Search Results (60)

Introduction: Recent technological progress in optical imaging—such as adaptive optics, interferometry and tomography—has greatly improved the resolution of retinal imaging. The ability to capture sequential images over time is particularly valuable for continuous monitoring and assessment of retinal diseases. Methods: This cross-sectional study involved patients with type 2 diabetes mellitus and age-matched controls from the Diabetes and Ophthalmology Department of the Emergency Military Clinical Hospital “Dr. Constantin Papilian” Cluj-Napoca between October 2023 and October 2024. These patients were assessed for inclusion and exclusion criteria and then categorized into two groups: the diabetes group and control group. Each participant underwent a comprehensive ophthalmological examination and retinal evaluation using SS-OCT (Spectralis Heidelberg Engineering, Heidelberg, Germany). The parameters measured included the superficial and deep foveal avascular zones (FAZ) in only one eye for each patient, selected based on image quality. Additionally, each patient underwent quantitative analysis of serum C-reactive protein (CRP) levels. Results: A total of 33 patients (33 eyes) featured, 13 men and 20 women. The DM group showed statistically significant higher results for CRP value compared to healthy subjects (p < 0.001). Also, both superficial and deep FAZ areas were statistically significantly higher for diabetes patients compared to the healthy controls (p < 0.05). The correlation analysis revealed that there was no significant correlation between CRP and either superficial FAZ (p = 0.809) or deep FAZ (p = 0.659). However, a significant positive moderate correlation was found between superficial FAZ and deep FAZ (r = 0.577, p = 0.015). Conclusions: Our findings showed a significantly enlarged FAZ in diabetic patients compared to healthy individuals, highlighting its potential as an early indicator of microvascular alterations in diabetes. While CRP levels were notably elevated in the diabetic group, no significant association was found between CRP and FAZ measurements, suggesting that FAZ changes may occur independently of systemic inflammatory status. Full article

A series of 11 Byzantine gold coins were investigated, including two examples of an extremely rare type called histamenon “stellatus”, from around the reign of the Byzantine emperor Constantine IX Monomachos (AD 1042–1055). The methods applied were X-ray fluorescence spectroscopy (XRF), specific density measurement (SD), and scanning electron microscopy (SEM). The debasement (decreasing gold content) of the Byzantine nomisma gold coinage during the 11th century was demonstrated. A method combining XRF and SD measurement combined with a graphical presentation/analysis called a ternary plot was also demonstrated. The measured gold content of the 11 coins was corrected for the possible “outwashing” effect and a potential cleaning of ancient gold. A model for the estimation of the gold content of Byzantine histamenon nomisma gold coins from the period AD 1020–1118, based on the specific density (SD), was derived. It was demonstrated that two analyzed histamenon “stellati” coins likely were minted around AD 1054–1055, possibly during the same period as the occurrence of the supernova SN1054, known as the Crab-nebula. It is further discussed if the gold content and size of the stars shown on those coins can be correlated to the visibility of the supernova from June AD 1054 to January AD 1055. Full article

The fourth-century historian Eusebius, bishop of Caesarea, lived during the anti-Christian persecutions of the Roman emperor Maximinus Daia and believed fervently that Jesus Christ would imminently return to alleviate the suffering of God’s people. When Constantine the Great became emperor and converted to Christianity, the bishop’s disposition towards the ‘last things’ or end times, known as eschatology, suddenly changed to a belief that God’s kingdom had already been inaugurated in this emperor’s reign. In this way, Eusebius conflated Church and Empire into a single organism governed by the emperor on behalf of Christ. This article demonstrates that this disposition in fact emerged from the bishop’s problematic Christology. Heretofore, the concept of the Logos had been applied to Son of God as creator of the world and who assumed human nature as Jesus. However, Eusebius’ disposition towards the Logos was subordinationist and dissociative, thus paving the way for him to depict the emperor as an agent of, and inhabited by, the Logos in the eschatological working out of earthly affairs from the vantage point of the city of Rome. Eusebius therefore essentially replaced Christ’s eschatological agency in the usurpation of the Church by the eternal city that was ultimately recapitulated within Constantine himself, even after the latter had died. Full article

