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13 Results Found

  • Article
  • Open Access
2 Citations
2,242 Views
23 Pages

This paper seeks to address the relation between semantics, pragmatics and the productivity of a low level lexico-grammatical construction, Have the N (body part/attitude) to ↔metapragmatic comment. The question posed is how semantics affects pr...

  • Article
  • Open Access
35 Citations
5,150 Views
18 Pages

31 December 2018

Hydroxyapatite has excellent biocompatibility and osteo-conductivity and, as the main inorganic component of human bones and teeth, is commonly used for bone repair. Its original characteristics can be changed by metal ion substitution. Cobalt ions c...

  • Article
  • Open Access
15 Citations
3,830 Views
14 Pages

3 February 2019

Magnetic nanoparticles are used to enhance the image contrast of magnetic resonance imaging (MRI). However, the development of magnetic nanoparticles with a low dose/high image contrast and non-toxicity is currently a major challenge. In this study,...

  • Article
  • Open Access
3 Citations
2,011 Views
12 Pages

Treatment-Related Risk Factors for Adverse Outcomes of COVID-19 in Patients Treated for Lymphoid Malignancies in the Pre-Omicron Era—A Study of KroHem, the Croatian Group for Hematologic Diseases

  • Igor Aurer,
  • Ozren Jakšić,
  • Sandra Bašić-Kinda,
  • Stefan Mrđenović,
  • Slobodanka Ostojić-Kolonić,
  • Dominik Lozić,
  • Hrvoje Holik,
  • Sabina Novaković-Coha,
  • Petra Berneš and
  • Ivan Krečak
  • + 4 authors

Patients with lymphoid malignancies are at increased risk of death or prolonged infection due to COVID-19. Data on the influence of different antineoplastic treatment modalities on outcomes are conflicting. Anti-CD20 monoclonal antibodies increase th...

  • Article
  • Open Access
1 Citations
1,674 Views
10 Pages

Outcomes of Ixazomib Treatment in Relapsed and Refractory Multiple Myeloma: Insights from Croatian Cooperative Group for Hematologic Diseases (KROHEM)

  • Josip Batinić,
  • Barbara Dreta,
  • Goran Rinčić,
  • Antonia Mrdeža,
  • Karla Mišura Jakobac,
  • Delfa Radić Krišto,
  • Milan Vujčić,
  • Mario Piršić,
  • Željko Jonjić and
  • Vlatka Periša
  • + 9 authors

20 November 2024

Background and Objectives: Ixazomib, used in combination with lenalidomide and dexamethasone (IRd), has shown efficacy in clinical trials for relapsed/refractory multiple myeloma (RRMM). Materials and Methods: This study evaluates the real-world effe...

  • Article
  • Open Access
1,599 Views
9 Pages

Obinutuzumab in Combination with Alternative Chlorambucil Schedules in Front-Line Treatment of Chronic Lymphocytic Leukemia: A Study by KroHem, the Croatian Cooperative Group for Hematologic Diseases

  • Igor Aurer,
  • Ozren Jakšić,
  • Sandra Bašić-Kinda,
  • Karla Mišura-Jakobac,
  • Jasminka Sinčić-Petričević,
  • Sabina Novaković-Coha,
  • Davor Galušić,
  • Hrvoje Holik,
  • Toni Valković and
  • Dubravka Županić-Krmek
  • + 3 authors

20 December 2024

Background/Objectives: Obinutuzumab was approved for front-line treatment of chronic lymphocytic leukemia in combination with chlorambucil pulses administered every 2 wks. Alternative schedules of chlorambucil enable the administration of higher tota...

  • Feature Paper
  • Article
  • Open Access
2 Citations
1,253 Views
15 Pages

Combination of Membrane-Based Pre-Treatment Techniques and Heterogeneous Photocatalysis to Obtain High-Quality Effluents from Produced Water

  • Greta Brocchetto,
  • Iván Sciscenko,
  • Marco Minella,
  • Lorenzo Craveri,
  • Erica Bertozzi,
  • Marco Malaguti,
  • Marco Coha,
  • Alberto Tiraferri and
  • Davide Vione

10 June 2025

Produced water is the waste aqueous phase from petroleum extraction. As it contains salts, a high organic load, and toxic organic compounds, it should be treated before disposal or reuse. In this research, the combination of membrane processes (micro...

