Search Results (6)

Background/Objectives: Fabry disease (FD) is a lysosomal storage disorder often associated with early-onset neuropathic pain, attributed to small fibre neuropathy (SFN). The dorsal root ganglion (DRG) has emerged as a critical site of early pathophysiological involvement in FD, with structural and functional alterations implicated in the development of neuropathic symptoms. This exploratory study introduces DRG proton density (DRG-PD) as a novel MRI-derived biomarker and evaluates its association with SFN. Methods: Eighty genetically confirmed FD patients underwent high-resolution 3T MRI with DRG-PD quantification at the lumbosacral levels L5 and S1. DRG-PD was derived from B1-corrected multi-echo spin echo sequences and normalised to cerebrospinal fluid intensity. All patients underwent clinical, biochemical and histological evaluation to determine SFN status. Associations between DRG imaging parameters and clinical variables were analysed using correlation and regression models. Diagnostic performance was evaluated using receiver operating characteristic curve analysis. Results: DRG-PD values were significantly increased in patients with classical FD and SFN, demonstrating a large effect size (Cliff’s δ = 0.92) and excellent discriminatory performance (AUC = 0.96). In contrast, DRG volume and T2 relaxation time were not significantly associated with SFN status. DRG-PD remained an independent predictor of SFN in multivariable logistic regression (p = 0.019). Conclusions: DRG-PD is a non-invasive correlate of SFN in classical FD. It may provide superior diagnostic value compared to existing MRI metrics and reflects proximal ganglionic pathology not captured by distal histological assessments. Full article

Coasts are continually changing and remote sensing from satellite has the potential to both map and monitor coastal change at multiple scales. This study aims to assess the application of shorelines extracted from Multi-Spectral Imagery (MSI) and Synthetic Aperture Radar (SAR) from publicly available satellite imagery to map and capture sub-annual to inter-annual shoreline variability. This is assessed at three macro-tidal study sites along the coastline of England, United Kingdom (UK): estuarine, soft cliff environment, and gravel pocket-beach. We have assessed the accuracy of MSI-derived lines against ground truth datum tideline data and found that the satellite derived lines have the tendency to be lower (seaward) on the Digital Elevation Model than the datum-tideline. We have also compared the metric of change derived from SAR lines differentiating between ascending and descending orbits. The spatial and temporal characteristics extracted from SAR lines via Principal Component Analysis suggested that beach rotation is captured within the SAR dataset for descending orbits but not for the ascending ones in our study area. The present study contributes to our understanding of a poorly known aspect of using coastlines derived from publicly available MSI and SAR satellite missions. It outlines a quantitative approach to assess their mapping accuracy with a new non-foreshore method. This allows the assessment of variability on the metrics of change using the Open Digital Shoreline Analysis System (ODSAS) method and to extract complex spatial and temporal information using Principal Component Analysis (PCA) that is transferable to coastline evolution assessments worldwide. Full article

In this study, we propose a new baseline and transect method, the open-source digital shoreline analysis system (ODSAS), which is specifically designed to deal with very irregular coastlines. We have compared the ODSAS results with those obtained using the digital shoreline analysis system (DSAS). Like DSAS, our proposed method uses a single baseline parallel to the shoreline and offers the user different smoothing and spacing options to generate the transects. Our method differs from DSAS in the way that the transects’ starting points and orientation are delineated by combining raster and vector objects. ODSAS uses SAGA GIS and R, which are both free open-source software programs. In this paper, we delineate the ODSAS workflow, apply it to ten study sites along the very irregular Galician coastline (NW Iberian Peninsula), and compare it with the one obtained using DSAS. We show how ODSAS produces similar values of coastline changes in terms of the most common indicators at the aggregated level (i.e., using all transects), but the values differ when compared at the transect-by-transect level. We argue herein that explicitly requesting the user to define a minimum resolution is important to reduce the subjectivity of the transect and baseline method. Full article