Hemolymph enables communication between organs in insects and ensures necessary coordination and homeostasis. Its composition can provide important information about the physiological state of an insect and can have diagnostic significance, which might be particularly important in the case of harmful insects subjected to biological control. Galleria mellonella Linnaeus 1758 (Lepidoptera: Pyralidae) is a global pest to honey bee colonies. The hemolymph of its larvae was examined after infection with the soil fungus Conidiobolus coronatus (Constantin) Batko 1964 (Entomophthorales). It was found that after one hour of contact with the fungus, the volume of the hemolymph increased while its total protein content decreased. In larvae with a high pathogen load, just before death, hemolymph volume decreased to nearly initial levels, while total protein content and synthesis (incorporation of ³⁵S-labeled methionine) increased. The hemolymph polypeptide profile (SDS-PAGE followed by autoradiography) of infected insects was significantly different from that of healthy larvae. Hemocytes of infected larvae did not surround the fungal hyphae, although they encapsulated small foreign bodies (phase contrast microscopy). Infection had a negative effect on hemocytes, causing oenocyte and spherulocyte deformation, granulocyte degranulation, plasmatocyte vacuolization, and hemocyte disintegration. GC-MS analysis revealed the presence of 21 compounds in the hemolymph of control insects. C. coronatus infection caused the appearance of 5 fatty acids absent in healthy larvae (heptanoic, decanoic, adipic, suberic, tridecanoic), the disappearance of 4 compounds (monopalmitoylglycerol, monooleoylglycerol, monostearin, and cholesterol), and changes in the concentrations of 8 compounds. It remains an open question whether substances appearing in the hemolymph of infected insects are a product of the fungus or if they are released from the insect tissues damaged by the growing hyphae. Full article

A group of Romanesque sculptures today at the Gosudarstvennyj Istoričeskij Muzej in Moscow, coming from the restoration of the Cathedral of Saint Sophia in Kijv, can be related to the commission of Vladimir II Monomak, Grand Prince of Kijv, cultural heir of both his great-grandfather, the grand prince Vladimir I (who had founded the church between 1011 and 1037), and of his grandfather, the Eastern Roman Emperor Constantine IX: It is argued here that, alongside the Byzantine mosaicists certainly present, the sculptures are the work of a group of artists from the Lombardy lakes (also known as Comacine masters), attested in central and eastern Europe through Bavaria, Bohemia, Poland and then arriving in Sweden, active in Kijv between 1113 and 1125. It is probable that their specific origin is from Valchiavenna. Full article

Landraces are a critical genetic resource for resilience breeding, offering solutions to prepare agriculture for the challenges posed by climate change. Their efficient utilisation depends on understanding their history and genetic relationships. The current study investigates the phylogenetic relationships of barley landraces from Algeria, varieties from the Near and Middle East, traditional landraces, and modern cultivars from Europe. Using a core set of 33 varieties, including the wild ancestor Hordeum spontaneum from Armenia, genetic diversity was analysed with Random Amplified Polymorphic DNA (RAPD) and Simple Sequence Repeat (SSR) markers spanning all barley chromosomes. Based on the SSR-based phylogeny, the Algerian varieties are well clustered with those from the Near East, while distinct from the European varieties. The findings from RAPD markers partially support these results. Using exclusively traditional landraces, where a region of origin can be defined, the SSR markers are analysed separately for each chromosome individually, and the resulting clades are represented by the respective region of origin. This strategy resolves qualitative differences in geographic resolution, depending on the chromosome. While marker HvB23D (chromosome 4) separated the wild H. spontaneum from all domesticated genotypes, markers Bmag19 and Hv13GIII (chromosome 3) reveal four distinct geographic clusters (Maghreb, Near and Middle East, West Europe, Central Europe). These biogeographic patterns suggest a model, where divergence of domesticated barley due to human activity interacted with introgression of individual chromosomes from wild barley, yielding adaptive diversity. These biogeographic patterns suggest a model in which the divergence of domesticated barley, driven by human activity, interacts with the introgression of chromosomes from wild barley, resulting in the creation of adaptive genetic diversity. Our research advances our knowledge of barley landraces’ functional genomics and highlights their potential in molecular breeding, particularly for developing resilient varieties suited to diverse environmental conditions. Full article

