Skip Content
You are currently on the new version of our website. Access the old version .

293 Results Found

  • Article
  • Open Access
25 Citations
5,683 Views
21 Pages

16 February 2023

The deployment of wearable wireless systems that collect physiological indicators to aid in diagnosing neurological disorders represents a potential solution for the new generation of e-health systems. Electroencephalography (EEG), a recording of the...

  • Review
  • Open Access
1 Citations
2,623 Views
17 Pages

21 August 2025

While technology has influenced today’s society in many aspects, how does it advance research and practice in the field of autism spectrum disorder (ASD)? In this article, we provide a narrative review of how technology enhances early detection...

  • Article
  • Open Access
2 Citations
2,034 Views
21 Pages

Background/Objectives: Repetitive behaviors such as hand flapping, body rocking, and head shaking characterize Autism Spectrum Disorder (ASD) while functioning as early signs of neurodevelopmental variations. Traditional diagnostic procedures require...

  • Article
  • Open Access
11 Citations
3,231 Views
10 Pages

12 February 2022

Autism spectrum disorder (ASD) is a heterogeneous condition characterized by deficits in social communication and a repetitive pattern of behavior, with recent Italian prevalence estimates of 1 in 77. Although the core behavioral features of ASD appe...

  • Article
  • Open Access
1 Citations
1,601 Views
20 Pages

Background/Objectives: Nonverbal synchrony—the temporal coordination of physical behaviors such as head movement and gesture—is a critical component of effective social communication. Individuals with autism spectrum disorder (ASD) are of...

  • Article
  • Open Access
4 Citations
6,266 Views
19 Pages

Early Detection of Autism Spectrum Disorder Through Automated Machine Learning

  • Khafsa Ehsan,
  • Kashif Sultan,
  • Abreen Fatima,
  • Muhammad Sheraz and
  • Teong Chee Chuah

Background/Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder distinguished by an extensive range of symptoms, including reduced social interaction, communication difficulties and tiresome behaviors. Early detection of ASD is...

  • Article
  • Open Access
68 Citations
8,072 Views
17 Pages

19 October 2018

Detecting and monitoring of abnormal movement behaviors in patients with Parkinson’s Disease (PD) and individuals with Autism Spectrum Disorders (ASD) are beneficial for adjusting care and medical treatment in order to improve the patient&rsquo...

  • Article
  • Open Access
6 Citations
3,021 Views
18 Pages

Identification of Neurotransmission and Synaptic Biological Processes Disrupted in Autism Spectrum Disorder Using Interaction Networks and Community Detection Analysis

  • Joana Vilela,
  • Hugo Martiniano,
  • Ana Rita Marques,
  • João Xavier Santos,
  • Muhammad Asif,
  • Célia Rasga,
  • Guiomar Oliveira and
  • Astrid Moura Vicente

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by communication deficits and repetitive behavioral patterns. Hundreds of candidate genes have been implicated in ASD, including neurotransmission and synaptic (NS) genes;...

  • Systematic Review
  • Open Access
3 Citations
7,326 Views
81 Pages

Leveraging AI-Driven Neuroimaging Biomarkers for Early Detection and Social Function Prediction in Autism Spectrum Disorders: A Systematic Review

  • Evgenia Gkintoni,
  • Maria Panagioti,
  • Stephanos P. Vassilopoulos,
  • Georgios Nikolaou,
  • Basilis Boutsinas and
  • Apostolos Vantarakis

Background: This systematic review examines artificial intelligence (AI) applications in neuroimaging for autism spectrum disorder (ASD), addressing six research questions regarding biomarker optimization, modality integration, social function predic...

  • Article
  • Open Access
12 Citations
3,218 Views
12 Pages

A Convolutional Neural Network-Based Connectivity Enhancement Approach for Autism Spectrum Disorder Detection

  • Fatima Zahra Benabdallah,
  • Ahmed Drissi El Maliani,
  • Dounia Lotfi and
  • Mohammed El Hassouni

Autism spectrum disorder (ASD) represents an ongoing obstacle facing many researchers to achieving early diagnosis with high accuracy. To advance developments in ASD detection, the corroboration of findings presented in the existing body of autism-ba...