This article investigates the performance of various sophisticated channel coding and transmission schemes for achieving reliable transmission of a highly compressed video stream. Novel error protection schemes including Non-Convergent Coding (NCC) scheme, Non-Convergent Coding assisted with Differential Space Time Spreading (DSTS) and Sphere Packing (SP) modulation (NCDSTS-SP) scheme and Convergent Coding assisted with DSTS and SP modulation (CDSTS-SP) are analyzed using Bit Error Ratio (BER) and Peak Signal to Noise Ratio (PSNR) performance metrics. Furthermore, error reduction is achieved using sophisticated transceiver comprising SP modulation technique assisted by Differential Space Time Spreading. The performance of the iterative Soft Bit Source Decoding (SBSD) in combination with channel codes is analyzed using various error protection setups by allocating consistent overall bit-rate budget. Additionally, the iterative behavior of SBSD assisted RSC decoder is analyzed with the aid of Extrinsic Information Transfer (EXIT) Chart in order to analyze the achievable turbo cliff of the iterative decoding process. The subjective and objective video quality performance of the proposed error protection schemes is analyzed while employing H.264 advanced video coding and H.265 high efficient video coding standards, while utilizing diverse video sequences having different resolution, motion and dynamism. It was observed that in the presence of noisy channel the low resolution videos outperforms its high resolution counterparts. Furthermore, it was observed that the performance of video sequence with low motion contents and dynamism outperforms relative to video sequence with high motion contents and dynamism. More specifically, it is observed that while utilizing H.265 video coding standard, the Non-Convergent Coding assisted with DSTS and SP modulation scheme with enhanced transmission mechanism results in $E_b/N_0$ gain of 20 dB with reference to the Non-Convergent Coding and transmission mechanism at the objective PSNR value of 42 dB. It is important to mention that both the schemes have employed identical code rate. Furthermore, the Convergent Coding assisted with DSTS and SP modulation mechanism achieved superior performance with reference to the equivalent rate Non-Convergent Coding assisted with DSTS and SP modulation counterpart mechanism, with a performance gain of 16 dB at the objective PSNR grade of 42 dB. Moreover, it is observed that the maximum achievable PSNR gain through H.265 video coding standard is 45 dB, with a PSNR gain of 3 dB with reference to the identical code rate H.264 coding scheme. Full article

A key factor limiting our understanding of rock slope behavior and associated geohazards is the interaction between internal and external system controls on the nature, rates, and timing of rockfall activity. We use high-resolution, monthly terrestrial light detection and ranging (LiDAR) surveys over a 2 year monitoring period to quantify rockfall patterns across a 0.6 km-long (15.3 × 10³ m²) section of a limestone rock cliff on the northeast coast of England, where uncertainty in rates of change threaten the effective planning and operational management of a key coastal cliff top road. Internal system controls, such as cliff material characteristics and foreshore geometry, dictate rockfall characteristics and background patterns of activity and demonstrate that layer-specific analyses of rockfall inventories and sequencing patterns are essential to better understand the timing and nature of rockfall risks. The influence of external environmental controls, notably storm activity, is also evaluated, and increased storminess corresponds to detectable rises in both total and mean rockfall volume and the volumetric contribution of large (>10 m³) rockfalls at the cliff top during these periods. Transient convergence of the cumulative magnitude–frequency power law scaling exponent (ɑ) during high magnitude events signals a uniform erosion response across the wider cliff system that applies to all lithologies. The tracking of rockfall distribution metrics from repeat terrestrial LiDAR in this way demonstrably improves the ability to identify, monitor, and forecast short-term variations in rockfall hazards, and, as such, provides a powerful new approach for mitigating the threats and impacts of coastal erosion. Full article

We perform a theoretical and empirical analysis of a set of Cascading Style Sheets (CSS) document complexity metrics. The metrics are validated using a practical framework that demonstrates their viability. The theoretical analysis is performed using the Weyuker’s properties−a widely adopted approach to conducting empirical validations of metrics proposals. The empirical analysis is conducted using visual and statistical analysis of distribution of metric values, Cliff’s delta, Chi-square and Liliefors statistical normality tests, and correlation analysis on our own dataset of CSS documents. The results show that five out of the nine metrics (56%) satisfy Weyuker’s properties except for the Number of Attributes Defined per Rule Block (NADRB) metric, which satisfies six out of nine (67%) properties. In addition, the results from the statistical analysis show good statistical distribution characteristics (only the Number of Extended Rule Blocks (NERB) metric exceeds the rule-of-thumb threshold value of the Cliff’s delta). The correlation between the metric values and the size of the CSS documents is insignificant, suggesting that the presented metrics are indeed complexity rather than size metrics. The practical application of the presented CSS complexity metric suite is to assess the risk of CSS documents. The proposed CSS complexity metrics suite allows identification of CSS files that require immediate attention of software maintenance personnel. Full article