Search Results (27)

Mucins 5AC (MUC5AC) and 5B (MUC5B) are the major mucins providing the organizing framework for the airway’s mucus gel. We retrieved bronchial mucosal biopsies and bronchial wash (BW) samples through bronchoscopy from patients with chronic obstructive pulmonary disease (n = 38), healthy never-smokers (n = 40), and smokers with normal lung function (n = 40). The expression of MUC5AC and MUC5B was assessed immunohistochemically. The mucin concentrations in BW were determined using the slot-blot technique. The immunohistochemical expression of MUC5AC and MUC5B was localized to goblet cells and submucosal glands. Smokers had higher MUC5AC and lower MUC5B goblet cell expression and higher concentrations of soluble MUC5AC in BW than never-smokers. The MUC5B expression in goblet cells correlated positively with expiratory air flows, diffusing capacity, and the dyspnoea score. Chronic bronchitis, emphysema, and the progression of chronic airflow limitation during a median follow-up time of 8.4 years were associated with higher MUC5AC and lower MUC5B expression in goblet cells. Sustainers, slow progressors, and rapid progressors of airflow obstruction differed in their MUC5B expression at baseline. Emphysema and bronchial wall thickening on CT at a follow-up visit were associated with lower MUC5B expression at baseline. Our findings strengthen the hypothesis that MUC5AC and MUC5B are yet another contributing factor to smoking-associated lung disease progression. Full article

On the basis of a self-developed albatross imitation unmanned aerial vehicle (UAV), three different dihedral angle configurations for the wing’s mid and outer sections are explored: fixed at −50°, fixed at −5°, and varying arbitrarily between −50° and −5°. By solving the optimal loitering dynamic soaring trajectory optimization problem for each configuration, the effect of dihedral angle variation on the dynamic soaring performance of the bio-inspired wings is investigated. The results indicate that under all three configurations, the UAV achieves energy-neutral flight in specific wind field environments. Compared to the fixed dihedral angle of −5°, the UAV demonstrated superior dynamic soaring performance when the dihedral angle was fixed at −50°. When the dihedral angle varied dynamically, the UAV outperformed both fixed configurations across all relevant parameters. Specifically, compared to the fixed dihedral angle of −5°, the total energy increased by 25.43%, and the minimum required wind gradient decreased by 15.56%. Similarly, compared to the fixed dihedral angle of −50°, the total energy increased by 2.52%, and the minimum required wind gradient decreased by 2.07%. These findings suggest that the use of variable dihedral angle technology in bio-inspired UAV wings can significantly enhance dynamic soaring performance and provide theoretical support for the design of morphing wings with superior dynamic soaring capabilities. Full article

Floating offshore wind turbines (FOWTs) are suitable for Japan’s coastal waters. As one of the unique concepts of FOWTs, the floating axis wind turbine (FAWT) is a type of vertical axis wind turbine (VAWT) that actively uses the features of VAWTs to specialize in an area of the floating type. In this study, FAWT behaviors under wind and wave conditions were experimentally investigated in a water tank to understand its dynamic characteristics. The experimental results reveal that although the floater of the FAWT is relatively small compared to its rotor size, its heave response is comparable to those of the other FOWTs using different floaters. Moreover, the FAWT shows a high stability under rated operation and during sudden changes in the wind. Full article

The receptor for advanced glycation end-products (RAGE) has been implicated in driving prostate cancer (PCa) growth, aggression, and metastasis through the fueling of chronic inflammation in the tumor microenvironment. This systematic review and meta-analysis summarizes and analyzes the current clinical and preclinical data to provide insight into the relationships among RAGE levels and PCa, cancer grade, and molecular effects. A multi-database search was used to identify original clinical and preclinical research articles examining RAGE expression in PCa. After screening and review, nine clinical and six preclinical articles were included. The associations of RAGE differentiating benign prostate hyperplasia (BPH) or normal prostate from PCa and between tumor grades were estimated using odds ratios (ORs) and associated 95% confidence intervals (CI). Pooled estimates were calculated using random-effect models due to study heterogeneity. The clinical meta-analysis found that RAGE expression was highly likely to be increased in PCa when compared to BPH or normal prostate (OR: 11.3; 95% CI: 4.4–29.1) and that RAGE was overexpressed in high-grade PCa when compared to low-grade PCa (OR: 2.5; 95% CI: 1.8–3.4). In addition, meta-analysis estimates of preclinical studies performed by albatross plot generation found robustly positive associations among RAGE expression/activation and PCa growth and metastatic potential. This review demonstrates that RAGE expression is strongly tied to PCa progression and can serve as an effective diagnostic target to differentiate between healthy prostate, low-grade PCa, and high-grade PCa, with potential theragnostic applications. Full article