  • Review
  • Open Access
2 Citations
2,279 Views
13 Pages

Salivary Biomarkers for Early Detection of Autism Spectrum Disorder: A Scoping Review

  • Margherita Tumedei,
  • Niccolò Cenzato,
  • Sourav Panda,
  • Funda Goker and
  • Massimo Del Fabbro

4 August 2025

Background: Autism spectrum disorder (ASD) represents a neurobiological disorder with a high prevalence in the children’s population. The aim of the present review was to assess the current evidence on the use of salivary biomarkers for the ear...

  • Article
  • Open Access
94 Citations
10,095 Views
22 Pages

Efficient Machine Learning Models for Early Stage Detection of Autism Spectrum Disorder

  • Mousumi Bala,
  • Mohammad Hanif Ali,
  • Md. Shahriare Satu,
  • Khondokar Fida Hasan and
  • Mohammad Ali Moni

16 May 2022

Autism spectrum disorder (ASD) is a neurodevelopmental disorder that severely impairs an individual’s cognitive, linguistic, object recognition, communication, and social abilities. This situation is not treatable, although early detection of A...

  • Article
  • Open Access
2 Citations
2,650 Views
12 Pages

Detection of Electroencephalographic Abnormalities and Its Associated Factors among Children with Autism Spectrum Disorder in Thailand

  • Duangkamol Tangviriyapaiboon,
  • Patrinee Traisathit,
  • Vorasith Siripornpanich,
  • Chidawan Suyakong,
  • Hataichanok Apikomonkon,
  • Nontiya Homkham,
  • Salinee Thumronglaohapun and
  • Pimwarat Srikummoon

8 October 2022

Epilepsy often causes more severe behavioral problems in children with autism spectrum disorder (ASD) and is strongly associated with poor cognitive functioning. Interestingly, individuals with ASD without a history of epilepsy can have abnormal elec...

  • Article
  • Open Access
10 Citations
3,947 Views
12 Pages

PFT: A Novel Time-Frequency Decomposition of BOLD fMRI Signals for Autism Spectrum Disorder Detection

  • Samir Brahim Belhaouari,
  • Abdelhamid Talbi,
  • Saima Hassan,
  • Dena Al-Thani and
  • Marwa Qaraqe

23 February 2023

Diagnosing Autism spectrum disorder (ASD) is a challenging task for clinicians due to the inconsistencies in existing medical tests. The Internet of things (IoT) has been used in several medical applications to realize advancements in the healthcare...

  • Letter
  • Open Access
39 Citations
4,472 Views
11 Pages

Deep-Learning-Based Detection of Infants with Autism Spectrum Disorder Using Auto-Encoder Feature Representation

  • Jung Hyuk Lee,
  • Geon Woo Lee,
  • Guiyoung Bong,
  • Hee Jeong Yoo and
  • Hong Kook Kim

26 November 2020

Autism spectrum disorder (ASD) is a developmental disorder with a life-span disability. While diagnostic instruments have been developed and qualified based on the accuracy of the discrimination of children with ASD from typical development (TD) chil...

  • Article
  • Open Access
2 Citations
2,125 Views
28 Pages

Modified Meta Heuristic BAT with ML Classifiers for Detection of Autism Spectrum Disorder

  • Mohemmed Sha,
  • Abdullah Alqahtani,
  • Shtwai Alsubai and
  • Ashit Kumar Dutta

29 December 2023

ASD (autism spectrum disorder) is a complex developmental and neurological disorder that impacts the social life of the affected person by disturbing their capability for interaction and communication. As it is a behavioural disorder, early treatment...

  • Article
  • Open Access
7 Citations
2,417 Views
17 Pages

11 October 2024

Automated Machine Learning (AutoML) enhances productivity and efficiency by automating the entire process of machine learning model development, from data preprocessing to model deployment. These tools are accessible to users with varying levels of e...