The post-communist period has seen several wars in regions with a majority of Eastern Orthodox Christians. These conflicts have prompted Eastern Orthodox churches to formulate stances on war and develop new doctrines of righteous war. These responses draw on a long lineage of Eastern Roman and Slavonic traditions, particularly the Cyrillian doctrine of righteous war expounded in the Life of Constantine-Cyril. This paper examines the theological responses of the Serbian Orthodox Church to the wars in the former Yugoslavia, providing a reference point for comparison with the current theological debates and assessment of doctrines of warfare in light of the war in Ukraine. The focus is on the biblical hermeneutics and theological framing of various Serbian-centered doctrines. These new outlines draw on diverse traditions within Slavonic and Eastern Orthodox theology. The paper aims to provide insights into the shaping of Eastern Orthodox positions on war and the theological genesis of justifications for war. The discussion sheds light on the intricate relationship between war and Christianity within the Eastern Orthodox context in Serbia. Full article

During the covid pandemic period of 2019–2020, teaching was carried out via homeschooling, and secondary vocational schools had to deal with the problem of ensuring the implementation of excursions, which were a part of their apprentices’ practical training. In the context of the COVID-19 pandemic, a group of people at Constantine the Philosopher University in Nitra (Slovakia) came up with a plan to develop some virtual excursions to help secondary vocational schools replace field trips with their virtual counterparts. In the paper, the authors describe the results of the stated intention: two virtual excursions aimed at the production and processing of metal products and verification of their applicability in educational practice based on a qualitative analysis of expert opinions collected by means of individually led semi-structured interviews. The conclusions of the analysis confirm the high degree of usability of the created excursions and verify some positive impacts of the implementation of virtual excursions into the teaching practice, e.g., it increased student motivation to learn, increased student interest in lesson content, increased student activity, and intensified study activities overall, including various forms of self-study. Full article

This study investigates morpho-geometric variations in wing conformations among honeybee (Apis mellifera L.) populations in Algeria, focusing on Apis mellifera intermissa in the northern zone. It addresses the threats posed by human beekeeping practices and hybridization. The analysis involves collecting and digitizing 445 honeybee specimens from nine localities in northern Algeria: Batna, Blida, Constantine, Cheffa, Jijel, Mila, Setif, Skikda, and Tipaza. Statistical assessments reveal significant wing anatomy variations across these zones. Principal Component Analysis identifies distinct shapes within populations, with notable differences in specific regions. Discriminant Analysis classifies samples into three groups, showcasing the model’s effectiveness. The Mahalanobis D distances provides insights into population similarities and differences, emphasizing the potential of morpho-geometric analysis in differentiating bee populations. The study concludes by highlighting the significance of size-independent data, offering recommendations for capturing honeybee diversity in different climatic zones of northern Algeria. This research advances our understanding of honeybee morphology in relation to environmental dynamics, providing valuable insights for preserving indigenous bee races and exploring biodiversity. Full article

The notion of Roman $\left\{2\right\}$-domination was introduced in 2016 as a variant of Roman domination, a concept inspired by a defending strategy used by the emperor Constantine (272–337 AD) to protect the Roman Empire. Since then, a considerable number of papers on Roman $\left\{2\right\}$-domination and its variants have been published. In this paper, we survey published results on Roman $\left\{2\right\}$-domination as well as the main findings on Roman $\left\{2\right\}$-domination variants found in the literature. A list of open problems related to this notion and its variants are also given. Full article

In the early stages of building design, decisions are made about the building’s form and envelope, but designers rarely base their decisions on sophisticated energy simulations, even though these features are critical to a building’s energy performance. This paper employs three methods—empirical, parametric, and uncertainty—to assess the interconnectedness of building form, envelope, orientation, and occupancy regarding thermal comfort and energy consumption for heating and cooling a residential building across three regions: Gdyel (mediterranean climate), Oum El Bouaghi, and Constantine (semi-arid climate). The study variables include indoor air temperature, relative humidity, and energy consumption. The initial findings stem from an experiment conducted in an apartment on the top floor of a building in Gdyel, which allowed us to record the evolution of the variables mentioned throughout the year and validate the parametric results of the multi-zone model created in TRNSYS16 software. This study showed that for the considered climates, a compact form is more suitable; it was found that the top floor with SF = 0.57 needs about 30% to 54% more energy than the inter-floor with SF = 0.21. In addition, the heating and cooling methods and habits adopted by Algerian households are responsible for 18% to 35% on the top floor and the inter-floor, respectively. Full article