The molecular mechanisms and signal transduction cascades evoked by the activation of aryl hydrocarbon receptor (AhR) are becoming increasingly understandable. AhR is a ligand-activated transcriptional factor that integrates environmental, dietary and metabolic cues for the pleiotropic regulation of a wide variety of mechanisms. AhR mediates transcriptional programming in a ligand-specific, context-specific and cell-type-specific manner. Pioneering cutting-edge research works have provided fascinating new insights into the mechanistic role of AhR-driven downstream signaling in a wide variety of cancers. AhR ligands derived from food, environmental contaminants and intestinal microbiota strategically activated AhR signaling and regulated multiple stages of cancer. Although AhR has classically been viewed and characterized as a ligand-regulated transcriptional factor, its role as a ubiquitin ligase is fascinating. Accordingly, recent evidence has paradigmatically shifted our understanding and urged researchers to drill down deep into these novel and clinically valuable facets of AhR biology. Our rapidly increasing realization related to AhR-mediated regulation of the ubiquitination and proteasomal degradation of different proteins has started to scratch the surface of intriguing mechanisms. Furthermore, AhR and epigenome dynamics have shown previously unprecedented complexity during multiple stages of cancer progression. AhR not only transcriptionally regulated epigenetic-associated molecules, but also worked with epigenetic-modifying enzymes during cancer progression. In this review, we have summarized the findings obtained not only from cell-culture studies, but also from animal models. Different clinical trials are currently being conducted using AhR inhibitors and PD-1 inhibitors (Pembrolizumab and nivolumab), which confirm the linchpin role of AhR-related mechanistic details in cancer progression. Therefore, further studies are required to develop a better comprehension of the many-sided and “diametrically opposed” roles of AhR in the regulation of carcinogenesis and metastatic spread of cancer cells to the secondary organs. Full article

Aberrant mucus secretion is a hallmark of chronic obstructive pulmonary disease (COPD). Expression of the membrane-tethered mucins 3A and 3B (MUC3A, MUC3B) in human lung is largely unknown. In this observational cross-sectional study, we recruited subjects 45–65 years old from the general population of Stockholm, Sweden, during the years 2007–2011. Bronchial mucosal biopsies, bronchial brushings, and bronchoalveolar lavage fluid (BALF) were retrieved from COPD patients (n = 38), healthy never-smokers (n = 40), and smokers with normal lung function (n = 40). Protein expression of MUC3A and MUC3B in bronchial mucosal biopsies was assessed by immunohistochemical staining. In a subgroup of subjects (n = 28), MUC3A and MUC3B mRNAs were quantified in bronchial brushings using microarray. Non-parametric tests were used to perform correlation and group comparison analyses. A value of p < 0.05 was considered statistically significant. MUC3A and MUC3B immunohistochemical expression was localized to ciliated cells. MUC3B was also expressed in basal cells. MUC3A and MUC3B immunohistochemical expression was equal in all study groups but subjects with emphysema had higher MUC3A expression, compared to those without emphysema. Smokers had higher mRNA levels of MUC3A and MUC3B than non-smokers. MUC3A and MUC3B mRNA were higher in male subjects and correlated negatively with expiratory air flows. MUC3B mRNA correlated positively with total cell concentration and macrophage percentage, and negatively with CD4/CD8 T cell ratio in BALF. We concluded that MUC3A and MUC3B in large airways may be a marker of disease or may play a role in the pathophysiology of airway obstruction. Full article

People have raised their expectations for UAV performance due to the widespread use of UAVs in both military and non-military settings. One of the most significant fields of research right now is how to enhance UAVs’ endurance capabilities. Many birds in the wild have the ability to fly for extended periods of time or great distances using the wind, which is called energy harvesting. A seabird called an albatross can use the wind’s horizontal gradient on the water’s surface to generate energy. By gliding, they may fly for a very long time without flapping their wings, thus lowering their own energy consumption. Due to the albatrosses’ nostrils sensitive sensory nerves and sensitivity to environmental information, such as airflow, the albatrosses can modify its flight attitude. Similar to this, real-time dynamic planning of the trajectory can only be done for UAVs in order to realize energy-capturing flying if correct and real-time wind field information is obtained. As a result, developing wind field sensing technology is crucial to the realization of energy-capturing gliding. In this study, we built a 3D wind field sensing system with wind vane sensor and pitot tube. Wind tunnel tests were used to calibrate and alter it. The system’s operation is initially validated by real flight, which may give environmental information, enabling UAVs to utilize the wind field as a reference for planning their flight paths. Full article