  • Systematic Review
  • Open Access
2 Citations
7,195 Views
40 Pages

Summarizing Recent Developments on Autism Spectrum Disorder Detection and Classification Through Machine Learning and Deep Learning Techniques

  • Masroor Ahmed,
  • Sadam Hussain,
  • Farman Ali,
  • Anna Karen Gárate-Escamilla,
  • Ivan Amaya,
  • Gilberto Ochoa-Ruiz and
  • José Carlos Ortiz-Bayliss

19 July 2025

Autism Spectrum Disorder (ASD) encompasses various neurological disorders with symptoms varying by age, development, genetics, and other factors. Core symptoms include decreased pain sensitivity, difficulty sustaining eye contact, incorrect auditory...

  • Article
  • Open Access
7 Citations
2,799 Views
14 Pages

End-to-End Model-Based Detection of Infants with Autism Spectrum Disorder Using a Pretrained Model

  • Jung Hyuk Lee,
  • Geon Woo Lee,
  • Guiyoung Bong,
  • Hee Jeong Yoo and
  • Hong Kook Kim

25 December 2022

In this paper, we propose an end-to-end (E2E) neural network model to detect autism spectrum disorder (ASD) from children’s voices without explicitly extracting the deterministic features. In order to obtain the decisions for discriminating bet...

  • Article
  • Open Access
29 Citations
10,364 Views
17 Pages

Characterizing Olfactory Function in Children with Autism Spectrum Disorder and Children with Sensory Processing Dysfunction

  • Julia R. Sweigert,
  • Tanya St. John,
  • Kristin Kawena Begay,
  • Greg E. Davis,
  • Jeffrey Munson,
  • Eric Shankland,
  • Annette Estes,
  • Stephen R. Dager and
  • Natalia M. Kleinhans

Abnormalities in olfactory function have been identified in a number of neurological and psychiatric disorders, including Parkinson’s disease and schizophrenia. However, little is known about olfactory function in autism spectrum disorder (ASD)...

  • Proceeding Paper
  • Open Access
31 Citations
13,333 Views
10 Pages

22 January 2024

Autism spectrum disorder (ASD) is a complex neurological disorder that results in aberrant personality traits, cognitive function, and interpersonal relationships. It impacts the child’s linguistic and social skills, interaction abilities, and...

  • Article
  • Open Access
171 Citations
21,471 Views
27 Pages

Eye Tracking-Based Diagnosis and Early Detection of Autism Spectrum Disorder Using Machine Learning and Deep Learning Techniques

  • Ibrahim Abdulrab Ahmed,
  • Ebrahim Mohammed Senan,
  • Taha H. Rassem,
  • Mohammed A. H. Ali,
  • Hamzeh Salameh Ahmad Shatnawi,
  • Salwa Mutahar Alwazer and
  • Mohammed Alshahrani

10 February 2022

Eye tracking is a useful technique for detecting autism spectrum disorder (ASD). One of the most important aspects of good learning is the ability to have atypical visual attention. The eye-tracking technique provides useful information about childre...

  • Systematic Review
  • Open Access
20 Citations
4,865 Views
27 Pages

9 January 2025

This paper presents a systematic review of the emerging applications of artificial intelligence (AI), Internet of Things (IoT), and sensor-based technologies in the diagnosis of autism spectrum disorder (ASD). The integration of these technologies ha...

  • Article
  • Open Access
37 Citations
7,493 Views
31 Pages

Hybrid Techniques of Facial Feature Image Analysis for Early Detection of Autism Spectrum Disorder Based on Combined CNN Features

  • Bakri Awaji,
  • Ebrahim Mohammed Senan,
  • Fekry Olayah,
  • Eman A. Alshari,
  • Mohammad Alsulami,
  • Hamad Ali Abosaq,
  • Jarallah Alqahtani and
  • Prachi Janrao

14 September 2023

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by difficulties in social communication and repetitive behaviors. The exact causes of ASD remain elusive and likely involve a combination of genetic, environmental,...

  • Article
  • Open Access
10 Citations
5,375 Views
12 Pages

A Two-Stage Screening Approach with I-TC and Q-CHAT to Identify Toddlers at Risk for Autism Spectrum Disorder within the Italian Public Health System

  • Raffaella Devescovi,
  • Lorenzo Monasta,
  • Maura Bin,
  • Giulia Bresciani,
  • Alice Mancini,
  • Marco Carrozzi and
  • Costanza Colombi

Standardized screening programs ensure that children are monitored for early signs of autism spectrum disorder (ASD) in order to promote earlier diagnosis and intervention. The aim of this study is to identify early signs of atypical development cons...