The late Roman discourse on divinatory dreams and their interpretation reflects a context of cultural fragmentation. The political turbulence of the 350s to 360s was due partly to the ongoing external war with the (Persian) Sasanians, but also to the internal struggle between the heirs of Constantine for rule over the Roman empire, still undergoing a process of Christianization when Julian was acclaimed Augustus in 360. A third arena of fragmentation was religious beliefs and practices during the 350s and 360s. The contested transformation of Rome in the religious sphere was the context of Julian’s dynastic vision of the two trees, received in late 358 or 359. Full article

Optimal oxygen management during pediatric cardiopulmonary bypass (CPB) is unknown. We previously demonstrated an increase in cortical mitochondrial reactive oxygen species and decreased mitochondrial function after CPB using hyperoxic oxygen management. This study investigates whether controlled oxygenation (normoxia) during CPB reduces cortical mitochondrial dysfunction and oxidative injury. Ten neonatal swine underwent three hours of continuous CPB at 34 °C (flow > 100 mL/kg/min) via cervical cannulation targeting a partial pressure of arterial oxygen (PaO₂) goal < 150 mmHg (normoxia, n = 5) or >300 mmHg (hyperoxia, n = 5). The animals underwent continuous hemodynamic monitoring and serial arterial blood sampling. Cortical microdialysate was serially sampled to quantify the glycerol concentration (represents neuronal injury) and lactate-to-pyruvate ratio (represents bioenergetic dysfunction). The cortical tissue was analyzed via high-resolution respirometry to quantify mitochondrial oxygen consumption and reactive oxygen species generation, and cortical oxidized protein carbonyl concentrations were quantified to assess for oxidative damage. Serum PaO₂ was higher in hyperoxia animals throughout CPB (p < 0.001). There were no differences in cortical glycerol concentration between groups (p > 0.2). The cortical lactate-to-pyruvate ratio was modestly elevated in hyperoxia animals (p < 0.03) but the values were not clinically significant (<30). There were no differences in cortical mitochondrial respiration (p = 0.48), protein carbonyls (p = 0.74), or reactive oxygen species generation (p = 0.93) between groups. Controlled oxygenation during CPB does not significantly affect cortical mitochondrial function or oxidative injury in the acute setting. Further evaluation of the short and long-term effects of oxygen level titration during pediatric CPB on cortical tissue and other at-risk brain regions are needed, especially in the presence of cyanosis. Full article

Church governance is not often debated within a philosophical or theological sphere. This is perhaps because church governance has been part of tradition since Constantine and the initial Greek philosophical world view of sovereignty and hierarchy. Such a stance has led towards a managerial mindset that follows and conforms to the world, which plays out within the Anglican polity in the setting of an adversarial parliamentary style synod. This style encourages bounded communities of power that often refute the burgeoning inspirations of the Spirit. In changing the underlying theological basis of such a stance, by invoking the understanding of an undeniable community in the singularity of the Triune God, governance becomes more open. Engaging with, primarily, Agamben but also others from philosophy, a new viewpoint is presented to challenge the manner through which tradition is wielded as the only possibility. In seeing through a differing lens, communities can be conceived as both porous and interconnected, thus allowing the body of Christ to respond with transformative action as opposed to a continuum of conformance with secular legality. In this manner, the bishop’s role may become more centralised towards a Eucharistic one, as opposed to the managerial mindset and role, to enhance the possibilities of God’s love. This then removes the need for a hierarchy driven by a sovereign mindset that tradition bolsters, whilst maintaining loving and authoritative oversight that tradition suggests. Full article

Although John Chrysostom is critical of the theatre, delivering a homily was never a tiresome monologue of the preacher in Byzantium; it was a theatrical performance combining text-reading and multiple ceremonies, during which spaces, lights, and materials were manipulated to create marvellous spectacles and enslave the audience spiritually and emotionally. At times, orators described the physical features of the venues where they spoke, as did Leo VI the Wise for two newly founded churches and Constantine VII Porphyrogenitus for the second most important church of the Empire, the Holy Apostles. But in most cases, the performance aspect of their speeches could only be known indirectly from two ceremonial handbooks, Kletorologion and De Ceremoniis. It is also necessary to indicate that the spectacles in homilies were not always real and present; they sometimes came to exist in listeners’ minds through picturesque descriptions (ekphraseis) and fictional figures (ethopoiiai) composed by preachers. Full article