Dynamic soaring helps albatross achieve long-distance migration. From a bionic view, dynamic soaring has great potential to enhance unmanned aerial vehicles (“UAVs”) flight range and endurance. The previous application studies focus on flight strategies to guide UAV soaring. However, the energy harvesting efficiency problem emerges. The lack of clear dynamic soaring influencing factors hinders dynamic soaring UAV design and flight strategy design from a theoretical perspective. Hence this paper aims to analyze the influence law of different UAV mass, initial airspeed, and entering angle. Trajectories and flight data in different factors are obtained through trajectory optimization. The results show that UAV mass has a positive influence on energy harvesting. The initial airspeed and entering angle affect both energy efficiency and trajectory. For UAV design, weight balance needs to be considered rather than a pursuit of the lightest. For flight strategy design, finding an optimal initial state will improve energy efficiency. Full article

Renewable energy has received a lot of attention. In recent years, offshore wind power has received particular attention among renewable energies. Fixed-type offshore wind turbines are now the most popular. However, because of the deep seas surrounding Japan, floating types are more preferable. The floating system is one of the factors that raises the cost of floating wind turbines. Vertical axis wind turbines (VAWT) have a low center of gravity and can tilt their rotors. As a result, a smaller floating body and a lower cost are expected. A mechanism called a floating axis wind turbine (FAWT) is expected to further reduce the cost. FAWT actively employs the features of VAWT in order to specialize itself in the area of offshore floating-type wind turbines. The lifting line theory simulation was used in this study to discuss the performance of the FAWT under the tilted conditions and its wake field. The results show that a tilted VAWT recovers faster than an upright VAWT. This suggests that FAWTs can be deployed in high density and efficiently generate energy as an offshore wind farm using VAWTs. Full article

Albatross have a significant gliding ability called dynamic soaring. In the bionic study, dynamic soaring has a great potential to enhance Unmanned Aerial Vehicles (UAVs) flight range and endurance. The previous study on dynamic soaring mainly focused on the energy harvesting mechanism, trajectory optimization, and flight test. However, the longtime optimization became the challenge of the UAV dynamic soaring application. Similarly, due to the difficulty of the dynamic soaring test flight, both the feasibility of dynamic soaring application and the energy harvesting mechanism model’s accuracy lack validation. This paper proposes a new method to give a dynamic soaring trajectory, and a flight simulation program is built to realize the dynamic soaring flight test. The results show that the new method can guide the UAV to achieve dynamic soaring and verify the improvement of its flight performance through dynamic soaring. Meanwhile, the accuracy of the energy harvesting mechanism model is verified. The results indicate the indirect way to achieve the UAV dynamic soaring and provide a flight test foundation for a profound dynamic soaring mechanism study. Full article

Albatrosses are among the most threatened seabird species. Often entangled in gillnets or hooked while longline fishing gear is being set, albatrosses are affected by fishing. This is assumed to be especially true in cases where illegal longline fishing vessels are involved, as they are less likely to implement the bycatch mitigation measures implemented to reduce the risk of albatrosses being caught on their hooks. This is the assumption that was tested in the current study, which uses environmental criminology as its guiding theoretical framework. Using the spatial units of one-half-degree by one-half-degree longitude/latitude cells, this research examined the patterns of concentration of potentially illegal longlining efforts and their relationships to commercially sought-out and illegally caught (i.e., CRAAVED—concealable, removable, abundant, accessible, valuable, enjoyable, disposable) fish species concentrations, as well as their effects on the average risk of albatrosses. The results indicated that (a) potentially illegal longlining activity is spatially concentrated; (b) this concentration is exhibited in areas with the highest concentrations of the presence of CRAAVED fish; and (c) the average risk score of albatrosses, as measured by their International Union for Conservation of Nature (IUCN) Red List status, is significantly higher in the areas where illegal longlining vessels are found controlling for the activities of legal longlining vessels. These findings provide strong grounding that illegal longline fishing poses a particularly serious threat to the survival of albatrosses. These activities, however, are not randomly spread across the vast oceans, but rather are highly spatially concentrated. Therefore, the bird conservation lobby should work closely with regional fisheries management organizations to devise and implement targeted interventions aimed at reducing potential illegal longline fishing, which, in turn, will likely have positive effects on albatrosses. Full article