  • Article
  • Open Access
2 Citations
2,444 Views
25 Pages

Autism Spectrum Disorder Detection Using Skeleton-Based Body Movement Analysis via Dual-Stream Deep Learning

  • Jungpil Shin,
  • Abu Saleh Musa Miah,
  • Manato Kakizaki,
  • Najmul Hassan and
  • Yoichi Tomioka

Autism Spectrum Disorder (ASD) poses significant challenges in diagnosis due to its diverse symptomatology and the complexity of early detection. Atypical gait and gesture patterns, prominent behavioural markers of ASD, hold immense potential for fac...

  • Review
  • Open Access
133 Citations
21,668 Views
23 Pages

19 February 2021

This review discusses early diagnostics and early intervention in developmental disorders in the light of brain development. The best instruments for early detection of cerebral palsy (CP) with or without intellectual disability are neonatal magnetic...

  • Article
  • Open Access
29 Citations
5,916 Views
15 Pages

19 April 2021

Time is a key factor to consider in Autism Spectrum Disorder. Detecting the condition as early as possible is crucial in terms of treatment success. Despite advances in the literature, it is still difficult to identify early markers able to effective...

  • Article
  • Open Access
2 Citations
2,723 Views
9 Pages

Male predominance is a known feature of autism spectrum disorder (ASD). Although ASD mouse models can be useful for elucidating mechanisms underlying abnormal behaviors relevant to human ASD, suitable models to analyze sex differences in ASD pathogen...

  • Article
  • Open Access
3 Citations
2,494 Views
14 Pages

Individual Deviation-Based Functional Hypergraph for Identifying Subtypes of Autism Spectrum Disorder

  • Jialong Li,
  • Weihao Zheng,
  • Xiang Fu,
  • Yu Zhang,
  • Songyu Yang,
  • Ying Wang,
  • Zhe Zhang,
  • Bin Hu and
  • Guojun Xu

Heterogeneity has been one of the main barriers to understanding and treatment of autism spectrum disorder (ASD). Previous studies have identified several subtypes of ASD through unsupervised clustering analysis. However, most of them primarily depic...

  • Communication
  • Open Access
11 Citations
5,044 Views
27 Pages

Important Preliminary Insights for Designing Successful Communication between a Robotic Learning Assistant and Children with Autism Spectrum Disorder in Germany

  • Aike C. Horstmann,
  • Lisa Mühl,
  • Louisa Köppen,
  • Maike Lindhaus,
  • Dunja Storch,
  • Monika Bühren,
  • Hanns Rüdiger Röttgers and
  • Jarek Krajewski

4 December 2022

Early therapeutic intervention programs help children diagnosed with Autism Spectrum Disorder (ASD) to improve their socio-emotional and functional skills. To relieve the children’s caregivers while ensuring that the children are adequately sup...

  • Review
  • Open Access
1,172 Views
18 Pages

AI-Enabled Technologies and Biomarker Analysis for the Early Identification of Autism and Related Neurodevelopmental Disorders

  • Rohan Patel,
  • Beth A. Jerskey,
  • Jennifer Shannon,
  • Neelkamal Soares and
  • Jason M. Fogler

9 December 2025

Background: Autism spectrum disorder (ASD) and related neurodevelopmental conditions are a significant public health concern, with diagnostic delays hindering timely intervention. Traditional assessments often lead to waiting times exceeding a year....

  • Article
  • Open Access
2 Citations
4,385 Views
17 Pages

Implementation of M-Chat for Screening of Early Signs of Autism in the Brazilian Health Care System: A Feasibility Study

  • Nadia Maria Giaretta,
  • Sabrina Pires Trufeli,
  • Felipe Alckmin-Carvalho and
  • Maria Cristina Triguero Veloz Teixeira

31 March 2025

Background: Although screening for early signs of autism spectrum disorder (ASD) using the Modified Checklist for Autism in Toddlers (M-CHAT) has been recommended by the Brazilian Ministry of Health since 2014, the feasibility of this intervention an...