  • Article
  • Open Access
1 Citations
846 Views
15 Pages

Efficacy, Toxicity and Effect of Pretreatment Cardiologic Consultation on Outcomes of Ibrutinib Therapy for Chronic Lymphocytic Leukemia—A KroHem Study

  • Inga Mandac Smoljanović,
  • Igor Aurer,
  • Nikola Bulj,
  • Barbara Dreta,
  • Antonija Miljak,
  • Fran Petričević,
  • Marija Ivić,
  • Sandra Bašić-Kinda,
  • Viktor Zatezalo and
  • Sanja Madunić
  • + 10 authors

10 July 2025

Background/Objectives: Ibrutinib has revolutionized the treatment of chronic lymphocytic leukemia but has off-target side effects, most notably cardiac. In order to evaluate the efficacy and toxicity of ibrutinib treatment, risk factors for adverse o...

  • Article
  • Open Access
5 Citations
2,814 Views
14 Pages

Hip and Knee Osteoarthritis in Patients with Chronic Myeloproliferative Neoplasms: A Cross-Sectional Study

  • Hrvoje Holik,
  • Ivan Krečak,
  • Marko Lucijanić,
  • Ivan Samardžić,
  • Danijel Pilipac,
  • Ivana Vučinić Ljubičić,
  • Božena Coha,
  • Alma Kitter Pipić,
  • Blaženka Miškić and
  • Silva Zupančić-Šalek

14 June 2023

Background: Osteoarthritis (OA) is a progressive degenerative disease with an inflammatory background. Chronic myeloproliferative neoplasms (MPN) are clonal hematopoietic disorders characterized by chronic inflammation and a tendency for connective t...

  • Article
  • Open Access
5 Citations
2,849 Views
11 Pages

Non-Myelofibrosis Chronic Myeloproliferative Neoplasm Patients Show Better Seroconversion Rates after SARS-CoV-2 Vaccination Compared to Other Hematologic Diseases: A Multicentric Prospective Study of KroHem

  • Zrinka Sertić,
  • Marko Lucijanić,
  • Sandra Bašić-Kinda,
  • Ranka Serventi Seiwerth,
  • Vlatka Periša,
  • Dubravka Sertić,
  • Božena Coha,
  • Dražen Pulanić,
  • Zinaida Perić and
  • Lana Desnica
  • + 8 authors

11 November 2022

Disease- and treatment-mediated immunodeficiency might render SARS-CoV-2 vaccines less effective in patients with hematologic diseases. We performed a prospective non-interventional study to evaluate humoral response after one and two doses of mRNA-1...

  • Article
  • Open Access
23 Citations
4,687 Views
15 Pages

22 November 2020

Diabetic foot ulcers (DFUs) caused by diabetes are prone to serious and persistent infections. If not treated properly, it will cause tissue necrosis or septicemia due to peripheral blood vessel embolism. Therefore, it is an urgent challenge to accel...

  • Article
  • Open Access
2 Citations
3,010 Views
15 Pages

18 November 2020

Calcium ions and phosphate ions are usually present in biological organisms and human bodies. Different ratios of calcium to phosphorus result in different types of calcium-to-phosphorus crystals. Hydroxyapatite (HA) is the main component of human ha...

  • Article
  • Open Access
3 Citations
3,621 Views
18 Pages

Development of a Cardio-Oncology Service in Lithuania: Prediction, Prevention, Monitoring and Treatment of Cancer Treatment-Induced Cardiotoxicity

  • Eglė Čiburienė,
  • Sigita Aidietienė,
  • Greta Ščerbickaitė,
  • Birutė Brasiūnienė,
  • Monika Drobnienė,
  • Edita Baltruškevičienė,
  • Tadas Žvirblis and
  • Jelena Čelutkienė

Background: Advances in cancer therapy have dramatically improved outcomes for cancer pa-tients. However, cancer treatment can cause several cardiovascular (CV) complications, increasing cardiac mortality and morbidity in cancer patients and survivor...