Search Results (8)

Pyrrole derivatives are natural organic molecules that are important to the pharmaceutical industry due to their occurrence in nature and their use in a wide range of medical applications. In general, non-symmetric, 1,2,5-triaryl-substituted pyrroles are prepared either by Paal–Knorr condensation or cycloaddition that present synthetic challenges particularly if late-stage functionalization is required. The present study describes a modular approach to synthesizing 1,2,5-triarylpyrroles containing three different arene substituents. Using pyrrole ester building blocks, a sequence of decarboxylative cross-coupling and C–H arylation provides unsymmetrical 1,2,5-triarylpyrroles in a regioselective, stepwise manner; the scope and limitations of the sequence are disclosed. Full article

This work presents a highly compact and scalable 1.2-kV SiC MOSFET half-bridge building-block module enabled by a die-integrated 3D PCB packaging technology. Compared with conventional DBC-based or TO-247-based SiC half-bridge modules, the proposed design reduces the physical volume and weight by more than 90% while maintaining full compatibility with standard PCB manufacturing processes. The vertically laminated DC+/DC− conductors and symmetric PCB–die–PCB stack establish a tightly confined commutation loop, resulting in a measured power-loop inductance of 2.2 nH and a 3.8 nH gate-loop inductance—representing up to 94% and 89% reduction relative to discrete device implementations. Because the parasitic parameters are intrinsically well-balanced across replicated units and the mutual inductance between adjacent modules remains extremely small, the structure naturally supports current sharing during parallel operation. Thermal and insulation evaluations further confirm the suitability of copper filling via high-Tg laminated PCB substrates for high-power SiC applications, achieving withstand voltages exceeding twice the rated bus voltage. The proposed module is experimentally validated through finite-element parasitic extraction and 950 V double-pulse testing, demonstrating controlled dv/dt behavior and robust switching performance. This work establishes a manufacturable and parallel-friendly packaging approach for high-density SiC power conversion systems. Full article

In this paper, the use of nilpotent Lie algebras as the basis for homomorphic encryption based on additive operations is explored. The $g$-setting is set up over $g{l}_n\left({\mathbb{Z}}_q\right)$) and the group $G=exp\left(g\right)$, and it is noted that the exponential and logarithm series are truncated by nilpotency in a natural way. From this, an additive symmetric conjugation scheme is constructed: given a message element $M$ and a central randomizer $U\in z\left(g\right),$ we encrypt $=Kexp\left(M+U\right)K^{-1}$ and decrypt to $M=log\left(K^{-1}CK\right)-U$. The scheme is additive in nature, with the security defined in the IND-CPA model. Integrity is ensured using an encrypt-then-MAC construction. These properties together provide both confidentiality and robustness while preserving the homomorphic functionality. The scheme realizes additive homomorphism through a truncated BCH-sum, so it is suitable for ciphertext summations. We implemented a prototype and took reproducible measurements (Python 3.11/NumPy) of the series $\{{10,10}^2,{10}^3,{10}^4,{10}^5\}$ over 10 iterations, reporting the medians and 95% confidence intervals. The graphs exhibit that the latency per operation remains constant at fixed values, and the total time scales approximately linearly with the batch size; we also report the throughput, peak memory usage, $\mid C\mid /\mid M\mid$ expansion rate, and achievable aggregation depth. The applications are federated reporting, IoT telemetry, and privacy-preserving aggregations in DBMS; the limitations include its additive nature (lacking general multiplicative homomorphism), IND-CPA (but not CCA), and side-channel resistance requirements. We place our approach in contrast to the standard FHE building blocks BFV/BGV/CKKS nd the emerging NIST PQC standards (FIPS 203/204/205), as a well-established security model with future engineering optimizations. Full article