  • Review
  • Open Access
20 Citations
10,986 Views
13 Pages

Detection of Early Warning Signs in Autism Spectrum Disorders: A Systematic Review

  • José María Salgado-Cacho,
  • María del Pilar Moreno-Jiménez and
  • Yolanda de Diego-Otero

22 February 2021

Due to the exponential increase of autism spectrum disorders’ prevalence in Western countries, it is necessary to improve early detection and intervention to enhance developmental milestones. This systematic review identified the most effective scree...

  • Article
  • Open Access
9 Citations
2,872 Views
18 Pages

Clustering Analysis Supports the Detection of Biological Processes Related to Autism Spectrum Disorder

  • Leonardo Emberti Gialloreti,
  • Roberto Enea,
  • Valentina Di Micco,
  • Daniele Di Giovanni and
  • Paolo Curatolo

9 December 2020

Genome sequencing has identified a large number of putative autism spectrum disorder (ASD) risk genes, revealing possible disrupted biological pathways; however, the genetic and environmental underpinnings of ASD remain mostly unanswered. The present...

  • Article
  • Open Access
35 Citations
4,976 Views
19 Pages

An Integrated Statistical and Clinically Applicable Machine Learning Framework for the Detection of Autism Spectrum Disorder

  • Md. Jamal Uddin,
  • Md. Martuza Ahamad,
  • Prodip Kumar Sarker,
  • Sakifa Aktar,
  • Naif Alotaibi,
  • Salem A. Alyami,
  • Muhammad Ashad Kabir and
  • Mohammad Ali Moni

Autism Spectrum Disorder (ASD) is a neurological impairment condition that severely impairs cognitive, linguistic, object recognition, interpersonal, and communication skills. Its main cause is genetic, and early treatment and identification can redu...

  • Article
  • Open Access
16 Citations
4,195 Views
19 Pages

The study of human gut microbiota has attracted increasing interest in the fields of life science and healthcare. However, the complicated and interconnected associations between gut microbiota and human diseases are still difficult to determine in a...

  • Review
  • Open Access
717 Views
20 Pages

Tools for Detecting Ageing in People with Autism Spectrum Disorder: A Scoping Review

  • Maider Ugartemendia-Yerobi,
  • Beatriz Pereda-Goikoetxea,
  • Maria Isabel Trespaderne and
  • Jaione Lacalle

20 October 2025

Background: People with Autism Spectrum Disorder (ASD) require a customised, multidisciplinary plan throughout their lifetime to support optimal health. The purpose of this scoping review was to synthesise research on the main scales used to detect s...

  • Article
  • Open Access
29 Citations
11,290 Views
27 Pages

Applying Eye Tracking with Deep Learning Techniques for Early-Stage Detection of Autism Spectrum Disorders

  • Zeyad A. T. Ahmed,
  • Eid Albalawi,
  • Theyazn H. H. Aldhyani,
  • Mukti E. Jadhav,
  • Prachi Janrao and
  • Mansour Ratib Mohammad Obeidat

3 November 2023

Autism spectrum disorder (ASD) poses a complex challenge to researchers and practitioners, with its multifaceted etiology and varied manifestations. Timely intervention is critical in enhancing the developmental outcomes of individuals with ASD. This...

  • Article
  • Open Access
3 Citations
4,094 Views
15 Pages

11 February 2025

Background: Research evidence has recently shown an association between autism spectrum disorder (ASD) and inflammation. For example, the expression of inflammatory cytokines is abnormal in children with ASD, and maternal inflammation can lead to ASD...

  • Review
  • Open Access
1,643 Views
18 Pages

19 September 2025

To uncover neurobiological indicators related to autism spectrum disorders and developmental dyslexia, this article gives a full overview of the most recent advances in machine learning and deep learning methods based on electroencephalography. We lo...