Avipoxviruses have been characterized from many avian species. Two recent studies have reported avipoxvirus-like viruses with varying pathogenicity in reptiles. Avipoxviruses are considered to be restricted to avian hosts. However, reports of avipoxvirus-like viruses from reptiles such as the green sea turtle (Chelonia mydas) and crocodile tegu (Crocodilurus amazonicus) suggest that cross-species transmission, within avian species and beyond, may be possible. Here we report evidence for a possible host switching event with a fowlpox-like virus recovered from an endangered northern royal albatross (Diomodea sanfordi)—a species of Procellariiformes, unrelated to Galliformes, not previously known to have been infected with fowlpox-like viruses. Complete genome sequencing of this virus, tentatively designated albatrosspox virus 2 (ALPV2), contained many fowlpox virus-like genes, but also 63 unique genes that are not reported in any other poxvirus. The ALPV2 genome contained 296 predicted genes homologous to different avipoxviruses, 260 of which were homologous to an American strain of fowlpox virus (FWPV). Subsequent phylogenetic analyses indicate that ALPV2 likely originated from a fowlpox virus-like progenitor. These findings highlight the importance of host-switching events where viruses cross species barriers with the risk of disease in close and distantly related host populations. Full article

Marine bird populations have been declining globally with the factors driving this decline not fully understood. Viral diseases, including those caused by poxviruses, are a concern for endangered seabird species. In this study we have characterised a novel avipoxvirus, tentatively designated albatrosspox virus (ALPV), isolated from a skin lesion of an endangered New Zealand northern royal albatross (Diomedea sanfordi). The ALPV genome was 351.9 kbp in length and contained 336 predicted genes, seven of which were determined to be unique. The highest number of genes (313) in the ALPV genome were homologs of those in shearwaterpox virus 2 (SWPV2), while a further 10 were homologs to canarypox virus (CNPV) and an additional six to shearwaterpox virus 1 (SWPV1). Phylogenetic analyses positioned the ALPV genome within a distinct subclade comprising recently isolated avipoxvirus genome sequences from shearwater, penguin and passerine bird species. This is the first reported genome sequence of ALPV from a northern royal albatross and will help to track the evolution of avipoxvirus infections in this endangered species. Full article

This dataset contains 4-millisecond snapshots of the GPS radio spectrum stored by wildlife tracking tags deployed on adult Southern Royal Albatross (Diomedea epomophora) in New Zealand. Approximately 60,000 snapshots were recovered from nine birds over two southern-hemisphere summers in 2012 and 2013. The data can be post-processed using snapshot positioning algorithms, and are made available as a test dataset for further development of these algorithms. Included are post-processed position estimates for reference, as well as test data from stationary tags positioned under various test conditions for the purposes of characterizing tag performance. Full article

This review aimed to investigate the efficacy of integrative medicine (herbal medicine combined with drug therapy) in the treatment of Behcet’s disease (BD). Eleven databases were searched from their inception to 7 December 2020, for randomized control trials (RCTs) that reported the effects of integrative medicine in treating BD. The risk of bias was assessed using seven domain criteria from the Cochrane Collaboration tool. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the quality of evidence. The direction of the effect is also shown in the form of an albatross plot. Sixteen trials met the inclusion criteria and were analyzed. The overall risk of bias was determined to be uncertain. The meta-analysis showed a superior response rate with herbal medicine plus drug therapy (relative risk (RR) 1.19, 95% confidence interval (CI) 1.13 to 1.25, n = 1034, p < 0.00001, I² = 0%, low certainty of evidence (CoE)) compared to drug therapy. Integrative medicine also lowered the recurrence rate after 2 months of follow-up (RR 0.27, 95% CI 0.09 to 0.76, n = 120, p = 0.01, I² = 0%, low CoE). The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, and skin lesions were also significantly improved using integrative medicine, but equivalent effects were seen for oral ulcers, genital ulcers, and eye inflammation. Minor adverse events were reported in both groups. Our findings suggest that herbal medicine combined with drug therapy is more effective for the treatment of BD than drug therapy alone. Although the type of drug therapy used varied across the studies, integrative medicine was shown to improve the total response rate, skin lesions, the ESR, and the CRP level. However, the overall risk of bias of the studies was concerning, and the CoE was low. Information on adverse events (AEs) was also insufficient. In addition, the number of studies included for data synthesis for most outcomes was small. Future studies with rigorous RCTs may help establish the efficacy of integrative medicine in the treatment of BD. Full article