This work goes beyond conventional THz spectroscopic measurements and demonstrates the capacity...

The importance of research and development (R&D) for business sustainability have gained increasing interests, especially in the high-tech sector. However, the efforts of R&D might cause complex and mixed impacts on the financial results cons...

The primary treatment for chronic myeloid leukemia (CML) involves first- and second-generation tyrosine kinase inhibitors (TKIs), such as imatinib, nilotinib, bosutinib, and dasatinib. However, these medications are ineffective against mutations in t...

Software vulnerabilities pose a significant threat to computer systems because they can jeopardize the integrity of both software and hardware. The existing tools for detecting vulnerabilities are inadequate. Machine learning algorithms may struggle...

This manuscript develops for the first time a mathematical formulation of the dynamical behavior of bi-directional functionally graded porous plates (BDFGPP) resting on a Winkler–Pasternak foundation using unified higher-order plate theories (U...

The Revealed Comparative Advantage (RCA) index is an important metric for evaluating competitiveness of a country in exporting certain commodity. While it is desirable to have a normally distributed RCA index, the opposite is often found in empirical...

The crop harvest index (HI) is of great significance for research on the application of crop variety breeding, crop growth simulation, crop management in precision agriculture and crop yield estimation, among other topics. To obtain spatial informati...

Hyperuricemia, induced by monosodium urate (MSU) crystals that accumulate in articular joints and periarticular soft tissues, can impair macrophages. Possible causes of macrophage injury include uric acid-induced oxidative stress or inflammation. Thi...

Urease is a nickel-containing enzyme that is essential for the survival of several and often deadly pathogenic bacterial strains, including Helicobacter pylori. Notwithstanding several attempts, the development of direct urease inhibitors without sid...

The probiotic viability, physicochemical, mechanical, barrier, and microstructure properties of synbiotic edible films (SEFs) based on duck feet gelatin (DFG) were evaluated. Four synbiotic systems were obtained by mixing four types of prebiotics, na...

Background: Dialogic Feminist Gatherings (DFGs) fostered gender violence prevention among adolescents and young women in diverse educational settings. However, little was known about their impact on adult and older women without higher education, par...

Mid-infrared (MIR) ultrashort laser pulses have a wide range of applications in the fields of environmental monitoring, laser medicine, food quality control, strong-field physics, attosecond science, and some other aspects. Recent years have seen gre...

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is the only approved vaccine against tuberculosis (TB). However, its efficacy in preventing pulmonary TB in adults is limited. Despite its variable efficacy, BCG offers a number of unique and...

Virtual planning and patient-specific surgical guides have become standard practice to achieve accurate mandibular reconstruction with fibula free flaps. Although these technologies have greatly improved surgical precision, slight deviations may stil...

This study presents a compact intracavity difference-frequency generation (DFG) source designed for mid-infrared (mid-IR) applications. By optimizing overlap between the pump and signal beams, we obtained a black-box efficiency (${\eta }_{BB}$) of 3.4% W...

Field-deflecting optical elements play a crucial role in various high-resolution and field-expandable optical systems. However, for widely used prism-based field-deflecting optical elements, the issue of chromatic aberration correction under wide-fie...

Phyllophorus proteus is a low-value sea cucumber from Indonesia and other tropical peripheral waters. In this study, a fucosylated glycosaminoglycan (FG) was extracted from P. proteus. It consists of GlcA, GalNAc, and Fuc, with a molecular weight of...

We performed the polarization imaging of a liquid crystal polymer with a terahertz difference-frequency generation (THz DFG) source. The DFG source is an easy-to-operate and practical THz source. Liquid crystal polymers (LCPs) are suitable for applic...

This paper reports on the new Sellmeier and thermo-optic dispersion formulas that provide a good reproduction of the temperature-dependent phase-matching conditions for second-harmonic generation (SHG) and sum-frequency generation (SFG) of a CO₂ lase...

A mid-infrared difference frequency generator (DFG) based on a periodically poled thin-film lithium niobate rib waveguide on a sapphire substrate is theoretically studied. A mode analysis is carried out at the mid-infrared region, and the analysis fo...

This study was conducted to investigate the adherence of Daily Food Guides (DFGs) among older Taiwanese, and the relationship of dietary quality and frailty. 154 functional independent older adults who were retirement home residents or community dwel...

In this paper, we demonstrated efficient mid-infrared generation using a low-power 1064 nm single-frequency (SF) fiber laser based on phase-matched intracavity difference frequency generation (DFG) in a continuous-wave (CW) periodically poled lithium...

The research reports broadband, continuous-wave (CW), mid-infrared generation based on an optical parametric oscillator (OPO), pumped by an amplified spontaneous emission (ASE) fiber source. The ASE fiber source has a ytterbium (Yb)-doped fiber maste...

It was reported that a double-peaked mid-infrared laser was generated based on an intracavity difference frequency generation (DFG). The double-peaked pump source was achieved by suppressing the intensity at the central wavelength of the pump source....

Fungal cell walls, composed of polysaccharides and proteins, play critical roles in adaptation, cell division, and protection against environmental stress. Their polyglucan components are continuously remodeled by various types of glycosyl hydrolases...

The quality and yield of ginseng are significantly affected by ecological factors, especially soil, which is a complex environment. This study compared the quality, yield, and soil differences of ginseng in a Mongolian oak forest (MOFG), birch forest...

Regular shelves configuration forms unique characteristics of internal obstacles in a supermarket. It is crucial to study the crowd evacuation affected by obstacles during accidents or disasters in supermarkets as assembly occupancies. Based on the T...

cAMP-dependent protein kinase (PKA) is the major receptor of the second messenger cAMP and a prototype for Ser/Thr-specific protein kinases. Although PKA strongly prefers serine over threonine substrates, little is known about the molecular basis of...

These memoirs about Walter Lachenmeier (1945–2022) concentrate on his activities as head of the engineering sciences group of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG), for which he worked from 1977 to 2007, and his...

This work presents an innovative, energy-efficient IoT routing protocol that combines advanced data fusion grouping and routing strategies to effectively tackle the challenges of data management in smart cities. Our protocol employs hierarchical Data...

Angiogenesis, primarily driven by the vascular endothelial growth factor (VEGF) and its receptor, the VEGFR, plays a key role in various pathological processes such as cancer progression. Here, we investigated the anti-angiogenic effects of Lucknolid...

LYN proto-oncogene, Src family tyrosine kinase (Lyn) is a tyrosine kinase that belongs to the Src family (SFK). It is expressed as two isoforms in humans, LynA and LynB. Like other SFKs, Lyn consists of five protein domains, an N-terminal SH4 domain...

In view of in vivo surgical smoke studies a difference-frequency-generation (DFG) laser spectrometer (spectral range 2900–3144 cm^-1) and a Fourier-transform infrared (FTIR) spectrometer were employed for infrared absorption spectroscopy. The chemical...

The intensity fluctuation induced spectral phase-change of the laser pulse during nonlinear spectral broadening is theoretically investigated. The oscillation of the phase-change curves at the central part of the spectra is explained by the two-wave...

All manufacturing processes have an impact on the surface layer state of a component, which in turn significantly determines the properties of parts in service. Although these effects should certainly be exploited, knowledge on the conditioning of th...