  • Article
  • Open Access
11 Citations
4,907 Views
27 Pages

Innovative Approach to Detecting Autism Spectrum Disorder Using Explainable Features and Smart Web Application

  • Mohammad Abu Tareq Rony,
  • Fatama Tuz Johora,
  • Nisrean Thalji,
  • Ali Raza,
  • Norma Latif Fitriyani,
  • Muhammad Syafrudin and
  • Seung Won Lee

11 November 2024

Autism Spectrum Disorder (ASD) is a complex developmental condition marked by challenges in social interaction, communication, and behavior, often involving restricted interests and repetitive actions. The diversity in symptoms and skill profiles acr...

  • Article
  • Open Access
30 Citations
5,000 Views
15 Pages

Diagnosis of Autism Spectrum Disorder Using Convolutional Neural Networks

  • Amna Hendr,
  • Umar Ozgunalp and
  • Meryem Erbilek Kaya

Autism spectrum disorder as a condition has posed significant early diagnosis challenges to the medical and health community for a long time. The early diagnosis of ASD is crucial for early intervention and adequate management of the condition. Sever...

  • Review
  • Open Access
17 Citations
4,487 Views
26 Pages

Metabolomics: Perspectives on Clinical Employment in Autism Spectrum Disorder

  • Martina Siracusano,
  • Lucrezia Arturi,
  • Assia Riccioni,
  • Antonio Noto,
  • Michele Mussap and
  • Luigi Mazzone

29 August 2023

Precision medicine is imminent, and metabolomics is one of the main actors on stage. We summarize and discuss the current literature on the clinical application of metabolomic techniques as a possible tool to improve early diagnosis of autism spectru...

  • Article
  • Open Access
3 Citations
3,286 Views
18 Pages

Supporting ASD Diagnosis with EEG, ML and Swarm Intelligence: Early Detection of Autism Spectrum Disorder Based on Electroencephalography Analysis by Machine Learning and Swarm Intelligence

  • Flávio Secco Fonseca,
  • Adrielly Sayonara de Oliveira Silva,
  • Maria Vitória Soares Muniz,
  • Catarina Victória Nascimento de Oliveira,
  • Arthur Moreira Nogueira de Melo,
  • Maria Luísa Mendes de Siqueira Passos,
  • Ana Beatriz de Souza Sampaio,
  • Thailson Caetano Valdeci da Silva,
  • Alana Elza Fontes da Gama and
  • Wellington Pinheiro dos Santos
  • + 11 authors

Deficits in social interaction and communication characterize Autism Spectrum Disorder (ASD). Although widely recognized by its symptoms, diagnosing ASD remains challenging due to its wide range of clinical presentations. Methods: In this study, we p...

  • Review
  • Open Access
11 Citations
12,973 Views
26 Pages

20 December 2024

Some previous studies have focused on using physiological signals to detect stress in individuals with ASD through wearable devices, yet few have focused on how to design such solutions. Wearable technology may be a valuable tool to aid parents and c...

  • Article
  • Open Access
16 Citations
4,534 Views
13 Pages

Paternal—but Not Maternal—Autistic Traits Predict Frontal EEG Alpha Asymmetry in Infants with Later Symptoms of Autism

  • Valentina Riva,
  • Cecilia Marino,
  • Caterina Piazza,
  • Elena M Riboldi,
  • Giulia Mornati,
  • Massimo Molteni and
  • Chiara Cantiani

26 November 2019

Previous research found that the parental autism phenotype is associated with child autism spectrum disorder (ASD), even if the pathway between autistic traits in parents and child ASD is still largely unknown. Several studies investigated frontal as...

  • Article
  • Open Access
1 Citations
2,302 Views
20 Pages

21 August 2025

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors. Recent studies have suggested that gut microbiota may play a role in the pathophysiology of A...

  • Article
  • Open Access
83 Citations
12,694 Views
21 Pages

Recent studies suggest that some children with autism prefer robots as tutors for improving their social interaction and communication abilities which are impaired due to their disorder. Indeed, research has focused on developing a very promising for...

  • Article
  • Open Access
19 Citations
5,576 Views
23 Pages

28 February 2024

Autism spectrum disorder (ASD) is a developmental disorder that encompasses difficulties in communication (both verbal and non-verbal), social skills, and repetitive behaviors. The diagnosis of autism spectrum disorder typically involves specialized...

of 6