4-(4-nitrophenyl)thiomorpholine, the title compound, has been used as a precursor for the corresponding 4-thiomorpholinoaniline, which is a useful building block in medicinal chemistry. The crystal and molecular structures of the title compound, however, have not been described thus far. We synthesized the title compound by means of a nucleophilic aromatic substitution reaction of 4-fluoronitrobenzene and thiomorpholine and structurally characterized it by X-ray crystallography, DFT calculations, and Hirshfeld surface analysis. In the crystal, the molecule exhibits an approximately C_S-symmetric structure, with the nitrogen-bound 4-nitrophenyl group in a quasi axial position on the six-membered thiomorpholine ring in a low-energy chair conformation. The solid-state structure of the title compound is markedly different from that of its morpholine analogue. This can be ascribed to the formation of centrosymmetric dimers through intermolecular C–H···O weak hydrogen bonds involving the methylene groups adjacent to the sulfur atom and face-to-face aromatic stacking. Full article

Effective natural ventilation reduces humidity, cools the space, and enhances thermal comfort. In light of the frequent ventilation issues in the Lingnan area, this research suggests a successful ventilation technique using Jiangmen’s “Yunshan Poetic” Moon Island houses as an example. With its symmetrical architectural layout of townhouses and its primary courtyard villa product, the community typifies the Lingnan area. First off, we discovered that the district’s average temperature is as high as 30.95 °C and its average humidity is as high as 83.592%RH using actual measurements and simulation of heat and humidity data. The district’s buildings’ issues with dampness, peeling walls, and substance mold are primarily caused by poor ventilation. Secondly, the PHOENICS program was used to provide efficient ventilation solutions for the following six aspects: external wind infusion organization, group orientation layout, planar grouping optimization, building façade combination, monolithic building openings, and indoor ventilation block. In order to determine if the technique is effective, the ventilation variables are compared before and after optimization using the Building Ventilation Effectiveness Test and Evaluation Criteria. The study concluded that the building’s architectural characteristics and the local climate have an impact on natural ventilation’s effectiveness. This serves as a guide for both the scientific layout development of future urban settlements and the optimization of ventilation of existing villa buildings in humid and hot areas. Full article

A series of C₃-symmetric fully substituted benzenes were prepared based on alkyl triamino-benzene-tricarboxylates. Starting with a one step-synthesis, the alkyl triamino-benzene-tricarboxylates were synthesized using the corresponding cyanoacetates. The reactivity of these electronically sophisticated compounds was investigated by the formation of azides, the click reaction of the azides and a Sandmeyer-like reaction. Caused by the low stability of triaminobenzenes, direct N-alkylation was rarely reported. The use of the stable alkyl triamino-benzene-tricarboxylates allowed us total N-alkylation under standard alkylation conditions. The molecular structures of the C₃-symmetric structures have been corroborated by an X-ray analysis. Full article

In this study, we examined the Aureobasidium pullulans strains DSM 14940 and DSM 14941 included in the Blossom Protect™ agent to be used in the bioreduction reaction of a symmetrical dicarbonyl compound. Both chiral 2-hydroxy-1,2-diphenylethanone antipodes were obtained with a high enantiomeric purity. Mild conditions (phosphate buffer [pH 7.0, 7.2], 30 °C) were successfully employed in the synthesis of (S)-benzoin using two different methodologies: benzyl desymmetrization and rac-benzoin deracemization. Bioreduction carried out with higher reagent concentrations, lower pH values and prolonged reaction time, and in the presence of additives, enabled enrichment of the reaction mixture with (R)-benzoin. The described procedure is a potentially useful tool in the synthesis of chiral building blocks with a defined configuration in a simple and economical process with a lower environmental impact, enabling one-pot biotransformation. Full article

Herein we report a significant, valuable extension of a recently implemented pyrrole benzannulation methodology that, employing versatile nitrodienes from our lab as useful C₄ building blocks, led to indole derivatives characterized by unusual patterns of substitution. The 6-nitro-7-arylindoles resulting from suitably derivatized, non-symmetric dienes are of foreseeable synthetic interest in search for new polyheterocyclic systems. As an example, pyrrolocarbazoles with a rarely reported ring fusion were synthesized with the classical Cadogan protocol. Furthermore, the proven easy reducibility of the nitro group to amine will surely open the way to further interesting elaborations. Full article